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\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

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\u5176\u6b21\uff0cApPdC\u80f6\u675f\u5728\u751f\u7406\u6761\u4ef6\u4e0b\u5904\u4e8e\u9759\u9ed8\u72b6\u6001\uff0c\u4f46\u901a\u8fc7\u53d7\u4f53\u4ecb\u5bfc\u7684\u764c\u7ec6\u80de\u5185\u5316\u540e\u4f1a\u5f15\u53d1\u7ea7\u8054\u7684\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u3002\u8d1f\u8f7d\u7684\u8840\u7ea2\u7d20\uff08Fe3+<\/sup>\uff09\u88ab\u7ec6\u80de\u5185GSH\u8fd8\u539f\u6210\u8840\u7ea2\u7d20\uff08Fe2+<\/sup>\uff09\uff0c\u4ece\u800c\u89e6\u53d1T\u6d3b\u5316\uff0c\u8fdb\u800c\u4ea7\u751f\u57fa\u4e8eC\u7684\u6709\u6bd2\u81ea\u7531\u57fa\uff0c\u800c\u8fd9\u4e00\u8fc7\u7a0b\u4e0d\u4f9d\u8d56\u4e8e\u80bf\u7624\u9178\u5ea6\u6216H2<\/sub>O2<\/sub>\u7684\u542b\u91cf\u3002\u6b64\u5916\uff0c\u8840\u7ea2\u7d20\u80fd\u591f\u6d88\u8017\u764c\u7ec6\u80de\u5185GSH\uff0c\u8fdb\u4e00\u6b65\u964d\u4f4e\u4e86\u764c\u7ec6\u80de\u7684\u6297\u6c27\u5316\u80fd\u529b\uff0c\u4ece\u800c\u53d1\u6325\u534f\u540c\u6cbb\u7597\u4f5c\u7528\u3002\u540c\u65f6\uff0c\u4ea7\u751f\u7684\u8840\u7ea2\u7d20\uff08Fe2+<\/sup>\uff09\u4f1a\u5bfc\u81f4\u764c\u7ec6\u80de\u4e2dFe2+<\/sup>\u79bb\u5b50\u542b\u91cf\u7684\u5347\u9ad8\uff0c\u8fdb\u4e00\u6b65\u6d3b\u5316ApPdC\u80f6\u675f\u4e2d\u7684\u524d\u836f\u78b1\u57fa\uff0c\u901a\u8fc7\u81ea\u5faa\u73af\u7684\u65b9\u5f0f\u4fc3\u8fdb\u6bd2\u6027C\u57fa\u81ea\u7531\u57fa\u7684\u7d2f\u79ef\u3002\u6b64\u5916\uff0cApPdC\u53ef\u901a\u8fc7\u4e9a\u78f7\u9178\u9170\u80fa\u5316\u5b66\u5728DNA\u5408\u6210\u4eea\u4e0a\u81ea\u52a8\u5408\u6210\uff0c\u56e0\u6b64\u53ef\u4ee5\u7cbe\u51c6\u5730\u63a7\u5236\u524d\u836f\u78b1\u57fa\u7684\u5076\u8054\u4f4d\u70b9\u548c\u6570\u91cf\uff0c\u5177\u6709\u4f18\u826f\u7684\u8d28\u91cf\u63a7\u5236\u6027\u80fd\uff0c\u6709\u5229\u4e8e\u672a\u6765\u7684\u4e34\u5e8a\u8f6c\u5316\u3002\u603b\u4e4b\uff0c\u8be5\u751f\u7269\u6b63\u4ea4\u5316\u5b66\u548c\u524d\u836f\u8bbe\u8ba1\u7684\u7ec4\u5408\u7b56\u7565\u53ef\u4ee5\u6269\u5c55\u5230\u5176\u5b83\u6838\u9178\u9002\u4f53\uff0c\u4ece\u800c\u6784\u5efa\u51fa\u4e00\u7cfb\u5217ApDC\u7528\u4e8e\u5404\u79cd\u764c\u75c7\u7684\u9776\u5411\u6cbb\u7597\u3002\u540c\u65f6\uff0c\u8be5\u5de5\u4f5c\u4e5f\u4e3a\u81ea\u7531\u57fa\u76f8\u5173\u7684\u5206\u5b50\u673a\u5236\u5960\u5b9a\u4e86\u91cd\u8981\u57fa\u7840\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cMolecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520aJ. Am. Chem. Soc.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u57fa\u4e8e\u751f\u7269\u6b63\u4ea4\u7684ApPdC\u80f6\u675f\u7528\u4e8e\u764c\u7ec6\u80de\u81ea\u5faa\u73af\u548c\u539f\u4f4d\u6269\u589e\u6709\u6bd2\u81ea\u7531\u57fa\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001ApPdC\u7684\u5408\u6210\u4e0e\u5206\u5b50\u7ec4\u88c5\u53ca\u5176\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09\u201cT\u201d\u5408\u6210\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09\uff081\uff09\u6e38\u79bbAS1411\u3001\uff082\uff09Ap-6G-\u201cT\u201d\u548c\uff083\uff09Ap-6G-H-\u201cT\u201d\u7684\u51dd\u80f6\u7535\u6cf3\u5206\u6790\uff1b<\/p>\n

