{"id":184185,"date":"2019-08-25T06:30:14","date_gmt":"2019-08-24T22:30:14","guid":{"rendered":"\/\/m.iemloyee.com\/?p=184185"},"modified":"2019-08-24T21:42:13","modified_gmt":"2019-08-24T13:42:13","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91acc-chem-res-%ef%bc%9a%e5%8a%9f%e8%83%bddna%e5%88%86%e5%ad%90%e6%9e%84%e7%ad%91%e5%85%b7%e6%9c%89%e9%80%89%e6%8b%a9%e6%80%a7%e5%92%8c%e5%88%ba%e6%bf%80","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=184185","title":{"rendered":"Acc. Chem. Res.\uff1a\u529f\u80fdDNA\u5206\u5b50\u6784\u7b51\u5177\u6709\u9009\u62e9\u6027\u548c\u523a\u6fc0\u54cd\u5e94\u6027\u7eb3\u7c73\u7c92\u5b50\u7528\u4e8e\u751f\u7269\u533b\u5b66\u5e94\u7528"},"content":{"rendered":"<p><strong>\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n<p>\u7eb3\u7c73\u7c92\u5b50\uff08NPs\uff09\u7531\u4e8e\u5176\u56fa\u6709\u7684\u7535\u5b50\u3001\u5149\u5b66\u3001\u78c1\u6027\u3001\u673a\u68b0\u548c\u751f\u7406\u7279\u6027\uff0c\u5728\u6539\u5584\u75be\u75c5\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002\u4e3a\u4e86\u5145\u5206\u53d1\u6325\u7eb3\u7c73\u533b\u5b66\u7684\u6f5c\u529b\uff0c\u7eb3\u7c73\u7c92\u5b50\u5fc5\u987b\u5177\u6709\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u5e76\u53ef\u4ee5\u7279\u5f02\u6027\u9776\u5411\u548c\u8bc6\u522b\u7279\u5b9a\u7684\u751f\u7269\u5206\u5b50\uff0c\u4ee5\u786e\u4fdd\u5728\u590d\u6742\u73af\u5883\uff08\u5982\u6d3b\u7ec6\u80de\uff0c\u7ec4\u7ec7\uff0c\u52a8\u7269\u548c\u4eba\u4f53\uff09\u4e2d\u8fdb\u884c\u9009\u62e9\u6027\u4f20\u611f\u3001\u6210\u50cf\u548c\u836f\u7269\u9012\u9001\u3002\u529f\u80fdDNA\uff08fDNA\uff09\u5206\u5b50\u5305\u62ec\u9002\u914d\u4f53\u3001DNA\u9176\u548c\u9002\u914d\u4f53\u9176\uff0c\u53ef\u901a\u8fc7\u4f53\u5916\u9009\u62e9\u6216\u901a\u8fc7\u6307\u6570\u5bcc\u96c6\u7684\u914d\u4f53\u7cfb\u7edf\u8fdb\u5316\u83b7\u5f97\uff08SELEX\uff09\u3002\u6b64\u5916\uff0cfDNA\u5728\u751f\u7269\u5e94\u7528\u4e0a\u5177\u6709\u8bb8\u591a\u4f18\u70b9\uff0c\u5982\u4f53\u79ef\u5c0f\u3001\u514d\u75ab\u539f\u6027\u4f4e\u3001\u6613\u4e8e\u5408\u6210\u548c\u5316\u5b66\u4fee\u9970\u3001\u4ee5\u53ca\u6613\u4e8e\u8868\u9762\u56fa\u5b9a\u3002\u5c06fDNA\u6574\u5408\u5230\u7eb3\u7c73\u7c92\u5b50\u4e0a\u53ef\u4ee5\u8d4b\u4e88\u7eb3\u7c73\u7c92\u5b50\u5bf9\u591a\u79cd\u9776\u6807\u7684\u7279\u5f02\u6027\u8bc6\u522b\u80fd\u529b\uff0c\u5305\u62ec\u5c0f\u5206\u5b50\u3001\u751f\u7269\u5927\u5206\u5b50\u3001\u751a\u81f3\u75c5\u6bd2\u6216\u7ec6\u80de\u3002\u8bb8\u591a\u7814\u7a76\u5c0f\u7ec4\u5df2\u7ecf\u63a2\u7d22\u4e86\u6784\u5efafDNA\u5de5\u7a0b\u5316\u7eb3\u7c73\u7c92\u5b50\u7684\u65b0\u65b9\u6cd5\uff0c\u5e76\u7814\u7a76\u5176\u5728\u7eb3\u7c73\u533b\u5b66\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u7684\u5e94\u7528\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u8fd1\u671f\uff0c<strong>\u56fd\u5bb6\u7eb3\u7c73\u4e2d\u5fc3\u674e\u4e50\u4e50\u7814\u7a76\u5458\u4e0e\u7f8e\u56fd\u4f0a\u5229\u8bfa\u4f0a\u5927\u5b66\u5384\u5df4\u7eb3<\/strong><strong>&#8211;<\/strong><strong>\u9999\u69df\u5206\u6821\u9646\u827a\u6559\u6388<\/strong>\u7cfb\u7edf\u5730\u603b\u7ed3\u4e86\u4ed6\u4eec\u53d1\u5c55\u7684\u5c06\u529f\u80fdDNA\u6574\u5408\u5230\u7eb3\u7c73\u6750\u6599\u7684\u65b0\u65b9\u6cd5\u548c\u65b0\u7b56\u7565\u53ca\u5176\u5728\u751f\u7269\u4f20\u611f\u3001\u9776\u5411\u836f\u7269\u9012\u9001\u7b49\u65b9\u9762\u7684\u5e94\u7528\u3002\u901a\u8fc7\u5c06\u91d1\u7eb3\u7c73\u7c92\u5b50\u3001\u91cf\u5b50\u70b9\u3001\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\u7b49\u65e0\u673a\u7