{"id":196614,"date":"2020-02-27T06:11:53","date_gmt":"2020-02-26T22:11:53","guid":{"rendered":"\/\/m.iemloyee.com\/?p=196614"},"modified":"2020-02-26T20:12:26","modified_gmt":"2020-02-26T12:12:26","slug":"nature-nanotechnol-%ef%bc%9a%e7%94%a8%e4%ba%8e%e7%9b%91%e6%b5%8b%e8%84%91%e9%83%a8%e7%bb%86%e8%83%9e%e5%a4%96k%e5%90%ab%e9%87%8f%e7%9a%84%e8%b6%85%e7%81%b5%e6%95%8f%e6%8e%a2%e9%92%88","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=196614","title":{"rendered":"Nature Nanotechnol.\uff1a\u7528\u4e8e\u76d1\u6d4b\u8111\u90e8\u7ec6\u80de\u5916K+\u542b\u91cf\u7684\u8d85\u7075\u654f\u63a2\u9488"},"content":{"rendered":"<p>\u3010\u5f15\u8a00\u3011<\/p>\n<p>\u7ec6\u80de\u5916\u94be\u79bb\u5b50\u6d53\u5ea6([K<sup>+<\/sup>]<sub>o<\/sub>)\u53d8\u5316\u4f1a\u5f71\u54cd\u795e\u7ecf\u5143\u7684\u819c\u7535\u4f4d\uff0c\u4ece\u800c\u5f71\u54cd\u795e\u7ecf\u5143\u6d3b\u6027\u3002\u540c\u65f6\uff0c[K<sup>+<\/sup>]<sub>o<\/sub>\u7684\u6539\u53d8\u53ef\u80fd\u4e0e\u795e\u7ecf\u7cfb\u7edf\u75be\u75c5\u6709\u5173\uff0c\u4f8b\u5982\u766b\u75eb\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u6c0f\u75c7\u7b49\uff0c\u56e0\u6b64\uff0c\u9009\u62e9\u6027\u68c0\u6d4b[K<sup>+<\/sup>]<sub>o<\/sub>\u53ef\u4ee5\u76d1\u6d4b\u75be\u75c5\u3002\u4f46\u662f\uff0c\u73b0\u6709\u7684\u63a2\u9488\u6280\u672f\u4e0d\u80fd\u68c0\u6d4b[K<sup>+<\/sup>]<sub>o<\/sub>\u7684\u5fae\u5c0f\u53d8\u5316\uff0c\u7279\u522b\u662f\u5728\u81ea\u7531\u79fb\u52a8\u7684\u52a8\u7269\u4e2d\u3002\u6b64\u5916\uff0c\u5b83\u4eec\u5bb9\u6613\u53d7\u5230\u94a0\u79bb\u5b50\u7684\u5e72\u6270\u3002\u5728\u8fd9\u91cc\uff0c\u6211\u4eec\u62a5\u544a\u4e86\u4e00\u79cd\u8d85\u7075\u654fK<sup>+<\/sup>\u63a2\u9488\uff0c\u901a\u8fc7\u914d\u4f53\u8868\u754c\u9762\u81ea\u7ec4\u88c5\u65b9\u6cd5\uff0c\u5c06\u201c\u4e09\u811a\u67b6\u201d\u914d\u4f53\u5728\u8d1f\u8f7d\u6709\u8367\u5149\u67d3\u6599\u7684\u4ecb\u5b54\u7845\u7eb3\u7c73\u7c92\u8868\u9762\u81ea\u7ec4\u88c5\u5f62\u6210\u53ef\u4ee5\u7b5b\u9009\u51fa\u76ee\u6807\u79bb\u5b50\u7684\u8584\u819c\uff0c\u4ece\u800c\u8d4b\u4e88\u8be5\u63a2\u9488\u9ad8\u7075\u654f\u6027\u548c\u9ad8\u7279\u5f02\u6027\uff0c\u5b9e\u73b0\u766b\u75eb\u53d1\u4f5c\u7684\u81ea\u7531\u79fb\u52a8\u5c0f\u9f20\u5927\u8111\u4e2d[K<sup>+<\/sup>]<sub>o<\/sub>\u53d8\u5316\u7684\u52a8\u6001\u76d1\u6d4b\u3002<\/p>\n<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u6d59\u6c5f\u5927\u5b66<\/strong>\u7684<strong>\u51cc\u4ee3\u821c<\/strong>\u6559\u6388\u3001<strong>\u9648\u5fe0<\/strong>\u6559\u6388\u4ee5\u53ca<strong>\u9996\u5c14\u5927\u5b66<\/strong>\u7684<strong>Taeghwan Hyeon<\/strong>\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\uff09\u5728<strong>Nature