{"id":190813,"date":"2019-12-03T06:30:07","date_gmt":"2019-12-02T22:30:07","guid":{"rendered":"\/\/m.iemloyee.com\/?p=190813"},"modified":"2019-12-02T17:18:20","modified_gmt":"2019-12-02T09:18:20","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e6%9d%9c%e9%87%91%e5%bf%97%e7%8e%8b%e5%9d%87nano-lett-%ef%bc%9a%e7%b0%87%e7%8a%b6%e7%ba%b3%e7%b1%b3%e9%a2%97%e7%b2%92%e8%b4%9f%e8%bd%bd%e7%9a%84pamam","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=190813","title":{"rendered":"\u675c\u91d1\u5fd7&amp;\u738b\u5747Nano Lett.\uff1a\u7c07\u72b6\u7eb3\u7c73\u9897\u7c92\u8d1f\u8f7d\u7684PAMAM\u6811\u72b6\u5927\u5206\u5b50\u7684\u7624\u5185\u884c\u4e3a\u53ca\u7597\u6548\u7814\u7a76"},"content":{"rendered":"<p><strong>\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u8fd1\u51e0\u5341\u5e74\u6765\uff0c\u5927\u91cf\u7684\u7814\u7a76\u8868\u660e\uff0c\u6297\u764c\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\u7684\u5927\u5c0f\u5728\u51b3\u5b9a\u5176\u7ec4\u7ec7\u5206\u5e03\u3001\u80bf\u7624\u7a7f\u900f\u3001\u7ec6\u80de\u5185\u5316\u548c\u4f53\u5185\u6e05\u9664\u7b49\u65b9\u9762\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76ee\u524d\u5927\u90e8\u5206\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u5728\u5c3a\u5bf8\u4e3a20\u5230100 nm\u7684\u7eb3\u7c73\u9897\u7c92\u4e0a\u3002\u751f\u7269\u4f53\u5185\u5982\u6297\u4f53\u3001\u9176\u3001\u6838\u9178\u7b49\u591a\u79cd\u751f\u7269\u5927\u5206\u5b50\u5c3a\u5bf8\u4e3b\u8981\u572810 nm\u5de6\u53f3\u53ca\u4ee5\u4e0b\u3002\u8fd9\u4e2a\u5c3a\u5ea6\u8303\u56f4\u5185\u7eb3\u7c73\u9897\u7c92\u7684\u5c3a\u5bf8\u5bf9\u5176\u6548\u5e94\u6240\u4ea7\u751f\u7684\u5f71\u54cd\u8fd1\u5e74\u6765\u6b63\u5f15\u8d77\u5e7f\u6cdb\u7684\u5173\u6ce8\uff0c\u4f46\u662f\u53d7\u9650\u4e8e\u8fd9\u4e00\u5c3a\u5bf8\u9897\u7c92\u5feb\u901f\u7684\u6e05\u9664\u6548\u5e94\u53ca\u4f4e\u6548\u7387\u7684\u9776\u7ec4\u7ec7\u5bcc\u96c6\u80fd\u529b\uff0c\u5982\u4f55\u5c06\u76f8\u540c\u91cf\u7684\u4e0d\u540c\u5c3a\u5bf8\u7eb3\u7c73\u9897\u7c92\u9012\u9001\u81f3\u80bf\u7624\u7ec4\u7ec7\u4e00\u76f4\u662f\u4e2a\u91cd\u8981\u6311\u6218\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c\u534e\u5357\u7406\u5de5\u5927\u5b66\u675c\u91d1\u5fd7\u7814\u7a76\u5458\u4e0e\u738b\u5747\u6559\u6388\u8054\u5408\u201c\u5927\u8f7d\u5c0f\u201d\u7684\u591a\u7ea7\u7eb3\u7c73\u836f\u7269\u8f93\u9001\u4f53\u7cfb\uff0c\u80fd\u591f\u5728\u201c\u5927\u201d\u5c3a\u5bf8\u8f7d\u4f53\u4e0a\u8377\u8f7d\u5177\u6709\u4e0d\u540c\u4f53\u79ef\u7684\u201c\u5c0f\u201d\u5c3a\u5bf8\u8f7d\u4f53\uff0c\u800c\u5f53\u8fdb\u5165\u5230\u80bf\u7624\u7ec4\u7ec7\u540e\uff0c\u201c\u5c0f\u201d\u8f7d\u4f53\u5728\u80bf\u7624\u5fae\u73af\