{"id":185347,"date":"2019-09-17T06:30:12","date_gmt":"2019-09-16T22:30:12","guid":{"rendered":"\/\/m.iemloyee.com\/?p=185347"},"modified":"2019-09-16T14:44:56","modified_gmt":"2019-09-16T06:44:56","slug":"accounts-chem-res-%ef%bc%9a%e8%82%bf%e7%98%a4%e8%a1%80%e7%ae%a1%e9%9d%b6%e5%90%91%e7%9a%84%e6%99%ba%e8%83%bd%e7%ba%b3%e7%b1%b3%e6%b2%bb%e7%96%97%e5%89%82","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=185347","title":{"rendered":"Accounts Chem. Res. \uff1a\u80bf\u7624\u8840\u7ba1\u9776\u5411\u7684\u667a\u80fd\u7eb3\u7c73\u6cbb\u7597\u5242"},"content":{"rendered":"<p><a href=\"\/\/m.iemloyee.com\/?p=185347&amp;preview=true\" target=\"_blank\" rel=\"noopener\"><strong>Accounts Chem. Res. <\/strong><strong>\uff1a\u80bf\u7624\u8840\u7ba1\u9776\u5411\u7684\u667a\u80fd\u7eb3\u7c73\u6cbb\u7597\u5242<\/strong><\/a><\/p>\n<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p><strong>\u00a0 <\/strong>\u8fc7\u53bb\u7684\u51e0\u5341\u5e74\u89c1\u8bc1\u4e86\u80bf\u7624\u8840\u7ba1\u9776\u5411\u6cbb\u7597\u9886\u57df\u7684\u53d1\u5c55\u3002\u4e0e\u4f20\u7edf\u7684\u5316\u7597\u836f\u7269\u9700\u8981\u6e17\u900f\u5230\u80bf\u7624\u7ec4\u7ec7\u4e2d\u6740\u6b7b\u80bf\u7624\u7ec6\u80de\u76f8\u6bd4\uff0c\u9776\u5411\u80bf\u7624\u8840\u7ba1\u7cfb\u7edf\u7684\u836f\u7269\u6709\u4e24\u5927\u4f18\u70b9\uff1a\u76f4\u63a5\u4e0e\u8840\u7ba1\u5185\u76ae\u7ec6\u80de\u6216\u8840\u6db2\u63a5\u89e6\uff0c\u8bf1\u5bfc\u8010\u836f\u7684\u53ef\u80fd\u6027\u8f83\u4f4e\u548c\u5185\u76ae\u7ec6\u80de\u7684\u9ad8\u57fa\u56e0\u7a33\u5b9a\u6027\u3002\u5c3d\u7ba1\u5404\u79cd\u8840\u7ba1\u751f\u6210\u6291\u5236\u5242\uff08AIS\uff09\u548c\u8840\u7ba1\u963b\u65ad\u5242\uff08VDAS\uff09\u53ef\u4ee5\u963b\u65ad\u80bf\u7624\u7684\u8840\u6db2\u4f9b\u5e94\uff0c\u6291\u5236\u80bf\u7624\u7684\u6076\u6027\u589e\u6b96\uff0c\u5176\u4e2d\u4e00\u4e9b\u6cbb\u7597\u5242\u5df2\u7ecf\u5728\u4e34\u5e8a\u4e0a\u5f97\u5230\u5e94\u7528\uff0c\u7136\u800c\uff0c\u975e\u9776\u5411\u6548\u5e94\u548c\u9ad8\u6709\u6548\u5242\u91cf\u9650\u5236\u4e86\u8fd9\u4e9b\u5236\u5242\u5728\u764c\u75c7\u60a3\u8005\u4e2d\u7684\u5e94\u7528\u3002\u56e0\u6b64\uff0c\u80bf\u7624\u8840\u7ba1\u9776\u5411\u6cbb\u7597\u9700\u8981\u65b0\u7684\u7b56\u7565\u6765\u63d0\u9ad8\u7597\u6548\u548c\u5b89\u5168\u6027\u3002\u968f\u7740\u7eb3\u7c73\u6280\u672f\u7684\u8fc5\u901f\u53d1\u5c55\uff0c\u667a\u80fd\u7eb3\u7c73\u6cbb\u7597\u6280\u672f\u5728\u80bf\u7624\u8840\u7ba1\u9776\u5411\u6cbb\u7597\u65b9\u9762\u63d0\u4f9b\u4e86\u524d\u6240\u672a\u6709\u7684\u6f5c\u529b\u3002\u57fa\u4e8e\u80bf\u7624\u8840\u7ba1\u7684\u7279\u6b8a\u7ed3\u6784\u548c\u529f\u80fd\u7279\u70b9\uff0c\u4eba\u4eec\u63d0\u51fa\u4e86\u591a\u79cd\u4e0d\u540c\u7684\u7eb3\u7c73\u6cbb\u7597\u5242\u6784\u5efa\u65b9\u6cd5\u7528\u4e8e\u6297\u80bf\u7624\u6cbb\u7597\u7814\u7a76\u3002<strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u00a0 \u8fd1\u65e5\uff0c<strong>\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u6768\u7965\u826f\u6559\u6388\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u8042\u5e7f\u519b\u7814\u7a76\u5458\u548c\u674e\u7d20\u840d\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5bf9\u4ee5\u80bf\u7624\u8840\u7ba1\u4e3a\u9776\u70b9\u7684\u667a\u80fd\u7eb3\u7c73\u7597\u6cd5\u8fdb\u884c\u4e86\u7efc\u8ff0\uff0c\u6587\u7ae0\u53d1\u8868\u5728<strong>Accounts Chem. Res.