{"id":183487,"date":"2019-08-18T06:30:26","date_gmt":"2019-08-17T22:30:26","guid":{"rendered":"\/\/m.iemloyee.com\/?p=183487"},"modified":"2019-08-17T21:26:15","modified_gmt":"2019-08-17T13:26:15","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-adv-mater-%e6%8a%a5%e9%81%93-x%e5%b0%84%e7%ba%bf%e5%93%8d%e5%ba%94%e6%80%a7%e6%a0%b8%e7%a2%b1%e5%9f%ba%e9%85%8d%e5%af%b9%e7%9b%b8%e4%ba%92%e4%bd%9c%e7%94%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=183487","title":{"rendered":"Adv. Mater.\u62a5\u9053: X\u5c04\u7ebf\u54cd\u5e94\u6027\u6838\u78b1\u57fa\u914d\u5bf9\u76f8\u4e92\u4f5c\u7528\u7a33\u5b9a\u7684\u4eff\u751f\u7eb3\u7c73\u80f6\u56ca\u7528\u4e8e\u8109\u51b2\u836f\u7269\u9012\u9001"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u7ec6\u80de\u5668\u901a\u8fc7\u53cc\u5c42\u78f7\u8102\u9009\u62e9\u6027\u7684\u4ea4\u6362\u751f\u7269\u5206\u5b50\u548c\u7ec6\u80de\u95f4\u901a\u8baf\u3002\u56e0\u6b64\uff0c\u5df2\u5236\u5907\u51fa\u5177\u6709\u9009\u62e9\u6027\u819c\u6e17\u900f\u80fd\u529b\u7684\u5404\u79cd\u4eba\u5de5\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7ed3\u6784\u4f5c\u4e3a\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff0c\u4ee5\u54cd\u5e94\u7279\u5b9a\u523a\u6fc0\u3001\u52a0\u901f\u836f\u7269\u91ca\u653e\u3002\u7136\u800c\u8fd9\u4e9b\u7eb3\u7c73\u7ed3\u6784\u54cd\u5e94\u4e8e\u523a\u6fc0\u4e14\u4e0d\u53ef\u9006\u7684\u89e3\u79bb\uff0c\u56e0\u6b64\u4e0d\u80fd\u63a7\u5236\u836f\u7269\u7684\u91ca\u653e\u3002\u540c\u65f6\u4e0d\u540c\u7684\u80bf\u7624\u7ec6\u80de\u5bf9\u8fd9\u4e9b\u836f\u7269\u9012\u9001\u7cfb\u7edf\u7684\u53cd\u5e94\u4e0d\u540c\uff0c\u5c06\u5bfc\u81f4\u9776\u5411\u4f4d\u70b9\u6548\u7387\u964d\u4f4e\uff0c\u4ece\u800c\u964d\u4f4e\u6cbb\u7597\u6548\u7387\u3002\u56e0\u6b64\uff0c\u8bbe\u8ba1\u7eb3\u7c73\u7ed3\u6784\u4f7f\u4f7f\u836f\u7269\u5728\u7ec6\u80de\u819c\u4e0a\u53ef\u63a7\u91ca\u653e\uff0c\u540c\u65f6\u4fdd\u6301\u9ad8\u7684\u7a33\u5b9a\u6027\uff0c\u4ee5\u5b9e\u73b0\u836f\u7269\u7279\u5f02\u6027\u9776\u5411\u9012\u9001\u548c\u7cbe\u786e\u7684\u6297\u764c\u7597\u6cd5\u3002\u5076\u6c2e\u82ef\u662f\u4e00\u7c7b\u5149\u81f4\u7ed3\u6784\u53ef\u53d8\u5316\u7684\u5316\u5408\u7269\uff0c\u53ef\u7528\u4e8e\u836f\u7269\u7eb3\u7c73\u8f7d\u4f53\u3001\u5149\u5b66\/\u7535\u5b50\u5f00\u5173\u3001\u78c1\u8bb0\u5fc6\u548c\u592a\u9633\u80fd\u50a8\u5b58\u7b49\u3002\u7136\u800c\uff0c\u867d\u7136\u5149\u63a7\u836f\u7269\u9012\u9001\u7cfb\u7edf\u662f\u975e\u4fb5\u5165\u6027\u7684\u5e76\u4e14\u5177\u6709\u9ad8\u5c40\u90e8\u9776\u5411\u80fd\u529b\uff0c\u4f46\u662f\u5176\u9700\u8981\u9ad8\u80fdUV\u523a\u6fc0\uff0c\u4ece\u800c\u4e25\u91cd\u9650\u5236\u4e86\u5b83\u4eec\u7684\u4f53\u5185\u5e94\u7528\u3002\u6b64\u5916\uff0c\u5076\u6c2e\u82ef\u7684\u5149\u81f4\u53d8\u8272\u5f02\u6784\u5316\u4f34\u968f\u7740\u5fae\u7ed3\u6784\u91cd\u6392\u548c\u4e0d\u53ef\u9006\u7684\u7eb3\u7c73\u80f6\u56ca\u7834\u574f\u3002\u5c3d\u7ba1\u5316\u5b66\u4ea4\u8054\u53ef\u4