{"id":190080,"date":"2019-11-16T06:30:54","date_gmt":"2019-11-15T22:30:54","guid":{"rendered":"\/\/m.iemloyee.com\/?p=190080"},"modified":"2019-11-15T20:35:40","modified_gmt":"2019-11-15T12:35:40","slug":"%e3%80%90%e6%8a%95%e7%a8%bf%e3%80%91%e4%b8%ad%e7%a7%91%e9%99%a2%e4%b8%8a%e6%b5%b7%e8%8d%af%e7%89%a9%e6%89%80%e6%9d%8e%e4%ba%9a%e5%b9%b3%e5%9b%a2%e9%98%9fnano-today%ef%bc%9a%e5%88%a9%e7%94%a8%e7%ba%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=190080","title":{"rendered":"\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u6240\u674e\u4e9a\u5e73\u56e2\u961fNano Today\uff1a\u5229\u7528\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u514b\u670dPD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u5c4f\u969c"},"content":{"rendered":"

\u5f15\u8a00<\/b><\/strong><\/p>\n

\u57fa\u4e8ePD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7684\u80bf\u7624\u514d\u75ab\u7597\u6cd5\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u4e34\u5e8a\uff0c\u5728\u90e8\u5206\u80bf\u7624\u60a3\u8005\u4e2d\u8868\u73b0\u51fa\u663e\u8457\u7597\u6548\u3002PD-1\u5206\u5b50\u662fCD28\u8d85\u5bb6\u65cf\u7684\u5171\u6291\u5236\u53d7\u4f53\uff0c\u5e7f\u6cdb\u8868\u8fbe\u4e8eT\u7ec6\u80de\u3001B\u7ec6\u80de\u548c\u9ad3\u7cfb\u7ec6\u80de\u7b49\uff1bPD-L1\u5206\u5b50\u662fPD-1\u7684\u914d\u4f53\uff0c\u5e38\u8868\u8fbe\u4e8e\u6dcb\u5df4\u7ec6\u80de\u3001\u6297\u539f\u5448\u9012\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\u7b49\u3002\u6b63\u5e38\u60c5\u51b5\u4e0b\uff0cPD-1\u4e0ePD-L1\u7ed3\u5408\u80fd\u591f\u6291\u5236\u514d\u75ab\u76f8\u5173\u7ec6\u80de\u56e0\u5b50\u5982\u767d\u4ecb\u7d20-2\u548c\u5e72\u6270\u7d20-\u03b3\u7b49\u4ea7\u751f\uff0c\u6291\u5236\u7ec6\u80de\u6bd2\u6027T\u7ec6\u80de\uff08CTLs\uff09\u7684\u589e\u6b96\u548c\u529f\u80fd\u53d1\u6325\uff0c\u7ef4\u6301\u673a\u4f53\u514d\u75ab\u7a33\u6001\u3002\u4f46\u662f\u8fd9\u4e00\u7279\u6027\u4e5f\u88ab\u80bf\u7624\u7ec6\u80de\u6240\u5229\u7528\uff0c\u4fc3\u8fdb\u80bf\u7624\u53d1\u751f\u514d\u75ab\u9003\u9038\u3002\u56e0\u6b64\uff0c\u963b\u65adPD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u901a\u8def\uff0c\u80fd\u591f\u6062\u590d\u673a\u4f53\u5bf9\u80bf\u7624\u7684\u514d\u75ab\u8bc6\u522b\u529f\u80fd\uff0c\u6709\u5229\u4e8e\u53d1\u6325CTLs\u5bf9\u80bf\u7624\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\u3002\u4f46\u662f\uff0c\u4e34\u5e8a\u4e0aPD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u4ecd\u5b58\u5728\u4e24\u4e2a\u95ee\u9898\uff1a1\uff0c\u5176\u5728\u591a\u6570\u80bf\u7624\u7c7b\u578b\u4e2d\u7684\u4e34\u5e8a\u54cd\u5e94\u7387\u4e0d\u8d85\u8fc730%\uff0c\u8f83\u4f4e\u7684\u54cd\u5e94\u7387\u4ec5\u80fd\u4f7f\u90e8\u5206\u75c5\u4eba\u83b7\u76ca\uff1b2\uff0cAnti-PD\u6297\u4f53\u5b58\u5728\u201con\u00a0target\u00a0but off tumor\u201d\u6548\u5e94\uff0c\u53ef\u80fd\u5bfc\u81f4\u514d\u75ab\u76f8\u5173\u6bd2\u526f\u4f5c\u7528\uff0c\u9650\u5236\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u63d0\u9ad8PD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u54cd\u5e94\u7387\u5e76\u964d\u4f4e\u5176\u514d\u75ab\u76f8\u5173\u6bd2\u526f\u4f5c\u7528\u4ecd\u4e9f\u5f85\u89e3\u51b3\u3002<\/p>\n

