{"id":184247,"date":"2019-08-26T06:30:02","date_gmt":"2019-08-25T22:30:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=184247"},"modified":"2019-08-25T22:27:13","modified_gmt":"2019-08-25T14:27:13","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e6%b9%96%e5%8d%97%e5%a4%a7%e5%ad%a6%e5%bc%a0%e6%99%93%e5%85%b5j-am-chem-soc-%e5%8f%8c%e5%9b%a0%e7%b4%a0%e6%bf%80%e6%b4%bb%e7%ba%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=184247","title":{"rendered":"\u6e56\u5357\u5927\u5b66\u5f20\u6653\u5175J. Am. Chem. Soc.:\u53cc\u56e0\u7d20\u6fc0\u6d3b\u7eb3\u7c73\u63a2\u9488\u7528\u4e8e\u4f53\u5185\u5206\u5b50\u6210\u50cf\u548c\u9ad8\u7279\u5f02\u6027\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u76ee\u524d\uff0c\u5927\u591a\u6570\u764c\u75c7\u6cbb\u7597\uff0c\u5305\u62ec\u5316\u5b66\u7597\u6cd5\uff0c\u653e\u5c04\u7597\u6cd5\u6216\u5149\u7597\u6cd5\uff0c\u4f1a\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u4ea7\u751f\u975e\u7279\u5f02\u6027\u5316\u5b66\u6bd2\u6027\uff0c\u653e\u5c04\u6027\u6bd2\u6027\u6216\u5149\u6bd2\u6027\uff0c\u4ece\u800c\u5f15\u8d77\u4e25\u91cd\u611f\u67d3\uff0c\u6076\u5fc3\uff0c\u795e\u7ecf\u6027\u75bc\u75db\u548c\u80be\u810f\u7b49\u95ee\u9898\u3002\u57fa\u4e8e\u80bf\u7624\u5fae\u73af\u5883\uff08TME\uff09\u7684\u7279\u5f81\uff0c\u79d1\u5b66\u5bb6\u4eec\u5f00\u53d1\u591a\u79cd\u53ef\u6fc0\u6d3b\u7eb3\u7c73\u6750\u6599\uff0c\u5728\u764c\u75c7\u751f\u7269\u6807\u5fd7\u7269\u7684\u523a\u6fc0\u4e0b\uff0c\u8fd9\u4e9b\u7eb3\u7c73\u6750\u6599\u80fd\u591f\u5bf9\u764c\u7ec6\u80de\u8fdb\u884c\u7279\u5f02\u6027\u7834\u574f\uff0c\u4ece\u800c\u964d\u4f4e\u7ea2\u5916\u6fc0\u5149\u6216X\u5c04\u7ebf\u7167\u5c04\u7b49\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u6bd2\u526f\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u53ef\u6fc0\u6d3b\u7684\u7eb3\u7c73\u6750\u6599\u4ec5\u5bf9\u5355\u4e00\u523a\u6fc0\u54cd\u5e94\u3002\u8fd9\u79cd\u5355\u56e0\u5b50\u6fc0\u6d3b\u901a\u5e38\u4e0d\u8db3\u4ee5\u63d0\u4f9b\u5145\u5206\u7684\u533a\u5206\u764c\u75c7\u75c5\u53d8\u90e8\u4f4d\u4e0e\u6b63\u5e38\u7ec4\u7ec7\u6240\u9700\u7684\u4fe1\u53f7\uff0c\u5bfc\u81f4\u6f5c\u5728\u7684\u5047\u9633\u6027\u6216\u5047\u9634\u6027\u8bca\u65ad\u548c\u6cbb\u7597\u7ed3\u679c\u3002\u4e3a\u4e86\u8fdb\u4e00\u6b65\u63d0\u9ad8\u764c\u75c7\u6210\u50cf\u548c\u6cbb\u7597\u7684\u7cbe\u51c6\u6027\uff0c\u8feb\u5207\u9700\u8981\u591a\u79cd\u764c\u75c7\u76f8\u5173\u751f\u7269\u6807\u5fd7\u7269\u5171\u540c\u6fc0\u6d3b\u7684\u667a\u80fd\u7eb3\u7c73\u63a2\u9488\u3002<\/p>\n