ee5\u6539\u5584\u7ed3\u6784\u7a33\u5b9a\u6027\uff0c\u4f46\u662f\u8fd9\u9650\u5236\u4e86\u4eb2\u6c34\u6027\u548c\u758f\u6c34\u6027\u7269\u8d28\u7684\u6e17\u900f\u6027\u3002\u56e0\u6b64\uff0c\u9700\u8981\u5f00\u53d1\u51fa\u5141\u8bb8\u6709\u6548\u8f7d\u8377\u53ef\u63a7\u6269\u6563\u540c\u65f6\u4fdd\u6301\u5b8c\u6574\u7684\u7ed3\u6784\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u798f\u5dde\u5927\u5b66\u7684\u5b8b\u7ee7\u5f6c\u6559\u6388\u3001\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u9648\u5c0f\u5143\u7814\u7a76\u5458\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8054\u5408\u62a5\u9053\u4e86\u5229\u7528\u6838\u78b1\u57fa\u914d\u5bf9\u4ea4\u8054\u805a\u80f8\u817a\u5627\u5576\u548c\u5149\u5f02\u6784\u5316\u7684\u805a\u5076\u6c2e\u82ef\uff08PETAzo\uff09\u4e0e\u817a\u560c\u5464\u4fee\u9970\u7684ZnS\uff08ZnS-A\uff09\u7eb3\u7c73\u9897\u7c92\uff08NPs\uff09\u8bbe\u8ba1\u7684\u4eff\u751f\u7eb3\u7c73\u80f6\u56ca\u3002ZnS-A NPs\u5c06X\u5c04\u7ebf\u8f6c\u6362\u6210\u7d2b\u5916\u7ebf\u8f90\u5c04\uff0c\u4f7f\u5076\u6c2e\u82ef\u57fa\u56e2\u5f02\u6784\u5316\uff0c\u4ece\u800c\u5b9e\u73b0\u5bf9\u53cc\u5c42\u819c\u4e0a\u53ef\u63a7\u6269\u6563\u3002\u6b64\u5916\uff0cPETAzo\u548cZnS-A\u4e4b\u95f4\u7684\u6838\u78b1\u57fa\u914d\u5bf9\u76f8\u4e92\u4f5c\u7528\u4f7f\u5176\u5728\u4f53\u5185\u5faa\u73af\u671f\u95f4\u5ef6\u957f\u4e14\u53ef\u4ee5\u9632\u6b62\u836f\u7269\u6cc4\u6f0f\uff0c\u4e0d\u4ec5\u589e\u5f3a\u836f\u7269\u5728\u80bf\u7624\u5904\u7684\u7d2f\u79ef\u800c\u4e14\u8fd8\u4fdd\u6301\u7a33\u5b9a\u6027\u3002\u8fd9\u4e9b\u7eb3\u7c73\u80f6\u56ca\u5177\u6709\u957f\u7684\u4fdd\u7559\u65f6\u95f4\u3001\u53ef\u8fdc\u7a0b\u63a7\u5236\u836f\u7269\u91ca\u653e\u3001\u5f3a\u7684\u9776\u5411\u79ef\u7d2f\u548c\u6709\u6548\u7684\u6297\u80bf\u7624\u6548\u679c\u7684\u4f18\u70b9\uff0c\u6240\u4ee5\u5b83\u4eec\u5177\u6709\u5f88\u5927\u6f5c\u529b\u4f5c\u4e3a\u4e00\u79cd\u65b0\u578b\u7684\u6297\u764c\u836f\u7269\u9012\u9001\u7cfb\u7edf\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cX-ray-Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002\u7b2c\u4e00\u4f5c\u8005\u4e3a\u9093\u5b8f\u7ae0\u535a\u58eb<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001PEG-b-\u805a\u80f8\u817a\u5627\u5576-b-\u805a\u5076\u6c2e\u82ef\uff08PETAzo\uff09\u4e09\u5d4c\u6bb5\u805a\u5408\u7269\u81ea\u7ec4\u88c5\u6210\u7eb3\u7c73\u80f6\u56ca\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001\u6838\u78b1\u57fa\u914d\u5bf9\u7eb3\u7c73\u80f6\u56ca\u7684\u5236\u5907\u548c\u8868\u5f81<\/strong>
\n \"\"\uff08a-c\uff09ZnS-A\u7eb3\u7c73\u9897\u7c92\uff08a\uff09\u3001PETAzo\u7eb3\u7c73\u80f6\u56ca\uff08b\uff09\u548cPETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\uff08c\uff09\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09ZnS NPs\u3001PETAzo\u548cPETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684\u6d41\u4f53\u52a8\u529b\u5b66\u5c3a\u5bf8\u5206\u5e03\u76f4\u65b9\u56fe\uff1b<\/p>\n

