{"id":184692,"date":"2019-09-02T09:51:10","date_gmt":"2019-09-02T01:51:10","guid":{"rendered":"\/\/m.iemloyee.com\/?p=184692"},"modified":"2019-09-02T09:51:10","modified_gmt":"2019-09-02T01:51:10","slug":"%e5%8d%8e%e7%a7%91%e5%bc%a0%e5%bf%97%e5%b9%b3%e5%9b%a2%e9%98%9f-nano-lett-%e6%8a%a5%e9%81%93-%e8%83%9e%e5%86%85%e4%ba%a7%e7%94%9f%e5%85%b7%e6%9c%89%e5%85%8d%e7%96%ab%e5%8a%9f%e8%83%bd%e7%9a%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=184692","title":{"rendered":"\u534e\u79d1\u5f20\u5fd7\u5e73\u56e2\u961f Nano Lett. \u62a5\u9053: \u80de\u5185\u4ea7\u751f\u5177\u6709\u514d\u75ab\u529f\u80fd\u7684\u91d1\u7eb3\u7c73\u7c92\u5b50\u7528\u4e8e\u7ed3\u5408\u5149\u70ed\u7597\u548c\u514d\u75ab\u7597\u6cd5"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u91d1\u7eb3\u7c73\u7c92\u5b50\uff08AuNPs\uff09\u5df2\u88ab\u5e7f\u6cdb\u7814\u7a76\u7528\u4e8e\u5149\u70ed\u7597\u6cd5\uff08PTT\uff09\u548c\u6cbb\u7597\u8bca\u65ad\u5242\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff0c\u662f\u751f\u7269\u533b\u5b66\u5e94\u7528\u7684\u4e00\u79cd\u6709\u5e0c\u671b\u7684\u5019\u9009\u7269\u3002\u56e0\u4e3aAuNPs\u5177\u6709\u9ad8\u6548\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\u3001\u826f\u597d\u7684\u5149\u7a33\u5b9a\u6027\u3001\u4f4e\u6bd2\u6027\u3001\u660e\u786e\u7684\u7269\u7406\u5316\u5b66\u6027\u8d28\u7b49\u4f18\u70b9\u3002\u4f46\u662f\u4f20\u7edf\u7684AuNPs\u5927\u591a\u91c7\u7528\u5316\u5b66\u65b9\u6cd5\u5408\u6210\uff0c\u9700\u8981\u4f7f\u7528\u6709\u6bd2\u7684\u5c01\u7aef\u5242\u548c\u8fd8\u539f\u5242\uff0c\u4ee5\u53ca\u9ad8\u6e29\u6216\u9ad8\u538b\u7b49\u5371\u9669\u6761\u4ef6\u3002\u9274\u4e8e\u67d0\u4e9b\u8fc7\u6e21\u91d1\u5c5e\u53ef\u4ee5\u5728\u7ec6\u80de\u5185\u501f\u52a9\u7ec6\u80de\u819c\u548c\u7ec6\u80de\u8d28\u7684\u78b3\u6c34\u5316\u5408\u7269\u548c\u6c27\u5316\u8fd8\u539f\u9176\u4ee5\u8f6c\u5316\u4e3a\u91d1\u5c5e\u7eb3\u7c73\u7c92\u5b50\uff0c\u6240\u4ee5\u5728\u7ec6\u80de\u5185\u4ea7\u751fAuNPs\u662f\u4e00\u79cd\u7eff\u8272\u4e14\u7b80\u4fbf\u7684\u65b9\u6cd5\uff0c\u4e14\u53ef\u4ee5\u8d4b\u4e88\u5176\u751f\u7269\u4fe1\u606f\u3002\u4f46\u662fAuNPs\u5728\u73b0\u9636\u6bb5\u4e0d\u8db3\u4ee5\u6291\u5236\u80bf\u7624\u8f6c\u79fb\u548c\u590d\u53d1\u3002\u4f17\u6240\u5468\u77e5\uff0c\u51e0\u4e4e\u6240\u6709\u7ec6\u80de\u90fd\u80fd\u5206\u6ccc\u53c2\u4e0e\u5404\u79cd\u751f\u7269\u4ea4\u6d41\u7684\u56ca\u6ce1\uff0c\u4f5c\u4e3a\u6bcd\u4f53\u7ec6\u80de\u7684\u7f29\u5f71\u3002\u636e\u62a5\u9053\uff0c\u56ca\u6ce1\u53ef\u7528\u4f5c\u764c\u75c7\u75ab\u82d7\uff0c\u7528\u4e8e\u8c03\u8282\u7cfb\u7edf\u514d\u75ab\u529b\u7684\u6cbb\u7597\u5242\uff0c\u6216\u7528\u4e8e\u5bf9\u6297\u764c\u75c7\u7684\u836f\u7269\u9012\u9001\u8f7d\u4f53\u3002\u5176\u4e2d\uff0c\u80bf\