\u5149\u58f0\uff08PA\uff09\u6210\u50cf\u4f5c\u4e3a\u4e00\u79cd\u975e\u4fb5\u5165\u6027\u6210\u50cf\u6280\u672f\uff0c\u662f\u7ec4\u7ec7\u6216\u9020\u5f71\u5242\u901a\u8fc7\u8109\u51b2\u6fc0\u5149\u7167\u5c04\u4ea7\u751f\u7684\u70ed\u81a8\u80c0\u5f15\u8d77\u7684\u58f0\u5b66\u4fe1\u53f7\u3002\u4e0e\u4f20\u7edf\u7684\u8367\u5149\u6216\u751f\u7269\u53d1\u5149\u6210\u50cf\u6280\u672f\u76f8\u6bd4\uff0cPA\u6210\u50cf\u80fd\u591f\u663e\u7740\u6539\u5584\u4f53\u5185\u6210\u50cf\u6df1\u5ea6\u548c\u7a7a\u95f4\u5206\u8fa8\u7387\u3002\u76ee\u524d\uff0c\u5927\u591a\u6570PA\u63a2\u9488\u53d7\u9650\u4e8e\u5355\u56e0\u5b50\u6fc0\u6d3b\u6216\u5355\u4fe1\u53f7\u8f93\u51fa\u3002\u57fa\u4e8e\u5355\u4e2a\u4fe1\u53f7\u8f93\u51fa\uff0cPA\u6210\u50cf\u7684\u7cbe\u5ea6\u8fd8\u53ef\u80fd\u53d7\u6210\u50cf\u6df1\u5ea6\uff0c\u63a2\u9488\u542b\u91cf\u6216\u5f02\u8d28\u5206\u5e03\u7684\u5f71\u54cd\u3002\u4e3a\u4e86\u63d0\u9ad8\u6210\u50cf\u7cbe\u5ea6\u7b49\u95ee\u9898\uff0c\u8feb\u5207\u9700\u8981\u5f00\u53d1\u51fa\u591a\u56e0\u7d20\u6fc0\u6d3b\u7684\u3001\u591a\u4fe1\u53f7\u8f93\u51fa\u7684PA\u6210\u50cf\u63a2\u9488\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u5728\u6e56\u5357\u5927\u5b66\u5f20\u6653\u5175\u6559\u6388\u5e26\u9886\u4e0b\u3001\u5176\u56e2\u961f\u6210\u5458\u5b8b\u56fd\u80dc\u6559\u6388\u534f\u52a9\u6307\u5bfc\u6ed5\u4e3d\u4e3d\u535a\u58eb\u751f\u8bbe\u8ba1\u4e86\u4e00\u79cd\u53cc\u6fc0\u6d3b\u7eb3\u7c73\u63a2\u9488\uff0c\u7528\u4e8e\u9ad8\u7279\u5f02\u6027\u7684\u764c\u75c7\u6210\u50cf\u548c\u5149\u70ed\u6cbb\u7597\u3002\u57fa\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u8f83\u9ad8\u6c34\u5e73\u7684NO\u548c\u4f4epH\u503c\u7684\u7279\u6027\uff0c\u8bbe\u8ba1\u5408\u6210NO \/\u9178\u5171\u6fc0\u6d3b\u7684\uff08D-\u03c0-A-\u03c0-D\uff09\u578b\u54cd\u5e94\u5206\u5b50\uff0c\u540c\u65f6\u5408\u6210\u53e6\u4e00\u79cd\u60f0\u6027\u5206\u5b50\u4f5c\u4e3a\u5185\u53c2\uff0c\u901a\u8fc7\u7ec4\u88c5\u5f62\u6210\u7eb3\u7c73\u7c92\u5b50\u3002\u53ea\u6709\u5728NO\u548c\u9178\u7684\u5171\u6fc0\u6d3b\u4e0b\uff0c\u7eb3\u7c73\u63a2\u9488\u7684\u5149\u58f0\u3001\u5149\u70ed\u6027\u80fd\u5f00\u542f\uff0c\u901a\u8fc7\u8f93\u51fa\u6bd4\u4f8b\u5149\u58f0\u3001\u5149\u70ed\u4fe1\u53f7\uff0c\u7528\u4e8e\u9ad8\u7279\u6027\u7684\u80bf\u7624\u6210\u50cf\u548c\u80bf\u7624\u5149\u70ed\u6cbb\u7597\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cNitric Oxide-Activated \u201cDual-Key-One-Lock\u201d Nanoprobe for In Vivo<\/em> Molecular Imaging and High-Specificity Cancer Therapy\u201d\u53d1\u8868\u5728J. Am. Chem. Soc.\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

Figure 1.<\/strong>\u7eb3\u7c73\u63a2\u9488\u5206\u5b50\u7684\u5408\u6210\u3001\u7ed3\u6784\u4e0e\u5e94\u7528<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09\u5728TME\u5185\u7684NO\u548c\u9178\u7684\u5171\u6d3b\u5316\u4e0b\uff0cDATN\u5b9e\u73b0\u4e86\u80bf\u7624\u7279\u5f02\u6027PA\u6210\u50cf\u548c\u53cc\u6fc0\u6d3b\u5149\u70ed\u6cbb\u7597<\/p>\n

Figure 2.NRM<\/strong>\u548c<\/strong>NIM<\/strong>\u7684\u5408\u6210\u8def\u5f84<\/strong><\/p>\n

\"\"<\/p>\n

Figure 3.<\/strong>\u7eb3\u7c73<\/strong>\u63a2\u9488\u8868\u5f81\u4e0e\u54cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09DATN\u7684TEM\u56fe\u50cf<\/p>\n

\uff08b\uff09DATN\u7684\u7c92\u5f84\u5206\u6790<\/p>\n

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\uff08d\uff09DATN\u5728\u4e0d\u540cpH\u6761\u4ef6\u4e0b\u54cd\u5e94NO<\/p>\n