Nanotechnology<\/strong>\u4e0a\u53d1\u8868\u4e86\u4e00\u7bc7\u9898\u4e3a\u201c<strong>A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain<\/strong>\u201d\u7684\u6587\u7ae0\u3002\u8fd9\u9879\u5de5\u4f5c\u62a5\u544a\u4e86\u4e00\u79cd\u901a\u8fc7\u914d\u4f53\u8868\u754c\u9762\u81ea\u7ec4\u88c5\u5236\u5907\u8d85\u7075\u654f\u63a2\u9488\u7684\u65b9\u6cd5\uff0c\u8be5\u79bb\u5b50\u63a2\u9488\u53ef\u4ee5\u76d1\u6d4b\u81ea\u7531\u79fb\u52a8\u5c0f\u9f20\u5927\u8111\u4e2d\u7ec6\u80de\u5916\u79bb\u5b50\u7684\u52a8\u6001\u53d8\u5316\u3002\u7814\u7a76\u56e2\u961f\u901a\u8fc7\u5408\u6210\u4e09\u7ef4\u7684\u201c\u4e09\u811a\u67b6\u201d\u914d\u4f53\uff0c\u4f7f\u5176\u5728\u8d1f\u8f7d\u6709\u8367\u5149\u67d3\u6599\u7684\u4ecb\u5b54\u7845\u7eb3\u7c73\u7c92\u8868\u9762\u81ea\u7ec4\u88c5\u5f62\u6210\u5bf9\u4e0d\u540c\u79bb\u5b50\u5177\u6709\u9009\u62e9\u6027\u7684\u8584\u819c\uff0c\u5236\u5907\u5f97\u5230\u65b0\u578b\u79bb\u5b50\u63a2\u9488\u3002\u5176\u4e2d\uff0c\u5229\u7528K<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u5b54\u4e2d\u5b58\u5728\u7684\u516d\u4e2a\u7fb0\u57fa\u6c27\u539f\u5b50\u53ca\u5b54\u5f84\u4e0eK-O\u952e\u952e\u957f\u76f8\u8fd1\u7684\u7279\u5f81\uff0c\u5b9e\u73b0\u4e86\u5bf9K<sup>+<\/sup>\u7684\u7279\u5f02\u6027\u7b5b\u9009\uff0c\u968f\u4e4b\u6355\u83b7\u5230\u7684K<sup>+<\/sup>\u5728\u4ecb\u5b54\u7845\u7eb3\u7c73\u7c92\u5b54\u9053\u5185\u5bcc\u96c6\uff0c\u589e\u5f3a\u4e86\u8be5\u63a2\u9488\u68c0\u6d4bK<sup>+<\/sup>\u7684\u7075\u654f\u5ea6\u3002\u57fa\u4e8e\u8be5\u63a2\u9488\uff0c\u9996\u6b21\u5728\u81ea\u7531\u6d3b\u52a8\u7684\u751f\u547d\u4f53\u4e2d\u5b9e\u73b0\u4e86\u975e\u4fb5\u5165\u6027\u7684\u5b9e\u65f6\u52a8\u6001\u7684\u8111\u90e8\u795e\u7ecf\u6d3b\u52a8\u76d1\u6d4b\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>1 K<sup>+<\/sup><\/strong><strong>\u63a2\u9488\u7684\u539f\u5b50\u7ea7\u8bbe\u8ba1\u548c\u6027\u80fd\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-196615 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/1-2.png\" alt=\"\" width=\"600\" height=\"558\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/1-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/1-2-300x279.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff0cK<sup>+<\/sup>\u63a2\u9488\u7684\u8bbe\u8ba1\u793a\u610f\u56fe\u3002K<sup>+<\/sup>\u6307\u793a\u5242\u8f7d\u5165MSN\u4e2d\u3002MSN\u8868\u9762\u7684K<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u4ec5\u5141\u8bb8K<sup>+<\/sup>\u8fdb\u5165\uff1b<\/p>\n<p>b\uff0cK<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u4e2d\u201c\u4e09\u811a\u67b6\u201d\u914d\u4f53\u7684\u5316\u5b66\u7ed3\u6784\u793a\u610f\u56fe\uff1b<\/p>\n<p>c\uff0c\u6355\u83b7K<sup>+<\/sup>\u540e\uff0cK<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u7684\u5316\u5b66\u7ed3\u6784\u793a\u610f\u56fe\uff1aK\u539f\u5b50\uff0c\u7ea2\u8272\uff1bC\u539f\u5b50\uff0c\u7070\u8272\uff1bO\u539