\u6210\u679c\u7b80\u4ecb<\/b><\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u6240\u674e\u4e9a\u5e73\u56e2\u961f<\/b><\/strong>\u7efc\u8ff0\u4e86\u5229\u7528\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u514b\u670dPD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6cbb\u7597\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u8be5\u6210\u679c\u4ee5\u201cRecent advances in nanosized drug delivery systems for overcoming the barriers to anti-PD immunotherapy of cancer<\/b><\/strong>\u201d\u4e3a\u9898\u53d1\u8868\u5728N<\/b><\/strong>ano Today<\/b><\/strong>\u3002\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u7684\u8fdb\u6b65\u4e3a\u6539\u5584PD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u8be5\u7efc\u8ff0\u56f4\u7ed5\u63d0\u9ad8anti-PD\u7597\u6cd5\u7684\u54cd\u5e94\u7387\u53ca\u964d\u4f4e\u5176\u514d\u75ab\u76f8\u5173\u6bd2\u526f\u4f5c\u7528\u5c55\u5f00\u8bba\u8ff0\uff1a\uff081\uff09\u901a\u8fc7\u5229\u7528\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u6539\u5584\u80bf\u7624\u514d\u75ab\u5fae\u73af\u5883\uff0c\u4fc3\u8fdbCTLs\u7624\u5185\u6d78\u6da6\u5e76\u589e\u5f3a\u5176\u529f\u80fd\uff0c\u4e3aanti-PD\u6cbb\u7597\u521b\u9020\u6709\u5229\u6761\u4ef6\u3002\u5305\u62ec\u57fa\u4e8e\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u7684\u80bf\u7624\u75ab\u82d7\u3001\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u53ca\u514d\u75ab\u76f8\u5173\u4ee3\u8c22\u901a\u8def\u8c03\u63a7\u3002\uff082\uff09\u901a\u8fc7\u5229\u7528\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u9012\u9001\u591a\u79cd\u7c7b\u578b\u7684PD-1\/PD-L1\u6291\u5236\u5242\uff0c\u63d0\u9ad8\u6291\u5236\u5242\u7684\u80bf\u7624\u7279\u5f02\u6027\u5206\u5e03\uff0c\u4ee5\u964d\u4f4e\u5176\u201con\u00a0target\u00a0but\u00a0off\u00a0tumor\u201d\u6548\u5e94\u3002\u5305\u62ec\u5229\u7528\u7eb3\u7c73\u9012\u9001\u7cfb\u7edf\u8f93\u9001\u6297\u4f53\u836f\u7269\u3001\u6838\u9178\u836f\u7269\u53ca\u591a\u80bd\u7c7b\u836f\u7269\u7b49\u3002<\/p>\n

\u56fe\u6587\u5bfc\u8bfb<\/b><\/strong><\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>1.<\/b><\/strong>\u00a0<\/b><\/strong>\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u901a\u8fc7\u591a\u79cd\u9014\u5f84\u514b\u670d<\/b><\/strong>PD-1\/PD-L1<\/b><\/strong>\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u6297\u80bf\u7624\u6cbb\u7597\u7684\u5c4f\u969c<\/b><\/strong><\/p>\n

\"\" \u00a0\u00a0\u00a0<\/p>\n

\uff08A\uff09\u57fa\u4e8e\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u7684\u75ab\u82d7\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54<\/p>\n

