{"id":197594,"date":"2020-03-17T06:43:16","date_gmt":"2020-03-16T22:43:16","guid":{"rendered":"\/\/m.iemloyee.com\/?p=197594"},"modified":"2020-03-16T22:12:28","modified_gmt":"2020-03-16T14:12:28","slug":"%e4%b8%ad%e5%9b%bd%e8%8d%af%e5%a4%a7%e5%a7%9a%e9%9d%99nano-lett-%ef%bc%9a%e5%8f%af%e7%a8%8b%e5%ba%8f%e5%8c%96%e6%94%b9%e5%96%84%e8%82%bf%e7%98%a4%e8%8d%af%e7%89%a9%e9%80%92%e9%80%81%e7%9a%84%e7%b1%bb","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=197594","title":{"rendered":"\u4e2d\u56fd\u836f\u5927\u59da\u9759Nano Lett.\uff1a\u53ef\u7a0b\u5e8f\u5316\u6539\u5584\u80bf\u7624\u836f\u7269\u9012\u9001\u7684\u7c7b\u86cb\u767d\u8d28\u7eb3\u7c73\u8f6c\u5316\u5668"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u7eb3\u7c73\u836f\u7269\u7531\u4e8e\u5176\u66f4\u597d\u7684\u836f\u7269\u4f20\u9012\u80fd\u529b\uff0c\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u663e\u793a\u51fa\u5353\u8d8a\u7684\u4f18\u52bf\u3002\u7136\u800c\uff0c\u836f\u7269\u8f6c\u8fd0\u7684\u751f\u7269\u969c\u788d\uff0c\u5305\u62ec\u7f51\u72b6\u5185\u76ae\u7cfb\u7edf\uff08RES\uff09\u7684\u6d88\u9664\u3001\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u6548\u7387\u4f4e\u3001\u6eb6\u9176\u4f53\u836f\u7269\u5931\u6d3b\u3001\u80bf\u7624\u7ec6\u80de\u6709\u6548\u8f7d\u8377\u91ca\u653e\u65e0\u6548\u4ee5\u53ca\u80bf\u7624\u7a7f\u900f\u529b\u51cf\u5f31\uff0c\u963b\u788d\u4e86\u7eb3\u7c73\u836f\u7269\u7684\u6210\u529f\u6cbb\u7597\u3002\u4ee5\u5f80\u7684\u7814\u7a76\u8868\u660e\uff0c\u4eb2\u6c34\u6027\u9897\u7c92\u8868\u9762\u6709\u5229\u4e8e\u5ef6\u957f\u8840\u6db2\u5faa\u73af\u548c\u6709\u6548\u7684\u7ec6\u80de\u5185\u836f\u7269\u91ca\u653e\uff0c\u800c\u758f\u6c34\u6027\u9897\u7c92\u8868\u9762\u66f4\u6709\u5229\u4e8e\u80bf\u7624\u7ec6\u80de\u7684\u6709\u6548\u5185\u541e\u3002\u6b64\u5916\uff0c\u8d85\u5927\u5c3a\u5bf8\u7684\u7eb3\u7c73\u836f\u7269\u901a\u8fc7\u673a\u68b0\u7834\u574f\u6eb6\u9176\u4f53\u819c\u5bb9\u6613\u4ece\u6eb6\u9176\u4f53\u9003\u9038\uff0c\u800c\u5c0f\u5c3a\u5bf8\u7684\u7eb3\u7c73\u836f\u7269\u53ef\u4ee5\u6709\u6548\u5730\u5c06\u836f\u7269\u8f93\u9001\u5230\u80bf\u7624\u7ec6\u80de\u6df1\u5c42\uff0c\u5e76\u5728\u7ec6\u80de\u8d28\u4e2d\u8fc5\u901f\u91ca\u653e\u3002\u663e\u7136\uff0c\u4e3a\u4e86\u6ee1\u8db3\u6240\u6709\u8fd9\u4e9b\u77db\u76fe\u548c\u590d\u6742\u7684\u8981\u6c42\uff0c\u4ee5\u76f8\u7ee7\u514b\u670d\u4e0a\u8ff0\u6bcf\u4e00\u79cd\u751f\u7269\u5c4f\u969c\uff0c\u7eb3\u7c73\u836f\u7269\u9700\u8981\u901a\u8fc7\u6539\u53d8\u5176\u7269\u7406\u6216\u8868\u9762\u6027\u8d28\uff08\u5982\u53d8\u5f62\u91d1\u521a\uff09\u6765\u4fdd\u6301\u5bf9\u4e0d\u540c\u4f53\u5185\u751f\u7269\u73af\u5883\u7684\u