{"id":196403,"date":"2020-02-25T06:19:47","date_gmt":"2020-02-24T22:19:47","guid":{"rendered":"\/\/m.iemloyee.com\/?p=196403"},"modified":"2020-02-24T20:20:21","modified_gmt":"2020-02-24T12:20:21","slug":"%e6%96%bd%e5%89%91%e6%9e%97%e9%99%a2%e5%a3%ab%e5%9b%a2%e9%98%9f-adv-mater-%ef%bc%9a%e5%88%a9%e4%ba%8e%e9%87%91%e5%b1%9e%e6%9c%89%e6%9c%ba%e6%a1%86%e6%9e%b6%ef%bc%88mof-fe%ef%bc%89fenton%e7%ba%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=196403","title":{"rendered":"\u65bd\u5251\u6797\u9662\u58eb\u56e2\u961f Adv. Mater.\uff1a\u5229\u4e8e\u91d1\u5c5e\u6709\u673a\u6846\u67b6\uff08MOF-Fe\uff09Fenton\u7eb3\u7c73\u5242\u4e0e\u6291\u5236\u81ea\u566c\u4f5c\u7528\uff0c\u4ece\u800c\u534f\u540c\u6cbb\u7597\u764c\u75c7"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u6d3b\u6027\u6c27\uff08ROS\uff09\u662f\u7531\u4e8e\u6c27\u6c14\u7684\u4e0d\u5b8c\u5168\u8fd8\u539f\u53cd\u5e94\u5f62\u6210\u7684\u4e00\u7cfb\u5217\u5206\u5b50\uff0c\u5176\u5305\u62ec\u8d85\u6c27\u9634\u79bb\u5b50\uff08O2<\/sub>\u2022\u2212<\/sup>\uff09\u3001\u8fc7\u6c27\u5316\u6c22\uff08H2<\/sub>O2<\/sub>\uff09\u3001\u7f9f\u57fa\u81ea\u7531\u57fa\uff08\u2022OH\uff09\u7b49\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u7ec6\u80de\u4ee3\u8c22\u6539\u53d8\uff0cROS\uff08\u7279\u522b\u662fH2<\/sub>O2<\/sub>\uff09\u5728\u764c\u7ec6\u80de\u4e2d\u662f\u8fc7\u8868\u8fbe\u7684\uff0c\u4ee5\u652f\u6301\u5176\u6076\u6027\u589e\u6b96\u3002\u901a\u8fc7\u6d88\u9664\u6c27\u5316\u8fd8\u539f\u7a33\u6001\u4ee5\u4f18\u5148\u6740\u6b7b\u764c\u7ec6\u80de\uff0c\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u7ea7\u6297\u80bf\u7624\u7597\u6cd5\u7684\u88ab\u5e7f\u6cdb\u5173\u6ce8\u3002\u56e0\u6b64\uff0c\u4e00\u822c\u8003\u8651\u662f\u5229\u7528\u6c27\u5316\u8fd8\u539f\u5316\u5b66\u6765\u4fc3\u8fdb\u7ec6\u80de\u5185H2<\/sub>O2<\/sub>\u8f6c\u5316\u4e3a\u2022OH\uff0c\u4ece\u800c\u4ec5\u5728\u764c\u7ec6\u80de\u5185\u51fa\u73b0\u5f3a\u529b\u7684\u6c27\u5316\u635f\u4f24\u3002\u5176\u4e2d\uff0c\u5229\u7528\u7eb3\u7c73\u50ac\u5316\u836f\u7269\u53ef\u5728\u764c\u7ec6\u80de\u4e2d\u7279\u5b9a\u5730\u5f15\u53d1Fenton\u6216Fenton-like\u53cd\u5e94\uff0c\u4ece\u800c\u5c06H2<\/sub>O2<\/sub>\u8f6c\u6210\u9ad8\u6bd2\u6027\u7684\u2022OH\uff0c\u53ef\u6709\u6548\u6740\u6b7b\u5468\u56f4\u7684\u7ec6\u80de\u86cb\u767d\u548c\u7ec6\u80de\u5668\u3002<\/p>\n