\uff08e\uff09PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u58f3\u7684\u9ad8\u5206\u8fa8\u7387TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08f\uff09PETAzo@ZnS-A<\/sup>\u7684\u9009\u533a\u7535\u5b50\u884d\u5c04\uff08SAED\uff09\uff1b<\/p>\n

\uff08g-h\uff09Zn\uff08g\uff09\u548cS\uff08h\uff09\u7684\u5143\u7d20\u6620\u5c04\uff1b<\/p>\n

\uff08i\uff09PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684STEM\u7535\u5b50\u80fd\u91cf\u635f\u5931\u5149\u8c31\u7ebf\u626b\u63cf\u56fe\uff1b<\/p>\n

\uff08j\uff09\u5b75\u80b230\u5929\u524d\u540e\uff0cPETAzo@ZnS-A<\/sup>\u7684\u5c3a\u5bf8\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e09\u3001PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u5728X\u5c04\u7ebf\u8f90\u7167\u8fc7\u7a0b\u4e2d\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08a\uff09\u5728X\u5c04\u7ebf\u7167\u5c04\uff086 Gy\uff09\u524d\u540e\uff0c\u7eb3\u7c73\u80f6\u56ca\u7684UV-\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09\u901a\u8fc7ZnS\u7eb3\u7c73\u9897\u7c92\u5c06X\u5c04\u7ebf\u8f6c\u79fb\u5230UV\u5149\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08c\uff09\u5728\u7528X\u5c04\u7ebf\u548c\u53ef\u89c1\u5149\u5207\u6362\u7167\u5c04\u51e0\u4e2a\u5faa\u73af\u540ePETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684\u5c3a\u5bf8\u53d8\u5316\uff1b<\/p>\n

