{"id":181794,"date":"2019-07-30T06:30:45","date_gmt":"2019-07-29T22:30:45","guid":{"rendered":"\/\/m.iemloyee.com\/?p=181794"},"modified":"2019-07-29T21:09:36","modified_gmt":"2019-07-29T13:09:36","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e8%b0%ad%e8%94%9a%e6%b3%93%ef%bc%8c%e8%a2%81%e8%8d%83-chem%ef%bc%9a%e5%9f%ba%e4%ba%8e%e4%ba%8c%e8%8c%82%e9%93%81dna%e8%81%9a%e5%90%88%e7%89%a9%e7%9a%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=181794","title":{"rendered":"\u8c2d\u851a\u6cd3\uff0c\u8881\u8343 Chem\uff1a\u57fa\u4e8e\u4e8c\u8302\u94c1DNA\u805a\u5408\u7269\u7684\u5c3a\u5bf8\u53ef\u8c03\u7ec4\u88c5\u4f53\u7528\u4e8e\u80bf\u7624\u6df1\u5c42\u6e17\u900f\u53ca\u6cbb\u7597"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

\u805a\u5408\u7269\u7ec4\u88c5\u4f53\u7531\u4e8e\u5177\u6709\u5408\u9002\u7684\u5c3a\u5bf8\uff0c\u5728\u5236\u836f\u9886\u57df\u4e2d\u53d7\u5230\u8d8a\u6765\u8d8a\u591a\u7684\u5173\u6ce8\u3002\u7814\u7a76\u8868\u660e\uff0c\u7531\u4e8e\u80bf\u7624\u7ec4\u7ec7\u5468\u56f4\u7684\u8840\u7ba1\u901a\u900f\u6027\u6bd4\u6b63\u5e38\u7ec4\u7ec7\u7684\u66f4\u5927\uff0c100 nm\u5de6\u53f3\u7684\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50\u5177\u6709\u8f83\u597d\u7684ERP\u6548\u5e94\u5728\u80bf\u7624\u7ec4\u7ec7\u5904\u5bcc\u96c6\u3002\u4f46\u662f\uff0c\u5bf9\u4e8e\u5b9e\u4f53\u7624\u800c\u8a00\uff0c\u80bf\u7624\u7ec4\u7ec7\u4e2d\u81f4\u5bc6\u7684\u80f6\u539f\u57fa\u8d28\u53ef\u80fd\u963b\u788d\u7eb3\u7c73\u836f\u7269\u7684\u8fdb\u4e00\u6b65\u6e17\u900f\u548c\u5185\u5316\uff0c\u65e0\u6cd5\u5230\u8fbe\u80bf\u7624\u7ec4\u7ec7\u7684\u4e2d\u5fc3\u90e8\u5206\uff0c\u4ece\u800c\u964d\u4f4e\u6297\u764c\u5242\u7684\u529f\u6548\u3002\u4e00\u822c\u5c0f\u4e8e30 nm\u6750\u6599\u5177\u6709\u826f\u597d\u7684\u80bf\u7624\u7a7f\u900f\u6548\u679c\uff0c\u4f46\u8fd9\u4e0eEPR\u6548\u5e94\u8981\u6c42\u7684100 nm\u5c3a\u5bf8\u76f8\u77db\u76fe\u3002\u4e24\u4eb2\u805a\u5408\u7269\u53ef\u4ee5\u901a\u8fc7\u8c03\u8282\u4eb2\u6c34\/\u758f\u6c34\u94fe\u6bb5\u7684\u6bd4\u4f8b\u81ea\u7ec4\u88c5\u6210\u5177\u6709\u4e0d\u540c\u5c3a\u5bf8\u7684\u7ec4\u4ef6\uff0c\u56e0\u6b64\uff0c\u5408\u7406\u8bbe\u8ba1\u805a\u5408\u7269\u7684\u5316\u5b66\u7ed3\u6784\uff0c\u5f62\u6210\u5927\u5c0f\u53ef\u8c03\u7684\u7ec4\u88c5\u4f53\uff0c\u6709\u671b\u4e3a\u4e0a\u8ff0\u96