5feb\u901f\u53cd\u5e94\u3002\u5c3d\u7ba1\u4e00\u4e9b\u523a\u6fc0\u53cd\u5e94\u6216\u6d3b\u6027\u9776\u5411\u7eb3\u7c73\u836f\u7269\u514b\u670d\u4e86\u4e0a\u8ff0\u4e00\u5230\u4e24\u4e2a\u836f\u7269\u4f20\u9012\u96be\u9898\uff0c\u5305\u62ec\u590d\u6742\u7684\u7eb3\u7c73\u6750\u6599\u5408\u6210\u548c\u5ef6\u8fdf\u7684\u523a\u6fc0\u53cd\u5e94\u5316\u5b66\u53cd\u5e94\uff08\u9700\u8981\u51e0\u4e2a\u5c0f\u65f6\u624d\u80fd\u53bb\u9664\u5916\u5c42\uff09\u7b49\u95ee\u9898\u9650\u5236\u4e86\u5168\u529f\u80fd\u7eb3\u7c73\u836f\u7269\u7684\u5f00\u53d1\u53ca\u5176\u4e34\u5e8a\u8f6c\u5316\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u59da\u9759\u6559\u6388<\/strong>\u901a\u8fc7\u7ec4\u88c5\u963f\u9709\u7d20\u3001\u5355\u5b81\u9178\u548c\u5432\u54da\u83c1\u7eff\u6765\u5236\u5907\u7eb3\u7c73\u8f6c\u6362\u5668\uff08DTIG\uff09\uff0c\u4ee5\u514b\u670d\u8fd9\u4e00\u96be\u9898\u3002\u4eb2\u6c34\u6027DTIG\u53ef\u5ef6\u957f\u8840\u6db2\u5faa\u73af\u65f6\u95f4\uff0c\u6b64\u5916\u8fd8\u5728\u9178\u6027\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8f6c\u5316\u4e3a\u758f\u6c34\u6027\u9897\u7c92\uff0c\u88ab\u80bf\u7624\u7ec6\u80de\u6709\u6548\u5185\u5316\u3002\u968f\u540e\uff0c\u5728\u9178\u6027\u6eb6\u9176\u4f53\u4e2d\u8fdb\u4e00\u6b65\u5f62\u6210\u8fc7\u5927\u7684\u758f\u6c34\u9897\u7c92\uff0c\u901a\u8fc7\u7834\u88c2\u6eb6\u9176\u4f53\u9003\u9038\u3002\u8fd9\u4e9b\u758f\u6c34\u6027DTIGs\u80fd\u8fc5\u901f\u56de\u590d\u5230\u8f83\u5c0f\u7684\u4eb2\u6c34\u6027\u7eb3\u7c73\u7ec4\u88c5\u4f53\uff0c\u5e76\u5728\u7ec6\u80de\u8d28\u4e2d\u91ca\u653e\u6709\u6548\u8f7d\u8377\u3002\u7531\u4e8e\u8d28\u5b50\u7684\u4f5c\u7528\uff0c\u8fd9\u4e9b\u8f6c\u5316\u5177\u6709\u7c7b\u4f3c\u4e8e\u86cb\u767d\u8d28\u7684\u53d8\u6027\u548c\u590d\u6027\u3002\u6b64\u5916\uff0cDTIG\u5149\u70ed\u7597\u6cd5\u53ef\u63d0\u9ad8\u836f\u7269\u5728\u80bf\u7624\u4e2d\u7684\u6e17\u900f\u6548\u7387\u3002\u8fd9\u79cd\u4f18\u5316\u7684DTIG\u7ed9\u836f\u5de5\u827a\u6700\u7ec8\u63d0\u4f9b\u4e86\u6709\u6548\u7684\u6297\u80bf\u7624\u7597\u6548\u548c\u660e\u663e\u7684\u9884\u540e\u4f18\u52bf\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cTransforming Complexity to Simplicity: Protein-Like Nanotransformer for Improving Tumor Drug Delivery Programmatically<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aNano Letters<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001<\/strong>DTIG<\/strong>\u7684\u5206\u5b50\u81ea\u7ec4\u88c5\u3001\u8f6c\u53d8\u53ca\u6cbb\u7597\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5206\u6b65\u7ec4\u88c5\u8fc7\u7a0b\u548c\u9178\u6027\u73af\u5883\u8bf1\u5bfcDTIG\u7684\u91cd\u7ec4\u8fc7\u7a0b\u3002<\/p>\n