\uff08d\uff09\u5728\u4ea4\u66ff\u5b58\u5728X\u5c04\u7ebf\u8f90\u5c04\u548c\u53ef\u89c1\u5149\u7684\u60c5\u51b5\u4e0b\uff0c\u6765\u81eaPETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684DOX\u7684\u7d2f\u79ef\u91ca\u653e\u7279\u5f81\uff1b<\/p>\n

\uff08e\uff09FRET\u6548\u5e94\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08f\uff09PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u5728\u7528X\u5c04\u7ebf\u7167\u5c04\u540e4 h\u7684\u8367\u5149\u5149\u8c31\u3002<\/p>\n

\u56fe\u56db\u3001\u5229\u7528CLSM\u89c2\u5bdf\u4e0d\u540c\u5236\u5242\u5904\u7406\u7684U87MG\u7ec6\u80de<\/strong>
\n \"\"\uff08a\uff09\u6e38\u79bbDOX\u548c\u8d1f\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684\u7ec6\u80de\u5185\u541e\uff1b<\/p>\n

\uff08b\uff09CLSM\u5bf9\u5171\u57f9\u517b\u7cfb\u7edf\u7684\u4e09\u7ef4\u53ef\u89c6\u5316\uff1b<\/p>\n

\uff08c\uff09\u5728\u5b75\u80b24 h\u540e\uff0c\u7528\u8d1f\u8f7dDiO\u548cDiI\u7684PETAzo\u7eb3\u7c73\u80f6\u56ca\u5b75\u80b2\u7684U87MG\u7ec6\u80de\u7684\u4ee3\u8868\u6027CLSM\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09U87MG\u7ec6\u80de\u4e2d\u8367\u5149\u5f3a\u5ea6\u7684\u7ebf\u626b\u63cf\u8c31\u3002<\/p>\n

\u56fe\u4e94\u3001PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684\u4f53\u5916\u7ec6\u80de\u6bd2\u6027\u8bc4\u4ef7<\/strong>
\n \"\"\uff08a\uff09\u901a\u8fc7Annexin V-FITC\/7-ADD\u7528PBS\u3001X\u5c04\u7ebf\uff086 Gy\uff09\u3001\u6e38\u79bbDOX\u3001PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u548cPETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u4e0eX\u5c04\u7ebf\u5904\u7406\u7684U87MG\u7ec6\u80de\u7684\u6d41\u5f0f\u7ec6\u80de\u5b9e\u9a8c\uff1b<\/p>\n

\uff08b\uff09\u4e0e\u6e38\u79bbDOX\u3001PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u548cPETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u4ee5\u53ca\u5404\u79cd\u6307\u5b9a\u6d53\u5ea6\u7684X\u5c04\u7ebf\u5b75\u80b224 h\u540e\uff0cU87MG\u7ec6\u80de\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\uff1b<\/p>\n

\uff08c\uff09\u5728U87MG\u7ec6\u80de\u4e2d\u6e38\u79bbDOX\u3001\u88c5\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u548c\u88c5\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u4e0eX\u5c04\u7ebf\u7684IC50<\/sub>\u503c\uff1b<\/p>\n

\uff08d\uff09\u7528PBS\u3001X\u5c04\u7ebf\u3001\u6e38\u79bbDOX\u3001\u8d1f\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u548c\u8d1f\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56caX\u5c04\u7ebf\u5904\u7406\u540e\u534a\u80f1\u5929\u51ac\u9176\u5bb6\u65cf\u6210\u5458\u8868\u8fbe\u6c34\u5e73\u7684Western\u5370\u8ff9\u5206\u6790\uff1b<\/p>\n

\uff08e\uff09\u7528\u4e0d\u540c\u6837\u54c1\u5904\u740624 h\u7684\u7ec6\u80de\u6d41\u5f0f\u5b9e\u9a8c\uff0c\u5e76\u7528TUNEL-FITC\u51cb\u4ea1\u8bd5\u5242\u76d2\u67d3\u8272\u3002<\/p>\n