\u00a0\u7136\u800c\uff0c\u764c\u7ec6\u80de\u901a\u8fc7\u81ea\u566c\uff0c\u53ef\u4ee5\u98df\u7528\u548c\u6d88\u5316\u8fd9\u4e9b\u6709\u6bd2\u86cb\u767d\u8d28\u548c\u53d7\u635f\u7684\u7ec6\u80de\u5668\uff0c\u4ece\u800c\u6291\u5236\u4e86\u4e0a\u8ff0\u6548\u679c\u3002\u6b64\u5916\uff0c\u81ea\u566c\u964d\u89e3\u4ea7\u751f\u7684\u6c28\u57fa\u9178\u3001\u4e59\u9170\u8f85\u9176A\u548c\u4e19\u916e\u9178\uff0c\u5c06\u901a\u8fc7anaplerotic\u53cd\u5e94\u8865\u5145\u4e09\u7fa7\u9178\u5faa\u73af\u4e2d\u95f4\u4f53\uff0c\u4ece\u800c\u652f\u6301\u7ebf\u7c92\u4f53\u4ee3\u8c22\u548c\u764c\u7ec6\u80de\u7684\u751f\u7269\u5408\u6210\uff0c\u8d4b\u4e88\u5b83\u4eec\u989d\u5916\u7684\u751f\u5b58\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u5728\u6709\u6548\u4ea7\u751fFenton\u6216Fenton-like\u53cd\u5e94\u65f6\uff0c\u5e94\u540c\u65f6\u51fa\u73b0\u9002\u5f53\u7684\u5e72\u9884\u63aa\u65bd\u6765\u5e72\u6270\u81ea\u566c\u964d\u89e3\u8fc7\u7a0b\uff0c\u4ee5\u63d0\u9ad8\u6cbb\u7597\u764c\u75c7\u7684\u6548\u679c\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u57fa\u4e8e\u6b64\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u4e0a\u6d77\u7845\u9178\u76d0\u7814\u7a76\u6240\u7684\u65bd\u5251\u6797\u7814\u7a76\u5458\u548c\u9648\u96e8\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u5728\u901a\u8fc7\u7eb3\u7c73\u50ac\u5316\u836f\u7269\u4ea7\u751fROS\u4e2d\uff0c\u91c7\u7528\u4e86\u4e00\u79cd\u836f\u7406\u5b66\u81ea\u566c\u6291\u5236\u7684\u7b56\u7565\uff0c\u4ee5\u589e\u5f3aROS\u8bf1\u5bfc\u7684\u6c27\u5316\u635f\u4f24\u534f\u540c\u6cbb\u7597\u764c\u75c7\u3002\u5229\u4e8e\u542b\u94c1\uff08Fe\uff09\u7684\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6[MOF(Fe)]\u7eb3\u7c73\u50ac\u5316\u5242\u4f5c\u4e3a\u8fc7\u6c27\u5316\u7269\u9176\u6a21\u62df\u7269\uff0c\u7528\u4e8e\u50ac\u5316\u764c\u7ec6\u80de\u5185\u8fc7\u8868\u8fbe\u7684H2<\/sub>O2<\/sub>\u8f6c\u5316\u4e3a\u9ad8\u6bd2\u6027\u7684\u2022OH\uff0c\u540c\u65f6\u6c2f\u55b9\uff08CQ\uff09\u7528\u4e8e\u4f7f\u6eb6\u9176\u4f53\u8131\u9178\u5e76\u6291\u5236\u81ea\u566c\uff0c\u4ece\u800c\u5207\u65ad\u764c\u7ec6\u80de\u5728\u4e25\u91cd\u6c27\u5316\u5e94\u6fc0\u4e0b\u7684\u4fdd\u62a4\u9014\u5f84\u3002\u5728\u7eb3\u7c73\u50ac\u5316\u6cbb\u7597\u8fc7\u7a0b\u4e2d\uff0c\u764c\u7ec6\u80de\u65e0\u6cd5\u63d0\u53d6\u5176\u6210\u5206\u4ee5\u4f7f\u5176\u89e3\u6bd2\u548c\u589e\u5f3a\u81ea\u8eab\uff0c\u6700\u7ec8\u5728ROS\u8bf1\u5bfc\u51fa\u73b0\u4e25\u91cd\u7684\u6c27\u5316\u635f\u4f24\u3002\u901a\u8fc7\u4f53\u5916\u548c\u4f53\u5185\u5b9e\u9a8c\u7ed3\u679c\u90fd\u8bc1\u5b9e\u4e86\u7eb3\u7c73\u50ac\u5316\u7597\u6cd5\u4e0e\u81ea\u566c\u6291\u5236\u4e4b\u95f4\u7684\u534f\u540c\u4f5c\u7528\uff0c\u8868\u660e\u8fd9\u79cd\u8054\u5408\u7b56\u7565\u9002\u7528\u4e8e\u653e\u5927\u80bf\u7624\u7279\u5f02\u6027\u7684\u6c27\u5316\u635f\u4f24\uff0c\u5e76\u4e14\u4e3a\u5c06\u6765\u8bbe\u8ba1\u6cbb\u7597\u65b9\u6848\u63d0\u4e00\u79cd\u65b0\u601d\u8def\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cA Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u6750\u6599\u5316\u5b66\u548c\u6cbb\u7597\u6982\u5ff5\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001NH2<\/sub>-MIL-88B(Fe)\u7eb3\u7c73\u50ac\u5316\u836f\u7269\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08a-c\uff09NH2<\/sub>-MIL-88B\uff08Fe\uff09\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08d-e\uff09NH2<\/sub>-MIL-88B\uff08Fe\uff09\u7684XPS\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09NH2<\/sub>-MIL-88B\uff08Fe\uff09\u7684FTIR\u5149\u8c31\uff1b<\/p>\n