\uff08b\uff09DTIG\u7684\u80bf\u7624\u4f20\u9012\u548c\u80bf\u7624\u7ec6\u80de\u6444\u53d6\u3002<\/p>\n

\uff08c\uff09DTIG\u7684\u7ec6\u80de\u5185\u8f6c\u79fb\u3001\u6eb6\u9176\u4f53\u9003\u9038\u548c\u6fc0\u5149\u4fc3\u8fdb\u836f\u7269\u91ca\u653e\u8fc7\u7a0b\u3002<\/p>\n

\uff08d\uff09\u5149\u70ed\uff08PT\uff09\u4f5c\u7528\u5f15\u8d77\u7684\u80bf\u7624\u6e17\u900f\u3002<\/p>\n

\u56fe\u4e8c\u3001<\/strong>DTIG<\/strong>\u7684\u8868\u5f81\u548c\u81ea\u7ec4\u88c5\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09DTIG\u7684TEM\u56fe\u50cf\u3002<\/p>\n

\uff08b\uff09DTIG\u7684AFM\u56fe\u50cf\u3002<\/p>\n

\uff08c\uff09DOX\uff0cTA\uff0cICG\uff0cDT\u548cDTIG\u7684\u7ea2\u5916\u5149\u8c31\u3002<\/p>\n

\uff08d\uff09DT\u7684\u7ec4\u88c5\u673a\u5236\uff0c\u5305\u62ec \u03c0\u2212\u03c0\u4f5c\u7528\u548c\u7535\u5b50\u76f8\u4e92\u4f5c\u7528\u3002<\/p>\n

\uff08e\uff09DOX\u3001TA\u3001ICG\u3001DT\u548cDTIG\u7684\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\uff08f\uff09DOX\uff0cTA\uff0cICG\uff0cDT\u548cDTIG\u7684\u7d2b\u5916\u5149\u8c31\u3002<\/p>\n

\uff08g\uff09DTIG\u7684\u7ec4\u88c5\u673a\u5236\u3002<\/p>\n

\uff08h\uff09DT\u548cDTIG\u7684\u5e26\u9699\u5206\u6790\u3002<\/p>\n

\uff08i\uff09\u5229\u7528Amber\u8f6f\u4ef6\u5bf9DOX\u5206\u5b50\u3001TA\u548cICG\u7684\u7ec4\u88c5\u6a21\u62df\u3002<\/p>\n

\u56fe\u4e09\u3001<\/strong>DTIG<\/strong>\u7684\u8d28\u5b50\u89e6\u53d1\u8f6c\u53d8\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09DTIG\u5728\u4e0d\u540c\u73af\u5883\u4e2d\u7684\u5c3a\u5bf8\u53d8\u5316\u3002\u63d2\u56fe\u4e3a\u4e0d\u540cDTIG\u7167\u7247\u3002<\/p>\n

\uff08b\uff09rDTIG\u548cDTIG\u5728pH 6.5\u548cpH 4.5 PBS\u4e2d\u7684TEM\u56fe\u50cf\u3002<\/p>\n

\uff08c\uff09rDTIG\u548cDTIG\u5728pH 6.5\u548cpH 4.5 PBS\u4e2d\u7684AFM\u56fe\u50cf\u3002<\/p>\n

\uff08d\uff09DTIG\u3001DT\u3001DOX\u3001TA\u548cICG\u5728pH 6.5 PBS\u4e2d\u7684\u7d2b\u5916\u5149\u8c31\u3002<\/p>\n

\uff08e\uff09DTIG\u3001DT\u3001DOX\u3001TA\u548cICG\u5728pH 4.5 PBS\u4e2d\u7684\u7d2b\u5916\u5149\u8c31\u3002<\/p>\n

\uff08f\uff09DTIG\u548cDTIG-pH 4.5\u7684XRD\u8c31\u56fe\u3002<\/p>\n

\uff08g\uff09DTIG\u5728pH 4.5 PBS\uff08DTIG-pH4.5\uff09\u548crDTIG\u4e2d\u7684\u7d2b\u5916\u5149\u8c31\u3002<\/p>\n

\uff08h\uff09DTIG\u5904\u7406MCF7\u7ec6\u80de0.5\u30011.5\u548c4h\u540e\u7684TEM\u56fe\u50cf\u3002<\/p>\n

\uff08i\uff09\u5728\u6709\u65e0\u6fc0\u5149\u7167\u5c04\uff08808nm\uff0c1.6w cm-2<\/sup>\uff0c5min\uff09\u6761\u4ef6\u4e0b\uff0c\u4e0d\u540cpH\u503cPBS\u4e2dDTIG\u7684DOX\u91ca\u653e\u3002<\/p>\n

\uff08j\uff09\u5728\u6709\u65e0\u6fc0\u5149\u7167\u5c04\uff08808nm\uff0c1.6w cm-2<\/sup>\uff0c5min\uff09\u6761\u4ef6\u4e0b\uff0c\u4e0d\u540cpH\u503cPBS\u4e2dDTIG\u7684ICG\u91ca\u653e\u3002<\/p>\n

