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\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u4f5b\u7f57\u91cc\u8fbe\u5927\u5b66\u7684\u8c2d\u851a\u6cd3\u6559\u6388\u548c\u53a6\u95e8\u5927\u5b66\u6768\u671d\u52c7\u6559\u6388<\/strong>\u62a5\u9053\u4e86\u80a0\u9053\u7ec6\u83cc\u4f53\u5185\u6210\u50cf\u7684\u7b2c\u4e8c\u79cd\u57fa\u4e8e\u8fd1\u7ea2\u5916\uff08NIR-II\uff09\u7684\u65b9\u6cd5\u7684\u53d1\u5c55\u3002\u4f5c\u8005\u4f7f\u7528D-\u7094\u4e19\u57fa\u7518\u6c28\u9178\uff0c\u7136\u540e\u4e0e\u542b\u53e0\u6c2e\u5316\u7269\u7684NIR-II\u67d3\u6599\u53d1\u751f\u70b9\u51fb\u53cd\u5e94\uff0c\u4f9b\u4f53\u5c0f\u9f20\u7684\u80a0\u9053\u83cc\u7fa4\u5728\u5176\u80bd\u805a\u7cd6\u4e0a\u88abNIR-II\u8367\u5149\u5f3a\u70c8\u6807\u8bb0\u3002\u7ec6\u83cc\u5f88\u5bb9\u6613\u5728\u8fd1\u7ea2\u5916\u8f90\u5c04\u4e0b\u4ee5\u9ad8\u7a7a\u95f4\u5206\u8fa8\u7387\u548c\u6df1\u5c42\u7ec4\u7ec7\u7a7f\u900f\u529b\u5728\u53d7\u4f53\u5c0f\u9f20\u80a0\u9053\u4e2d\u53ef\u89c6\u5316\u3002\u7136\u540e\uff0c\u4f5c\u8005\u91c7\u7528\u8fd9\u79cd\u5316\u5b66\u7b56\u7565\u5bf9\u4e0d\u540c\u7ec6\u83cc\u79cd\u7c7b\u8fdb\u884c\u6210\u50cf\uff0c\u4ece\u800c\u6269\u5927\u4e86\u5176\u5728\u5fae\u751f\u7269\u5b66\u4e2d\u7684\u9002\u7528\u6027\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u91c7\u7528\u8fd9\u79cd\u65b9\u6cd5\uff0c\u4f5c\u8005\u53d1\u73b0\u80a0\u9053\u83cc\u7fa4\u7684\u751f\u7269\u5730\u7406\u5b66\u53d7\u5230\u5bbf\u4e3b\u80c3\u80a0\u52a8\u529b\u7684\u663e\u7740\u5f71\u54cd\u3002\u636e\u6211\u4eec\u6240\u77e5\uff0c\u6b64\u5904\u62a5\u9053\u7684\u57fa\u4e8eNIR-II\u7684\u4ee3\u8c22\u6807\u8bb0\u7b56\u7565\u4e3a\u5728\u4f53\u5185\u6df1\u5c42\u7ec4\u7ec7\u4e2d\u7684\u80a0\u9053\u5fae\u751f\u7269\u7fa4\u63d0\u4f9b\u4e86\u4fbf\u6377\u7684\u4f53\u5185\u53ef\u89c6\u5316\u65b9\u6cd5\uff0c\u5e76\u4e3a\u89e3\u5bc6\u8fd9\u4e9b\u80a0\u9053\u201c\u6697\u7269\u8d28\u201d\u7684\u590d\u6742\u751f\u7269\u5b66\u63d0\u4f9b\u4e86\u4e00\u79cd\u5de5\u5177\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201c<\/strong>Metabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota<\/strong>\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe<\/strong>1.NIR-II<\/strong>\u7684\u80a0\u9053\u83cc\u7fa4\u8367\u5149\u6210\u50cf\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u57fa\u4e8eNIR-II\u7684\u80a0\u9053\u83cc\u7fa4\u8367\u5149\u6210\u50cf\u65b9\u6848<\/p>\n

\uff08b\uff09\u672c\u7814\u7a76\u4e2d\u4f7f\u7528\u7684\u4ee3\u8c22\u6807\u8bb0\u63a2\u9488D-\u7094\u4e19\u57fa\u7518\u6c28\u9178\uff08DPG\uff09\u548cNIR-II\u67d3\u6599IR-FGN\u7684\u5316\u5b66\u7ed3\u6784<\/p>\n

\uff08c\uff09\u672c\u7814\u7a76\u4e2d\u4f7f\u7528\u7684IR-FGN\u7684\u5f52\u4e00\u5316\u5438\u6536\u548c\u53d1\u5c04\u5149\u8c31<\/p>\n

\uff08d\uff09\u5728\u660e\u573a\u6216NIR-II\u7167\u660e\u4e0b\u4e0eIR-FGN\u53d1\u751f\u70b9\u51fb\u53cd\u5e94\u4e4b\u524d\u548c\u4e4b\u540eDPG\u6807\u8bb0\u7684\u83cc\u7fa4\u7684\u6210\u50cf<\/p>\n

\u56fe<\/strong>2.SPF<\/strong>\u548c<\/strong>GF<\/strong>\u5c0f\u9f20\u79fb\u690d\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u6807\u8bb0\u80a0\u9053\u83cc\u7fa4\u7684\u57fa\u4e8e<\/strong>NIR-II<\/strong>\u7684\u8367\u5149\u6210\u50cf<\/strong>\"\"<\/strong><\/p>\n

\u56fe<\/strong>3.SPF<\/strong>\u5c0f\u9f20\u79fb\u690d\u540e\u6807\u8bb0\u7ec6\u83cc\u7684\u57fa\u4e8e<\/strong>NIR-II<\/strong>\u7684\u8367\u5149\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09NIR-II\u6210\u50cf\u663e\u793a\uff0c\u5728\u4f53\u5916\u7528DPG\u4ee3\u8c22\u6807\u8bb0\u7684\u4e09\u79cd\u7ec6\u83cc\uff0c\u5373\u5927\u80a0\u6746\u83cc\uff0c\u67af\u8349\u82bd\u5b62\u6746\u83cc\u548c\u80a0\u708e\u6c99\u95e8\u6c0f\u83cc\u8840\u6e05\u9f20\u4f24\u5bd2\u6c99\u95e8\u6c0f\u83cc\uff0c\u5728\u7528IR-FGN\u5355\u51fb\u540e\u5747\u663e\u793a\u5f3a\u8367\u5149<\/p>\n

\uff08b-d\uff09\u5728\u5bf9\u76f8\u5e94\u7ec6\u83cc\u8fdb\u884c\u7ba1\u9972\u540e5\u5c0f\u65f6\uff0c\u5bf9\u6807\u8bb0\u7ec6\u83cc\u8fdb\u884c\u4f53\u5185NIR-II\u6210\u50cf<\/p>\n

\u56fe<\/strong>4.NIR-II<\/strong>\u8367\u5149\u6210\u50cf\u663e\u793a\u80c3\u80a0\u8815\u52a8\u663e\u7740\u5f71\u54cd\u80a0\u9053\u83cc\u7fa4\u7684\u5206\u5e03<\/strong><\/p>\n

\"\"<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5<\/strong>\uff1aMetabolic Labeling of Peptidoglycan with NIR-II Dye Enables in vivo Imaging of Gut Microbiota. Angew. Chem. Int. Ed., <\/em>2019<\/strong>, DOI: 10.1002\/anie.201910555.<\/p>\n

\u672c\u6587\u7531tt\u4f9b\u7a3f\u3002\u00a0<\/p>\n

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