u7624\u884d\u751f\u7684\u56ca\u6ce1\u53ef\u4ee5\u5c06\u80bf\u7624\u6297\u539f\u4f20\u9012\u7ed9\u6811\u7a81\u7ec6\u80de\uff08DC\uff09\u5e76\u5b9e\u73b0\u6297\u539f\u7684\u52a0\u5de5\u548c\u5448\u9012\u7ed9T\u7ec6\u80de\u4ee5\u8bf1\u5bfc\u968f\u540e\u7684\u514d\u75ab\u5e94\u7b54\u3002DC\u884d\u751f\u7684\u56ca\u6ce1\u53ef\u4ee5\u4f5c\u4e3aDC\u7684\u7f29\u5f71\uff0c\u6539\u5584\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5e76\u4fdd\u6301\u589e\u5f3a\u514d\u75ab\u5e94\u7b54\u7684\u80fd\u529b\u3002\u56e0\u6b64\uff0c\u5c06\u56ca\u6ce1\u548cAuNPs\u7ed3\u5408\u6216\u8bb8\u53ef\u4ee5\u5c06\u4e24\u8005\u7684\u4f18\u52bf\u7ec4\u5408\uff0c\u5728\u4fdd\u6301AuNPs\u539f\u6709\u529f\u80fd\u5916\uff0c\u8fd8\u53ef\u4ee5\u6291\u5236\u80bf\u7624\u7684\u590d\u53d1\u548c\u8f6c\u79fb\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c<strong>\u534e\u4e2d\u79d1\u6280\u5927\u5b66\u7684\u5f20\u5fd7\u5e73\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u901a\u8fc7\u7ec6\u80de\u5185\u751f\u6210\u548c\u80de\u5410\u4f5c\u7528\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u7684\u5177\u6709\u514d\u75ab\u529f\u80fd\u7684AuNPs\uff0c\u7528\u4e8e\u7ed3\u5408PTT\u548c\u514d\u75ab\u6cbb\u7597\u3002\u9996\u5148\u4f7f\u7528\u9ed1\u7d20\u7624B16F10\u7ec6\u80de\u4ea7\u751fAuNPs\uff0c\u7136\u540e\u5c06AuNPs\u6355\u83b7\u7684\u56ca\u6ce1\u91ca\u653e\u5230\u5177\u6709\u4fdd\u7559\u80bf\u7624\u6297\u539f\u7684\u7ec6\u80de\u5916\u73af\u5883\u4e2d\uff08AuNP@B16F10\uff09\u3002\u901a\u8fc7\u8fdb\u4e00\u6b65\u5c06\u7eb3\u7c73\u9897\u7c92\u5f15\u5165\u6811\u7a81\u7ec6\u80de\uff08DC\uff09\uff0c\u4ea7\u751f\u5177\u6709\u589e\u5f3a\u751f\u7269\u5b89\u5168\u6027\u7684DC\u884d\u751f\u7684AuNPs\uff08AuNP@DC<sub>B16F10<\/sub>\uff09\uff0c\u5176\u53ef\u4ee5\u8bf1\u5bfc\u4ea7\u751f\u9ad8\u6e29\u5e76\u5f15\u8d77\u6297\u80bf\u7624\u7684\u514d\u75ab\u5e94\u7b54\u3002\u8be5\u514d\u75ab\u7eb3\u7c73\u5e73\u53f0\u663e\u793a\u51fa\u6709\u6548\u6291\u5236\u751a\u81f3\u6839\u9664\u539f\u53d1\u6027\u80bf\u7624\u3001\u80bf\u7624\u8f6c\u79fb\u4ee5\u53ca\u80bf\u7624\u590d\u53d1\uff0c\u8fdb\u800c\u663e\u7740\u63d0\u9ad8\u4e86\u5c0f\u9f20\u7684\u603b\u4f53\u5b58\u6d3b\u7387\u3002\u603b\u4e4b\uff0c\u901a\u8fc7\u8be5\u65b9\u6cd5\u5236\u5907\u7684\u5177\u6709\u514d\u75ab\u5b66\u7279\u6027\u7684\u7ec6\u80de\u5185\u4ea7\u751f\u7684AuNPs\u53ef\u4ee5\u4f5c\u4e3a\u764c\u75c7\u7684\u6709\u6548\u6cbb\u7597\u65b9\u5f0f\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a<strong>\u201cIntracellularly Generated Immunological Gold Nanoparticles for Combinatorial Photothermal Therapy and Immunotherapy against Tumor\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520a<strong>Nano Lett.