\uff08g\uff09NH2<\/sub>-MIL-88B\uff08Fe\uff09\u7eb3\u7c73\u6676\u4f53\u6837\u54c1\u7684\u7c89\u672bXRD\u56fe\u8c31\uff1b<\/p>\n

\uff08h\uff09NH2<\/sub>-MIL-88B\uff08Fe\uff09\u4e9a\u94c1\u76843D\u7acb\u4f53\u5316\u5b66\u7ed3\u6784\uff1b<\/p>\n

\uff08i-l\uff09MOF\uff08Fe\uff09\u7684\u50ac\u5316\u6027\u80fd\u3002<\/p>\n

\u56fe\u4e09\u3001\u7eb3\u7c73\u50ac\u5316\u836f\u7269\u53ef\u5728\u7ec6\u80de\u5185\u4ea7\u751f\u2022OH<\/strong>
\n \"\"\uff08a\uff09\u7528\u8367\u5149\u63a2\u9488DCFH-DA\u67d3\u8272\u4e0d\u540c\u5904\u7406\u540e\u7684A375\u7ec6\u80de\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u5904\u7406\u540e\uff0c\u6d41\u5f0f\u7ec6\u80de\u4eea\u5206\u6790A375\u7ec6\u80de\u7684\u7ec6\u80de\u5185\u2022OH\u6c34\u5e73\uff1b<\/p>\n

\uff08c\uff09\u514d\u75ab\u5370\u8ff9\u5206\u6790A375\u7ec6\u80de\u4e2d\u6c27\u5316\u8fd8\u539f\u6307\u793a\u86cb\u767dSOD1\u3001GPX4\u3001NRF2\u548cp53\u7684\u8868\u8fbe\u3002<\/p>\n

\u56fe\u56db\u3001\u7ec6\u80de\u5b9e\u9a8c\u8bc1\u5b9e\u7eb3\u7c73\u50ac\u5316\u836f\u7269\u548cCQ\u8fdb\u884c\u81ea\u566c\u8c03\u8282<\/strong>
\n \"\"\uff08a\uff09\u4e0d\u540c\u5904\u7406\u540e\uff0c\u8868\u8fbeGFP-LC3B\u7684A375\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u5904\u7406\u540e\uff0cA375\u7ec6\u80de\u7684\u751f\u7269TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\u514d\u75ab\u5370\u8ff9\u5206\u6790A375\u7ec6\u80de\u4e2d\u81ea\u566c\u6307\u793a\u86cb\u767dbeclin 1\u3001Atg7\u3001LC3B\u548cp62\u7684\u8868\u8fbe\u3002<\/p>\n

\u56fe\u4e94\u3001\u534f\u540c\u6cbb\u7597\u8bf1\u5bfc\u764c\u7ec6\u80de\u51cb\u4ea1<\/strong>
\n \"\"\uff08a-f\uff09\u7ecf\u8fc7a-c\uff0924 h\u548cd-f\uff0948 h\u5404\u79cd\u5904\u7406\u540e\u7684a\uff0cd\uff09A375\u7ec6\u80de\u3001b\uff0ce\uff09HeLa\u7ec6\u80de\u548cc\uff0cf\uff09HUVEC\u7684\u6807\u51c6\u5316\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08g-l\uff09\u514d\u75ab\u5370\u8ff9\u5206\u6790\u4e0d\u540c\u5904\u7406\u540e\u7684g\uff0cj\uff09A375\u7ec6\u80de\u3001h\uff0ck\uff09HeLa\u7ec6\u80de\u548ci\uff0cl\uff09HUVEC\u4e2d\u51cb\u4ea1\u6307\u793a\u86cb\u767dc-CAS3\u548cc-PARP\u7684\u8868\u8fbe\u3002<\/p>\n