\u56fe\u516d\u3001PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u7684\u4f53\u5185\u6210\u50cf\u548c\u6cbb\u7597\u6548\u679c<\/strong>
\n \"\"\uff08a\uff09\u52a8\u7269\u6cbb\u7597\u64cd\u4f5c\u65f6\u95f4\u8868\uff1b<\/p>\n

\uff08b\uff09\u9759\u8109\u5185\u6ce8\u5c04\u8d1f\u8f7dICG\u7684PETAzo\u6216PETAzo@ZnS-A\u7eb3\u7c73\u80f6\u56ca\u540e\uff0c\u643a\u5e26U87MG\u80bf\u7624\u7684\u88f8\u9f20\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf\u548c\u5149\u58f0\u6210\u50cf\uff1b<\/p>\n

\uff08c\uff09\u80bf\u7624\u8367\u5149\u4fe1\u53f7\u7684\u5b9a\u91cf\u611f\u5174\u8da3\u533a\u57df\uff08ROI\uff09\uff1b<\/p>\n

\uff08d\uff09\u5728\u6ce8\u5c04\u8d1f\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u540e36 h\uff0cDOX\u5728\u8840\u6d46\u5185\u7684\u6d53\u5ea6\uff1b<\/p>\n

\uff08e\uff09\u5728\u8d1f\u8f7dDOX\u7684PETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u540e\uff0cDOX\u5728\u4e0d\u540c\u5668\u5b98\u548c\u7ec4\u7ec7\u4e2d\u7684\u5206\u5e03\uff1b<\/p>\n

\uff08f\uff09\u5728\u6ce8\u5c04DOX\u7684\u7eb3\u7c73\u80f6\u56ca36 h\u540e\uff0cPETAzo@ZnS-A<\/sup>\u7eb3\u7c73\u80f6\u56ca\u5728\u4e0d\u540c\u5668\u5b98\u548c\u7ec4\u7ec7\u4e2d\u7684\u751f\u7269\u5206\u5e03\uff1b<\/p>\n

\uff08g\uff09\u4f53\u5185\u6cbb\u7597\u65b9\u6848\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08h\uff09\u4e0d\u540c\u6837\u54c1\u5904\u7406\u540e\u7684\u76f8\u5bf9\u80bf\u7624\u4f53\u79ef\uff1b<\/p>\n

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\uff08j\uff09\u80bf\u7624\u7ec4\u7ec7\u7684\u514d\u75ab\u8367\u5149\u548c\u7ec4\u7ec7\u5b66\u67d3\u8272\uff1b<\/p>\n

\uff08k\uff09\uff08j\uff09\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aX-ray-Controlled Bilayer Permeability of Bionic Nanocapsules Stabilized by Nucleobase Pairing Interactions for Pulsatile Drug Delivery<\/a><\/strong>\uff08Adv. Mater.<\/em>, 2019<\/strong>, DOI: 10.1002\/adma.201903443\uff09<\/p>\n