u5883\u7684\u523a\u6fc0\u4e0b\u5feb\u901f\u89e3\u79bb\u5e76\u91ca\u653e\u51fa\u6765\uff0c\u5e76\u8fdb\u4e00\u6b65\u9012\u9001\u836f\u7269\u81f3\u80bf\u7624\u7ec4\u7ec7\u4e2d\u3002\u501f\u7531\u8fd9\u4e00\u8f93\u9001\u5e73\u53f0\uff0c\u6211\u4eec\u53ef\u4ee5\u514b\u670d\u5c0f\u5c3a\u5bf8\u8f7d\u4f53\u4ee3\u8c22\u6e05\u9664\u5feb\uff0c\u5bcc\u96c6\u91cf\u4f4e\u4ee5\u53ca\u4e0d\u540c\u7684\u6e05\u9664\u901f\u5ea6\u5bf9\u80bf\u7624\u7ec4\u7ec7\u521d\u59cb\u5bcc\u96c6\u91cf\u7684\u5f71\u54cd\uff0c\u8fdb\u800c\u53ef\u4ee5\u7cfb\u7edf\u6027\u7814\u7a76\u5c3a\u5bf8\u6548\u5e94\u5bf9\u4e8e\u5c0f\u5c3a\u5ea6\u8303\u56f4\u5185\u7eb3\u7c73\u8f7d\u4f53\u7684\u6297\u80bf\u7624\u836f\u7269\u9012\u9001\u8fc7\u7a0b\u7684\u5f71\u54cd\u3002\u5229\u7528\u591a\u7ea7\u7eb3\u7c73\u836f\u7269\u8f93\u9001\u4f53\u7cfb\uff08iCluster\uff09\uff0c\u88c5\u8f7d\u4e0d\u540c\u4ee3\u6570\u7684PAMAM\u6811\u72b6\u5927\u5206\u5b50 (G3-\u3001G5-\u3001G7-PAMAM)\u3002\u901a\u8fc7\u8c03\u63a7\u5236\u5907\u8fc7\u7a0b\u548c\u5404\u7ec4\u5206\u6bd4\u4f8b\uff0c\u83b7\u5f97\u5177\u6709\u76f8\u4f3c\u5c3a\u5bf8\u548c\u8868\u9762\u5316\u5b66\u6027\u8d28\uff0c\u5b9e\u73b0iCluster\u7eb3\u7c73\u9897\u7c92\u5177\u6709\u76f8\u4f3c\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u76f8\u4f3c\u7684\u80bf\u7624\u521d\u59cb\u7d2f\u79ef\u3002\u5728\u80bf\u7624\u90e8\u4f4d\u79ef\u7d2f\u540e\uff0c\u5355\u4e2a\u5c0f\u6811\u72b6\u5206\u5b50\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u89e3\u79bb\u5e76\u91ca\u653e\uff0c\u4ece\u800c\u8fdb\u4e00\u6b65\u5bf9\u5176\u7624\u5185\u8868\u73b0\u8fdb\u884c\u6bd4\u8f83\u548c\u63a2\u7a76\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5c0f\u5c3a\u5bf8\u8303\u56f4\u4e0b\uff0c\u7eb3\u7c73\u8f7d\u4f53\u6027\u8d28\u7ec6\u5fae\u7684\u53d8\u5316\u5bf9\u5176\u7624\u5185\u6d3b\u52a8\u6709\u663e\u8457\u7684\u5f71\u54cd\uff0c\u8fd9\u4e5f\u5f3a\u8c03\u4e86\u5c0f\u7684NPs\u5728\u7624\u5185\u8868\u73b0\u4e0a\u7684\u7ec6\u5fae\u5dee\u5f02\u7684\u800c\u5f15\u8d77\u7684\u5de8\u5927\u5f71\u54cd\u3002\u8be5\u6587\u7ae0\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201c<strong>Intratumor Performance and Therapeutic Efficacy of PAMAM Dendrimers Carried by Clustered Nanoparticles<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>Nano lett.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001<\/strong><strong>G3-<\/strong><strong>\u3001<\/strong><strong>G5-<\/strong><strong>\u3001<\/strong><strong>G7- iCluster<\/strong><strong>\u9012\u9001\u7cfb\u7edf\u5728\u80bf\u7624\u5185\u8868\u73b0\u7684\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-190815\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/1-31.jpg\" alt=\"\" width=\"600\" height=\"411\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/1-31.