\uff08B\uff09\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u9012\u9001\u591a\u80bd\u3001\u6838\u9178\u7c7b\u836f\u7269\u963b\u65adPD-1\/PD-L1\u901a\u8def<\/p>\n

\uff08C\uff09\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u5305\u8f7danti-PD\u6297\u4f53<\/p>\n

\uff08D\uff09\u4eff\u751f\u578b\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u9012\u9001anti-PD\u6297\u4f53<\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>2.<\/b><\/strong>\u00a0<\/b><\/strong>\u57fa\u4e8e\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u7684\u5316\u7597\u7b56\u7565\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u534f\u540c\u589e\u6548anti-<\/b><\/strong>PD-L1<\/b><\/strong>\u6cbb\u7597<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A) \u8f7d\u836f\u7eb3\u7c73\u7c92\u7684\u5236\u5907<\/p>\n

(B) TEM\u8868\u5f81\u00a0<\/p>\n

(C) DLS\u6d4b\u5b9a\u7eb3\u7c73\u7c92\u7684\u7c92\u5f84\u5206\u5e03<\/p>\n

(D) \u8f7d\u836f\u7eb3\u7c73\u7c92\u7684\u7a33\u5b9a\u6027\u00a0<\/p>\n

(E) \u7eb3\u7c73\u7c92\u8bf1\u5bfc\u514d\u75ab\u539f\u6027\u7ec6\u80de\u6b7b\u4ea1\u8054\u5408anti-PD-L1\u63d0\u9ad8CD8+ <\/sup>T\u7ec6\u80de\u6bd4\u4f8b\u00a0<\/p>\n

(F) \u57fa\u4e8e\u8f7d\u836f\u7eb3\u7c73\u7c92\u7684\u8054\u5408\u7597\u6cd5\u6291\u5236\u80bf\u7624\u751f\u957f<\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>3.<\/b><\/strong>\u00a0<\/b><\/strong>\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u5305\u8f7danti-<\/b><\/strong>PD-L1<\/b><\/strong>\u6297\u4f53\u5b9e\u73b0\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u6027\u91ca\u653e<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A) MMP-2 \u54cd\u5e94\u6027\u7eb3\u7c73\u7c92\u7684\u5236\u5907\u8def\u7ebf<\/p>\n

(B) TEM \u8868\u5f81\u7eb3\u7c73\u7c92\u7684\u7ec4\u88c5\u00a0<\/p>\n

(C) \u57fa\u4e8e\u758f\u6c34\u6027\u76f8\u4e92\u4f5c\u7528\u7684\u7eb3\u7c73\u7ec4\u88c5\u8def\u7ebf\u5bf9\u5305\u8f7d\u86cb\u767d\u6d3b\u6027\u7684\u5f71\u54cd\u00a0<\/p>\n

(D) \u6297\u4f53\u7eb3\u7c73\u7c92\u5728\u80bf\u7624\u7ec4\u7ec7\u7684\u5206\u5e03\u884c\u4e3a\u00a0<\/p>\n

(E) \u6e38\u79bb\u6297\u4f53\u53ca\u6297\u4f53\u7eb3\u7c73\u7c92\u5728\u80ba\u810f\u7ec4\u7ec7\u7684\u5206\u5e03\u884c\u4e3a<\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>4.<\/b><\/strong>\u00a0<\/b><\/strong>\u57fa\u4e8e\u8840\u5c0f\u677f\u7684\u4eff\u751f\u578b\u836f\u7269\u9012\u9001\u7cfb\u7edf\u8868\u9762\u4fee\u9970anti-<\/b><\/strong>PD-L1<\/b><\/strong>\u6297\u4f53<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A) \u57fa\u4e8e\u8840\u5c0f\u677f\u7684\u4eff\u751f\u578b\u836f\u7269\u9012\u9001\u7cfb\u7edf\u7684\u4f5c\u7528\u673a\u5236<\/p>\n

(B) \u6e38\u79bbanti-PD-L1\u6297\u4f53\u4e0e\u4fee\u9970\u6027\u6297\u4f53\u836f\u7269\u7684\u4f53\u5185\u836f\u52a8\u5b66\u884c\u4e3a<\/p>\n