\u5b8b\u7ee7\u5f6c\u6559\u6388\u7b80\u4ecb<\/strong> \"\"<\/p>\n

\u798f\u5dde\u5927\u5b66\uff0c\u5316\u5b66\u5b66\u9662\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u5165\u9009\u201c\u6d77\u5916\u9ad8\u5c42\u6b21\u5f15\u8fdb\u4eba\u624d\u5f15\u8fdb\u8ba1\u5212\uff08\u9752\u5e74\u9879\u76ee\uff09\u201d\u53ca\u798f\u5efa\u7701\u201c\u95fd\u6c5f\u5b66\u8005\u7279\u8058\u6559\u6388\u201d<\/strong>\u3002\u535a\u58eb\u6bd5\u4e1a\u4e8e\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\uff0c\u4e13\u4e1a\u4e3a\u751f\u7269\u533b\u5b66\u5de5\u7a0b\uff0c\u4e4b\u540e\u5728\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u5206\u5b50\u5f71\u50cf\u4e2d\u5fc3\u4ece\u4e8b\u535a\u58eb\u540e\u7814\u7a76\uff0c\u7814\u7a76\u65b9\u5411\u4e3a\u5206\u5b50\u5f71\u50cf\u4e0e\u764c\u75c7\u8bca\u7597\u3002\u5b8b\u7ee7\u5f6c\u8bfe\u9898\u7ec4\u4e00\u76f4\u4ece\u4e8b\u57fa\u4e8e\u53d1\u5149\u6709\u673a\u53ca\u65e0\u673a\u6750\u6599\u7684\u5236\u5907\u3001\u54cd\u5e94\u6027\u9ad8\u5206\u5b50\u5408\u6210\u53ca\u54cd\u5e94\u6027\u7684\u7eb3\u7c73\u7c92\u5b50\u81ea\u7ec4\u88c5\uff0c\u5e76\u7814\u7a76\u5176\u5728\u5206\u5b50\u5f71\u50cf\u3001\u751f\u7269\u5206\u6790\u3001\u533b\u5b66\u68c0\u6d4b\u3001\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u7b49\u7684\u7814\u7a76\uff0c\u6d89\u53ca\u5316\u5b66\u3001\u6750\u6599\u3001\u751f\u7269\u3001\u533b\u5b66\u7b49\u591a\u5b66\u79d1\u4ea4\u53c9\u7814\u7a76\u9886\u57df\u3002\u8bba\u6587\u53d1\u8868\u65b9\u9762\uff0c\u5171\u53d1\u8868SCI\u8bba\u658760\u4f59\u7bc7\uff0c\u5176\u4e2d\u4ee5\u7b2c\u4e00\u4f5c\u8005\/\u901a\u8baf\u4f5c\u8005\u53d1\u8868\u7684\u8bba\u6587\u4e3a30\u4f59\u7bc7\uff08IF > 10\u5206\u7684\u4e3a26\u7bc7\uff09\uff0c\u4e3b\u8981\u5305\u62ec\uff1aNat. Protoc., Nat. Commun.. Acc. Chem. Res., J. Am. Chem. Soc., Angew. Chem. Int. Ed., Adv. Mater., ACS Nano, Chem. Soc. Rev. \u7b49\u3002<\/p>\n

\u7814\u7a76\u65b9\u5411\uff1a\u65b0\u578b\u751f\u7269\u6210\u50cf\u63a2\u9488\u7684\u5236\u5907\u3001\u5206\u6790\u5316\u5b66\u3001\u5206\u5b50\u5f71\u50cf\u3001\u533b\u5b66\u68c0\u6d4b\u3001\u65b0\u578b\u836f\u7269\u8f7d\u4f53\u7b49<\/strong><\/p>\n

\u4e2a\u4eba\u7f51\u7ad9\uff1a<\/strong><\/p>\n

http:\/\/chem.fzu.edu.cn\/html\/szdw\/jsml\/zgj\/2018\/03\/15\/260d3cf9-12be-453e-a971-be7a13b38cb9.html<\/p>\n