<\/strong>\u4e0a\u3002<br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184693\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/TOC.jpeg\" alt=\"\" width=\"600\" height=\"416\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/TOC.jpeg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/TOC-300x208.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><br \/>\n <strong>\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u7ec6\u80de\u5185\u5f62\u6210\u548c\u8868\u5f81AuNP@DC<sub>B16F10<\/sub><\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184694\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/1.jpeg\" alt=\"\" width=\"600\" height=\"351\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/1.jpeg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/1-300x176.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08A\uff09\u57284 d\u5185\u4eceB16F10\u7ec6\u80de\u4ea7\u751f\u548c\u6392\u51faAuNPs\u7684\u5178\u578bTEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08B\uff09AuNP@B16F10\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08C\uff09AuNP@B16F10\u7684EDX\u5149\u8c31\uff1b<\/p>\n<p>\uff08D\uff09\u4eceDC2.4\u4e0a\u8131\u843d\u7684AuNP@DC<sub>B16F10<\/sub>\u7684Cryo-TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08E\uff09AuNP DC<sub>B16F10<\/sub>\u7684TEM\u56fe\u50cf\uff1b<\/p>\n<p>\uff08F\uff09\u4e0d\u540c\u6d53\u5ea6\u7684AuNP@DC<sub>B16F10<\/sub>\u7684UV\u5438\u6536\uff1b<\/p>\n<p>\uff08G\uff09\u6fc0\u5149\u7167\u5c045 min\u671f\u95f4\uff0c\u5316\u5b66\u5408\u6210\u7684AuNP\u3001AuNP@DC<sub>L929<\/sub>\u548cAuNP@DC<sub>B16F10<\/sub>\u7684IR\u56fe\u50cf\u548c\u76f8\u5e94\u7684\u6e29\u5ea6\u66f2\u7ebf\uff1b<\/p>\n<p>\uff08H\uff09\u5316\u5b66\u5408\u6210\u7684AuNP\u3001AuNP@DC<sub>L929<\/sub>\u548cAuNP@DC<sub>B16F10<\/sub>\u5728\u91cd\u590d\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u6e29\u5ea6\u53d8\u5316\uff08\u0394T\uff09\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001\u7eb3\u7c73\u7c92\u5b50\u7684\u86cb\u767d\u8d28\u7ec4\u5b66\u5206\u6790<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184695\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/2.jpeg\" alt=\"\" width=\"600\" height=\"531\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/2.jpeg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/2-300x266.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08A\uff09\u4ece\u7eb3\u7c73\u9897\u7c92\u548c\u6bcd\u4f53\u7ec6\u80de\u88c2\u89e3\u7684\u86cb\u767d\u8d28\u7684\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08B\uff09\u4eceAuNP@B16F10\u3001AuNP@DC<sub>L929<\/sub>\u53ca\u5176\u6bcd\u4f53\u7ec6\u80de\u88c2\u89e3\u7684\u86cb\u767d\u8d28\u7684\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08C\uff09\u4ece\u4e09\u79cd\u4e0d\u540c\u7eb3\u7c73\u9897\u7c92\u88c2\u89e3\u7684\u86cb\u767d\u8d28\u7684\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08D\uff09AuNP@B16F10\u548cAuNP@DC<sub>B16F10<\/sub>\u4e4b\u95f4\u768456\u79cd\u5e38\u89c1\u86cb\u767d\u8d28\uff0c\u4ee5\u53caAuNP@B16F10\u548cAuNP@DC<sub>L929<\/sub>\u4e4b\u95f4\u768441\u79cd\u5e38\u89c1\u86cb\u767d\u8d28\u7684\u70ed\u56fe\uff1b<\/p>\n<p>\uff08E\uff09\u4eceAuNP@B16F10\u3001AuNP@DC<sub>B16F10<\/sub>\u548cAuNP@DC<sub>L929<\/sub>\u83b7\u5f97\u7684\u65b0\u6297\u539f\u548cDAMP\u7684\u6bd4\u8f83\uff1b<\/p>\n<p>\uff08F\uff09\u80bf\u7624\u6297\u539f\u7684Western\u5370\u8ff9\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001AuNP@DC<sub>B16F10<\/sub>\u7684\u7ec6\u80de\u6bd2\u6027\u548c\u4f53\u5185\u7279\u5f81<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184696\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/3.jpeg\" alt=\"\" width=\"600\" height=\"504\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/3.jpeg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/3-300x252.jpeg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/>\uff08A\uff09\u5728\u5b75\u80b224 h\u540e\uff0c\u7528\u6709\u6216\u65e0NIR\u7684AuNP@DC<sub>B16F10<\/sub>\u5904\u7406\u7684B16F10\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n<p>\uff08B\uff09B16F10\u7ec6\u80de\u7684\u5149\u70ed\u7ec6\u80de\u6bd2\u6027\u56fe\u50cf\uff1b<\/p>\n<p>\uff08C\uff09\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u5728\u8377\u7624\u5c0f\u9f20\u4e2d\u7528DiR\u6807\u8bb0\u7684AuNP@DC<sub>B16F10<\/sub>\u7684\u4f53\u5185\u5206\u5e03\uff1b<\/p>\n<p>\uff08D\uff09\u7eb3\u7c73\u9897\u7c92\u5411iLNs\u548caLNs\u8fc1\u79fb\u7684\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n<p>\uff08E\uff0cF\uff09\u7528\u6fc0\u5149\u7167\u5c04\uff0c\u5206\u522b\u6ce8\u5c04PBS\u3001AuNP@DC<sub>L929<\/sub>\u548cAuNP@DC<sub>B16F10<\/sub>\u7684\u8377\u7624\u5c0f\u9f20\u7684IR\u70ed\u56fe\u50cf\u548c\u76f8\u5e94\u7684\u6e29\u5ea6\u66f2\u7ebf\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001\u7ed3\u5408\u5149\u70ed\u548c\u514d\u75ab\u6cbb\u7597\u5bf9\u5c0f\u9f20\u9ed1\u8272\u7d20\u7624\u6a21\u578b\u7684\u6297\u80bf\u7624\u6548\u679c<\/strong><br 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href=\"https:\/\/pubs.acs.org\/doi\/full\/10.1021\/acs.nanolett.9b02903\" target=\"_blank\" rel=\"noopener\">Intracellularly Generated Immunological Gold Nanoparticles for Combinatorial Photothermal Therapy and Immunotherapy against Tumor<\/a><\/strong>\uff08<em>Nano Lett.<\/em>, <strong>2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b02903\uff09<\/p>\n<p>\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 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