{"id":183090,"date":"2019-08-14T06:30:39","date_gmt":"2019-08-13T22:30:39","guid":{"rendered":"\/\/m.iemloyee.com\/?p=183090"},"modified":"2019-08-13T11:32:05","modified_gmt":"2019-08-13T03:32:05","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e4%b8%ad%e7%a7%91%e9%99%a2%e7%94%9f%e7%89%a9%e7%89%a9%e7%90%86%e6%89%80acc-chem-res%e7%bb%bc%e8%bf%b0%ef%bc%9a%e6%96%b0%e4%b8%80","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=183090","title":{"rendered":"\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240Acc. Chem. Res\u7efc\u8ff0\uff1a\u65b0\u4e00\u4ee3\u4eba\u5de5\u9176\u2014\u2014\u7eb3\u7c73\u9176\u7684\u65b0\u6982\u5ff5\u53ca\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/p>\n

\u7eb3\u7c73\u9176<\/span>\u662f\u4e00\u7c7b\u672c\u8eab\u8574\u542b\u9176\u5b66\u7279\u6027\u7684\u7eb3\u7c73\u6750\u6599<\/span>\uff0c<\/span>\u5177\u6709\u50ac\u5316\u6d3b\u6027<\/span>\u5f3a<\/span>\u3001\u7a33\u5b9a\u6027<\/span>\u597d<\/span>\u3001\u6210\u672c\u4f4e\u7b49\u4f18\u52bf\u3002<\/span>\u81ea\u4ece<\/span>2007<\/span>\u5e74\u960e\u9521\u8574<\/span>\u9662\u58eb<\/span>\u56e2\u961f\u9996\u6b21\u62a5\u9053<\/span>\u7eb3\u7c73\u9176<\/span>\u65b0\u6982\u5ff5<\/span>\u4ee5\u6765\uff08<\/span>Nature Nanotechnology<\/span>\uff0c<\/span>2007<\/span>\uff09\uff0c\u8fc4\u4eca\uff0c<\/span>\u5168\u7403\u5df2\u6709<\/span>2<\/span>9<\/span>\u4e2a\u56fd\u5bb6\u7684<\/span>2<\/span>9<\/span>0<\/span>\u591a\u4e2a\u5b9e\u9a8c\u5ba4\u62a5\u9053\u4e86<\/span>3<\/span>2<\/span>0<\/span>\u4f59\u79cd\u7eb3\u7c73\u9176<\/span>\uff0c<\/span>\u9010\u6e10\u5f62\u6210\u4e86\u7eb3\u7c73\u9176\u65b0\u578b\u4ea4\u53c9\u5b66\u79d1\u9886\u57df\u3002<\/span> \u7eb3\u7c73\u9176\u7684\u51fa\u73b0\u662f\u4eba\u5de5\u6a21\u62df\u9176\u7814\u7a76\u9886\u57df\u7684\u91cd\u5927\u8fdb\u5c55\uff0c\u5b83\u4e0d\u4ec5\u63ed\u793a\u4e86\u60f0\u6027\u65e0\u673a\u6750\u6599\u5728\u7eb3\u7c73\u5c3a\u5ea6\u5448\u73b0\u51fa\u4e0d\u53ef\u9884\u89c1\u7684\u9176\u5b66\u7279\u6027\uff0c\u8fd8\u4f7f\u6a21\u62df\u9176\u7814\u7a76\u9886\u57df\u4ece\u6709\u673a\u5316\u5b66\u62d3\u5c55\u5230\u65e0\u673a\u7eb3\u7c73\u6750\u6599<\/span>\u9886\u57df<\/span>\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u7eb3\u7c73\u9176\u514b\u670d\u4e86\u5929\u7136\u9176\u8106\u5f31\u548c\u6602\u8d35\u7684\u5f0a\u7aef\uff0c\u7a81\u7834\u4e86\u4ee5\u5f80\u6a21\u62df\u9176\u50ac\u5316\u6548\u7387\u4e0d\u9ad8\u7684\u5c40\u9650\u6027\uff0c\u76ee\u524d\u5df2\u88ab\u5e7f\u6cdb\u5e94\u7528\u5230\u75be\u75c5\u8bca\u65ad\u548c\u6cbb\u7597\u3001\u4f20\u67d3\u75c5\u9632\u63a7\u3001\u73af\u5883\u76d1\u6d4b\u548c\u6c61\u6c34\u5904\u7406\u7b49\u591a\u4e2a\u9886\u57df\u3002\u7eb3\u7c73\u9176\u662f\u76ee\u524d\u4e3a\u6570\u4e0d\u591a\u7684\u7531\u4e2d\u56fd\u79d1\u5b66\u5bb6\u53d1\u73b0\u3001\u88ab\u56fd\u9645\u540c\u884c\u8ba4\u53ef\uff0c\u5e76\u8fc5\u901f\u5b9e\u73b0\u6210\u679c\u8f6c\u5316\u7684\u65b0\u578b\u4ea4\u53c9\u5b66\u79d1\u9886\u57df\u3002<\/span><\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u751f\u7269\u7269\u7406\u6240\u7814\u7a76\u5458\u960e\u9521\u8574\u7814\u7a76\u9662\u4ee5\u53ca\u6881\u654f\u654f\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u5728Acc<\/b><\/strong>ounts