f\u5b50\uff0c\u7eff\u8272\uff1bN\u539f\u5b50\uff0c\u84dd\u8272\uff1b<\/p>\n<p>d\uff0cK<sup>+<\/sup>\u63a2\u9488\u7684TEM\u56fe\uff1b<\/p>\n<p>e\uff0c\u6cbfd\u4e2d\u767d\u7ebf\u7684EDS\u5143\u7d20\u7ebf\u626b\u63cf\u63ed\u793a\u4e86\u5143\u7d20\u5206\u5e03\u5e76\u8bc1\u5b9e\u4e86K<sup>+<\/sup>\u63a2\u9488\u7684\u7ed3\u6784\uff1b<\/p>\n<p>f\uff0c\u8be5\u56fe\u663e\u793a\u4e86K<sup>+<\/sup>\u63a2\u9488\u5728\u4e2d\u6027\u73af\u5883\u4e0b\u5bf9150 mM [K<sup>+<\/sup>]\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u3002\u7136\u800c\uff0c\u5728\u9178\u6027\u6216\u78b1\u6027\u73af\u5883\u4e2d\u89c2\u5bdf\u5230\u8367\u5149\u5f3a\u5ea6\u7565\u6709\u4e0b\u964d\u3002\u6dfb\u52a0\u5176\u4ed6\u751f\u7406\u9633\u79bb\u5b50\u540e\uff0c\u8367\u5149\u5f3a\u5ea6\u6ca1\u6709\u660e\u663e\u53d8\u5316\u3002\u0394F\uff1d F-F<sub>0<\/sub>\uff0c\u5176\u4e2d\uff0cF\u662f\u7ed9\u5b9a\u79bb\u5b50\u6d53\u5ea6\u4e0b\u7684\u8367\u5149\u5f3a\u5ea6\uff0cF<sub>0<\/sub>\u662f0 mM [K<sup>+<\/sup>]\u4e0b\u7684\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n<p>g\uff0c[K<sup>+<\/sup>]\u4ece0\u589e\u52a0\u5230150 mM\u4ee5\u53ca\u4ece150\u51cf\u5c0f\u52300 mM\u65f6K<sup>+<\/sup>\u63a2\u9488\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\uff1b<\/p>\n<p>h\uff0c\u5728\u5bcc\u542bK<sup>+<\/sup>\uff08150 mM [K<sup>+<\/sup>]\uff09\u548c\u4e0d\u542bK<sup>+<\/sup>\uff080 mM [K<sup>+<\/sup>]\uff09\u7684\u6c34\u6eb6\u6db2\u4e2d\u5b75\u80b220\u4e2a\u5faa\u73af\u7684K<sup>+<\/sup>\u63a2\u9488\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\u3002\u5728\u8fbe\u5230\u5e73\u7a33\u4e4b\u524d\u7684\u524d\u516d\u4e2a\u5faa\u73af\u4e2d\uff0c\u6bcf\u6b21\u5faa\u73af\u8367\u5149\u5f3a\u5ea6\u7565\u6709\u51cf\u5c11\uff1b<\/p>\n<p>i\uff0c\u5728\u5bcc\u542bK<sup>+<\/sup>\u548c\u4e0d\u542bK<sup>+<\/sup>\u7684\u6c34\u6eb6\u6db2\u4e2d\u5b75\u80b2\u65f6\uff0cK<sup>+<\/sup>\u63a2\u9488\u8367\u5149\u5f3a\u5ea6\u968f\u65f6\u95f4\u7684\u53d8\u5316\u7ed3\u679c\u3002<\/p>\n<p><strong>\u56fe<\/strong><strong>2 K<sup>+<\/sup><\/strong><strong>\u63a2\u9488\u9ad8\u9009\u62e9\u6027\u548c\u9ad8\u7075\u654f\u5ea6\u7684\u673a\u7406\u7814\u7a76<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-196616 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/2-2.png\" alt=\"\" width=\"600\" height=\"623\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/2-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/2-2-289x300.png 