\uff08C-D\uff09Ap-6G-\u201cT\u201d\u548cAp-6G-H-\u201cT\u201d\u7684DLS\u5206\u6790\u3001AFM\u6210\u50cf\u548cZeta\u7535\u4f4d\u3002<\/p>\n

\u56fe\u4e09\u3001\u6e38\u79bb\u6838\u9178\u9002\u4f53\u548c\u4e0d\u540cApPdC\u80f6\u675f\u5728\u8840\u6e05\u548c\u6838\u9178\u9176\u4e2d\u7684\u7a33\u5b9a\u6027<\/strong>
\n \"\"\uff08A-B\uff09\u743c\u8102\u7cd6\u51dd\u80f6\u5206\u6790\u6e38\u79bb\u6838\u9178\u9002\u4f53\u548c\u4e0d\u540cApPdC\u80f6\u675f\u5728FBS\u4e2d\u7684\u964d\u89e3\u901f\u7387\uff1b<\/p>\n

\uff08C-D\uff09\u743c\u8102\u7cd6\u51dd\u80f6\u5206\u6790\u6e38\u79bb\u6838\u9178\u9002\u4f53\u548c\u4e0d\u540cApPdC\u80f6\u675f\u5728\u6838\u9178\u9176\u4e2d\u7684\u964d\u89e3\u901f\u7387\u3002<\/p>\n

\u56fe\u56db\u3001\u6fc0\u6d3b\u673a\u5236<\/strong>
\n \"\"\uff08A-B\uff09\u6e38\u79bbFe2+<\/sup>\u6216\u8840\u7ea2\u7d20\uff08Fe2+<\/sup>\uff09\u4ecb\u5bfc\u7684\u524d\u836f\u78b1\u57fa\u201cT\u201d\u7684\u6fc0\u6d3b\u673a\u5236\uff1b<\/p>\n

\uff08C-D\uff09\u5229\u7528DEPMPO\u4f5c\u4e3a\u81ea\u7531\u57fa\u6355\u83b7\u5242\uff0c\u5728\u6e38\u79bbFe2+<\/sup>\u6216\u7531\u8fde\u4e8c\u4e9a\u786b\u9178\u76d0\u8fd8\u539f\u4ea7\u751f\u7684\u8840\u7ea2\u7d20\uff08Fe2+<\/sup>\uff09\u6d3b\u5316\u4e0b\uff0c\u7531\u201cT\u201d\u4ea7\u751f\u7684\u81ea\u7531\u57fa\u7684ESR\u6d4b\u91cf\u3002<\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aMolecular Self-Assembly of Bioorthogonal Aptamer-Prodrug Conjugate Micelles for Hydrogen Peroxide and pH-Independent Cancer Chemodynamic Therapy<\/a><\/strong>\uff08JACS<\/em>, 2019<\/strong>, DOI: 0.1021\/jacs.9b10755\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

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\u56e2\u961f\u7f51\u9875\uff1ahttp:\/\/tanhnugroup.com\/Home<\/strong><\/p>\n

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