eb3\u7c73\u7c92\u5b50\u4ee5\u53ca\u8102\u8d28\u4f53\u3001\u5171\u805a\u7269\u7eb3\u7c73\u9897\u7c92\u7b49\u6709\u673a\u7eb3\u7c73\u7c92\u5b50\u4e0e\u529f\u80fdDNA\u7ec4\u88c5\uff0c\u4ed6\u4eec\u8bbe\u8ba1\u4e86\u5177\u6709\u523a\u6fc0\u54cd\u5e94\u6027\u7684fDNA-NPs\u7ec4\u88c5\u4f53\uff0c\u4e0d\u4ec5\u53ef\u4f5c\u4e3a\u57fa\u4e8e\u6bd4\u8272\u3001\u8367\u5149\u548c\u78c1\u5171\u632f\u6210\u50cf(MRI)\u7684\u4f20\u611f\u5668\uff0c\u7528\u4e8e\u8bca\u65ad\u5404\u79cd\u5206\u6790\u7269\uff1b\u4e5f\u53ef\u4ee5\u4f5c\u4e3a\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u7684\u9776\u5411\u6210\u50cf\u548c\u836f\u7269\u9012\u9001\u5e73\u53f0\u3002\u4ed6\u4eec\u8fd8\u5c55\u793a\u4e86DNA\u4ecb\u5bfc\u7684\u7eb3\u7c73\u7c92\u5b50\u8868\u9762\u529f\u80fd\u5316\u548c\u5f62\u8c8c\u63a7\u5236\u5408\u6210\uff0c\u4ee5\u53ca\u53ef\u4f5c\u4e3a\u7279\u5b9a\u751f\u7269\u63a2\u9488\u7684\u7eb3\u7c73\u7c92\u5b50\u7ec4\u88c5\u4f53\u3002\u4e3a\u5b9e\u73b0\u5bf9\u529f\u80fdDNA\u8bc6\u522b\u7279\u6027\u9ad8\u65f6\u7a7a\u5206\u8fa8\u7387\u7684\u7cbe\u786e\u63a7\u5236\uff0c\u4ed6\u4eec\u8fd8\u6784\u5efa\u4e86\u4e00\u7cfb\u5217\u5177\u6709\u5149\u6fc0\u6d3b\u4f20\u611f\u548c\u6210\u50cf\u529f\u80fd\u7684fDNA\u4fee\u9970\u7684\u7eb3\u7c73\u63a2\u9488\uff0c\u5e76\u5b9e\u73b0\u4e86\u8be5\u7c7b\u63a2\u9488\u5bf9\u76ee\u6807\u7269\u7684\u7279\u5f02\u6027\u54cd\u5e94\u548c\u7cbe\u51c6\u68c0\u6d4b\u3002\u3002\u6700\u540e\uff0c\u4f5c\u8005\u8ba8\u8bba\u4e86\u529f\u80fdDNA\u5de5\u7a0b\u5316\u7eb3\u7c73\u6750\u6599\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e0a\u9762\u4e34\u7684\u6311\u6218\u548c\u672a\u6765\u53d1\u5c55\u524d\u666f\u3002\u8fd9\u4e9b\u6210\u679c\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201c<strong>Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520a<strong>Acc. Chem. Res.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p>fDNA\u901a\u5e38\u4e0d\u5177\u6709\u80fd\u591f\u76f4\u63a5\u4ea7\u751f\u53ef\u68c0\u6d4b\u4fe1\u53f7\u7684\u5b98\u80fd\u56e2\u3002\u4e3a\u4e86\u5c06fDNA\u8f6c\u5316\u4e3a\u4f20\u611f\u63a2\u9488\uff0c\u53ef\u4ee5\u5c06fDNA\u4e0e\u65e0\u673aNPs\u7ed3\u5408\u8d77\u6765\uff0c\u5229\u7528\u5176\u72ec\u7279\u7684\u5149\u5b66\u548c\u78c1\u5b66\u7279\u6027\uff0c\u6784\u5efa\u65b0\u578b\u4f20\u611f\u5668\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184186\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/1-38.jpg\" alt=\"\" width=\"600\" height=\"290\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/1-38.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/1-38-300x145.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184187\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/2-36.jpg\" alt=\"\" width=\"600\" height=\"544\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/2-36.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/2-36-300x272.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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DNAzyme\u7528\u4e8e\u5728\u6d3b\u7ec6\u80de\u4e2d\u6210\u50cf\u91d1\u5c5e\u79bb\u5b50\u7684\u5e94\u7528\u76f4\u5230\u6700\u8fd1\u624d\u88ab\u62a5\u9053\u3002\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u5149\u5316\u5b66caging-decaging\u7b56\u7565\uff0c\u4ee5\u5b9e\u73b0\u5149\u6fc0\u6d3b\u7684DNAzyme\u7528\u4e8e\u6d3b\u7ec6\u80de\u4e2d\u7684\u91d1\u5c5e\u79bb\u5b50\u7684\u6210\u50cf\uff0c\u8fdb\u4e00\u6b65\uff0c\u4f5c\u8005\u5229\u7528UCNPs\u53d1\u5149\u7279\u6027\u5c06\u7ea2\u5916\u5149\u8f6c\u6362\u4e3a\u7d2b\u5916\u5149\uff0c\u5206\u522b\u5b9e\u73b0\u4e86\u6d3b\u4f53\u5185\u91d1\u5c5e\u79bb\u5b50\u548c\u80bf\u7624\u5fae\u73af\u5883\u4e2dATP\u7684\u9009\u62e9\u6027\u6210\u50cf\u68c0\u6d4b\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184188\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/3-35.jpg\" alt=\"\" width=\"600\" height=\"823\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/3-35.