<\/strong>\u3002\u8be5\u6587\u7ae0\u603b\u7ed3\u4e86\u51e0\u79cd\u4e0d\u540c\u7684\u8840\u7ba1\u9776\u5411\u6cbb\u7597\u7b56\u7565\uff0c\u7528\u4e0d\u540c\u7684\u667a\u80fd\u7eb3\u7c73\u6cbb\u7597\u5242\u8c03\u8282\u80bf\u7624\u8840\u7ba1\uff0c\u4ee5\u786e\u4fdd\u5f00\u53d1\u6280\u672f\u80fd\u591f\u5b89\u5168\u6709\u6548\u7684\u6cbb\u7597\u80bf\u7624\u3002\u53d7\u51dd\u8840\u7ea7\u8054\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u8be5\u7814\u7a76\u7ec4\u5f00\u53d1\u4e86\u7eb3\u7c73\u9897\u7c92\u4ecb\u5bfc\u7684\u80bf\u7624\u8840\u7ba1\u6897\u6b7b\u7b56\u7565\uff0c\u9009\u62e9\u6027\u5730\u963b\u65ad\u80bf\u7624\u8840\u4f9b\uff0c\u4f7f\u80bf\u7624\u9965\u997f\u574f\u6b7b\u3002\u901a\u8fc7DNA\u7eb3\u7c73\u673a\u5668\u4eba\uff08Nanorobot-Th\uff09\u7279\u5f02\u6027\u7684\u5c06\u51dd\u8840\u9176\u8f93\u9001\u5230\u80bf\u7624\u8840\u7ba1\uff0c\u89e6\u53d1\u80bf\u7624\u5185\u5f62\u6210\u8840\u6813\uff0c\u5bfc\u81f4\u8840\u7ba1\u6897\u6b7b\uff0c\u6700\u7ec8\u8bf1\u5bfc\u80bf\u7624\u574f\u6b7b\u3002\u6a21\u62df\u51dd\u8840\u7ea7\u8054\uff0c\u4e00\u79cd\u667a\u80fd\u805a\u5408\u7269\u7eb3\u7c73\u51dd\u80f6\u5b9e\u73b0\u4e86\u809d\u810f\u80bf\u7624\u7684\u6c38\u4e45\u6027\u548c\u5468\u8fb9\u6813\u585e\u3002\u8003\u8651\u5230\u8840\u5c0f\u677f\u5728\u7ef4\u6301\u80bf\u7624\u8840\u7ba1\u5b8c\u6574\u6027\u4e2d\u7684\u91cd\u8981\u4f5c\u7528\uff0c\u8be5\u7814\u7a76\u7ec4\u8fd8\u5f00\u53d1\u4e86\u4e00\u79cd\u6df7\u5408\u578b\u7eb3\u7c73\u9897\u7c92\uff08PLP-D-R\uff09\u9009\u62e9\u6027\u7684\u5220\u9664\u80bf\u7624\u8840\u7ba1\u5185\u8840\u5c0f\u677f\uff08TAP\uff09\u4ee5\u63d0\u9ad8\u8840\u7ba1\u901a\u900f\u6027\uff0c\u589e\u5f3a\u7624\u5185\u836f\u7269\u7d2f\u79ef\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u5bf9\u8840\u7ba1\u6b63\u5e38\u5316\u7684\u5206\u5b50\u548c\u7ec6\u80de\u57fa\u7840\u6709\u4e86\u66f4\u6df1\u5165\u7684\u4e86\u89e3\uff0c\u8be5\u7814\u7a76\u7ec4\u5f00\u53d1\u4e86\u51e0\u79cd\u80bf\u7624\u9178\u6027\u53cd\u5e94\u7eb3\u7c73\u6cbb\u7597\u5242\u3001\u5305\u5c01\u6cbb\u7597\u80bd\u548c\u5c0f\u5e72\u6270RNA\u6765\u7ea0\u6b63\u80bf\u7624\u7684\u5f02\u5e38\u7279\u5f81\u3002\u5212\u8239\u3002\u8fd9\u4f7f\u5f97\u80bf\u7624\u8840\u7ba1\u7684\u836f\u7269\u4f20\u9012\u6548\u7387\u66f4\u9ad8\u3002\u867d\u7136\u6211\u4eec\u4ecd\u5728\u63a2\u7d22\u8fd9\u4e9b\u65b0\u578b\u7eb3\u7c73\u5236\u5242\u7684\u4f5c\u7528\u673a\u5236\uff0c\u4f46\u6211\u4eec\u5e0c\u671b\u672c\u6587\u603b\u7ed3\u7684\u80bf\u7624\u8840\u7ba1\u9776\u5411\u7b56\u7565\u5c06\u4e3a\u8bbe\u8ba1\u6709\u6548\u7684\u4e0b\u4e00\u4ee3\u6297\u764c\u7eb3\u7c73\u836f\u7269\u8f7d\u4f53\u548c\u4fc3\u8fdb\u667a\u80fd\u7eb3\u7c73\u7597\u6cd5\u7684\u4e34\u5e8a\u8f6c\u5316\u63d0\u4f9b\u652f\u6491\u5e73\u53f0\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u7b80\u4ecb\u3011<\/strong><\/p>\n<p><strong>\u56fe1 <\/strong><strong>\u7528\u88c5\u8f7d\u51dd\u8840\u9176\u7684DNA<\/strong><strong>\u7eb3\u7c73\u7c92\uff08\u7eb3\u7c73\u673a\u5668\u4eba-Th<\/strong><strong>\uff09\u9009\u62e9\u6027\u963b\u65ad\u80bf\u7624\u8840\u7ba1<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185348\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/1-11.jpg\" alt=\"\" width=\"600\" height=\"466\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/1-11.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/1-11-300x233.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe2 <\/strong><strong>\u7eb3\u7c73\u673a\u5668\u4eba-Th<\/strong><strong>\u7684\u8bbe\u8ba1\u4e0e\u8868\u5f81<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185349\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/2-10.jpg\" alt=\"\" width=\"490\" height=\"380\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/2-10.jpg 490w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/2-10-300x233.jpg 300w\" sizes=\"(max-width: 490px) 100vw, 490px\" \/><\/p>\n<p>\uff08a\uff09\u88c5\u8f7d\u51dd\u8840\u9176\u7684DNA\u6298\u7eb8\u7eb3\u7c73\u673a\u5668\u4eba\u7ed3\u6784\u793a\u610f\u56fe\u3002<\/p>\n<p>\uff08b\uff09\u7528\u539f\u5b50\u529b\u663e\u5fae\u955c\u8868\u5f81\u5173\u95ed\u548c\u6253\u5f00\u72b6\u6001\u4e0b\u7684DNA\u7eb3\u7c73\u673a\u5668\u4eba\uff1b\u6bd4\u4f8b\u5c3a\u4e3a100 nm\u3002<\/p>\n<p><strong>\u56fe3 Ivalon, Lipiodo<\/strong><strong>\u548cPIBI-6150<\/strong><strong>\u7684\u6813\u585e\u673a\u5236<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185350\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/3-10.jpg\" alt=\"\" width=\"493\" height=\"494\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/3-10.jpg 