of<\/i><\/b><\/em><\/strong>\u00a0<\/i><\/b><\/em><\/strong>C<\/b><\/strong>hem<\/b><\/strong>ical<\/i><\/b><\/em><\/strong>\u00a0<\/i><\/b><\/em><\/strong>R<\/b><\/strong>es<\/b><\/strong>earch<\/i><\/b><\/em><\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201c<\/b><\/strong>Nanozymes: From New Concepts, Mechanisms, and Standards to<\/b><\/strong>\u00a0<\/b><\/strong>Applications<\/b><\/strong>\u201d<\/b><\/strong>\u7684\u7efc\u8ff0\u3002\u6587\u7ae0<\/span>\u6982\u8ff0<\/span>\u4e86<\/span>\u7eb3\u7c73\u9176\u7684\u53d1\u5c55\u5386\u7a0b<\/span>\u3001<\/span>\u6027\u80fd\u4f18\u52bf\u53ca<\/span>\u73b0\u6709\u7684\u5c40\u9650\u6027<\/span>\uff0c<\/span>\u6307\u51fa\u7eb3\u7c73<\/span>\u9176\u540c\u65f6<\/span>\u5177\u6709<\/span>\u7684\u9176\u50ac\u5316\u7279\u6027\u53ca\u7eb3\u7c73\u6750\u6599\u7279\u6709\u7684\u5149\u3001\u7535\u3001\u78c1\u7b49\u7406\u5316<\/span><\/a>\u7279\u6027<\/span>\uff0c\u4f7f\u5f97\u7eb3\u7c73<\/span>\u9176\u7279\u522b<\/span>\u9002\u5408\u4f5c\u4e3a\u591a\u529f\u80fd\u63a2\u9488\u7528\u4e8e\u75be\u75c5\u7684\u8bca\u65ad\u4e0e\u6cbb\u7597\uff0c\u53e6\u5916<\/span>\u6587\u7ae0<\/span>\u8fd8\u603b\u7ed3\u4e86\u7eb3\u7c73<\/span>\u9176<\/span>\u4f5c\u4e3a<\/span>\u5929\u7136<\/span>\u9176\u7684\u66ff\u4ee3<\/span>\u54c1\u5728\u5de5\u4e1a\u5236\u9020<\/span>\u3001<\/span>\u6c61\u6c34\u5904\u7406<\/span>\u3001\u6297\u83cc<\/span>\u6d17\u6d88<\/span>\u53ca<\/span>\u7eb3\u7c73<\/span>\u9176\u8f7d\u836f<\/span>\u7b49<\/span>\u591a\u4e2a\u9886\u57df<\/span>\u7684\u5e94\u7528\uff0c<\/span>\u968f\u4e4b<\/span>\u6587\u7ae0<\/span>\u63d0\u51fa<\/span>\u5982\u4f55\u5c06<\/span>\u4e00\u6279\u539f\u521b\u7684<\/span>\u7eb3\u7c73\u9176<\/span>\u65b0\u6280\u672f\u8fc5\u901f\u8f6c\u5316\u4e3a\u65b0\u4ea7\u54c1\uff0c<\/span>\u5982\u4f55<\/span>\u5236\u5b9a\u884c\u4e1a\u6807\u51c6\uff0c<\/span>\u8fdb\u884c\u7eb3\u7c73\u9176\u7684\u7406\u6027\u8bbe\u8ba1\uff0c<\/span>\u63a8\u52a8\u7eb3\u7c73\u9176\u5728\u4e34\u5e8a\u533b\u5b66\u3001\u519b\u5de5\u3001\u516c\u5171\u5b89\u5168\u3001\u73af\u5883\u6cbb\u7406\u7b49\u9886\u57df\u7684<\/span>\u5feb\u901f<\/span>\u5e94\u7528\uff0c\u5f00\u542f\u7eb3\u7c73<\/span>\u9176\u5e94\u7528<\/span>\u65b0\u65f6\u4ee3<\/span>\u3002<\/span>\u6700\u540e\uff0c\u4f5c\u8005<\/span>\u5c55\u671b\u4e86\u7eb3\u7c73\u9176\u5b66\u4ea7\u751f<\/span>\u7684<\/span>\u5ba2\u89c2\u6761\u4ef6\u53ca\u672a\u6765\u5bf9\u4f20\u7edf\u9176\u5b66\u5e26\u6765\u7684\u5f71\u54cd\u53ca\u673a\u9047<\/span>\u3002<\/span><\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe1<\/b><\/strong>\u00a0<\/b><\/strong>\u57fa\u4e8eFe3<\/sub>O4<\/sub>\u7684\u7c7b\u8fc7\u6c27\u5316\u9176\u7eb3\u7c73\u9176<\/p>\n