be\u9898\u63d0\u4f9b\u89e3\u51b3\u65b9\u6848\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u8c08\u6d01\u535a\u58eb\u5728\u6e56\u5357\u5927\u5b66\u8c2d\u851a\u6cd3\u6559\u6388\u548c\u8881\u8343\u6559\u6388\u7814\u7a76\u56e2\u961f<\/strong>\u505a\u535a\u58eb\u540e\u671f\u95f4\uff0c\u4e0e\u7814\u7a76\u56e2\u961f\u7684\u591a\u4f4d\u7814\u7a76\u751f\u4e00\u8d77\uff0c\u8bbe\u8ba1\u4e86\u5c3a\u5bf8\u53ef\u8c03\u7684\u6838\u9178\u9002\u914d\u4f53-\u4e8c\u8302\u94c1\u7ec4\u88c5\u4f53\uff08ApFA\uff09\uff0c\u4ee5\u89e3\u51b3EPR\u6548\u5e94\u548c\u6df1\u5c42\u7a7f\u900f\u80fd\u529b\u4e4b\u95f4\u7684\u51b2\u7a81\u3002ApFAs\u4e2d\u7684\u4e8c\u8302\u94c1\u90e8\u5206\u53ef\u4ee5\u8fdb\u884c\u7c7bFenton\u53cd\u5e94\uff0c\u5e76\u6539\u53d8\u5176\u758f\u6c34\u6027\uff0c\u5bfc\u81f4ApFAs\u7684\u5c3a\u5bf8\u663e\u8457\u6536\u7f29\u3002\u540c\u65f6\uff0c\u901a\u8fc7\u7c7bFenton\u53cd\u5e94\u4ea7\u751f\u7684Fe\uff08III\uff09\u53ef\u7528\u4f5cMRI\u9020\u5f71\u5242\uff0c\u4ee5\u8868\u5f81ApFAs\u5728\u4f53\u5185\u7684\u6e17\u900f\u80fd\u529b\u3002\u53e6\u5916\uff0c\u4f5c\u4e3a\u82ac\u987f\u53cd\u5e94\u7684\u526f\u4ea7\u7269\uff0cApFA\u7cfb\u7edf\u8fd8\u53ef\u4ee5\u91ca\u653e\u9ad8\u6bd2\u6027\u7f9f\u57fa\u81ea\u7531\u57fa\uff0c\u4ece\u800c\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\u3002\u4f5c\u4e3a\u6539\u8fdb\uff0c\u8d1f\u8f7d\u8461\u8404\u7cd6\u6c27\u5316\u9176\uff08GOD\uff09\u7684ApFAs\u53ef\u50ac\u5316\u8461\u8404\u7cd6\u4ea7\u751f\u5927\u91cfH2<\/sub>O2<\/sub>\uff0c\u5347\u9ad8\u7684H2<\/sub>O2<\/sub>\u8fdb\u4e00\u6b65\u53c2\u4e0eApFA\u4ecb\u5bfc\u7684\u7c7bFenton\u53cd\u5e94\uff0c\u91ca\u653e\u51fa\u5927\u91cf\u9ad8\u6bd2\u6027\u2022OH\uff0c\u53ef\u663e\u8457\u63d0\u9ad8\u80bf\u7624\u7ec6\u80de\u7684\u51cb\u4ea1\u6548\u7387\u3002\u5c06GOD\u548cApFAs\u5171\u540c\u9012\u9001\u81f3\u80bf\u7624\u7ec6\u80de\u65f6\uff0c\u53ef\u4ee5\u901a\u8fc7ApFAs\u7684\u5927\u5c0f\u6536\u7f29\u5b9e\u73b0\u7a7a\u95f4\u5747\u5300\u7684\u7ec4\u7ec7\u7a7f\u900f\u6548\u679c\uff0c\u5e76\u901a\u8fc7\u4ea7\u751f\u2022OH\u8fdb\u884c\u80bf\u7624\u6cbb\u7597\u3002\u8be5\u6838\u9178\u7ec4\u88c5\u4f53\u4e0d\u4ec5\u63d0\u4f9b\u4e86\u836f\u7269\u9012\u9001\u7cfb\u7edf\u7684\u8bbe\u8ba1\u6982\u5ff5\uff0c\u66f4\u4f53\u73b0\u4e86\u4f18\u5f02\u7684EPR\u6548\u5e94\u548c\u6df1\u5c42\u80bf\u7624\u6e17\u900f\u80fd\u529b\uff0c\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u751f\u7269\u836f\u5242\u5b66\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b9\u5411\u3002\u8be5\u6210\u679c\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cSize-Tunable