493w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/3-10-150x150.jpg 150w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/3-10-300x300.jpg 300w\" sizes=\"(max-width: 493px) 100vw, 493px\" \/><\/p>\n<p><strong>\u56fe4 PIBI-2240<\/strong><strong>\u7eb3\u7c73\u51dd\u80f6\u6539\u5584TAE<\/strong><strong>\u6cbb\u7597\u540e\u80bf\u7624\u7f3a\u6c27<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185351\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/4-10.jpg\" alt=\"\" width=\"481\" height=\"549\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/4-10.jpg 481w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/4-10-263x300.jpg 263w\" sizes=\"(max-width: 481px) 100vw, 481px\" \/><\/p>\n<p><strong>\u56fe5 GNP@PNA<\/strong><strong>\u7528\u4e8e\u8840\u7ba1\u6813\u585e\u548cx<\/strong><strong>\u7ebf\u8840\u7ba1\u9020\u5f71\u7684\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185352\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/5-7.jpg\" alt=\"\" width=\"583\" height=\"313\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/5-7.jpg 583w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/5-7-300x161.jpg 300w\" sizes=\"(max-width: 583px) 100vw, 583px\" \/><\/p>\n<p><strong>\u56fe6 NP-NGBR-SIRNA<\/strong><strong>\u7684\u5236\u5907\u53ca\u4f5c\u7528\u673a\u7406\u793a\u610f\u56fe<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185353\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/6-2.jpg\" alt=\"\" width=\"583\" height=\"377\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/6-2.jpg 583w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/6-2-300x194.jpg 300w\" sizes=\"(max-width: 583px) 100vw, 583px\" \/><\/p>\n<p><strong>\u56fe7<\/strong><strong>\u7eb3\u7c73\u6cbb\u7597\u5242\uff08PLP-D-R<\/strong><strong>\uff09\u9776\u5411\u6e05\u9664\u80bf\u7624\u8840\u7ba1\u5185\u8840\u5c0f\u677f\uff0c\u589e\u5f3a\u5316\u7597\u836f\u7269\u7624\u5185\u7d2f\u79ef<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-185354\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/7-2.jpg\" alt=\"\" width=\"409\" height=\"688\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/7-2.jpg 409w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/09\/7-2-178x300.jpg 178w\" sizes=\"(max-width: 409px) 100vw, 409px\" \/><\/p>\n<p>\uff08A\uff09PLP-D-R\u7684\u8bbe\u8ba1\u601d\u8def\u3002<\/p>\n<p>\uff08B\uff09\u63d0\u51faPLP-D-R\u5728\u4f53\u5185\u80bf\u7624\u8840\u7ba1\u4e2d\u7684\u4f5c\u7528\u673a\u5236\u3002<\/p>\n<p>\uff08C\uff09\u7528\u751f\u7406\u76d0\u6c34\u3001PLP\u3001DOX\u3001R300\u3001PLP-D\u3001PL-D-R\u6216PLP-D-R\u6cbb\u7597MCF7\u5c0f\u9f20\u80bf\u7624\u6a21\u578b\u540e\u7684\u80bf\u7624\u4f53\u79ef<\/p>\n<p>\uff08D\uff09\u663e\u793a\u6709\u8f6c\u79fb\u7684\u4ee3\u8868\u6027\u80ba\u7684\u56fe\u50cf\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u4e0e\u5c55\u671b\u3011<\/strong><\/p>\n<p>\u00a0 \u672c\u6587\u603b\u7ed3\u7684\u4e0a\u8ff0\u667a\u80fd\u7eb3\u7c73\u6cbb\u7597\u5242\uff0c\u5b83\u4eec\u662f\u901a\u8fc7\u64cd\u7eb5\u80bf\u7624\u8840\u7ba1\u7279\u6027\u8fbe\u5230\u6709\u6548\u80bf\u7624\u6cbb\u7597\u7684\u4e0d\u540c\u7b56\u7565\u7684\u8303\u4f8b\u3002\u5c3d\u7ba1\u8fd9\u4e9b\u667a\u80fd\u7eb3\u7c73\u5236\u5242\u5177\u6709\u5b89\u5168\u3001\u9ad8\u6548\u7684\u4f53\u5185\u6cbb\u7597\u6548\u679c\uff0c\u4f46\u5b83\u4eec\u4ea6\u5177\u6709\u5404\u81ea\u7684\u5c40\u9650\u6027\u3002\u5bf9\u4e8e\u5229\u7528PH\u4f5c\u4e3a\u89e6\u53d1\u56e0\u5b50\u7684\u7eb3\u7c73\u6cbb\u7597\u5242\uff08TTF-PHLIP\u3001NP-NGBR-SIRNA\u3001DEAPC16Y-NPS\uff09\uff0c\u5b83\u4eec\u6709\u4e00\u4e2a\u5171\u540c\u7684\u7279\u5f02\u6027\u95ee\u9898\uff0c\u4f8b\u5982\uff0c\u9664\u4e86\u80bf\u7624\u90e8\u4f4d\u5916\uff0c\u708e\u75c7\u7ec4\u7ec7\u7684PH\u5fae\u73