\uff08e\uff09A680<\/sub>\/ A950<\/sub>\u968f\u4e0d\u540cpH\u7684\u53d8\u5316<\/p>\n

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\uff08g\uff09DATN\u7684\u5149\u8c31\u968f\u4e0d\u540cNO\u6d53\u5ea6\u7684\u53d8\u5316<\/p>\n

\uff08h\uff09A680<\/sub>\/A950<\/sub>\u968f\u4e0d\u540cNO\u6d53\u5ea6\u7684\u53d8\u5316<\/p>\n

\uff08i\uff09DATN\u7684\u54cd\u5e94\u9009\u62e9\u6027<\/p>\n

Figure 4.<\/strong>\u63a2\u9488\u7684\u5149\u70ed\u4e0e\u5149\u58f0\u54cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a,b\uff09DATN\u5bf9\u4e0d\u540c\u6d53\u5ea6\u7684NO\u7684\u5149\u70ed\u54cd\u5e94<\/p>\n

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\uff08d\uff09T660<\/sub>\/T980<\/sub>\u968fNO\u6d53\u5ea6\u53d8\u5316<\/p>\n

\uff08e\uff09DATN\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u5149\u70ed\u54cd\u5e94<\/p>\n

\uff08f\uff09DATN\u7684\u5149\u70ed\u7a33\u5b9a\u6027<\/p>\n

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Figure 5.<\/strong>\u6d3b\u4f53\u5149\u58f0\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09\u76f8\u5e94\u7684PA680<\/sub>\/PA950<\/sub><\/p>\n

\uff08c\uff09\u80bf\u7624\u5185\u7684PA\u56fe\u50cf<\/p>\n

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\uff08e\uff09\u76f8\u5e94\u7684PA680<\/sub>\/PA950<\/sub><\/p>\n

Figure 6.<\/strong>\u6d3b\u4f53\u5149\u70ed\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5c0f\u9f20\u7684\u5149\u70ed\u56fe\u50cf<\/p>\n

\uff08b\uff09\u80bf\u7624\u533a\u57df\u7684\u4ee3\u8868\u6027\u6e29\u5ea6\u53d8\u5316<\/p>\n

\uff08c\uff09\u80bf\u7624\u533a\u57df\u7684T660<\/sub>\/T980<\/sub><\/p>\n

\uff08d\uff09\u80bf\u7624\u548c\u6b63\u5e38\u7ec4\u7ec7\u4e4b\u95f4\u7684\u6e29\u5dee<\/p>\n

Figure 7.DATN<\/strong>\u7684\u4f53\u5185\u764c\u75c7\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

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\uff08b\uff09\u80bf\u7624\u91cd\u91cf<\/p>\n

\uff08c\uff09\u8001\u9f20\u4f53\u91cd\u53d8\u5316<\/p>\n

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\uff08e\uff09\u4e3b\u8981\u5668\u5b98\u7684H&E\u67d3\u8272<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u53cc\u6fc0\u6d3b\u7eb3\u7c73\u63a2\u9488\uff0c\u7528\u4e8e\u6bd4\u7387\u578b\u5149\u58f0\u3001\u5149\u70ed\u6210\u50cf\u548c\u53cc\u6fc0\u6d3b\u764c\u75c7\u6cbb\u7597\u3002\u7531\u4e8e\u80bf\u7624\u4e2d\u5e38\u5e38\u5e76\u53d1\u708e\u75c7\uff0c\u8be5\u53cc\u56e0\u7d20\u6fc0\u6d3b\u7b56\u7565\uff0c\u6709\u671b\u63d0\u9ad8\u80bf\u7624\u6210\u50cf\u548c\u6cbb\u7597\u7684\u7279\u6027\u5f02\u6027\u548c\u7cbe\u51c6\u5ea6\uff0c\u4ece\u800c\u964d\u4f4e\u764c\u75c7\u6cbb\u7597\u7684\u4e25\u91cd\u6bd2\u526f\u4f5c\u7528\u3002\u672a\u6765\u8be5\u7b56\u7565\u8fd8\u53ef\u4ee5\u62d3\u5c55\u5230\u5bf9\u80bf\u7624\u66f4\u52a0\u7279\u5f02\u6027\u7684\u751f\u7269\u6807\u8bb0\u7269\uff08\u5982\u57fa\u8d28\u91d1\u5c5e\u86cb\u767d\u9176\uff09\uff0c\u6765\u8fdb\u4e00\u6b65\u63d0\u4f9b\u80bf\u7624\u6210\u50cf\u548c\u6cbb\u7597\u7684\u7cbe\u51c6\u5ea6\u3002<\/p>\n

Nitric Oxide-Activated \u201cDual-Key-One-Lock\u201d Nanoprobe for In Vivo<\/em> Molecular Imaging and High-Specificity Cancer Therapy<\/a><\/p>\n

(J. Am. Chem. Soc., 2019, DOI: 10.1021\/jacs.9b05901)<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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