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/1-31-300x206.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe\u4e8c\u3001<\/strong><strong>G3-, G5-, G7-iCluster<\/strong><strong>\u7684\u5236\u5907\u53ca\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-190816\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/2-29.jpg\" alt=\"\" width=\"600\" height=\"806\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/2-29.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/2-29-223x300.jpg 223w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u901a\u8fc7\u81ea\u7ec4\u88c5\u65b9\u6cd5\u5236\u5907iCluster NPs\u7684\u793a\u610f\u56fe\u4ee5\u53ca\u5728\u80bf\u7624\u9178\u6027\u523a\u6fc0\u4e0biClusters\u91ca\u653ePAMAM\u6811\u7a81\u72b6\u5927\u5206\u5b50\u3002<\/p>\n<p>\uff08b\uff09\u4e0d\u540c\u6dfb\u52a0\u6bd4\u4f8b\u7684PAMAM-CDM-PCL\/PEG-PCL\u5bf9G3-iCluster\u7684\u7535\u4f4d\u7684\u53d8\u5316\u3002<\/p>\n<p>\uff08c\uff09\u4e0d\u540c\u6dfb\u52a0\u6bd4\u4f8b\u7684PCL\/PEG-PCL\u5bf9G3-iCluster\u5c3a\u5bf8\u7684\u5f71\u54cd\u3002<\/p>\n<p>\uff08d\uff09\u4e0d\u540c\u6dfb\u52a0\u6bd4\u4f8b\u7684PAMAM-CDM-PCL\/PEG-PCL\u5bf9G7-iCluster\u7535\u4f4d\u7684\u53d8\u5316<\/p>\n<p>\uff08e\uff09\u4e0d\u540c\u6dfb\u52a0\u6bd4\u4f8b\u7684PCL\/PEG-PCL\u5bf9G7-iCluster\u5c3a\u5bf8\u7684\u5f71\u54cd<\/p>\n<p>\uff08f\uff09G3-\u3001G5-\u548cG7-iCluster TEM\u56fe\u50cf\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001<\/strong><strong>G3-<\/strong><strong>\u3001<\/strong><strong>G5-<\/strong><strong>\u3001<\/strong><strong>G7-iCluster<\/strong><strong>\u86cb\u767d\u8d28\u5438\u9644\u53ca\u836f\u52a8\u5b66\u7814\u7a76<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-190817\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/3-26.jpg\" alt=\"\" width=\"600\" height=\"347\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/3-26.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/3-26-300x174.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u86cb\u767d\u5438\u9644\u5bf9iCluster NPs\u5c3a\u5bf8\u7684\u5f71\u54cd\u3002<\/p>\n<p>\uff08b\uff09\u86cb\u767d\u5438\u9644\u5bf9iCluster NPs\u7535\u4f4d\u7684\u5f71\u54cd\u3002<\/p>\n<p>\uff08c\uff09\u5728\u8fdb\u884ciCluster NPs\u5438\u9644\u86cb\u767d\u5b9a\u91cf\u5206\u6790\u6d4b\u5b9a\u524d\uff0ciCluster NPs\u4e0e\u5c0f\u9f20\u8840\u6d46\u5b75\u80b21 h\u3002<\/p>\n<p>\uff08d\uff09iCluster