af\u5883\u4e5f\u5448\u73b0\u5fae\u9178\u6027\uff0c\u8fd9\u5728\u4e00\u5b9a\u7a0b\u5ea6\u4e0a\u4f1a\u5bfc\u81f4\u4f4ePH\u54cd\u5e94\u6027\u7eb3\u7c73\u6cbb\u7597\u836f\u7269\u7684\u975e\u7279\u5f02\u6027\u7d2f\u79ef\u3002\u4f7f\u7528PIB\u7eb3\u7c73\u51dd\u80f6\u4f5c\u4e3a\u6813\u585e\u5242\uff0c\u7ecf\u9a8c\u4e30\u5bcc\u7684\u624b\u672f\u64cd\u4f5c\u4eba\u5458\u662fTAE\u6216TACE\u6210\u529f\u6cbb\u7597\u7684\u5173\u952e\uff0c\u3002\u6b64\u5916\uff0c\u5b9e\u73b0\u5927\u89c4\u6a21\u751f\u4ea7\u7eb3\u7c73\u6cbb\u7597\u836f\u7269\u5bf9\u4e8e\u5927\u578b\u52a8\u7269\u6a21\u578b\u7684\u4e34\u5e8a\u524d\u8bd5\u9a8c\u4e5f\u662f\u5fc5\u4e0d\u53ef\u5c11\u7684\uff0c\u66f4\u4e0d\u7528\u8bf4\u4e34\u5e8a\u8bd5\u9a8c\u6240\u9700\u7684\u6570\u91cf\u4e86\u3002\u8fd9\u4e9b\u5173\u952e\u7684\u6311\u6218\u4ecd\u7136\u9700\u8981\u5728\u7eb3\u7c73\u836f\u7269\u80fd\u591f\u6210\u529f\u8fdb\u5165\u4e34\u5e8a\u5e94\u7528\u524d\u89e3\u51b3\u3002<\/p>\n<p>\u00a0\u00a0\u8bb8\u591a\u65b0\u7684\u7eb3\u7c73\u57fa\u7840\u7597\u6cd5\u8bbe\u60f3\uff0c\u5c06\u8fdb\u4e00\u6b65\u4e30\u5bcc\u672c\u6587\u603b\u7ed3\u7684\u4ee5\u4e0a\u7b56\u7565\u3002\u8b6c\u5982\uff0c\u5229\u7528TF\u6216\u51dd\u8840\u9176\u8d1f\u8f7dPIB\u7eb3\u7c73\u51dd\u80f6\uff0c\u5c06\u5b9e\u73b0\u7269\u7406\u6813\u585e\u548c\u751f\u7269\u51dd\u56fa\u7684\u8054\u5408\u5e94\u7528\uff0c\u8fbe\u5230\u534f\u540c\u963b\u585e\u80bf\u7624\u8840\u7ba1\u7684\u79d1\u5b66\u76ee\u7684\u3002\u5728\u6d77\u85fb\u9178\u9499\u5fae\u7403\u5185\u5305\u88f9\u653e\u5c04\u6027\u9565\u7eb3\u7c73\u9897\u7c92\u548c\u4e0d\u900f\u5c04\u7ebf\u94bd\u7eb3\u7c73\u9897\u7c92\uff0c\u53ef\u4ee5\u5236\u5907\u83b7\u5f97\u7eb3\u7c73-\u5fae\u7c73\u7ed3\u6784\uff0c\u7528\u4e8eTAE\u548c\u653e\u5c04\u8054\u5408\u6cbb\u7597\u3002\u72ec\u7279\u7684\u751f\u7269\u5206\u5b50\u6216\u7ec6\u80de\u6210\u4efd\uff0c\u5982E-\u9009\u62e9\u7d20\u3001CD105\u3001\u7ea4\u7ef4\u86cb\u767d\u3001\u80bf\u7624\u76f8\u5173\u5468\u7ec6\u80de\u548c\u5185\u76ae\u7ec6\u80de\uff0c\u53ef\u4ee5\u88ab\u7eb3\u7c73\u6cbb\u7597\u836f\u7269\u7279\u5f02\u6027\u9776\u5411\uff0c\u8fdb\u4e00\u6b65\u589e\u52a0\u80bf\u7624\u8840\u7ba1\u901a\u900f\u6027\u3002\u7531\u4e8e\u514d\u75ab\u6548\u5e94\u7ec6\u80de\u7684\u7624\u5185\u6e17\u900f\u53d7\u5230\u529f\u80fd\u5931\u8c03\u7684\u80bf\u7624\u8840\u7ba1\u7684\u4e25\u91cd\u963b\u788d\uff0c\u5229\u7528\u667a\u80fd\u7eb3\u7c73\u8bd5\u5242\u63d0\u9ad8\u514d\u75ab\u7ec6\u80de\u7684\u80bf\u7624\u8840\u7ba1\u901a\u900f\u6027\u5c06\u662f\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u514d\u75ab\u7597\u6cd5\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5\uff1a<\/strong><a href=\"http:\/\/dx.doi.org\/10.1021\/acs.accounts.9b00283\" target=\"_blank\" rel=\"noopener\">Smart Nanotherapeutic Targeting of Tumor Vasculature<\/a>, 2019, Accounts Chem. Res., DOI: 10.1021\/acs.accounts.9b00283.<\/p>\n<p><strong>\u6768\u7965\u826f\u6559\u6388<\/strong>\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u534e\u4e2d\u5b66\u8005\uff08\u9886\u519b\u5c97\uff09\uff0c\u4efb\u56fd\u5bb6\u7eb3\u7c73\u836f\u7269\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u4e2d\u5fc3\u4e3b\u4efb\u3001\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u201c\u7eb3\u7c73\u79d1\u6280\u201d\u91cd\u70b9\u4e13\u9879\u603b\u4f53\u4e13\u5bb6\u7ec4\u6210\u5458\u3001\u201c\u7eb3\u7c73\u7814\u7a76\u201d\u56fd\u5bb6\u91cd\u5927\u79d1\u5b66\u7814\u7a76\u8ba1\u5212\u201c\u809d\u764c\u6cbb\u7597\u7684\u65b0\u578b\u7eb3\u7c73\u836f\u7269\u7814\u7a76\u201d\u9879\u76ee\u9996\u5e2d\u79d1\u5b66\u5bb6\u3002\u56e2\u961f\u7814\u7a76\u5de5\u4f5c\u4e3b\u8981\u56f4\u7ed5\u7eb3\u7c73\u836f\u7269\u5236\u5242\u3001\u7eb3\u7c73\u533b\u7528\u6750\u6599\u3001\u7eb3\u7c73\u8bca\u65ad\u68c0\u6d4b\u6280\u672f\u7b49\u65b9\u9762\u5c55\u5f00\u3002\u5df2\u5728<em>Nature Biomedical Engineering, Accounts of Chemical Research, Nature Communications, Advanced