 <\/p>\n

\"\"<\/p>\n

\u9648\u5c0f\u5143\u7814\u7a76\u5458\u7b80\u4ecb\uff1a\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662 (NIH) \u7814\u7a76\u5458\uff0cTheranostics \u6742\u5fd7\u521b\u520a\u4e3b\u7f16\u3002\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\uff08NIH\uff09\u751f\u7269\u533b\u5b66\u5f71\u50cf\u53ca\u533b\u5b66\u5de5\u7a0b\u6240\uff08NIBIB\uff09\u4efb\u7ec8\u8eab\u8d44\u6df1\u7814\u7a76\u5458\uff0c\u5206\u5b50\u5f71\u50cf\u53ca\u7eb3\u7c73\u533b\u5b66\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u3002<\/strong>2012 \u5e74\u83b7NIBIB Mentor Award\uff0c2014 \u5e74\u83b7 NIH Director\u2019s Award\uff0c2016 \u5e74\u83b7 ACS Bioconjugate Chemistry Lecturer Award\uff0c2017 \u5e74\u5f53\u9009 AIMBE Fellow\uff0c 2019\u5e74\u83b7SNMMI\u3000Michael\u3000J.\u3000Welch\u3000Award\u3002\u662f ACS Nano \u7b49\u591a\u5bb6\u6742\u5fd7\u7684\u7f16\u59d4\uff0cTheranostics \u6742\u5fd7\u7684\u521b\u520a\u4e3b\u7f16\uff08201\uff18 \u5e74\u5f71\u54cd\u56e0\u5b508.063\uff09\uff0c\u4e2d\u7f8e\u6838\u533b\u5b66\u53ca\u5206\u5b50\u5f71\u50cf\u5b66\u4f1a(CASNMMI)\u524d\u4efb\u4e3b\u59d4\uff0c\u4e2d\u7f8e\u7eb3\u7c73\u533b\u5b66\u53ca\u7eb3\u7c73\u751f\u7269\u6280\u672f\u5b66\u4f1a\uff08CASNN\uff09\u524d\u4efb\u4e3b\u59d4\uff0c\u4ee5\u53ca\u7f8e\u56fd\u6838\u533b\u5b66\u53ca\u5206\u5b50\u5f71\u50cf\u5b66\u4f1a(SNMMI) Radiopharmaceutical Science Council (RPSC) \u524d\u4efb\u4e3b\u59d4\u3002<\/p>\n

\u7814\u7a76\u65b9\u5411\uff1a<\/strong>\u4e3b\u8981\u6d89\u53ca\u4f53\u5916\u8bca\u65ad\uff0c\u4f53\u5185\u6210\u50cf\uff0c\u57fa\u56e0\/\u836f\u7269\u7684\u7eb3\u7c73\u8f7d\u4f53\uff0c\u4ee5\u53ca\u8bca\u7597\u4e00\u4f53\u5316\u3002\u5177\u4f53\u5305\u62ec\uff1a1. \u65b0\u578b\u5206\u5b50\u5f71\u50cf\u9020\u5f71\u5242\u5f00\u53d1\uff0c\u5305\u62ec\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u626b\u63cf\uff08PET\uff09\uff0c\u5355\u5149\u5b50\u53d1\u5c04\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\uff08SPECT\uff09\uff0c\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\uff0c\u5149\u5b66\uff08\u751f\u7269\u53d1\u5149\uff0c\u8367\u5149\u548c\u62c9\u66fc\uff09\uff0c\u8d85\u58f0\uff0c\u5149\u58f0\u6210\u50cf\u7b49\uff1b2. \u7528\u4e8e\u591a\u91cd\u751f\u7269\u6807\u5fd7\u7269\u68c0\u6d4b\u7684\u8d85\u7075\u654f\u65b9\u6cd5\uff1b3. \u6784\u5efa\u667a\u80fd\u7eb3\u7c73\u5e73\u53f0\u7528\u4e8e\u836f\u7269\u548c\u57fa\u56e0\u7684\u9776\u5411\u9012\u9001\uff1b4. \u5206\u5b50\u5f71\u50cf\u63a2\u9488\u7684\u4e34\u5e8a\u8f6c\u5316\uff1b5. \u8bca\u7597\u4e00\u4f53\u5316\u7eb3\u7c73\u6750\u6599\u5f00\u53d1\u53ca\u4e34\u5e8a\u8f6c\u5316<\/p>\n

\u4e2a\u4eba\u7f51\u7ad9\uff1ahttps:\/\/www.nibib.nih.gov\/about-nibib\/staff\/xiaoyuan-chen<\/strong><\/p>\n

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