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/3-35-219x300.jpg 219w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184189\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/4-32.jpg\" alt=\"\" width=\"600\" height=\"1063\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/4-32.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/4-32-169x300.jpg 169w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/4-32-578x1024.jpg 578w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-184190\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/5-23.jpg\" alt=\"\" width=\"600\" height=\"448\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/5-23.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/08\/5-23-300x224.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe5\u3001\u7528\u4e8e\u5c0f\u5206\u5b50\u9776\u6807\u591a\u6a21\u6001\u68c0\u6d4b\u7684\u523a\u6fc0\u54cd\u5e94\u578b\u8102\u8d28\u4f53\u7b56\u7565\u7684\u5de5\u4f5c\u539f\u7406\u3002<\/p>\n<p>\u5bf9\u4e8e\u6d89\u53ca\u751f\u7269\u2212\u7eb3\u7c73\u754c\u9762\u76f8\u4e92\u4f5c\u7528\u7684\u57fa\u4e8efDNA\u7684\u7eb3\u7c73\u533b\u5b66\u5e94\u7528\uff0c\u9650\u5236\u5176\u5f00\u53d1\u8fc7\u7a0b\u7684\u4e00\u4e2a\u5173\u952e\u56e0\u7d20\u662f\u96be\u4ee5\u7cbe\u786e\u63a7\u5236\u8f7d\u4f53\u5185\u90e8\u548c\u8868\u9762\u7684\u5316\u5b66\u6027\u8d28\u3002\u901a\u8fc7\u6700\u8fd1\u4e0eSteve C. 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href=\"https:\/\/pubs.acs.org\/doi\/10.1021\/acs.accounts.9b00167\">Functional DNA Molecules Enable Selective and Stimuli-Responsive Nanoparticles for Biomedical Applications<\/a> (<em>Acc. Chem. Res.<\/em> <strong>2019<\/strong>, DOI: 10.1021\/acs.accounts.9b00167)<\/p>\n<p>\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com\">tougao@cailiaoren.com<\/a>\u3002<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u7814\u7a76\u80cc\u666f\u3011 \u7eb3\u7c73\u7c92\u5b50\uff08NPs\uff09\u7531\u4e8e\u5176\u56fa\u6709\u7684\u7535\u5b50\u3001\u5149\u5b66\u3001\u78c1\u6027\u3001\u673a\u68b0\u548c\u751f\u7406\u7279\u6027\uff0c\u5728\u6539\u5584\u75be\u75c5\u8bca\u65ad\u548c\u6cbb\u7597\u65b9\u9762\u5177\u6709\u5de8\u5927\u6f5c\u529b\u3002\u4e3a\u4e86\u5145\u5206\u53d1\u6325\u7eb3\u7c73\u533b\u5b66\u7684\u6f5c\u529b\uff0c\u7eb3\u7c73\u7c92\u5b50\u5fc5\u987b\u5177\u6709&#8230;<\/p>\n","protected":false},"author":1004,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[533],"tags":[4169],"class_list":["post-184185","post","type-post","status-publish","format-standard","hentry","category-zongshu","tag-dna"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/184185"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1004"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=184185"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/184185\/revisions"}],"predecessor-version":[{"id":184319,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/184185\/revisions\/184319"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=184185"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=184185"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=184185"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}