Science, ACS Nano, Nano Letters, Advanced Functional Materials<\/em>\u7b49\u4e00\u6d41\u5b66\u672f\u671f\u520a\u4e0a\u53d1\u8868\u8bba\u6587300\u4f59\u7bc7\uff0c\u4ed6\u5f158600\u4f59\u6b21\uff0cH-index\u4e3a54\uff0c2014-2018\u5e74\u8fde\u7eed\u4e94\u5e74\u5165\u9009\u4e2d\u56fd\u9ad8\u88ab\u5f15\u5b66\u8005\u699c\u5355(\u836f\u7406\u5b66\uff0c\u6bd2\u7406\u5b66\u548c\u836f\u5242\u5b66)\u3002<\/p>\n<p><strong>\u76f8\u5173\u5de5\u4f5c\u6c47\u603b\uff1a<\/strong><\/p>\n<p>\u7ecf\u5bfc\u7ba1\u52a8\u8109\u6813\u585e\uff08TAE\uff09\u662f\u4e00\u79cd\u5728\u533b\u5b66\u5f71\u50cf\u8bbe\u5907\u7684\u5f15\u5bfc\u4e0b\uff0c\u901a\u8fc7\u5bfc\u7ba1\u9009\u62e9\u6027\u5730\u5c06\u6813\u585e\u5242\u6ce8\u5165\u9776\u52a8\u8109\uff0c\u4ee5\u963b\u65ad\u9776\u52a8\u8109\u8fdb\u884c\u80bf\u7624\u6cbb\u7597\u7684\u6280\u672f\u3002TAE\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u9769\u547d\u6027\u7684\u80bf\u7624\u6cbb\u7597\u65b9\u6cd5\uff0c\u5176\u7597\u6548\u8fc5\u901f\uff0c\u5e76\u53d1\u75c7\u53d1\u751f\u7387\u4f4e\uff0c\u4e14\u6613\u4e8e\u4e0e\u5176\u5b83\u6cbb\u7597\u65b9\u6cd5\u7ed3\u5408\u3002\u4f8b\u5982\uff0cTAE\u4e0e\u5316\u7597\u836f\u7269\u7684\u7ed3\u5408\uff0c\u4e5f\u88ab\u79f0\u4e3a\u7ecf\u5bfc\u7ba1\u52a8\u8109\u5316\u7597\u6813\u585e\uff08TACE\uff09\uff0c\u662f\u4e0d\u53ef\u5207\u9664\u809d\u7ec6\u80de\u764c\uff08HCC\uff09\u4e00\u7ebf\u59d1\u606f\u7597\u6cd5\u7684\u91d1\u6807\u51c6\u6cbb\u7597\u65b9\u6848\u3002\u4f46\u662f\uff0c\u76ee\u524dTAE\u548cTACE\u4e34\u5e8a\u7597\u6548\u4e25\u91cd\u53d7\u9650\u4e8e\u8840\u7ba1\u6813\u585e\u5242\u3002\u4e34\u5e8a\u4e0a\u5e7f\u6cdb\u4f7f\u7528\u7684\u56fa\u4f53\u6813\u585e\u5242\uff08\u5305\u62ec\u660e\u80f6\u6d77\u7ef5\u3001\u805a\u4e59\u70ef\u9187\u5fae\u9897\u7c92\u3001\u6d77\u85fb\u9178\u9499\u5fae\u7403\uff09\u548c\u6db2\u4f53\u6813\u585e\u5242\uff08\u5305\u62ec\u65e0\u6c34\u9152\u7cbe\u548c\u7898\u6cb9\uff09\u90fd\u6709\u660e\u663e\u7684\u7f3a\u70b9\uff1a\u56fa\u4f53\u6813\u585e\u5242\u5177\u5907\u8f83\u597d\u7684\u6813\u585e\u6027\uff0c\u53ef\u4ee5\u6813\u585e\u80bf\u7624\u5927\u8840\u7ba1\u4f46\u5f88\u96be\u540c\u65f6\u5b9e\u73b0\u672b\u68a2\u8840\u7ba1\u6813\u585e\uff1b\u6db2\u4f53\u6813\u585e\u5242\u5177\u5907\u8f83\u597d\u7684\u6d41\u52a8\u6027\uff0c\u53ef\u4ee5\u6813\u585e\u80bf\u7624\u672b\u68a2\u8840\u7ba1\u4f46\u9762\u4e34\u6813\u585e\u5f3a\u5ea6\u8f83\u4f4e\u7684\u95ee\u9898\u3002\u8fd9\u4e9b\u6813\u585e\u5242\u65e0\u6cd5\u540c\u65f6\u517c\u987e\u6813\u585e\u6027\u548c\u6d41\u52a8\u6027\uff0c\u6813\u585e\u4e0d\u8db3\u5e38\u5f15\u8d77\u80bf\u7624\u8840\u7ba1\u518d\u901a\u548c\u80bf\u7624\u5185\u8840\u6db2\u5faa\u73af\uff0c\u6700\u7ec8\u5bfc\u81f4\u80bf\u7624\u7684\u590d\u53d1\u548c\u8f6c\u79fb\u3002\u53d7\u8840\u6db2\u51dd\u56fa\u7ea7\u8054\u53cd\u5e94\u7684\u542f\u53d1\uff0c\u6768\u7965\u826f\u6559\u6388\u548c\u8d75\u5f66\u5175\u6559\u6388\u8bfe\u9898\u7ec4\u4e0e\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u9644\u5c5e\u534f\u548c\u533b\u9662\u90d1\u4f20\u80dc\u6559\u6388\u5408\u4f5c2011\u5e74\u57fa\u4e8e\u805a\uff08N-\u5f02\u4e19\u57fa\u4e19\u70ef\u9170\u80fa-\u7532\u57fa\u4e19\u70ef\u9178\u4e01\u916f\uff09\uff08PIB\uff09\u7814\u53d1\u4e86\u4e00\u79cd\u667a\u80fd\u7eb3\u7c73\u51dd\u80f6\u3002\u8be5\u7eb3\u7c73\u51dd\u80f6\u5c55\u793a\u51fa\u72ec\u7279\u7684\u6e29\u5ea6\u89e6\u53d1\u7684\u6eb6\u80f6-\u51dd\u80f6\u76f8\u8f6c\u53d8\u8fc7\u7a0b\uff0c\u53ef\u5b9e\u73b0\u809d\u764c\u5927\u8840\u7ba1\u548c\u672b\u68a2\u8840\u7ba1\u6c38\u4e45\u6027\u540c\u6b65\u6813\u585e\u3002\u8fd9\u79cd\u65b0\u578b\u8840\u7ba1\u6813\u585e\u5242PIB\u7eb3\u7c73\u51dd\u80f6\u6709\u6548\u7684\u89e3\u51b3\u4e86\u4ecb\u5165\u6cbb\u7597\u6d41\u52a8\u6027\u548c\u6813\u585e\u6027\u7684\u77db\u76fe\u3002\u56e2\u961f\u7814\u5236\u62e5\u6709\u81ea\u4e3b\u77e5\u8bc6\u4ea7\u6743\u3001\u6548\u679c\u663e\u8457\u4f18\u4e8e\u73b0\u6709\u56fd\u5185\u5916\u4ea7\u54c1\u7684\u65b0\u578b\u809d\u764c\u4ecb\u5165\u6813\u585e\u6750\u6599\uff0c\u8fd110\u5e74\u5728Advanced