\"\"<\/p>\n

(a)\u4e0d\u540c\u5927\u5c0f\u7684Fe3<\/sub>O4<\/sub> NPs\u7684TEM\u56fe\uff1b<\/p>\n

(b) Fe3<\/sub>O4<\/sub> NPs\u5728H2<\/sub>O2<\/sub>\u5b58\u5728\u4e0b\u50ac\u5316\u5404\u79cd\u8fc7\u6c27\u5316\u7269\u9176\u5e95\u7269\uff08TMB\uff0cDAB\u548cOPD\uff09\uff0c\u4ea7\u751f\u4e0d\u540c\u7684\u989c\u8272\u53cd\u5e94\uff1b<\/p>\n

(c) Fe3<\/sub>O4<\/sub> NPs\u50ac\u5316\u673a\u7406\u3002AH\u4ee3\u8868\u8fc7\u6c27\u5316\u7269\u9176\u5e95\u7269\uff0c\u5b83\u662f\u6c22\u4f9b\u4f53\uff1b<\/p>\n

\u56fe<\/strong>2 <\/strong>\u57fa\u4e8e\u6c2e\u63ba\u6742\u78b3\u7eb3\u7c73\u7c92\u5b50\u7684\u7eb3\u7c73\u9176<\/strong>\"\"<\/p>\n

(a) \u6c2e\u63ba\u6742\u7684\u78b3\u7eb3\u7c73\u9897\u7c92\uff08N-PCNS\uff09TEM\u56fe\uff1b<\/p>\n