Assemblies Based on Ferrocene-Containing DNA Polymers for Spatially Uniform Penetration<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u671f\u520aChem<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1aApFAs\u7684\u7ed3\u6784\u3001\u5236\u5907\u548c\u6df1\u5c42\u80bf\u7624\u7a7f\u900f\u793a\u610f\u56fe<\/strong>
\n \"\"
\n \uff08A\uff09ApFAs\u7684\u5236\u5907\u8fc7\u7a0b\u793a\u610f\u56fe\u3002
\n \uff08B\uff09ApFAs\u7684\u6df1\u5c42\u80bf\u7624\u7a7f\u900f\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u4e8c\uff1aApFAs\u7684\u5f62\u6001\u548c\u5c3a\u5bf8\u5206\u5e03<\/strong>
\n \"\"
\n \uff08A\uff09\u6838\u9178\u9002\u914d\u4f53-Fen\u4e24\u4eb2\u6027\u5206\u5b50\u7684\u793a\u610f\u56fe\u3002
\n \uff08B-E\uff09TEM\u56fe\u50cf\u8868\u5f81\u6838\u9178\u9002\u914d\u4f53-Fen\u7ec4\u88c5\u4f53\uff0c\u5176\u4e2dn=3\uff08B\uff09\uff0c5\uff08C\uff09\uff0c7\uff08D\uff09\u548c15\uff08E\uff09\u3002
\n \uff08F-I\uff09DLS\u5c3a\u5bf8\u8868\u5f81\u6838\u9178\u9002\u914d\u4f53-Fen\u7ec4\u88c5\u4f53ApFAs\uff0c\u5176\u4e2dn=3\uff08B\uff09\uff0c5\uff08C\uff09\uff0c7\uff08D\uff09\u548c15\uff08E\uff09\u3002<\/p>\n

\u56fe\u4e09\uff1aAptamer-Fe7<\/sub>\u6c27\u5316\u524d\u540e\u5f62\u6210\u7684ApFAs\u7ed3\u6784\u53ca\u7406\u5316\u6027\u8d28\u8868\u5f81<\/strong>
\n \"\"
\n \uff08A\uff09\u901a\u8fc7\u7c7bFenton\u53cd\u5e94\u7ec4\u88c5\u7684\u5c3a\u5bf8\u51cf\u5c0f\u7684\u793a\u610f\u56fe\u3002
\n \uff08B-G\uff09\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684ApFAs\u7684TEM\u56fe\u50cf\uff08B-D\uff09\u548c\u76f8\u5e94\u7684\u5c3a\u5bf8\u5206\u5e03\uff08E-G\uff09\u3002\uff08B\uff09\u548c\uff08E\uff09\u4e2d\u663e\u793a\u7684\u662f\u5728pH 7.4\u4e0b\u4e0d\u7528H2<\/sub>O2<\/sub>\u5904\u7406\u7684ApFAs\u3002\uff08C\uff09\u548c\uff08F\uff09\u4e2d\u663e\u793a\u7684\u662f\u7528pH 7.4\u7684H2<\/sub>O2<\/sub>\u5904\u74065\u5206\u949f\u7684ApFAs\u3002\uff08D\u548cG\uff09\u7528pH 6.0\u7684H2<\/sub>O2<\/sub>\u5904\u74065\u5206\u949f\u7684ApFAs\u3002<\/p>\n