NPs\u9759\u8109\u6ce8\u5c04\u540e\u836f\u52a8\u5b66\u66f2\u7ebf\u3002<\/p>\n<p>\u5173\u952e\u7684\u836f\u4ee3\u52a8\u529b\u5b66\u53c2\u6570\u5305\u62ec\u6d88\u9664\u534a\u8870\u671f\uff08e\uff09\uff0c\u66f2\u7ebf\u4e0b\u9762\u79ef\uff08f\uff09\uff0c\u6700\u5927\u8840\u6e05\u6d53\u5ea6\uff08g\uff09\u548c\u5e73\u5747\u505c\u7559\u65f6\u95f4\uff08h\uff09\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001<\/strong><strong>G3-<\/strong><strong>\u3001<\/strong><strong>G5-<\/strong><strong>\u548c<\/strong><strong>G7-iCluster\/Pt<\/strong><strong>\u7684\u4f53\u5185\u6297\u80bf\u7624\u7814\u7a76<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-190818\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/4-26.jpg\" alt=\"\" width=\"600\" height=\"565\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/4-26.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/4-26-300x283.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09C57BL\/6\u5c0f\u9f20\u7ecfiCluster\u6cbb\u7597\u540e\u539f\u4f4d\u80bf\u7624\u7684\u751f\u7269\u8367\u5149\u6210\u50cf\u7814\u7a76\u3002<\/p>\n<p>\uff08b\uff09\u5bf9\u5c0f\u9f20\u80bf\u7624\u4fe1\u53f7\u8fdb\u884c\u91cf\u5316\u5904\u7406\u3002<\/p>\n<p>\uff08c\uff09\u5bf9\u5c0f\u9f20\u80bf\u7624\u8d28\u91cf\u3002<\/p>\n<p>\uff08d\uff09\u6cbb\u7597\u7ed3\u675f\u65f6\u79bb\u4f53\u80bf\u7624\u7684\u7167\u7247<\/p>\n<p><strong>\u56fe\u4e94\u3001\u4e0d\u540c<\/strong><strong>PAMAM NPs<\/strong><strong>\u7684\u7a7f\u900f\u80fd\u529b<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-190819\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/5-19.jpg\" alt=\"\" width=\"600\" height=\"553\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/5-19.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/5-19-300x277.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff0937\u2103\u57f9\u517b\u6761\u4ef6\u4e0b\u67d3\u6599\u6807\u8bb0\u7684PAMAM NPs\u5728Panc02 \u80bf\u7624\u7ec6\u80de\u7403\u4e2d\u7684\u5fae\u5206\u5e03\u3002<\/p>\n<p>\uff08b\uff09\u8367\u5149\u7d20\u6807\u8bb0G3-PAMAM\u3001G5-PAMAM\u3001G7-PAMAM\u5b75\u80b24 h\u540e\u80bf\u7624\u7ec6\u80de\u7403\u4e2d\u7ec6\u80de\u7684\u6d41\u5f0f\u5206\u6790\u3002<\/p>\n<p>\uff08c\uff09FITC\u9633\u6027\u7ec6\u80de\u7684\u767e\u5206\u6bd4\u548c\u9633\u6027\u7ec6\u80de\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6(MFI)\u3002<\/p>\n<p>\uff08d\uff09\u4e0e\u80bf\u7624\u7ec6\u80de\u7403\u5b75\u80b24\u5c0f\u65f6\u540e\uff0c\u4e0a\u6e05\u6db2\u3001\u7ec6\u80de\u5916\u7a7a\u9699\u3001\u7ec6\u80de\u4e2d\u7684G3-PAMAM\u3001G5-PAMAM\u3001G7-PAMAM\u5728\u7684\u5242\u91cf\u3002<\/p>\n<p>\uff08e\uff09\u5fae\u6d41\u4f53\u88c5\u7f6e\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08f\uff09\u968f\u7740\u65f6\u95f4\u7684\u63a8\u79fb\uff0c\u57f9\u517b\u57fa\u4e2dPAMAM\u7684\u6d53\u5ea6\u9010\u6e10\u964d\u4f4e\uff0c\u4ee5