(b) N-PCNSs\u7684\u50ac\u5316\u673a\u7406\uff1b<\/p>\n

(c)\u57fa\u4e8eN-PCNSs\u7684\u7c7b\u6c27\u5316\u9176\uff0c\u8fc7\u6c27\u5316\u7269\u9176\uff0c\u8fc7\u6c27\u5316\u6c22\u9176\u548c\u8d85\u6c27\u5316\u7269\u6b67\u5316\u9176\u52a8\u529b\u5b66\u7814\u7a76\uff1b<\/p>\n

\u56fe<\/strong>3 <\/strong>\u7528\u4e8e\u514d\u75ab\u6d4b\u5b9a\u7684<\/strong>Fe3<\/sub>O4<\/sub><\/strong>\u7eb3\u7c73\u7c92\u5b50\u7eb3\u7c73\u9176\"\"<\/strong><\/p>\n

(a) ELISA\u514d\u75ab\u68c0\u6d4b\u6a21\u5f0f\uff1b<\/p>\n

(b)\u5939\u5fc3\u6355\u83b7\u514d\u75ab\u5206\u6790\u68c0\u6d4b\u6a21\u5f0f\uff1b<\/p>\n

(c)\u6761\u5e26\u514d\u75ab\u68c0\u6d4b\u6a21\u5f0f\uff1b<\/p>\n

\u56fe<\/strong>4 <\/strong>\u80bf\u7624\u7ec4\u7ec7\u7684<\/strong>M-HFn<\/strong>\u67d3\u8272<\/strong>\"\"<\/sup><\/p>\n

(a) M-HFn NPs\u7684\u5236\u5907\uff1b<\/p>\n

(b) \u80bf\u7624\u7ec4\u7ec7\u7684M-HFn NPs\u67d3\u8272\uff1b\uff08\u77f3\u8721\u5305\u57cb\u7684\u4e34\u5e8a\u80bf\u7624\u7ec4\u7ec7\u53ca\u5176\u76f8\u5e94\u7684\u6b63\u5e38\u548c\u635f\u4f24\u7ec4\u7ec7\u7528FITC\u7f00\u5408\u7684HFn\u86cb\u767d\u58f3\u548cM-HFn NP\u67d3\u8272\u3002\u80bf\u7624\u7ec4\u7ec7\u663e\u793aM-HFn NPs\uff08\u68d5\u8272\uff09\u548cFITC-\u7f00\u5408\u7684HFn\u86cb\u767d\u58f3\uff08\u7eff\u8272\u8367\u5149\uff09\u7684\u5f3a\u9633\u6027\u67d3\u8272\uff0c\u800c\u6b63\u5e38\u548c\u635f\u4f24\u7ec4\u7ec7\u5bf9\u7167\u5bf9M-HFn NP\u548cFITC\u7f00\u5408\u7684HFn\u662f\u9634\u6027\u7684\uff09<\/p>\n

\u4f20\u7edf\u514d\u75ab\u7ec4\u5316\u4e0e<\/strong>M-HFn<\/strong>\u7eb3\u7c73\u9176\u67d3\u8272\u80bf\u7624\u7ec4\u7ec7\u7684\u6bd4\u8f83<\/strong><\/p>\n

\"\"<\/p>\n

\u4f20\u7edf\u514d\u75ab\u7ec4\u5316\u4e0eM-HFn\u7eb3\u7c73\u9176\u67d3\u8272\u80bf\u7624\u7ec4\u7ec7\u7684\u6bd4\u8f83<\/p>\n

\u56fe<\/strong>6<\/strong>\u7528\u4e8e\u4e0d\u7a33\u5b9a\u52a8\u8109\u7ca5\u6837\u786c\u5316\u6591\u5757\u75c5\u7406\u5b66\u9274\u5b9a\u7684<\/strong>M-HFn<\/strong>\u7eb3\u7c73\u9176<\/strong><\/p>\n

\"\"<\/p>\n

(a) M-HFn NPs\u7684\u5236\u5907\u8fc7\u7a0b\u793a\u610f\u56fe\uff1b<\/p>\n

(b) HFn\u7eb3\u7c73\u7b3c\uff08\u5de6\uff09\u548cM-HFn NP\uff08\u53f3\uff09\u7684Cryo-EM\u56fe\u50cf\uff1b<\/p>\n