Functional Materials\uff0cTheranostics\uff0cJournal of Controlled Release\u7b49\u9ad8\u6c34\u5e73\u6742\u5fd7\u4e0a\u53d1\u8868\u8bba\u6587\u8fd120\u7bc7\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u8be5\u56e2\u961f\u638c\u63e1\u6838\u5fc3\u6750\u6599\u7684\u5c0f\u8bd5\u3001\u4e2d\u8bd5\u53ca\u653e\u5927\u751f\u4ea7\u7684\u5de5\u827a\u7814\u7a76\u3001\u9a8c\u8bc1\u53ca\u8d28\u91cf\u63a7\u5236\u7684\u5173\u952e\u6280\u672f\uff0c\u6709\u671b\u6253\u7834\u6211\u56fd\u809d\u764c\u4ecb\u5165\u6cbb\u7597\u4e25\u91cd\u4f9d\u8d56\u8fdb\u53e3\u7898\u6cb9\u7684\u5361\u8116\u5b50\u73b0\u72b6\u3002<\/p>\n<p>&nbsp;<\/p>\n<ul>\n<li>Yanbing Zhao, Chuansheng Zheng, Qin Wang, Jianlin Fang, Guofeng Zhou, Hui Zhao, Yajiang Yang, Huibi Xu, Gansheng Feng*, <u>Xiangliang Yang<\/u>*, <em>Advanced Functional Materials<\/em>, <strong>2011<\/strong>, 21(11), 2035-2042<\/li>\n<li>Huabing Chen, Hongda Zhu, Jingdong Hu, Yanbing Zhao, Qin Wang, Jiangling Wan, Yajiang Yang, Huibi Xu, <u>Xiangliang Yang<\/u>*, <em>ACS Nano, <\/em><strong>2011<\/strong>, 5(4), 2671-2680<\/li>\n<li>Lingyu Jiang, Qing Zhou, Ketao Mu, Hui Xie, Yanhong Zhu, Wenzhen Zhu, Yanbing Zhao*, Huibi Xu, <u>Xiangliang Yang<\/u>*, <em>Biomaterials<\/em>, <strong>2013<\/strong>, 34(30), 7418-7428<\/li>\n<li>Kun Qian, Yingying Ma, Jiangshan Wan, Shinan Geng, Han Li, Qianwen Fu, Xiaole Peng, Xuefeng Kan, Guofeng Zhou, Wei Liu, Bin Xiong, Yanbing Zhao*, Chuansheng Zheng*, <u>Xiangliang Yang<\/u>*, Huibi Xu, <em>Journal of Controlled Release<\/em>, <strong>2015<\/strong>, 212, 41-49<\/li>\n<li>Hao Yang, Qin Wang, Zifu Li, Fuying Li, Di Wu, Man Fan, Anbi Zheng, Bo Huang, Lu Gan*, Yuliang Zhao*, <u>Xiangliang Yang<\/u>*, <em>Nano Letters<\/em>, <strong>2018<\/strong>,18(12),7909-7918<\/li>\n<li>Jian Zeng, Ling Li, Hongsen Zhang, Jianye Li, Lingli Liu, Guofeng Zhou, Qing Du*, Chuansheng Zheng*, <u>Xiangliang Yang<\/u>*, <em>Theranostics<\/em>, <strong>2018<\/strong>, 8(17), 4591-4600<\/li>\n<li>Ling Li, Yiming Liu, Han Li, Xiaopeng Guo, Xiaojun He, Shinan Geng, Hao Zhao, Xiaole Peng, Dingwen Shi, Bin Xiong, Guofeng Zhou, Yanbing Zhao*, Chuansheng Zheng*, <u>Xiangliang Yang<\/u>*, <em>Theranostics<\/em>, <strong>2018<\/strong>, 8(22), 6291-6306<\/li>\n<\/ul>\n<p>&nbsp;<\/p>\n<p>\u4e3a\u4fc3\u8fdb\u4fb5\u88ad\u4e0e\u8f6c\u79fb\uff0c\u80bf\u7624\u53d1\u5c55\u51fa\u4e00\u79cd\u72ec\u7279\u7684\u8840\u7ba1\u65b0\u751f\u6a21\u5f0f\uff0c\u901a\u8fc7\u5728\u5df2\u6709\u7684\u6bdb\u7ec6\u8840\u7ba1\u4e0a\u840c\u82bd\u5f62\u6210\u65b0\u7684\u8840\u7ba1\u3002\u8fd9\u4e9b\u65b0\u751f\u8840\u7ba1\u8fc2\u66f2\u3001\u6e17\u6f0f\uff0c\u7ed3\u6784\u5b8c\u6574\u6027\u5dee\uff0c\u5185\u76ae\u7ec6\u80de\u95f4\u9699\u5927\uff0c\u5e73\u6ed1\u808c\u7ec6\u80de\u7f3a\u5931\uff0c\u5468\u7ec6\u80de\u548c\u57fa\u5e95\u819c\u8986\u76d6\u4e0d\u5168\u3002\u4e0e\u6b63\u5e38\u7684\u8840\u7ba1\u7cfb\u7edf\u4e0d\u540c\uff0c\u80bf\u7624\u8840\u7ba1\u4e2d\u7684\u8840\u6d41\u5e76\u4e0d\u603b\u662f\u6cbf\u7740\u56fa\u5b9a\u7684\u3001\u5355\u5411\u7684\u8f68\u8ff9\u6d41\u52a8\uff1b\u5e76\u975e\u6240\u6709\u7684\u8840\u7ba1\u90fd\u704c\u6ce8\u826f\u597d\uff0c\u8840\u6d41\u53ef\u80fd\u5728\u77ed\u65f6\u95f4\u5185\u901a\u8fc7\u540c\u4e00\u6839\u8840\u7ba1\u8d70\u4e0d\u540c\u7684\u8def\u5f84\uff0c\u751a\u81f3\u5728\u76f8\u53cd\u7684\u65b9\u5411\u6d41\u52a8\u3002\u80bf\u7624\u8840\u7ba1\u7ed3\u6784\u548c\u529f\u80fd\u6027\u5f02\u5e38\u5bfc\u81f4\u86c7\u5f62\u8840\u6d41\u548c\u704c\u6ce8\u4e0d\u826f\uff0c\u5f62\u6210\u4e00\u79cd\u72ec\u7279\u7684\u5fae\u73af\u5883\uff08\u80bf\u7624\u5fae\u73af\u5883\uff1bTME\uff09\uff0c\u8868\u73b0\u4e3a\u4e4f\u6c27\u3001\u9ad8\u51dd\u548c\u514d\u75ab\u6291\u5236\u3002\u6768\u7965\u826f\u6559\u6388\u548c\u674e\u5b50\u798f\u6559\u6388\u8bfe\u9898\u7ec4\u5de7\u5999\u7684\u5229\u7528\u4e34\u5e8a\u5e38\u7528\u7684\u9ad8\u538b\u6c27\u6cbb\u7597\u964d\u4f4e\u80bf\u7624\u8840\u7ba1\u4e2d\u8840\u6db2\u9ecf\u5ea6\u3001\u63d0\u9ad8\u8840\u6d41\u704c\u6ce8\u3001\u6539\u5584\u80bf\u7624\u5fae\u73af\u5883\u3001\u663e\u8457\u589e\u5f3a\u7eb3\u7c73\u836f\u7269\u6297\u80bf\u7624\u7597\u6548\uff0c\u76f8\u5173\u7814\u7a76\u5de5\u4f5c\u53d1\u8868\u5728Advanced