\u6a21\u62df\u4f53\u5185\u8840\u6db2\u4e2d\u5fae\u7c92\u7684\u6e05\u9664\u3002<\/p>\n<p>\uff08g\uff09\u5b9a\u91cf\u5206\u6790\u80bf\u7624\u7ec4\u7ec7\u5185\u65f6\u95f4\u76f8\u5173\u7684\u8367\u5149\u4fe1\u53f7(\u7eff\u8272\u5706\u5708\u5185)\u3002<\/p>\n<p>\uff08h\uff09\u80bf\u7624\u7ec4\u7ec7\u4e2d\u65f6\u95f4\u76f8\u5173\u7684\u8367\u5149\u4fe1\u53f7\u7684\u5bcc\u96c6\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001<\/strong><strong>G3<\/strong><strong>\u3001<\/strong><strong>G5<\/strong><strong>\u548c<\/strong><strong>G7-iCluster<\/strong><strong>\u5728\u80bf\u7624\u4e2d\u7684\u79ef\u7d2f\u548c\u7ec6\u80de\u5185\u5316<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-190820\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/6-9.jpg\" alt=\"\" width=\"600\" height=\"544\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/6-9.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/11\/6-9-300x272.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\uff08a\uff09\u5168\u8eab\u6027\u6ce8\u5c04\u540e\uff0ciCluster NPs\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u79ef\u7d2f(n = 5)\u3002<\/p>\n<p>\uff08b\uff09NP\u5728\u80bf\u7624\u7ec4\u7ec7\u5904\u79ef\u7d2f\u7684\u66f2\u7ebf\u4e0b\u9762\u79ef\u3002<\/p>\n<p>\uff08c\uff09NPs\u5728\u4f53\u51854h\uff0c16h\uff0c48h\u65f6\u7684\u80bf\u7624\u7ec6\u80de\u5185\u5316\u3002<\/p>\n<p>\uff08d\uff09\u7f57\u4e39\u660eB\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u3002<\/p>\n<p>\uff08e\uff09PCNA\u548cTUNEL\u5206\u6790\u4e86\u4e0d\u540c\u5242\u578b\u6cbb\u7597\u540ePanc02\u80bf\u7624\u7ec4\u7ec7\u7684\u53d8\u5316\u3002<\/p>\n<p>\uff08f\uff09PCNA\u548cTUNEL\u67d3\u8272\u56fe\u50cf\u91cf\u5316\u3002<\/p>\n<p><strong>\u3010\u7ed3\u8bba\u5c55\u671b\u3011<\/strong><\/p>\n<p>\u7efc\u8ff0\u6240\u8ff0\uff0c\u4f5c\u8005\u4ee5G3-\u3001G5-\u548cG7- PAMAM\u6811\u72b6\u5927\u5206\u5b50\u4e3a\u6a21\u578b\uff0c\u7814\u7a76\u4e86\u5c0f\u9897\u7c92\u7684\u7624\u5185\u8868\u73b0\u548c\u6297\u80bf\u7624\u6d3b\u6027\u3002\u4e3a\u4e86\u514b\u670d\u5c0f\u9897\u7c92\u7684\u5feb\u901f\u6e05\u9664\u548c\u5b9e\u73b0\u76f8\u4f3c\u7684\u521d\u59cb\u80bf\u7624\u79ef\u7d2f\u91cf\uff0c\u8fd9\u4e9bPAMAM\u6811\u72b6\u5927\u5206\u5b50\u88ab\u5236\u5907\u6210\u5177\u6709\u76f8\u4f3c\u5927\u5c0f\u548c\u8868\u9762\u7535\u8377\u6027\u8d28\u7684iCluster