{"id":190678,"date":"2019-11-30T06:30:26","date_gmt":"2019-11-29T22:30:26","guid":{"rendered":"\/\/m.iemloyee.com\/?p=190678"},"modified":"2019-11-29T20:33:43","modified_gmt":"2019-11-29T12:33:43","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6%e9%99%84%e5%b1%9e%e5%84%bf%e7%ab%a5%e5%8c%bb%e9%99%a2-acs-nano%ef%bc%9a%e5%9f%ba","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=190678","title":{"rendered":"\u82cf\u5dde\u5927\u5b66&\u82cf\u5dde\u5927\u5b66\u9644\u5c5e\u513f\u7ae5\u533b\u9662 ACS Nano\uff1a\u57fa\u4e8e\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u7684\u7eb3\u7c73\u75ab\u82d7\u7528\u4e8e\u764c\u75c7\u514d\u75ab\u6cbb\u7597"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u57282018\u5e74\u7684\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u9881\u53d1\u7ed9\u8a79\u59c6\u65af\u00b7\u827e\u5229\u68ee\u548c\u672c\u5eb6\u4f51\u4e24\u4f4d\u79d1\u5b66\u5bb6\uff0c\u4ee5\u5956\u52b1\u4ed6\u4eec\u5728\u201c\u53d1\u73b0\u8d1f\u6027\u514d\u75ab\u8c03\u8282\u6cbb\u7597\u764c\u75c7\u7684\u7597\u6cd5\u65b9\u9762\u7684\u8d21\u732e\u201d\u3002\u800c\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u901a\u5e38\u5305\u62ec\u7ec6\u80de\u56e0\u5b50\u7597\u6cd5\u3001\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u548c\u764c\u75c7\u75ab\u82d7\u3002\u5c24\u5176\u662f\u764c\u75c7\u75ab\u82d7\u80fd\u591f\u89e6\u53d1\u6301\u4e45\u7684\u80bf\u7624\u7279\u5f02\u6027\u514d\u75ab\u53cd\u5e94\u3002\u5176\u4e2d\uff0c\u80bf\u7624\u75ab\u82d7\u901a\u5e38\u7531\u7279\u5f02\u6027\u6297\u539f\u3001\u589e\u5f3a\u514d\u75ab\u53cd\u5e94\u7684\u4f50\u5242\u548c\u75ab\u82d7\u8f7d\u4f53\u7ec4\u6210\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5177\u6709\u53ef\u63a7\u7269\u7406\u5316\u5b66\u6027\u8d28\u7684\u7eb3\u7c73\u6750\u6599\u53ef\u7528\u4e8e\u6784\u5efa\u80bf\u7624\u7eb3\u7c73\u75ab\u82d7\u3002\u867d\u7136\u76ee\u524d\u5728\u7eb3\u7c73\u75ab\u82d7\u7684\u7814\u53d1\u65b9\u9762\u53d6\u5f97\u4e86\u4e0d\u9519\u6210\u7ee9\uff0c\u4f46\u662f\u4ecd\u4e9f\u9700\u5f00\u53d1\u53ef\u4ee5\u901a\u8fc7\u7b80\u4fbf\u65b9\u6cd5\u5408\u6210\u6709\u6548\u7684\u7eb3\u7c73\u75ab\u82d7\u7528\u4e8e\u764c\u75c7\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n

