{"id":183640,"date":"2019-08-17T06:30:56","date_gmt":"2019-08-16T22:30:56","guid":{"rendered":"\/\/m.iemloyee.com\/?p=183640"},"modified":"2019-08-16T10:44:11","modified_gmt":"2019-08-16T02:44:11","slug":"%e4%b8%ad%e5%9b%bd%e8%8d%af%e7%a7%91%e5%a4%a7%e5%ad%a6%e5%ad%99%e6%95%8f%e6%8d%b7%e7%bb%84adv-funct-mater-atp%e8%b6%85%e6%95%8f%e5%9e%8b%e8%9b%8b%e7%99%bd%e5%9b%a2%e7%b0%87%e7%94%a8%e4%ba%8e","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=183640","title":{"rendered":"\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5b59\u654f\u6377\u7ec4Adv. Funct. Mater: ATP\u8d85\u654f\u578b\u86cb\u767d\u56e2\u7c07\u7528\u4e8e\u80bf\u7624\u6df1\u5c42\u6e17\u900f\u53ca\u653e\u5927MRI\u5f15\u5bfc\u7684\u5149\u70ed\u6cbb\u7597"},"content":{"rendered":"

\u7814\u7a76\u80cc\u666f\uff1a<\/b><\/strong><\/h3>\n

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\u6210\u679c\u7b80\u4ecb\uff1a<\/b><\/strong><\/h3>\n

\u8fd1\u671f\uff0c\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u836f\u5b66\u9662\u5b59\u654f\u6377\u6559\u6388\u56e2\u961f<\/b><\/strong>\u57fa\u4e8e\u201c\u6c99\u62c9\uff08SALAD\uff0cSmall-Assembling-LArge-Disassembled\uff09\u201d\u5f0f\u9012\u836f\u539f\u7406\uff0c\u5f00\u53d1\u51fa\u4e00\u79cd\u7ec6\u80de\u5916\u5fae\u73af\u5883ATP\u8d85\u654f\u86cb\u767d\u56e2\u7c07\uff08DEP\/GdCuB\uff09\u6210\u529f\u653b\u514b\u8fd9\u4e00\u74f6\u9888\u3002\u7814\u7a76\u4eba\u5458\u9996\u5148\u5408\u6210\u4e86\u5305\u8f7d\u4e86Gd3<\/sup>+<\/sup>\u548cCuS\u7684\u8bca\u7597\u4e00\u4f53\u5316\u767d\u86cb\u767d\u7eb3\u7c73\u5c0f\u7c92\u5b50\uff08GdCuB,\u00a09\u00a0nm\uff09\uff0c\u5e76\u4e0eATP\u654f\u611f\u6750\u6599\u7cca\u7cbe-\u4e59\u4e8c\u80fa-\u82ef\u787c\u9178\uff08DEP\uff09\u7ec4\u88c5\u5f62\u6210\u86cb\u767d\u56e2\u7c07\uff08DEP\/GdCuB, 120 nm\uff09\u3002\u8f83\u5927\u7684\u86cb\u767d\u56e2\u7c07\u4e0d\u4ec5\u80fd\u591f\u5ef6\u957f\u5c0f\u7c92\u5b50\u7684\u5faa\u73af\u534a\u8870\u671f\uff0c\u8fd8\u80fd\u591f\u4f7f\u5f97\u5c0f\u7c92\u5b50\u5728\u8840\u6db2\u4e2d\u7684T1<\/sub>\u52a0\u6743\u6210\u50cf\u6548\u679c\u51cf\u5f31\uff0c\u964d\u4f4e\u80cc\u666f\u4fe1\u53f7\u3002\u800c\u5f53\u56e2\u7c07\u84c4\u79ef\u5230\u80bf\u7624\u90e8\u4f4d\uff0c\u80de\u5916\u7684ATP\u5206\u5b50\u80fd\u591f\u5feb\u901f\u53cd\u8f6cDEP\u7684\u7535\u8377\uff0c\u4ece\u800c\u89e6\u53d1GdCuB\u7684\u91ca\u653e\uff0c\u4fc3\u8fdb\u6df1\u5c42\u6e17\u900f\u4ee5\u53caT1<\/sub>\u52a0\u6743MRI\u7684\u6fc0\u6d3b\u3002\u8fd9\u4e00\u7b56\u7565\u540c\u65f6\u5b9e\u73b0\u4e86\u86cb\u767d\u7c92\u5b50\u5728\u80bf\u7624\u90e8\u4f4d\u6709\u6548\u84c4\u79ef\u53ca\u6df1\u5c42\u6e17\u900f\uff0c\u5e76\u7528\u4e8e\u653e\u5927T1<\/sub>\u52a0\u6743\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u5f15\u5bfc\u7684\u5149\u70ed\u6cbb\u7597\u3002\u8be5\u6210\u679c\u8fd1\u65e5\u4ee5\u201cSize Switchable Nanoclusters Fueled by Extracellular ATP for Promoting the Deep Penetration and MRI Guided Tumor Photothermal Therapy<\/b><\/strong>\u201d\u4e3a\u9898\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aAdvanced Functional Materials\u6742\u5fd7\u4e0a\u3002<\/p>\n

\u56fe\u6587\u5bfc\u8bfb\uff1a<\/b><\/strong><\/h3>\n

\u56fe\u4e00\u3001<\/b><\/strong>ATP\u8d85\u654f\u6027\u86cb\u767d\u56e2\u7c07<\/b><\/strong>\uff08DEP\/GdCuB\uff09\u7684\u5236\u5907\u53ca\u5176\u4f53\u5185\u4f5c\u7528\u539f\u7406\u793a\u610f\u56fe<\/h4>\n