Science\u3002<\/p>\n<p>&nbsp;<\/p>\n<p>Xian Wu, Yanhong Zhu, Wei Huang, Jingqiu Li, Bixiang Zhang, Zifu Li*, <u>Xiangliang Yang<\/u>*, <em>Advanced Science<\/em>, <strong>2018<\/strong>, 5(8), 1700859<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u8042\u5e7f\u519b\u7814\u7a76\u5458<\/strong>\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\uff0c\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\uff0c\u56e2\u961f\u5728\u6750\u6599\u5b66\u3001\u7eb3\u7c73\u836f\u7269\u3001\u80bf\u7624\u5b66\u7b49\u9886\u57df\u5177\u6709\u957f\u671f\u7684\u79ef\u7d2f\u548c\u96c4\u539a\u7684\u5b9e\u529b\u3002\u8fd1\u5e74\u6765\uff0c\u56e2\u961f\u5728\u79d1\u6280\u90e8973\u9879\u76ee\u3001\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\uff08\u7eb3\u7c73\u79d1\u6280\u3001\u6218\u7565\u6027\u56fd\u9645\u79d1\u6280\u521b\u65b0\u5408\u4f5c\u91cd\u70b9\u4e13\u9879\uff09\u3001\u56fd\u5bb6\u81ea\u7136\u57fa\u91d1\u59d4\u521b\u65b0\u7fa4\u4f53\u9879\u76ee\u3001\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u9879\u76ee\u7b49\u8d44\u52a9\u4e0b\u81f4\u529b\u4e8e\u53d1\u5c55\u80bf\u7624\u5fae\u73af\u5883\u8c03\u63a7\u7684\u667a\u80fd\u7eb3\u7c73\u836f\u7269\u3002\u76f8\u5173\u6210\u679c\u53d1\u8868\u5728\u56fd\u9645\u6743\u5a01\u671f\u520aNat Biotechnol, Nat Biomed Eng, JACS, Angew Chem Int Ed, Blood, Adv Mater, Acc Chem Res\u7b49\u3002\u88ab Nat Mater\uff0cSci Transl Med, Blood\uff0cChemSoc Rev\uff0cMaterials View \u7b49\u671f\u520a\u4f5c\u4e3a\u7814\u7a76\u4eae\u70b9\u62a5\u9053, \u8bc4\u4ef7\u4e3a\u201clandmark\u91cc\u7a0b\u724c\u201d\uff1b\u88ab\u7f8e\u56fdThe Scientist\u8bc4\u9009\u4e3a2018\u5e74\u6280\u672f\u8fdb\u6b65\uff08Technical Advances\uff09\uff0c\u5e76\u8363\u83b72018\u5e74\u5ea6\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\u3002\u7533\u8bf7\u53d1\u660e\u4e13\u522935\u9879\uff08\u6388\u6743\u4e2d\u56fd\u53d1\u660e\u4e13\u522922 \u9879\uff0c\u6388\u6743\u7f8e\u56fd\u4e13\u52292 \u9879\uff09\u3002\u5176\u4e2d\uff0c\u57fa\u4e8e\u80bf\u7624\u8840\u7ba1\u8c03\u63a7\u76842\u9879\u7eb3\u7c73\u836f\u7269\u4e13\u5229\u5df2\u5b8c\u6210\u8f6c\u8ba9\uff0c\u76ee\u524d\u4e0e\u5317\u4eac\u534e\u5b89\u79d1\u521b\u5408\u4f5c\u5f00\u5c55\u76f8\u5173\u7eb3\u7c73\u836f\u7269\u7684\u4ea7\u4e1a\u5316\u548c\u4e34\u5e8a\u524d\u7814\u7a76\u3002<\/p>\n<p><strong>\u674e\u7d20\u840d\u7814\u7a76\u5458<\/strong>\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\uff0c\u56e2\u961f\u4e3b\u8981\u4ece\u4e8b\u6297\u80bf\u7624\u7eb3\u7c73\u836f\u7269\u7814\u7a76\uff0c\u8bbe\u8ba1\u6784\u5efa\u9776\u5411\u8c03\u63a7\u80bf\u7624\u8840\u7ba1\u7cfb\u7edf\u7684\u7eb3\u7c73\u836f\u7269\u8f7d\u4f53\u3002\u5728\u5e94\u7528\u7eb3\u7c73\u6280\u672f\u53d1\u5c55\u65b0\u4e00\u4ee3\u6297\u80bf\u7624\u836f\u7269\u65b9\u9762\u53d6\u5f97\u4e00\u7cfb\u5217\u539f\u521b\u6027\u6210\u679c\uff0c\u5e76\u79ef\u6781\u63a8\u52a8\u5168\u65b0\u6297\u80bf\u7624\u7eb3\u7c73\u836f\u7269\u7684\u4e34\u5e8a\u524d\u8f6c\u5316\u3002\u4ee3\u8868\u6027\u79d1\u7814\u6210\u679c\u4e3b\u8981<strong>\u53d1\u8868\u5728<\/strong>Nat Biotechnol, Nat Biomed Eng, Nano Letters\u3001Acc Chem Res\u7b49\u91cd\u8981\u5b66\u672f\u671f\u520a\u3002\u53d1\u8868\u6210\u679c\u88abNature Reviews Cancer, Nature Reviews Drug Discovery, Sci Transl