\uff08k\uff09\u5728\u6709\u65e0\u6fc0\u5149\u7167\u5c04\uff08808nm\uff0c1.6w cm-2<\/sup>\uff0c5min\uff09\u6761\u4ef6\u4e0b\uff0crDTIG\u7684DOX\u91ca\u653e\u3002<\/p>\n

\uff08l\uff09\u5728\u6709\u65e0\u6fc0\u5149\u7167\u5c04\uff08808nm\uff0c1.6w cm-2<\/sup>\uff0c5min\uff09\u6761\u4ef6\u4e0b\uff0crDTIG\u7684ICG\u91ca\u653e\u3002<\/p>\n

\uff08m\uff09\u5728\u6709\u65e0\u6fc0\u5149\u7167\u5c04\uff08808nm\uff0c1.6w cm-2<\/sup>\uff0c5min\uff09\u6761\u4ef6\u4e0b\uff0cDTIG\u5728MCF7\u7ec6\u80de\u4e2d\u7684\u836f\u7269\u91ca\u653e\u3002<\/p>\n

\u56fe\u56db\u3001<\/strong>DTIG<\/strong>\u7684\u7ec6\u80de\u6444\u53d6\u3001\u7ec6\u80de\u6bd2\u6027\u3001\u6eb6\u9176\u4f53\u9003\u9038\u548c\u80bf\u7624\u7a7f\u900f\u5b9e\u9a8c<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u4e0d\u540cpH\u4e0bDTIG\u548cLIBOd\u7684\u7ec6\u80de\u6444\u53d6\u3002<\/p>\n

\uff08b\uff09DTIG\u5728MCF7\u7ec6\u80de\u4e2d\u7684\u6eb6\u9176\u4f53\u9003\u9038\u884c\u4e3a\u3002<\/p>\n

\uff08c\uff09DTIG+\u6fc0\u5149\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\uff08d\uff09CompuSyn\u5206\u6790\u5f97\u5230\u7684DOX\u4e0eICG+\u6fc0\u5149\u8054\u5408\u6cbb\u7597\u7684CI\u56fe\u3002<\/p>\n

\uff08e\uff09\u7528MTS\u89c2\u5bdfDOX\u3001DTIG\u548cDTIG+\u6fc0\u5149\u7684\u7a7f\u900f\u6548\u5e94\u3002<\/p>\n

\uff08f\uff09\u7528DTIG\u3001DTIG+\u6fc0\u5149\u548cLIBOd\u6cbb\u759724\u5c0f\u65f6\u7684\u5c0f\u9f20\u80bf\u7624\u7684CLSM\uff0cCD31\uff08\u7eff\u8272\uff09\u6807\u8bb0\u80bf\u7624\u8840\u7ba1\u90e8\u4f4d\u3002<\/p>\n

\u56fe\u4e94\u3001<\/strong>DTIG<\/strong>\u7684\u4f53\u5185\u80bf\u7624\u5206\u5e03\u3001\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u6297\u80bf\u7624\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09MCF7\u8377\u7624\u5c0f\u9f20\u9759\u8109\u6ce8\u5c04DTIG\u548c\u6e38\u79bbICG\u540e6\u300124\u300148h\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf\u3002<\/p>\n

\uff08b\uff09DTIG\u548cDOX\u7684\u836f\u7269\u6d53\u5ea6-\u65f6\u95f4\u66f2\u7ebf\u3002<\/p>\n

\uff08c\uff09\u4e0d\u540c\u5b9e\u9a8c\u7ec4\u7684MCF7\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

\uff08d\uff09\u6cbb\u7597\u8fc7\u7a0b\u4e2d\u5404\u7ec4\u80bf\u7624\u751f\u957f\u901f\u5ea6\u3002<\/p>\n

\uff08e\uff09MCF7\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u5265\u8131\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u68c0\u6d4b\u3002<\/p>\n

\uff08f\uff09\u7528TUNEL\u6cd5\u68c0\u6d4bMCF7\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u3002<\/p>\n

\uff08g\uff09Ki67\u6cd5\u68c0\u6d4bMCF7\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u3002<\/p>\n

\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aTransforming Complexity to Simplicity: Protein-Like Nanotransformer for Improving Tumor Drug Delivery Programmatically<\/a>\u00a0(Nano Letters<\/i>, 2020<\/strong>, DOI: 10.1021\/acs.nanolett.9b05008<\/span>)<\/p>\n

\u8bfe\u9898\u7ec4\u7b80\u4ecb\uff1a<\/strong><\/p>\n

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