\u5728\u75ab\u82d7\u63a5\u79cd\u8fc7\u7a0b\u4e2d\uff0c\u6297\u539f\u5448\u9012\u7ec6\u80de\u5728\u542f\u52a8\u548c\u8c03\u8282\u9002\u5e94\u6027\u514d\u75ab\u5e94\u7b54\u4e2d\u8d77\u7740\u91cd\u8981\u4f5c\u7528\u3002\u5bf9\u4e8e\u80bf\u7624\u75ab\u82d7\uff0c\u9700\u8981\u901a\u8fc7\u6811\u7a81\u72b6\u7ec6\u80de\uff08DCs\uff09\u4e2d\u7684\u6297\u539f\u4ea4\u53c9\u5448\u9012\u8fc7\u7a0b\u6765\u589e\u5f3a\u514d\u75ab\u7cfb\u7edf\u5bf9\u5916\u6e90\u6027\u80bf\u7624\u6297\u539f\u7684\u8bc6\u522b\u3002\u76ee\u524d\u5df2\u53d1\u73b0\u7531\u6838\u82f7\u9178\u5be1\u805a\u7ed3\u5408\u7ed3\u6784\u57df1\uff08Nod1\uff09\u53d7\u4f53\u4ecb\u5bfc\u7684\u4fe1\u53f7\u53ef\u4ee5\u589e\u5f3aDCs\u6210\u719f\u53ca\u6297\u539f\u4ea4\u53c9\u5448\u9012\u3002\u7136\u800c\uff0c\u5c1a\u672a\u62a5\u9053\u4f7f\u7528\u7eb3\u7c73\u75ab\u82d7\u6fc0\u6d3bNod1\u4fe1\u53f7\u9014\u5f84\u4ee5\u8fdb\u884c\u764c\u75c7\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u82cf\u5dde\u5927\u5b66\u5218\u5e84\u6559\u6388\u548c\u82cf\u5dde\u5927\u5b66\u9644\u5c5e\u513f\u7ae5\u533b\u9662\u6c6a\u5065\u6559\u6388<\/strong>\u5408\u4f5c\u62a5\u9053\u4e86\u4e00\u79cd\u7531Mn2+<\/sup>\u79bb\u5b50\uff0c\u5185\u6d88\u65cb-2, 6-\u4e8c\u6c28\u57fa\u5e9a\u4e8c\u9178\uff08DAP\uff0cNod1\u4fe1\u53f7\u901a\u8def\u6fc0\u52a8\u5242\uff09\u548c\u6a21\u5f0f\u6297\u539f\u9e21\u5375\u6e05\u767d\u86cb\u767d\uff08OVA\uff09\u5171\u540c\u5236\u5907\u5f97\u5230\u7684\u7eb3\u7c73\u80bf\u7624\u75ab\u82d7\uff08OVA@Mn-DAP\uff09\u3002\u6240\u5236\u5907\u7684OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u901a\u8fc7\u589e\u52a0\u7ec6\u80de\u5bf9\u6297\u539fOVA\u7684\u6444\u53d6\u5e76\u901a\u8fc7\u6fc0\u6d3bNod1\u9014\u5f84\u6765\u4fc3\u8fdbDCs\u6210\u719f\u4ee5\u53ca\u589e\u5f3a\u6297\u539f\u4ea4\u53c9\u5448\u9012\u3002\u901a\u8fc7\u78c1\u5171\u632f\u548c\u8367\u5149\u6210\u50cf\u53d1\u73b0\uff0c\u8fd9\u79cdOVA@Mn-DAP\u75ab\u82d7\u53ef\u4ee5\u5728\u5c40\u90e8\u6ce8\u5c04\u540e\u8fc1\u79fb\u5230\u6dcb\u5df4\u7ed3\u4e2d\u3002OVA@Mn-DAP\u75ab\u82d7\u4e0d\u4ec5\u53ef\u4ee5\u63d0\u4f9b\u9884\u9632\u6027\u4fdd\u62a4\uff0c\u4ee5\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7B16-OVA\u653b\u51fb\uff0c\u5f53\u4e0e\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u578b\u6297\u4f53\u03b1-PD-1\u8054\u5408\u4f7f\u7528\u65f6\uff0c\u8fd8\u53ef\u4ee5\u4ea7\u751f\u663e\u7740\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4ece\u800c\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u3002\u56e0\u6b64\uff0c\u8be5\u5de5\u4f5c\u4e3a\u6784\u5efa\u6709\u6548\u7684\u7528\u4e8e\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u7684\u7eb3\u7c73\u75ab\u82d7\u63d0\u4f9b\u4e86\u65b0\u5e73\u53f0\u3002\u8be5\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cNanoscale Coordination Polymer Based Nanovaccine for Tumor Immunotherapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u7684\u5408\u6210\u4e0e\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u7684\u5408\u6210\u548c\u4f5c\u7528\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09\u901a\u8fc7DLS\u6d4b\u91cf\u7684OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u7684\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n

\uff08D\uff09\u5f53pH=7.4\u65f6\uff0c\u5728\u4e0d\u540c\u6d53\u5ea6\u4e0b\u7684OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u7684T1\u52a0\u6743MR\u56fe\u50cf\u548c\u76f8\u5e94\u7684T1\u5f1b\u8c6b\u901f\u7387\u3002<\/p>\n