289w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff0c\u5728\u53bb\u79bb\u5b50\u6c34\u4e2dK<sup>+<\/sup>\u548cNa<sup>+<\/sup>\u6c34\u5408\u5c42\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>b\uff0cc\uff0c\u5de6\u8fb9\uff0c\u5206\u6563\u5728\u542bK<sup>+<\/sup>\u548cNa<sup>+<\/sup>\u6eb6\u6db2\u4e2d\u7684\u672a\u8986\u76d6K<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u7684\u63a2\u9488\uff08b\uff09\u548cK<sup>+<\/sup>\u63a2\u9488\uff08c\uff09\u7684TEM\u56fe\u50cf\u3002\u53f3\u8fb9\uff0c\u6cbf\u7740TEM\u56fe\u50cf\u4e2d\u767d\u7ebf\u7684EDS\u5143\u7d20\u7ebf\u626b\u63cf\u7ed3\u679c\uff1b<\/p>\n<p>d\uff0c\u5728c\u4e2d\u7528\u767d\u8272\u865a\u7ebf\u6846\u6807\u51fa\u533a\u57df\u7684EDS\u5143\u7d20\u6620\u5c04\uff0c\u5982\u767d\u8272\u7bad\u5934\u6240\u793a\uff1b<\/p>\n<p>e\uff0cK<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u8154\u4e0eK<sup>+<\/sup>\/ Na<sup>+<\/sup>\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u793a\u610f\u56fe\uff1a\u9664\u53bb\u6c34\u5408\u5c42\u540e\uff0cK<sup>+<\/sup>\u4e0e\u5b54\u4e2d\u7684\u6c27\u539f\u5b50\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u5728\u80fd\u91cf\u4e0a\u6709\u5229\u4e8eK<sup>+<\/sup>\u7684\u901a\u8fc7\u3002\u4f46\u662f\uff0cNa<sup>+<\/sup>\u65e0\u6cd5\u4e0e\u5b54\u4e2d\u7684\u6c27\u539f\u5b50\u5145\u5206\u76f8\u4e92\u4f5c\u7528\uff0c\u8fd9\u5728\u80fd\u91cf\u4e0a\u4e0d\u5229\u4e8e\u7c92\u5f84\u8f83\u5c0f\u7684Na<sup>+<\/sup>\u7684\u901a\u8fc7\uff1b<\/p>\n<p>f\uff0cK<sup>+<\/sup>\/Na<sup>+<\/sup>\u901a\u8fc7K<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u65f6\uff0c\u8584\u819c\u4e0eK<sup>+<\/sup>\/Na<sup>+<\/sup>\u4e4b\u95f4\u7684\u7ed3\u5408\u80fd\u8ba1\u7b97\u7ed3\u679c\u3002<strong>\u00a0<\/strong><\/p>\n<p><strong>\u56fe<\/strong><strong>3 <\/strong><strong>\u57f9\u517b\u7684\u795e\u7ecf\u5143\u4e2d<\/strong><strong>K<sup>+<\/sup><\/strong><strong>\u91ca\u653e\u7684\u6210\u50cf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-196617 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/3-2.png\" alt=\"\" width=\"600\" height=\"529\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/3-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/3-2-300x265.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff0c\u5728aCSF\u4e2d\u5bf9\u836f\u7406\u8c03\u8282K<sup>+<\/sup>\u91ca\u653e\u7684\u6d77\u9a6c\u795e\u7ecf\u5143\u8fdb\u884c\u6210\u50cf\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u56fe\uff1b<\/p>\n<p>b\uff0c\u9996\u5148\u5c06\u57f9\u517b\u7684\u6d77\u9a6c\u795e\u7ecf\u5143\u4e0e\u5404\u79cd\u4f20\u611f\u5668\u9884\u5b75\u80b2\u3002\u66b4\u9732\u4e8eCoriaria\u5185\u916f\u540e\uff0cK<sup>+<\/sup>\u63a2\u9488\u7684\u8367\u5149\u5f3a\u5ea6\u589e\u52a0\uff0c\u800c\u672a\u8986\u76d6K<sup>+<\/sup>\u9009\u62e9\u6027\u8584\u819c\u7684\u63a2\u9488\u548c\u6e38\u79bb\u6307\u793a\u5242\u672a\u89c2\u5bdf\u5230\u663e\u8457\u53d8\u5316\uff1b<\/p>\n<p>c\uff0c\u5728\u901a\u8fc7\u5fae\u901a\u9053\u8fde\u63a5\u7684\u4e24\u5ba4\u5fae\u8154\u4e2d\u57f9\u517b\u7684\u88abK<sup>+<\/sup>\u63a2\u9488\u6807\u8bb0\u7684\u795e\u7ecf\u5143\u7684CLSM\u56fe\u50cf\uff0c\u80de\u4f53\u548c\u8f74\u7a81\u5206\u79bb\u5728\u4e24\u4e2a\u9694\u95f4\u4e2d\uff1b<\/p>\n<p>d\uff0c\u4ece\u5c0f\u9f20\u6d77\u9a6c\u4f53\u5904\u8bb0\u5f55\u7684EEG\u6570\u636e\uff0c\u865a\u7ebf\u6240\u793a\u8303\u56f4\u4e3a\u653e\u5927\u56fe\uff1b<\/p>\n<p>e\uff0c\u5728\u4e0e5 \u00b5M\u6d77\u85fb\u9178\u5b75\u80b2\u524d\u540e\uff0cc\u4e2d\u4e24\u4e2a\u9009\u5b9a\u533a\u57df\u7684\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\u7ed3\u679c\uff1b<\/p>\n<p>d\uff0c\u5f53\u6d77\u85fb\u9178\u7684\u6d53\u5ea6\u589e\u52a0\u81f310 \u00b5M\u65f6\uff0c\u8367\u5149\u5f3a\u5ea6\u53d8\u5316\u7ed3\u679c\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe<\/strong><strong>4\u00a0<\/strong><strong>\u5927\u8111\u5207\u7247\u4e2d<\/strong><strong>K<sup>+<\/sup><\/strong><strong>\u91ca\u653e\u7684\u6210\u50cf<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-196618 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/4-2.png\" alt=\"\" width=\"600\" height=\"437\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/4-2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/4-2-300x219.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff0c\u5bf9\u6025\u6027\u80cc\u4fa7\u7eb9\u72b6\u4f53\u8111\u5207\u7247\u4e2d\u7535\u523a\u6fc0\u8bf1\u53d1\u7684K<sup>+<\/sup>\u91ca\u653e\u8fdb\u884c\u6210\u50cf\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u56fe\uff1b<\/p>\n<p>b\uff0c\u5728\u4e0d\u540c\u5f3a\u5ea6\u7684\u7ed9\u5b9a\u7535\u8109\u51b2\u4e0b\u7ec6\u80de\u5916\u8367\u5149\u54cd\u5e94\u7ed3\u679c\uff08\u53f3\uff09\uff0c\u7ea2\u70b9\u8868\u793a\u4fe1\u53f7\u54cd\u5e94\uff08\u2206F\/F<sub>0<\/sub>\uff09\u5927\u4e8e5\uff05\u7684\u533a\u57df\uff1b<\/p>\n<p>c\uff0c\u5bf9b\u4e2d\u5cf0\u503c\u8367\u5149\u54cd\u5e94\u7684\u53d8\u5316\u8fdb\u884c\u91cf\u5316\uff0c\u7ed3\u679c\u8868\u660e\u53ea\u6709K<sup>+<\/sup>\u63a2\u9488\u80fd\u591f\u7075\u654f\u68c0\u6d4b\u5230\u7535\u523a\u6fc0\u8111\u5207\u7247\u4e2d\u7684[K<sup>+<\/sup>]<sub>o<\/sub>\u53d8\u5316\uff1b<\/p>\n<p>d\uff0c\u5e94\u7528K<sup>+<\/sup>\u63a2\u9488\u7684\u8111\u5207\u7247\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n<p>e\uff0c\u901a\u8fc7K<sup>+<\/sup>\u9009\u62e9\u6027\u5fae\u7535\u6781\uff08\u84dd\u7ebf\uff09\u548cK<sup>+<\/sup>\u63a2\u9488\u5149\u5b66\u6210\u50cf\uff08\u7ea2\u7ebf\uff09\u8bb0\u5f55\u4e86\u7535\u523a\u6fc0\u65f6\u8111\u5207\u7247\u4e2d\u7684[K<sup>+<\/sup>]<sub>o<\/sub>\u53d8\u5316\u3002<strong>\u00a0<\/strong><\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u56fe<\/strong><strong>5 <\/strong><strong>\u81ea\u7531\u79fb\u52a8\u5c0f\u9f20\u5927\u8111\u4e2d\u7684\u52a8\u6001<\/strong><strong>[K<sup>+<\/sup>]<sub>o<\/sub><\/strong><strong>\u6ce2\u52a8\u76d1\u6d4b<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-196619 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/5-1.png\" alt=\"\" width=\"600\" height=\"655\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/5-1.