NPs\u3002\u901a\u8fc7iCluster\u5e73\u53f0\uff0c\u8fd9\u4e9b\u6811\u72b6\u5927\u5206\u5b50\u8868\u73b0\u51fa\u76f8\u4f3c\u7684\u8840\u6db2\u836f\u4ee3\u52a8\u529b\u5b66\u548c\u76f8\u4f3c\u7684\u80bf\u7624\u521d\u59cb\u79ef\u7d2f\u3002\u4f46\u4eceiCluster\u5e73\u53f0\u91ca\u653e\u540e\uff0c\u8fd9\u4e9b\u5dee\u5f02\u5fae\u5c0f\u7684PAMAM\u6811\u72b6\u5927\u5206\u5b50\u5728\u7624\u5185\u8868\u73b0\u548c\u6574\u4f53\u6297\u80bf\u7624\u6d3b\u6027\u4e0a\u5b58\u5728\u663e\u8457\u5dee\u5f02\u3002\u8fd9\u4e5f\u5f3a\u8c03\u4e86\u5fae\u5c0f\u9897\u7c92\u5728\u7624\u5185\u8868\u73b0\u548c\u6297\u80bf\u7624\u6d3b\u6027\u4e0a\u7684\u7ec6\u5fae\u5dee\u5f02\u6240\u4ea7\u751f\u7684\u5de8\u5927\u5f71\u54cd\uff0c\u8fd9\u53ef\u80fd\u6709\u52a9\u4e8e\u672a\u6765\u7684\u7eb3\u7c73\u533b\u5b66\u8bbe\u8ba1\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.nanolett.9b03913\">Intratumor Performance and Therapeutic Efficacy of PAMAM Dendrimers Carried by Clustered Nanoparticles<\/a> (<em>Nano Lett.<\/em> <strong>2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b03913)<\/p>\n<p><strong>\u8bfe\u9898\u7ec4\u7b80\u4ecb\uff1a<\/strong><\/p>\n<p><strong>\u738b\u5747\u6559\u6388<\/strong>\uff1a\u738b\u5747\uff0c\u535a\u58eb\uff0c\u534e\u5357\u7406\u5de5\u5927\u5b66\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u82f1\u56fd\u7687\u5bb6\u5316\u5b66\u5b66\u4f1a\u4f1a\u58eb\uff082016\uff09\uff0c\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\uff082011\uff09\u548c\u4e2d\u56fd\u79d1\u5b66\u9662\u201c\u767e\u4eba\u8ba1\u5212\u201d\u5165\u9009\u8005\uff082005\uff09\uff0c\u201c\u4e07\u4eba\u8ba1\u5212\u201d\u79d1\u6280\u521b\u65b0\u9886\u519b\u4eba\u624d\uff082016\uff09\u548c\u79d1\u6280\u90e8\u201c\u4e2d\u9752\u5e74\u79d1\u6280\u521b\u65b0\u9886\u519b\u4eba\u624d\u201d\u5165\u9009\u8005\uff082013\uff09\uff0c\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u9879\u76ee\u8d1f\u8d23\u4eba\uff082017\uff09\uff0c\u73b0\u4efb\u534e\u5357\u7406\u5de5\u5927\u5b66\u751f\u7269\u533b\u5b66\u79d1\u5b66\u4e0e\u5de5\u7a0b\u5b66\u9662\u9662\u957f\u3002\u76ee\u524d\u4efb\u7f8e\u56fd\u57fa\u56e0\u548c\u7ec6\u80de\u6cbb\u7597\u534f\u4f1a\uff08ASGCT\uff09\u56fd\u9645\u59d4\u5458\u4f1a\u59d4\u5458\uff0c\u4e2d\u56fd\u751f\u7269\u6750\u6599\u534f\u4f1a\u5e38\u52a1\u7406\u4e8b\uff0c\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u7eb3\u7c73\u751f\u7269\u6280\u672f\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3001\u4e2d\u56fd\u751f\u7269\u6750\u6599\u5b66\u4f1a\u667a\u80fd\u4eff\u751f\u751f\u7269\u6750\u6599\u5206\u4f1a\u5019\u4efb\u4e3b\u59d4\uff0cBiomaterials\u526f\u4e3b\u7f16\uff0c Acta Biomaterialia\u548cChemNanoMat\u6742\u5fd7\u7f16\u59d4\uff0cTheranostics\u5ba2\u5ea7\u7f16\u8f91\u3002\u5728Science Translational Medicine\u3001Nature Communications\u3001Nature Nanotechnology\u3001PNAS\u3001Nano Letters\u3001Angew Chem Int Ed\u3001J Am Chem Soc\u3001Advanced Materials\u3001ACS