Med\u7b49\u671f\u520a\u8fdb\u884c\u4eae\u70b9\u62a5\u9053\uff0c\u88ab\u8bc4\u4ef7\u4e3a\u201clandmark\u91cc\u7a0b\u724c\u201d\u5f0f\u5de5\u4f5c\uff1b\u5165\u90092018\u5e74\u4e2d\u56fd\u79d1\u5b66\u5341\u5927\u8fdb\u5c55\uff1b\u5165\u90092018\u5e74\u4e2d\u79d1\u9662\u7b2c\u4e00\u5c4a\u201c\u7387\u5148\u676f\u201d\u672a\u6765\u79d1\u6280\u521b\u65b0\u5927\u8d5b\u4f18\u80dc\u5956\u9879\uff08\u56e2\u961f\u5956\uff0c\u83b7\u5f97100\u4e07\u79d1\u7814\u9879\u76ee\u8d44\u52a9\uff09\uff1b\u88ab\u7f8e\u56fdThe Scientists\u8bc4\u9009\u4e3a2018\u5e74\u201c\u4e16\u754c\u4e03\u5927\u6280\u672f\u8fdb\u6b65\uff08Top Technical Advances\uff09\u201d\u3002\u5e94\u9080\u4e3aScience Advances\u3001Trends in 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Biotechnol, Nat Biomed Eng, Angew Chem Int Ed, Nano Letters\u7b49\u6743\u5a01\u671f\u520a\u3002<\/p>\n<p>Recommended Publications:<\/p>\n<p>1) Suping Li, Qiao Jiang, Shaoli Liu, Yinlong Zhang, Yanhua Tian, Chen Song, Jing Wang, Yiguo Zou, Gregory J Anderson, Jing-Yan Han, Yung Chang, Yan Liu, Chen Zhang, Liang Chen, Guangbiao Zhou, <strong>Guangjun Nie<\/strong>*, Hao Yan*, Baoquan Ding*, Yuliang Zhao*, A DNA nanorobot functions as a cancer therapeutic in response to a molecular trigger in vivo, <strong><em>Nature Biotechnology<\/em><\/strong> 2018, 36: 258\u2013264.<\/p>\n<p>2) Suping Li, Yinlong Zhang, Jing Wang, Ying Zhao, Tianjiao Ji, Xiao Zhao, Yanping Ding, Xiaozheng Zhao, Ruifang Zhao, Feng Li, Xiao Yang, Shaoli Liu, Zhaofei Liu, Jianhao Lai, Andrew K. Whittaker, Gregory J Anderson, Jingyan Wei, <strong>Guangjun Nie<\/strong>*, Nanoparticle-mediated local depletion of tumour-associated platelets disrupts vascular barriers and augments drug accumulation in tumours. <strong><em>Nature Biomedical Engineering<\/em><\/strong> 2017, 1: 667-679.<\/p>\n<p>3) Shaoli Liu, Yinlong Zhang, Xiao Zhao,Jing Wang, Chunzhi Di, Ying Zhao, Tianjiao Ji, Keman Cheng, Yongwei Wang, Long Chen, Yingqiu Qi, Suping Li*, Guangjun Nie*. Tumor-Specific Silencing of Tissue Factor Suppresses Metastasis and Prevents Cancer-Associated Hypercoagulability. <strong><em>Nano Letters<\/em><\/strong>, 2019, 19, 7, 4721-4730.<\/p>\n<p>4) Suping Li<sup>1<\/sup><sup>,2<\/sup><sup>#<\/sup>, Qiao Jiang<sup>1<\/sup><sup>,2<\/sup><sup>#<\/sup>, Baoquan Ding<sup>1<\/sup><sup>,2<\/sup>*, Guangjun Nie<sup>1<\/sup><sup>,2,3<\/sup>*. Anticancer Activities of Tumor-killing Nanorobots. <strong><em>Trends in Biotechnology<\/em><\/strong>, 2019, 6(37): 573-577<\/p>\n<p>5) Zifu Li<sup>1,2<\/sup>, Chunzhi Di<sup>3,4<\/sup>, Suping Li<sup>3,4*<\/sup>, Xiangliang Yang<sup>1,2*<\/sup> and Guangjun Nie<sup>3,4,5*<\/sup>. Smart Nanotherapeutics Targeting of Tumor Vasculature. Accounts of Chemical Research, 2019,<strong> DOI: 10.1021\/acs.accounts.9b00283<\/strong><\/p>\n<p>6) Quanwei Shi, Yinlong Zhang, Shaoli Liu, Guangna Liu, Junchao Xu, Xiao Zhao, Gregory J. Anderson, Guangjun Nie<strong>*<\/strong>, Suping Li*. Specific tissue factor delivery using a tumor-homing peptide for inducing tumor infarction. <strong><em>Biochemical Pharmacology<\/em><\/strong>, 2018, 156:501-510.<\/p>\n<p>7) Yinlong Zhang ;Jingyan Wei; Shaoli Liu; Jing Wang; Xuexiang Han; Hao Qin; Jiayan Lang; Keman Cheng; Yiye Li;Yingqiu Qi; Greg J Anderson; Saraswati Sukumar; Suping Li*, Guangjun Nie<strong>*<\/strong>. <a href=\"https:\/\/www.scholarmate.com\/ST\/0rhBSU\">Inhibition of platelet function using liposomal nanoparticles blocks tumor metastasis<\/a>. <strong><em>Theranostics<\/em><\/strong>, 2017,7(5): 1062-1071<\/p>\n<p>8) Yinlong Zhang, Jingyan Wei, Jiaqi Xu, Wei Sun Leong, Guangna Liu, Tianjiao Ji, Zhiqiang Cheng, Jing Wang, Jiayan Lang, Ying Zhao, Linhao You, Xiao Zhao, Taotao Wei, Greg J. Anderson, Sheng Qi, Jing Kong, Guangjun Nie,* and Suping Li*. Suppression of Tumor Energy Supply by Liposomal Nanoparticle-Mediated Inhibition of Aerobic Glycolysis. <em>A<strong>CS Appl. Mater. Interfaces.<\/strong><\/em> 2018, 10, 2347\u22122353.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Accounts Chem. 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