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/5-1-275x300.png 275w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a\uff0c\u76d1\u6d4b\u7535\u70b9\u71c3\u8bf1\u53d1\u7684\u766b\u75eb\u5c0f\u9f20\u6a21\u578b\u4e2d[K<sup>+<\/sup>]<sub>o<\/sub>\u52a8\u6001\u53d8\u5316\u7684\u4f53\u5185\u5b9e\u9a8c\u8bbe\u8ba1\u56fe\uff0c\u5176\u4e2d\u53cd\u590d\u7535\u523a\u6fc0\u4f1a\u589e\u52a0\u766b\u75eb\u53d1\u4f5c\u7684\u4e25\u91cd\u7a0b\u5ea6\uff1b<\/p>\n<p>b\uff0cc\uff0c\u540c\u65f6\u5bf9\u4e0d\u540c\u766b\u75eb\u53d1\u4f5c\u9636\u6bb5\uff08b\uff0c\u766b\u75eb\u53d1\u4f5c\u9636\u6bb53\uff1bc\uff0c\u766b\u75eb\u53d1\u4f5c\u9636\u6bb55\uff09\u7684\u5c0f\u9f20\u8fdb\u884c\u795e\u7ecf\u6d3b\u52a8\u8bb0\u5f55\u548c\u8367\u5149\u6210\u50cf\u3002\u9876\u90e8\uff0c\u766b\u75eb\u53d1\u4f5c\u65f6EEG\u6570\u636e\u53ca\u5176\u653e\u5927\u56fe\u3002\u4e2d\u95f4\uff0cEEG\u6570\u636e\u5bf9\u5e94\u7684\u80fd\u8c31\u3002\u5e95\u90e8\uff0cK<sup>+<\/sup>\u63a2\u9488\u5bf9\u7535\u70b9\u71c3\u8bf1\u53d1\u7684\u766b\u75eb\u53d1\u4f5c\u7684\u8367\u5149\u54cd\u5e94\uff1b<\/p>\n<p>d\uff0c\u81ea\u7531\u79fb\u52a8\u7684\u6b63\u5e38\u5c0f\u9f20\u6ce8\u5c04\u4e86K<sup>+<\/sup>\u63a2\u9488\u540e\uff0c\u6ca1\u6709\u8367\u5149\u53cd\u5e94\uff1b<\/p>\n<p>e\uff0c\u766b\u75eb\u5c0f\u9f20\uff08\u766b\u75eb\u53d1\u4f5c\u9636\u6bb55\uff09\u6ce8\u5c04\u4e86aCSF\u540e\uff0c\u6ca1\u6709\u8367\u5149\u53cd\u5e94\u3002\u9876\u90e8\uff0cEEG\u6570\u636e\u3002\u4e2d\u95f4\uff0cEEG\u6570\u636e\u5bf9\u5e94\u7684\u80fd\u8c31\u3002\u5e95\u90e8\uff0cK<sup>+<\/sup>\u63a2\u9488\u7684\u8367\u5149\u54cd\u5e94\uff1b<\/p>\n<p>f\uff0cg\uff0cK<sup>+<\/sup>\u63a2\u9488\u8367\u5149\u4fe1\u53f7\u7684\u632f\u5e45\uff08f\uff09\u548c\u6301\u7eed\u65f6\u95f4\uff08g\uff09\u7684\u53d8\u5316\u4e0e\u523a\u6fc0\u6b21\u6570\u4e4b\u95f4\u7684\u5173\u7cfb\uff1b<\/p>\n<p>h\uff0ci\uff0cK<sup>+<\/sup>\u63a2\u9488\u8367\u5149\u4fe1\u53f7\u7684\u632f\u5e45\uff08h\uff09\u548c\u6301\u7eed\u65f6\u95f4\uff08i\uff09\u7684\u766b\u75eb\u53d1\u4f5c\u9636\u6bb5\u4f9d\u8d56\u6027\u53d8\u5316\u3002<\/p>\n<p><strong>\u56fe<\/strong><strong>6 <\/strong><strong>\u81ea\u7531\u79fb\u52a8\u5c0f\u9f20\u7684\u8111\u90e8\u591a\u4f4d\u70b9<\/strong><strong>[K<sup>+<\/sup>]<sub>o<\/sub><\/strong><strong>\u76d1\u6d4b<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-196620 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/6-1.png\" alt=\"\" width=\"600\" height=\"514\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/6-1.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2020\/02\/6-1-300x257.