Nano\u3001Biomaterials\u7b49\u6742\u5fd7\u53d1\u8868\u7814\u7a76\u8bba\u6587180\u4f59\u7bc7\uff0c\u8bba\u6587\u88ab\u5f15\u752810000\u4f59\u6b21\u3002<\/p>\n<p><strong>\u675c\u91d1\u5fd7\u7814\u7a76\u5458<\/strong>\uff1a\u675c\u91d1\u5fd7\uff0c\u535a\u58eb\uff0c\u534e\u5357\u7406\u5de5\u5927\u5b66\u7279\u8058\u7814\u7a76\u5458\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u56fd\u5bb6\u4f18\u79c0\u9752\u5e74\u79d1\u5b66\u57fa\u91d1\u83b7\u5f97\u8005\u3001\u5e7f\u4e1c\u7701\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\u3002\u8fd1\u5e74\u6765\uff0c\u5728PNAS\u3001Acc. Chem. Res.\u3001J. Am. Chem. Soc.\u3001Angew. Chem. Int. Ed.\u3001ACS Nano\u3001Nano Lett.\u3001Adv. Mater.\u3001Biomaterials\u3001J. Controlled Release\u7b49\u56fd\u9645\u8457\u540d\u6742\u5fd7\u53d1\u8868\u7814\u7a76\u8bba\u658740\u4f59\u7bc7\u3002\u8bba\u6587\u88abSCI\u5f15\u75283000\u4f59\u6b21\uff0c\u5355\u7bc7\u5f15\u7528\u6700\u9ad8\u8fd1600\u6b21\u3002\u591a\u7bc7\u8bba\u6587\u5165\u9009ESI\u9ad8\u88ab\u5f15\u3002\u76ee\u524d\u62c5\u4efb\u300a\u6750\u6599\u5bfc\u62a5\u300b\u6267\u884c\u7f16\u59d4\uff1b\u4e2d\u56fd\u6297\u764c\u534f\u4f1a\u7eb3\u7c73\u80bf\u7624\u5b66\u4e13\u4e1a\u59d4\u5458\u4f1a\u7b2c\u4e00\u5c4a\u9752\u5e74\u59d4\u5458\u3001\u4e2d\u56fd\u751f\u7269\u5de5\u7a0b\u5b66\u4f1a\u7eb3\u7c73\u533b\u5b66\u4e0e\u5de5\u7a0b\u5206\u4f1a\u9752\u5e74\u59d4\u5458\u3002<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com\">tougao@cailiaoren.com<\/a><\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u7814\u7a76\u80cc\u666f\u3011 \u8fd1\u51e0\u5341\u5e74\u6765\uff0c\u5927\u91cf\u7684\u7814\u7a76\u8868\u660e\uff0c\u6297\u764c\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\u7684\u5927\u5c0f\u5728\u51b3\u5b9a\u5176\u7ec4\u7ec7\u5206\u5e03\u3001\u80bf\u7624\u7a7f\u900f\u3001\u7ec6\u80de\u5185\u5316\u548c\u4f53\u5185\u6e05\u9664\u7b49\u65b9\u9762\u8d77\u7740\u81f3\u5173\u91cd\u8981\u7684\u4f5c\u7528\u3002\u76ee\u524d\u5927\u90e8\u5206\u7814\u7a76\u4e3b\u8981&#8230;<\/p>\n","protected":false},"author":1004,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[4255],"class_list":["post-190813","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-pamam"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/190813"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=190813"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/190813\/revisions"}],"predecessor-version":[{"id":191554,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/190813\/revisions\/191554"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=190813"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=190813"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=190813"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}