\u56fe\u4e8c\u3001OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u589e\u5f3a\u4f53\u5916DCs\u6444\u53d6\u3001\u6210\u719f\u548c\u6297\u539f\u4ea4\u53c9\u5448\u9012<\/strong>
\n \"\"(A) OVA@Mn-DAP\u589e\u5f3a\u6297\u539f\u5728\u7ec6\u80de\u5185\u4f5c\u7528\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(B) \u4e0d\u540c\u6d53\u5ea6\u7684OVA@Mn-DAP\u7eb3\u7c73\u9897\u7c92\u5b75\u80b2\u540eDCs\u7684\u76f8\u5bf9\u5b58\u6d3b\u7387\uff1b<\/p>\n

(C-D) DCs\u4e0e\u4e0d\u540c\u6750\u6599\u7ec4\u5b75\u80b220 h\u540e\uff0cOVA-cy5.5\u5185\u541e\u7684\u6d41\u5f0f\u56fe\u548c\u7edf\u8ba1\u6570\u636e\uff1b<\/p>\n

\uff08E\uff09DCs\u4e0e\u6e38\u79bbOVA-cy5.5\u6216OVA-cy5.5@Mn-DAP\u5b75\u80b220 h\u540e\uff0cDCs\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08F\uff09\u7528PBS\u3001OVA\u3001DAP\u3001OVA+DAP\u6216OVA@Mn-DAP\u5904\u7406DCs 20h\u540e\uff0cDC\u6210\u719f\u7684\u7edf\u8ba1\u6570\u636e\uff1b<\/p>\n

\uff08G\uff09\u7528PBS\u3001OVA\u3001OVA+DAP\u6216OVA@Mn-DAP\u5904\u7406DCs 20 h\u540e\uff0c\u6297\u539fOVA\u4ea4\u53c9\u5448\u9012\u7684\u7edf\u8ba1\u6570\u636e\uff1b<\/p>\n

\uff08H-I\uff09\u7528\u4e0d\u540c\u6750\u6599\u7ec4\u5904\u7406DCs\u540e, DCs\u5206\u6ccc\u7684TNF-\u03b1\u548cIL-12 p40\u3002<\/p>\n

\u56fe\u4e09\u3001\u7eb3\u7c73\u75ab\u82d7\u7684\u4f53\u5185\u6210\u50cf<\/strong>
\n \"\"\uff08A-B\uff09\u6ce8\u5c04\u6e38\u79bb\u7684OVA-cy5.5\u6216OVA-cy5.5@Mn-DAP\u7eb3\u7c73\u75ab\u82d7\u540e\uff0c\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u6dcb\u5df4\u7ed3\uff08pLNs\uff09\u7684\u4f53\u5185\u8367\u5149\u56fe\u50cf\u548c\u5b9a\u91cf\u7684\u8367\u5149\u4fe1\u53f7\uff1b<\/p>\n

\uff08C-D\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684pLNs\u4e0a\u7684\u4f53\u5185T1\u52a0\u6743MR\u56fe\u50cf\u548c\u5b9a\u91cf\u7684\u78c1\u5171\u632f\u4fe1\u53f7\u5f3a\u5ea6\u3002<\/p>\n

\u56fe\u56db\u3001OVA@Mn-DAP\u4f5c\u4e3a\u9884\u9632\u6027\u75ab\u82d7\u7684\u6297\u80bf\u7624\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09\u514d\u75ab\u8fc7\u7a0b\u548c\u80bf\u7624\u6fc0\u53d1\u5b9e\u9a8c\u8bbe\u8ba1\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B-C\uff09\u7b2c\u4e00\u6b21\u514d\u75ab5\u5929\u540e\uff0c\u4e0d\u540c\u75ab\u82d7\u5236\u5242\u5bf9\u4f53\u5185DC\u6210\u719f\u548c\u6297\u539f\u4ea4\u53c9\u5448\u9012\u7684\u5f71\u54cd\uff1b<\/p>\n

\uff08D\uff09\u901a\u8fc7ELISPOT\u6cd5\uff0c\u6d4b\u5b9a\u813e\u7ec6\u80de\u4e2d\u5206\u6cccIFN-\u03b3\u7684\u76f8\u5bf9\u7ec6\u80de\u6570\uff1b<\/p>\n

\uff08E\uff09\u514d\u75ab21\u5929\u540e\uff0c\u5728\u514d\u75ab\u5c0f\u9f20\u7684\u8840\u6e05\u4e2d\u4ea7\u751fIFN-\u03b3\u6c34\u5e73\uff1b<\/p>\n

\uff08F-G\uff09\u514d\u75ab21\u5929\u540e\uff0c\u5404\u79cd\u75ab\u82d7\u5236\u5242\u5bf9B16-OVA\u9ed1\u8272\u7d20\u7624\u7684\u9884\u9632\u4f5c\u7528\uff1b<\/p>\n