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>a, \u5728\u7535\u70b9\u71c3\u8bf1\u53d1\u7684\u766b\u75eb\u5c0f\u9f20\u7684\u4e09\u4e2a\u4e0d\u540c\u8111\u533a\uff08\u6d77\u9a6c\u4f53\uff0c\u674f\u4ec1\u6838\u548c\u76ae\u8d28\uff09\u540c\u65f6\u8fdb\u884cEEG\u8bb0\u5f55\u548c\u5149\u5b66[K<sup>+<\/sup>]<sub>o<\/sub>\u52a8\u6001\u6210\u50cf\u7684\u5b9e\u9a8c\u8bbe\u8ba1\u56fe\uff1b<\/p>\n<p>b\uff0cc\uff0c\u6d77\u9a6c\u4f53\u7535\u70b9\u71c3\u523a\u6fc0\u5bfc\u81f4\u4e0d\u540c\u7a0b\u5ea6\u7684\u766b\u75eb\u6027\u53d1\u4f5c\u65f6\uff0c\uff08b\uff0c\u766b\u75eb\u53d1\u4f5c\u671f3\uff1b c\uff0c\u766b\u75eb\u53d1\u4f5c\u671f5\uff09\uff0cEEG\u7ed3\u679c\u548c\u8367\u5149\u6210\u50cf\u7ed3\u679c\u5747\u663e\u793a\u674f\u4ec1\u6838\u548c\u76ae\u5c42\u6709\u53cd\u5e94\u3002\u5de6\u56fe\u662f\u766b\u75eb\u53d1\u4f5c\u671f\u95f4\u7684\u6d77\u9a6c\u4f53\u3001\u674f\u4ec1\u6838\u548c\u76ae\u5c42\u4e2d\u8bb0\u5f55\u7684EEG\u6570\u636e\u53ca\u5176\u653e\u5927\u56fe\u3002\u4e2d\u95f4\uff0cEEG\u6570\u636e\u5bf9\u5e94\u7684\u80fd\u8c31\u3002\u53f3\u56fe\uff0c\u5728\u766b\u75eb\u53d1\u4f5c\u7684\u4e0d\u540c\u9636\u6bb5\uff0c\u4e09\u4e2a\u4e0d\u540c\u8111\u533a\u7684\u8367\u5149\u54cd\u5e94\uff1b<\/p>\n<p>d\uff0ce\uff0c\u5728\u5c0f\u9f20\u5927\u8111\u7684\u4e09\u4e2a\u4e0d\u540c\u533a\u57df\uff0cK<sup>+<\/sup>\u63a2\u9488\u8367\u5149\u4fe1\u53f7\u7684\u632f\u5e45\uff08d\uff09\u548c\u6301\u7eed\u65f6\u95f4\uff08e\uff09\u4e0e\u766b\u75eb\u53d1\u4f5c\u9636\u6bb5\u7684\u5173\u7cfb\u3002<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u7814\u7a76\u8868\u660e\uff0cK<sup>+<\/sup>\u63a2\u9488\u80fd\u591f\u76d1\u6d4b\u81ea\u7531\u79fb\u52a8\u5c0f\u9f20\u5927\u8111\u4e2d[K<sup>+<\/sup>]<sub>o<\/sub>\u53d8\u5316\u7684\u52a8\u529b\u5b66\u8fc7\u7a0b\u3002\u4e0e\u53ea\u80fd\u7528\u4e8e\u56fa\u5b9a\u6837\u54c1\u4e2d[K<sup>+<\/sup>]\u5355\u70b9\u6d4b\u91cf\u7684\u4fb5\u5165\u6027K<sup>+<\/sup>\u9009\u62e9\u5fae\u7535\u6781\u76f8\u6bd4\uff0c\u6b64\u7eb3\u7c73\u63a2\u9488\u662f\u975e\u4fb5\u5165\u6027\u7684\uff0c\u53ef\u4ee5\u5728\u8f83\u5927\u8303\u56f4\u5185\u4f20\u9012[K<sup>+<\/sup>]\u53d8\u5316\u7684\u7a7a\u95f4\u4fe1\u606f\u3002\u6b64\u5916\uff0c\u8fd8\u53ef\u4ee5\u8fdb\u4e00\u6b65\u5f00\u53d1\u57fa\u4e8e\u8fd1\u7ea2\u5916\u53d1\u5c04\u7684K<sup>+<\/sup>\u63a2\u9488\uff0c\u7528\u4e8e\u5728\u5168\u8111\u6210\u50cf\u4e2d\u7cbe\u786e\u68c0\u6d4b\u766b\u75eb\u7076\uff0c\u4ece\u800c\u4fc3\u8fdb\u766b\u75eb\u7684\u8bca\u65ad\u548c\u6cbb\u7597\uff0c\u51cf\u5c11\u4e0d\u5fc5\u8981\u7684\u8111\u90e8\u624b\u672f\u3002\u672c\u7814\u7a76\u4e3a\u79bb\u5b50\u7279\u5f02\u6027\u63a2\u9488\u7684\u8bbe\u8ba1\u548c\u5236\u5907\u63d0\u4f9b\u4e86\u4e00\u79cd\u8868\u754c\u9762\u914d\u4f53\u81ea\u7ec4\u88c5\u7684\u65b0\u601d\u8def\uff0c\u4e3a\u5728\u81ea\u7531\u6d3b\u52a8\u7684\u751f\u547d\u4f53\u4e0a\u63a2\u7a76\u795e\u7ecf\u5143\u653e\u7535\u6d3b\u52a8\u5