\u56fe\u516d\u3001\u4f53\u5185\u534f\u540c\u6cbb\u7597\u7684\u6297\u80bf\u7624\u6548\u679c<\/strong>
\n \"\"\uff08a\uff09\u7528\u4e0d\u540c\u65b9\u6cd5\u5904\u7406\u7684\u5c0f\u9f20\u4e2dA375\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540c\u6cbb\u7597\u540e\uff0c\u5b9a\u91cf\u7b2c14\u5929\u7684\u5f02\u79cd\u79fb\u690dA375\u80bf\u7624\u7684\u91cd\u91cf\uff1b<\/p>\n

\uff08c\uff09\u4e0d\u540c\u5904\u7406\u540e\uff0c\u5f02\u79cd\u79fb\u690d\u6709A375\u80bf\u7624\u5c0f\u9f20\u7684Kaplan-Meier\u751f\u5b58\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09\u5982\uff08a\uff09\u6240\u793a\uff0c\u4e0d\u540c\u5904\u7406\u540e\u7684\u5c0f\u9f20HeLa\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u7269\u7684\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08e\uff09\u6cbb\u7597\u540e\uff0c\u5b9a\u91cf\u7b2c14\u5929\u5f02\u79cd\u79fb\u690dHeLa\u80bf\u7624\u7684\u91cd\u91cf\uff1b<\/p>\n

\uff08f\uff09\u4e0d\u540c\u5904\u7406\u540e\uff0c\u5f02\u79cd\u79fb\u690d\u6709HeLa\u80bf\u7624\u5c0f\u9f20\u7684Kaplan-Meier\u751f\u5b58\u66f2\u7ebf\uff1b<\/p>\n

\uff08g\uff09\u4e0d\u540c\u6cbb\u7597\u540e\uff0c\u7b2c14\u5929\u5f02\u79cd\u79fb\u690dA375\u548cHeLa\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u5206\u6790\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u81f4\u529b\u4e8e\u5c06\u6700\u8fd1\u5f00\u53d1\u7684\u7eb3\u7c73\u50ac\u5316\u7597\u6cd5\u4e0e\u836f\u7269\u81ea\u566c\u6291\u5236\u76f8\u7ed3\u5408\uff0c\u4ee5\u5047\u5b9a\u589e\u5f3a\u5bf9\u80bf\u7624\u7684\u6c27\u5316\u635f\u4f24\u3002\u4f5c\u4e3a\u8fc7\u6c27\u5316\u7269\u9176\u6a21\u62df\u7269\u7684MOF(Fe)\u53ef\u4ee5\u50ac\u5316\u80bf\u7624\u7ec4\u7ec7\u5185\u8fc7\u8868\u8fbe\u7684H2<\/sub>O2<\/sub>\u8f6c\u5316\u4e3a\u2022OH\uff0c\u800cCQ\u53ef\u4ee5\u4f7f\u6eb6\u9176\u4f53\u8131\u9178\u5e76\u6291\u5236\u81ea\u566c\uff0c\u4ece\u800c\u963b\u65ad\u4e86\u5728\u4e25\u91cd\u6c27\u5316\u5e94\u6fc0\u4e0b\u764c\u7ec6\u80de\u7684\u81ea\u6211\u4fdd\u62a4\u9014\u5f84\u3002\u901a\u8fc7\u4f53\u5916\u548c\u4f53\u5185\u5b9e\u9a8c\u7ed3\u679c\u8bc1\u660e\u4e86\u7eb3\u7c73\u50ac\u5316\u7597\u6cd5\u4e0e\u81ea\u566c\u6291\u5236\u4e4b\u95f4\u7684\u534f\u540c\u4f5c\u7528\uff0c\u8868\u660e\u8fd9\u79cd\u8054\u5408\u7b56\u7565\u662f\u6709\u6548\u7684\uff0c\u5e76\u4e14\u53ef\u80fd\u5bf9\u672a\u6765\u6cbb\u7597\u65b9\u5f0f\u7684\u8bbe\u8ba1\u5177\u6709\u6307\u5bfc\u610f\u4e49\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5408\u7406\u7ba1\u7406\u5316\u7597\u5e72\u9884\u4e0b\u7684\u764c\u7ec6\u80de\u81ea\u566c\u8fc7\u7a0b\uff0c\u6709\u671b\u5728\u672a\u6765\u53d6\u5f97\u66f4\u5927\u7684\u533b\u5b66\u8fdb\u5c55\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aA Metal-Organic Framework (MOF) Fenton Nanoagent-Enabled Nanocatalytic Cancer Therapy in Synergy with Autophagy Inhibition<\/a><\/strong>\uff08Adv. Mater.<\/em>, 2020<\/strong>, DOI: 10.1002\/adma.201907152\uff09<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

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