\uff08H\uff09\u4e0d\u540c\u7ec4\u5c0f\u9f20\u5728B16-OVA\u80bf\u7624\u653b\u51fb\u4e0b\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe\u4e94\u3001OVA@Mn-DAP\u75ab\u82d7\u8054\u5408\u03b1-PD-1\u7684\u6297\u80bf\u7624\u6cbb\u7597\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09OVA@Mn-DAP\u75ab\u82d7\u548c\u03b1-PD-1\u8054\u5408\u6cbb\u7597\u80bf\u7624\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B-C\uff09PBS\u3001OVA@Mn-DAP\u3001\u03b1-PD-1\u548cOVA@Mn-DAP\u75ab\u82d7\u4e0e\u03b1-PD-1\u8054\u5408\u6cbb\u7597\u540e\uff0c\u4e0d\u540c\u7ec4B16-OVA\u8377\u7624\u5c0f\u9f20\u7684\u4e2a\u4f53\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u548c\u5e73\u5747\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08D\uff09\u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08E-F\uff09\u5b58\u6d3b\u7684\u5c0f\u9f20\uff0c\u5728\u7b2c\u4e00\u6b21\u63a5\u79cdB16-OVA\u80bf\u762460\u5929\u540e\uff0c\u518d\u6b21\u7528B16-OVA\u8fdb\u884c\u6311\u6218\uff0c\u5c0f\u9f20\u7684\u4e2a\u4f53\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u548c\u5e73\u5747\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08G\uff09\u4e8c\u6b21\u80bf\u7624\u6311\u6218\u7684\u5c0f\u9f20\u7684\u5b58\u6d3b\u6570\u636e\u3002<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u5229\u7528Mn2+<\/sup>\u79bb\u5b50\u3001DAP\u914d\u4f53\uff08Nod1\u6fc0\u52a8\u5242\uff09\u548c\u6297\u539f\u86cb\u767dOVA\u5236\u5907\u5f97\u5230OVA@Mn-DAP\u7eb3\u7c73\u75ab\u82d7\u5e76\u7528\u4e8e\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002\u8be5\u7eb3\u7c73\u75ab\u82d7\u53ef\u4ee5\u4fc3\u8fdb\u6297\u539f\u7684\u7ec6\u80de\u6444\u53d6\u3001\u4fc3\u8fdbDCs\u6210\u719f\uff0c\u589e\u5f3apLNs\u7684\u6ede\u7559\u65f6\u95f4\uff0c\u5e76\u901a\u8fc7\u6fc0\u6d3bNod1\u4fe1\u53f7\u9014\u5f84\u4fc3\u8fdb\u6297\u539f\u4ea4\u53c9\u5448\u9012\u3002OVA@Mn-DAP\u4e0d\u4ec5\u53ef\u4ee5\u7528\u4f5c\u9884\u9632\u6027\u7eb3\u7c73\u75ab\u82d7\u4ee5\u4fdd\u62a4\u5c0f\u9f20\u514d\u53d7\u9ed1\u7d20\u7624\u7684\u653b\u51fb\uff0c\u800c\u4e14\u8fd8\u53ef\u4ee5\u4f5c\u4e3a\u6cbb\u7597\u6027\u7eb3\u7c73\u75ab\u82d7\u4e0e\u03b1-PD-1\u8054\u5408\u6cbb\u7597\u4ee5\u6291\u5236\u80bf\u7624\u7684\u751f\u957f\u800c\u5ef6\u957f\u52a8\u7269\u7684\u5b58\u6d3b\u65f6\u95f4\u3002\u603b\u4e4b\uff0c\u8be5\u5de5\u4f5c\u63d0\u51fa\u4e86\u4e00\u79cd\u521b\u65b0\u7684\u7b56\u7565\u6765\u6784\u5efa\u57fa\u4e8e\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u7684\u7eb3\u7c73\u75ab\u82d7\u4ee5\u8fdb\u884c\u6709\u6548\u7684\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u3002<\/p>\n

\u8be5\u7814\u7a76\u53d1\u8868\u5728ACS Nano<\/strong>\u4e0a\uff0c\u6587\u7ae0\u94fe\u63a5\uff1aNanoscale Coordination Polymer Based Nanovaccine for Tumor Immunotherapy<\/a><\/strong>\uff08ACS Nano<\/em>, 2019<\/strong>, DOI:10.1021\/acsnano.9b05974\uff09\u3002<\/p>\n

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