f00\u8f9f\u4e86\u5b9e\u65f6\u52a8\u6001\u76d1\u6d4b\u79bb\u5b50\u6d53\u5ea6\u53d8\u5316\u7684\u65b0\u65b9\u6cd5\uff0c\u8fdb\u800c\u5f00\u521b\u4e86\u4e00\u79cd\u6d3b\u4f53\u8111\u90e8\u591a\u4f4d\u70b9\u65e0\u521b\u6210\u50cf\u7684\u65b0\u7b56\u7565\uff0c\u4e3a\u795e\u7ecf\u9000\u884c\u6027\u75be\u75c5\u673a\u5236\u3001\u795e\u7ecf\u51b2\u52a8\u4e0e\u884c\u4e3a\u5173\u8054\u7b49\u8111\u90e8\u5965\u79d8\u7684\u63a2\u7d22\u5e26\u6765\u4e86\u66d9\u5149\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41565-020-0634-4\">A sensitive and specific nanosensor for monitoring extracellular potassium levels in the brain<\/a>\uff08Nature Nanotechnology, DOI: 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<strong><em>Nano Letters<\/em><\/strong>, <strong><em>2018<\/em><\/strong>, 18, 1196<\/li>\n<li>Xi Hu, Fangyuan Li,* Shuying Wang, Fan Xia, <strong>Daishun Ling*<\/strong>, Biological Stimulus-Driven Assembly\/Disassembly of Functional Nanoparticles for Targeted Delivery, Controlled Activation, and Bioelimination, <strong><em>Advanced Healthcare Materials<\/em><\/strong>, <strong><em>2018<\/em><\/strong>, 7, 1800359<\/li>\n<li>Jingxiong Lu, Jin Wang, <strong>Daishun Ling*<\/strong>, Surface Engineering of Nanoparticles for Targeted Delivery to Hepatocellular Carcinoma, <strong><em>Small<\/em><\/strong>, <strong><em>2018<\/em><\/strong>, 14, 1702037<\/li>\n<li>Haibin Wu, Fangyuan Li, Shuaifei Wang, Jingxiong Lu, Jinquan Li, Yang Du, Xiaolian Sun, Xiaoyuan Chen, Jianqing Gao*, <strong>Daishun Ling*<\/strong>, Ceria Nanocrystals Decorated Mesoporous Silica Nanoparticle based ROS-Scavenging Tissue Adhesive for Highly Efficient Regenerative Wound Healing, 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<strong><em>2018<\/em><\/strong>, 54, 8218<\/li>\n<li>Xia Guo, Xiaotong Li, Shufang Kou, Xianfeng Yang, Xi Hu, <strong>Daishun Ling*<\/strong>, Jian Yang*, Plasmon-enhanced Electrocatalytic Hydrogen\/oxygen Evolution by Pt\/Fe\u2013Au Nanorods, <strong><em>Journal of Materials Chemistry A<\/em><\/strong>, <strong><em>2018<\/em><\/strong>, 6, 7364<\/li>\n<li>Taegyu Kang, Fangyuan Li, Seungmin Baik, Wei Shao, <strong><em>Daishun Ling*<\/em><\/strong>, Taeghwan Hyeon*, Surface design of magnetic nanoparticles for stimuli-responsive cancer imaging and therapy, <strong><em>Biomaterials<\/em><\/strong>, <strong><em>2017<\/em><\/strong>, 136, 98<\/li>\n<li>Xi Hu, Fangyuan Li, Nabila Noor, <strong>Daishun Ling*<\/strong>, Platinum drugs: from Pt(II) compounds, Pt(IV) prodrugs, to Pt nanocrystals\/nanoclusters, <strong><em>Science Bulletin<\/em><\/strong>, <strong><em>2017<\/em><\/strong>, 62, 589<\/li>\n<li>Fangyuan Li, Jingxiong Lu, Xueqian Kong, Taeghwan Hyeon, <strong>Daishun 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