\"\"<\/p>\n

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\"\"<\/p>\n

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\u00a0\u56fe\u4e09\u3001GdCuB\u7684\u5149\u70ed\u6548\u5e94\u4ee5\u53caATP\u6fc0\u6d3b\u7684\u8367\u5149\u6210\u50cf\u548cT1<\/sub>\u52a0\u6743MRI\u6210\u50cf<\/b><\/strong><\/h4>\n

\"\"<\/p>\n

\u00a0<\/b><\/strong>\uff08A\uff09GdCuB\u548cDEP\/GdCuB\u7684UV-Vis\u626b\u8c31\u56fe\uff1b\uff08B\uff091064 nm\u6fc0\u5149\u7167\u5c04\u540e\uff0c\u53bb\u79bb\u5b50\u6c34\u3001GdCuB\u4ee5\u53caDEP\/GdCuB\u7684\u7ea2\u5916\u70ed\u6210\u50cf\u56fe\uff1b\uff08C\uff09GdCuB\u4ee5\u53caDEP\/GdCuB\u5728\u6fc0\u5149\u548c\u975e\u6fc0\u5149\u5904\u7406\u4e0b\u5bf9\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\uff1b\uff08D\uff09ATP\u89e6\u53d1DEP\/GdCuB-FITC\u7684\u8367\u5149\u6062\u590d\u8c31\u56fe\uff1b\uff08E\uff09ATP\u6fc0\u6d3bDEP\/GdCuB-Cy7\u7684\u8fd1\u7ea2\u5916\u8367\u5149\u4fe1\u53f7\u653e\u5927\u6210\u50cf\uff1b\uff08F\uff09GdCuB\uff0cDEP\/GdCuB\u4ee5\u53caDEP\/GdCuB+0.1mM ATP\u7684T<\/span>1<\/sub>\u52a0\u6743MRI\u6210\u50cf\u56fe\uff1b\uff08G\uff09GdCuB\uff0cDEP\/GdCuB\u4ee5\u53caDEP\/GdCuB+0.1mM ATP\u7684T<\/span>1<\/sub>\u52a0\u6743MRI\u6210\u50cf\u5f1b\u8c6b\u7cfb\u6570\u6d4b\u5b9a\u3002<\/span><\/p>\n

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\"\"
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\"\"
\n \uff08A\uff09\u5c0f\u52a8\u7269\u8367\u5149\u6210\u50cf\u7cfb\u7edf\u89c2\u5bdfGdCuB-Cy7\u53caDEP\/GdCuB-Cy7\u7684\u6d3b\u4f53\u5206\u5e03\uff1b\uff08B\uff0924 h\u540e\u79bb\u4f53\u810f\u5668\u53ca\u80bf\u7624\u7684\u8367\u5149\u4fe1\u53f7\u5b9a\u91cf\u5206\u6790\uff1b\uff08C\uff09\u836f\u52a8\u5b66\u7814\u7a76\uff1b\uff08D\uff09GdCuB\u53caDEP\/GdCuB\u7684T1<\/sub>\u3001T2<\/sub>\u52a0\u6743\u78c1\u5171\u632f\u6210\u50cf\uff1b\uff08E\uff09\u6fc0\u5149\u7167\u5c04\u4e0d\u540c\u65f6\u95f4\u540e\uff0c\u6ce8\u5c04\u4e86Saline\u3001GdCuB\u53caDEP\/GdCuB\u7684\u5c0f\u9f20\u7ea2\u5916\u70ed\u6210\u50cf\u56fe\u3002<\/span><\/p>\n

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\"\"
\n \uff08A\uff09\u6ce8\u5c04\u4e0d\u540c\u5236\u5242\u540e4T1<\/sub>\u8377\u7624\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b\uff08B\uff09\u7ed9\u836f16\u5929\u540e\uff0c\u4ee3\u8868\u6027\u79bb\u4f53\u80bf\u7624\u7167\u7247\uff1b\uff08C\uff09\u7ed9\u836f16\u5929\u540e\uff0c\u5c0f\u9f20\u5404\u7ec4\u7624\u91cd\u7edf\u8ba1\u5206\u6790\uff1b\uff08D\uff09\u7ed9\u836f\u671f\u95f4\u5c0f\u9f20\u4f53\u91cd\u76d1\u6d4b\uff1b\uff08E\uff0916\u5929\u5904\u7406\u540e\uff0c\u80bf\u7624\u7ec4\u7ec7\u7684H&E\u53caTUNEL\u5207\u7247\u67d3\u8272\u3002<\/span><\/b><\/p>\n

\u603b\u7ed3\u4e0e\u5c55\u671b\uff1a<\/b><\/strong><\/h3>\n

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\u6587\u732e\u94fe\u63a5\uff1a<\/b><\/strong><\/p>\n

Size Switchable Nanoclusters Fueled by Extracellular ATP for Promoting Deep Penetration and MRI\u2010Guided Tumor Photothermal Therapy. Advanced Functional Materials, 2019: 1904144.DOI: 10.1002\/adfm.201904144.<\/p>\n

\u672c\u6587\u7531\u4e2d\u56fd\u836f\u79d1\u5927\u5b66\u5b59\u654f\u6377\u8bfe\u9898\u7ec4<\/strong>\u4f9b\u7a3f\u3002<\/p>\n

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