\u56fe\u56db\uff1a\u4f53\u5916\u8868\u5f81ApFAs\u7684\u50ac\u5316\u6027\u80fd\u548c\u6297\u764c\u6d3b\u6027<\/strong>
\n \"\"
\n \uff08A\uff09\u5728\u52a0\u5165\u4e0d\u540c\u6d53\u5ea6\u7684H2<\/sub>O2<\/sub>\u65f6ApFAs\u7684\u65f6\u95f4\u5206\u8fa8\u5438\u5149\u5ea6\u3002
\n \uff08B-C\uff09ApFAs\u7684\u7c73\u6c0f\u52a8\u529b\u5b66\u548c\u53cc\u5012\u6570\u6cd5\u56fe\u50cf\u3002
\n \uff08D\uff09\u5728pH 6.0\u4e0b\u6709\/\u65e0H2<\/sub>O2<\/sub>\u5904\u7406\u7684\u6838\u9178\u9002\u914d\u4f53\u548cApFAs\u7684T2\u52a0\u6743MR\u56fe\u50cf\u3002
\n \uff08E\uff09\u4e0d\u540c\u6d53\u5ea6\u7684H2<\/sub>O2<\/sub>\u5904\u7406\u7684ApFAs\u7684T2\u52a0\u6743MR\u4f2a\u56fe\u3002
\n \uff08F\uff09\uff08E\uff09\u4e2d\u4e0d\u540c\u6d53\u5ea6\u4e0b\u76f8\u5e94\u7684\u5b9a\u91cf\u6570\u636e\u3002
\n \uff08G\uff09\u5728\u9178\u6027\uff08pH=6.0\uff1b\u7ea2\u8272\uff09\u548c\u4e2d\u6027\uff08pH=7.4\uff1b\u9ed1\u8272\uff09\u6761\u4ef6\u4e0b\uff0cG-ApFAs\uff08\u8d1f\u8f7d0.1 nM GOD\u7684ApFAs\uff09\u5bf9A549\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u3002
\n \uff08H\uff09\u5728\u4e2d\u6027\uff08pH=7.4\uff09\u548c\u9178\u6027\uff08pH=6.0\uff09\u6761\u4ef6\u4e0b\u4e0ePBS\uff0cApFAs\u548cG-ApFAs\u5171\u5b75\u80b24\u5c0f\u65f6\u540eA549\u7ec6\u80de\u7684\u8367\u5149\u663e\u5fae\u955c\u56fe\u50cf\uff08DCFH-DA\u67d3\u8272\uff09\u3002<\/p>\n

\u56fe\u4e94\uff1aApFAs\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u6e17\u900f<\/strong>
\n \"\"
\n \uff08A-B\uff09\uff08A\uff09\u4ec5\u5728PBS\u4e2d\u548c\uff08B\uff09\u5728\u542b\u6709H2<\/sub>O2<\/sub>\u7684PBS\u4e2d\uff0cFAM-ApFAs\u5b75\u80b22\u5c0f\u65f6\u540e\u5728\u80bf\u7624\u7ec4\u7ec7\u4e2d\u7684\u6e17\u900f\u5b9e\u9a8c\u3002
\n \uff08C-D\uff09\u7531\u767d\u8272\u5b9e\u7ebf\u8868\u793a\u7684\u7ec4\u7ec7\u4e0a\u7684\u7070\u5ea6\u503c\u7684\u53d8\u5316\u3002
\n \uff08E\uff09\u4e0d\u542b\u548c\u542b\u6709H2<\/sub>O2<\/sub>\u7684ApFAs\u7684\u80bf\u7624\u7ec4\u7ec7\u7a7f\u900f\u6a21\u578b\u3002
\n \uff08F-G\uff09\u5206\u522b\u9759\u8109\u5185\u6ce8\u5c04PBS\u3001ApFAs\u548cG-ApFAs\u7684A549\u8377\u7624\u5c0f\u9f20\u7684HIF-\u03b1\uff08F\uff09\u548cVEGF\uff08G\uff09\u67d3\u8272\u3002<\/p>\n

\u56fe\u516d\uff1aG-ApFAs\u7684\u4f53\u5185\u6cbb\u7597\u6548\u679c\u8bc4\u4f30<\/strong>
\n \"\"