(c) M-HFn\u7eb3\u7c73\u9176\u7279\u5f02\u6027\u67d3\u8272\uff1b<\/p>\n

\u56fe<\/strong>7 <\/strong>\u7eb3\u7c73\u9176\u56ca\u6ce1\u7528\u4e8e\u80bf\u7624<\/strong>H2<\/sub>O2<\/sub><\/strong>\u54cd\u5e94\u6027\u50ac\u5316\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe<\/strong>\"\"<\/p>\n

\u56fe<\/strong>8<\/strong>\u6807\u51c6\u5316\u7c7b\u8fc7\u6c27\u5316\u7269\u7eb3\u7c73\u9176\u50ac\u5316\u6d3b\u6027<\/strong>\"\"<\/p>\n

(a) \u4e09\u79cd\u5178\u578b\u7684\u8fc7\u6c27\u5316\u7269\u7eb3\u7c73\u9176\uff08Fe3<\/sub>O4<\/sub>\uff0c\u78b3\u548cAu NP\uff09\u7684TEM\u56fe\uff1b<\/p>\n

(b) Fe3<\/sub>O4<\/sub>\uff0c\u78b3\u548cAu NPs\u50ac\u5316\u8fc7\u6c27\u5316\u7269\u9176\u5e95\u7269\uff1b<\/p>\n

(c) \u7531Fe3<\/sub>O4<\/sub>\uff08\u7ea2\u8272\uff09\uff0c\u78b3\uff08\u9ed1\u8272\uff09\u548cAu\uff08\u84dd\u8272\uff09\u7eb3\u7c73\u9176\u50ac\u5316TMB\u53cd\u5e94\u7684\u53cd\u5e94\u65f6\u95f4\u66f2\u7ebf\uff1b<\/p>\n

(d) Fe3<\/sub>O4<\/sub>\uff0c\u78b3\u548cAu\u7eb3\u7c73\u9176\u7684\u6bd4\u6d3b\u6027\uff08U \/ mg\uff09\uff1b<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u00a0\u00a0\u4f5c\u8005\u5728\u672c\u7efc\u8ff0\u4e2d\u5168\u9762\u4ecb\u7ecd\u4e86\u5404\u79cd\u7c7b\u578b\u7684\u7eb3\u7c73\u9176\u53ca\u5176\u5728\u751f\u7269\u4f20\u611f\u3001\u75be\u75c5\u8bca\u7597\u4ee5\u53ca\u73af\u5883\u68c0\u6d4b\u4e2d\u7684\u5e94\u7528\u3002\u540c\u65f6\u8be5\u7efc\u8ff0\u57fa\u4e8e\u76ee\u524d\u7684\u7eb3\u7c73\u9176\u7406\u8bba\u57fa\u7840\uff0c\u91cd\u65b0\u5b9a\u4e49\u5e76\u4e14\u8bc4\u4ef7\u7eb3\u7c73\u9176\u6027\u80fd\u7684\u6807\u51c6\u5e76\u4e14\u7814\u7a76\u76f8\u5173\u52a8\u529b\u5b66\uff0c\u5e76\u57fa\u4e8e\u6b64\u5bf9\u7eb3\u7c73\u9176\u672a\u6765\u524d\u666f\u8fdb\u884c\u8ba8\u8bba\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Nanozymes: From New Concepts, Mechanisms, and Standards to Applications<\/a><\/p>\n

\u539f\u6587\u94fe\u63a5\uff1ahttps:\/\/pubs.acs.org\/doi\/10.1021\/acs.accounts.9b00140<\/a> (Acc. Chem. Res. 2019, DOI: 10.1021\/acs.accounts.9b00140),<\/p>\n

\u672c\u6587\u7531LUMO\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002<\/p>\n

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