(C) \u6e38\u79bbanti-PD-L1\u6297\u4f53\u4e0e\u4fee\u9970\u6027\u6297\u4f53\u836f\u7269\u5728\u672f\u540e\u80bf\u7624\u90e8\u4f4d\u7684\u5206\u5e03<\/p>\n

(D) \u751f\u7269\u53d1\u5149\u6210\u50cf\u8003\u5bdf\u4e0d\u540c\u5904\u65b9\u7ed9\u836f\u540e4T1\u4e73\u817a\u764c\u80bf\u7624\u7684\u751f\u957f\u60c5\u51b5<\/p>\n

Figure<\/b><\/strong>\u00a0<\/b><\/strong>5.<\/b><\/strong>\u00a0<\/b><\/strong>\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u901a\u8fc7R<\/b><\/strong>NA<\/b><\/strong>i\u6280\u672f\u963b\u65ad<\/b><\/strong>PD-L1<\/b><\/strong>\u514d\u75ab\u68c0\u67e5\u70b9\u901a\u8def<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(A) \u8d1f\u8f7dsiRNA\u7684\u7eb3\u7c73\u80f6\u675f\u5236\u5907\u8def\u7ebf\u00a0<\/p>\n

(B) TEM \u8868\u5f81\u80f6\u675f\u7684\u9178\u54cd\u5e94\u7279\u6027<\/p>\n

(C) \u80f6\u675f\u7684\u8367\u5149\u7279\u6027\u968f\u6eb6\u6db2pH\u7684\u53d8\u5316<\/p>\n

(D) \u9178\u6027\u5e94\u80f6\u675f\u8054\u5408RNAi\u4e0e\u5149\u52a8\u529b\u6cbb\u7597\u63d0\u9ad8\u6297\u80bf\u7624\u8f6c\u79fb\u6cbb\u7597\u6548\u679c<\/p>\n

\u603b\u7ed3<\/b><\/strong><\/p>\n

\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u5177\u6709\u6539\u5584PD-1\/PD-L1\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad\u7597\u6cd5\u6297\u80bf\u7624\u6548\u679c\u7684\u5de8\u5927\u6f5c\u529b\u3002\u8be5\u7efc\u8ff0\u91cd\u70b9\u4ece\u5229\u7528\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u6fc0\u6d3b\u6297\u80bf\u7624\u514d\u75ab\u5e94\u7b54\uff0c\u5b9e\u73b0\u514d\u75ab\u68c0\u67e5\u70b9\u836f\u7269\u7684\u80bf\u7624\u7279\u5f02\u6027\u5206\u5e03\u65b9\u9762\u4ecb\u7ecd\u4e86\u8be5\u9886\u57df\u7684\u6700\u65b0\u8fdb\u5c55\u3002\u5728\u6587\u7ae0\u6700\u540e\uff0c\u4f5c\u8005\u5c55\u671b\u4e86\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u5728\u6539\u5584anti-PD\u6cbb\u7597\u65b9\u9762\u7684\u6f5c\u5728\u62d3\u5c55\u65b9\u5411\uff0c\u5305\u62ec\u6df1\u5165\u63a2\u7a76\u7eb3\u7c73\u9012\u836f\u7cfb\u7edf\u4e0e\u514d\u75ab\u7cfb\u7edf\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5229\u7528\u7eb3\u7c73\u9012\u9001\u7cfb\u7edf\u5b9e\u73b0anti-PD\u7597\u6cd5\u4e0e\u591a\u79cd\u624b\u6bb5\u8054\u5408\u7b49\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5<\/b><\/strong>:<\/b><\/strong>\u00a0<\/b><\/strong>Recent advances in nanosized drug delivery systems for overcoming the barriers to anti-PD immunotherapy of cancer. Nano Today, 2019\uff0cdoi:\u00a010.1016\/j.nantod.2019.100801<\/a><\/p>\n

\u672c\u6587\u7531\u4e2d\u79d1\u9662\u4e0a\u6d77\u836f\u7269\u6240\u674e\u4e9a\u5e73\u56e2\u961f<\/b><\/strong>\u4f9b\u7a3f\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1: tougao@cailiaoren.com.<\/p>\n

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