\n \uff08A\u548cB\uff09\u9759\u8109\u6ce8\u5c04\uff08A\uff09Cy5\u6807\u8bb0\u7684G-ApFAs\u548c\uff08B\uff09Cy5\u6807\u8bb0\u7684G-rDNA-Fe\u540eA549\u8377\u7624\u5c0f\u9f20\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u8367\u5149\u56fe\u50cf\u3002
\n \uff08C\uff09\u901a\u8fc7\u80bf\u7624\u5185\u6ce8\u5c04PBS\u3001ApFAs\u3001G-ApFAs\u548cG-rDNA-Fe\u540eA549\u8377\u7624\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u3002
\n \uff08D\uff09\u901a\u8fc7\u80bf\u7624\u5185\u6ce8\u5c04PBS\u3001ApFAs\u3001G-ApFAs\u548cG-rDNA-Fe\u540eA549\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\u3002
\n \uff08E\uff09\u6cbb\u759714\u5929\u540e\u89e3\u5256\u79bb\u4f53\u80bf\u7624\u7684\u7167\u7247\u3002<\/p>\n

\u3010\u603b\u7ed3\u5c55\u671b\u3011<\/strong><\/p>\n

\u5728\u8be5\u5de5\u4f5c\u4e2d\uff0c\u901a\u8fc7\u4f7f\u7528\u542b\u6709\u4e24\u4eb2\u6027\u4e8c\u8302\u94c1\u7684\u6838\u9178\u805a\u5408\u7269\uff0c\u5f00\u53d1\u4e86\u5c3a\u5bf8\u53ef\u8c03\u7684ApFA\u7cfb\u7edf\u4ee5\u89e3\u51b3EPR\u6548\u5e94\u548c\u6df1\u5c42\u80bf\u7624\u7a7f\u900f\u4e4b\u95f4\u7684\u5c3a\u5bf8\u51b2\u7a81\u3002\u521d\u59cbApFAs\u53ef\u901a\u8fc7EPR\u6548\u5e94\u5728\u80bf\u7624\u90e8\u4f4d\u7d2f\u79ef\uff0c\u5f53\u66b4\u9732\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u65f6\uff0cApFAs\u53ef\u4ee5\u7ecf\u5386\u7c7bFenton\u53cd\u5e94\uff0c\u5b9e\u73b0100 nm\u81f310 nm\u7684\u663e\u8457\u5c3a\u5bf8\u51cf\u5c0f\uff0c\u4ece\u800c\u63d0\u9ad8\u7ec4\u4ef6\u7684\u80bf\u7624\u7a7f\u900f\u80fd\u529b\u3002ApFAs\u8fd8\u53ef\u4ee5\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u91ca\u653e\u9ad8\u6bd2\u6027\u7f9f\u57fa\u81ea\u7531\u57fa\uff0c\u57fa\u4e8e\u50ac\u5316\u53cd\u5e94\u5b9e\u73b0\u764c\u75c7\u6cbb\u7597\u3002\u603b\u4f53\u800c\u8a00\uff0cApFAs\u4e0d\u4ec5\u4ee3\u8868\u5177\u6709EPR\u6548\u5e94\u548c\u80bf\u7624\u7a7f\u900f\u80fd\u529b\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff0c\u800c\u4e14\u8fd8\u4e3a\u764c\u75c7\u6cbb\u7597\u7684\u751f\u7269\u836f\u5242\u5b66\u63d0\u4f9b\u4e86\u6709\u5e0c\u671b\u7684\u65b9\u5411\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSize-Tunable Assemblies Based on Ferrocene-Containing DNA Polymers for Spatially Uniform Penetration<\/a> (Chem<\/em>, 2019<\/strong>, 5, 1775-1792)<\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

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