{"id":180848,"date":"2019-07-21T06:30:01","date_gmt":"2019-07-20T22:30:01","guid":{"rendered":"\/\/m.iemloyee.com\/?p=180848"},"modified":"2019-07-20T21:16:11","modified_gmt":"2019-07-20T13:16:11","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e5%8e%a6%e5%a4%a7%e9%ab%98%e9%94%a6%e8%b1%aa%e5%9b%a2%e9%98%9fnano-lett-%e6%8a%a5%e9%81%93-%e5%a4%9a%e5%8a%9f%e8%83%bd%e5%85%ab%e8%b6%b3%e5%bd%a2%e4%b8%ad","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=180848","title":{"rendered":"\u53a6\u5927\u9ad8\u9526\u8c6a\u56e2\u961fNano Lett.\u62a5\u9053: \u591a\u529f\u80fd\u516b\u8db3\u5f62\u4e2d\u7a7a\u591a\u5b54\u4e8c\u4ef7\u9530\u6c27\u5316\u7269\u7eb3\u7c73\u5e73\u53f0\u7528\u4e8e\u5b9e\u65f6\u53ef\u89c6\u5316\u7684\u836f\u7269\u9012\u9001"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u4f17\u6240\u5468\u77e5\uff0c\u5bf9\u764c\u75c7\u8fdb\u884c\u51c6\u786e\u8bca\u65ad\u548c\u53ca\u65f6\u6cbb\u7597\u5728\u4e34\u5e8a\u4e0a\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\uff0c\u4eba\u4eec\u81f4\u529b\u4e8e\u5f00\u53d1\u5177\u6709\u54cd\u5e94\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u7684\u8bca\u7597\u591a\u529f\u80fd\u7684\u667a\u80fd\u7eb3\u7c73\u6750\u6599\u3002\u57fa\u4e8e\u65e0\u673a\u7684\u548c\u57fa\u4e8e\u6709\u673a\u7269\u7684\u7eb3\u7c73\u6750\u6599\u7ecf\u5e38\u88ab\u7528\u4f5c\u7eb3\u7c73\u8f7d\u4f53\uff0c\u7528\u4e8e\u5728\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u63d0\u4f9b\u6cbb\u7597\u5242\u3002\u5c06\u751f\u7269\u76f8\u5bb9\u6027\u4e0e\u6210\u50cf\u6027\u80fd\u76f8\u7ed3\u5408\u7684\u591a\u529f\u80fd\u7eb3\u7c73\u8f7d\u4f53\u7684\u53d1\u5c55\u5c24\u4e3a\u5173\u952e\u3002\u7531\u4e8e\u9530\u6c27\u5316\u7269\u7eb3\u7c73\u7c92\u5b50\u80fd\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u5206\u89e3\u6210\u6c34\u6eb6\u6027\u7684Mn2+<\/sup>\u79bb\u5b50\uff0c\u589e\u5f3aT1\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u4fe1\u53f7\uff0c\u56e0\u6b64\u5e38\u88ab\u7528\u4f5c\u751f\u7269\u54cd\u5e94\u6027\u7eb3\u7c73\u63a2\u9488\u3002\u6b64\u5916\uff0c\u7531\u6b64\u4ea7\u751f\u7684Mn2+<\/sup>\u53ef\u4ee5\u901a\u8fc7\u80be\u810f\u5feb\u901f\u6392\u51fa\uff0c\u800c\u4e0d\u4f1a\u4ea7\u751f\u6f5c\u5728\u7684\u957f\u671f\u6bd2\u6027\u3002\u4f46\u5927\u5c3a\u5bf8\u6c27\u5316\u9530\u7eb3\u7c73\u9897\u7c92\u5f80\u5f80\u79ef\u805a\u5728\u5355\u6838\u541e\u566c\u7ec6\u80de\u7cfb\u7edf\uff08MPS\uff09\u4e2d\uff0c\u901a\u8fc7EPR\u6548\u5e94\u7834\u574f\u9776\u5411\u80bf\u7624\u7684\u4f18\u52bf\u3002\u56e0\u6b64\uff0c\u5177\u6709\u5c0f\u5c3a\u5bf8\u3001\u5927\u7a7a\u8154\u548c\u9002\u5f53\u8868\u9762\u6d82\u5c42\u7684\u7a7a\u5fc3\u6c27\u5316\u9530\u7eb3\u7c73\u9897\u7c92\u662f\u4e00\u79cd\u7406\u60f3\u7684\u836f\u7269\u9012\u9001\u5e73\u53f0\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u53a6\u95e8\u5927\u5b66\u7684\u9ad8\u9526\u8c6a\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u5c0f\u5c3a\u5bf8\u516b\u8db3\u5f62\u7684\u4e2d\u7a7a\u591a\u5b54\u9530\uff08II\uff09\u6c27\u5316\u7269\uff08HPMO\uff09\u7eb3\u7c73\u9897\u7c92\uff0c\u7528\u4e8e\u80bf\u7624\u7279\u5f02\u6027\u836f\u7269\u9012\u9001\u548c\u5b9e\u65f6\u76d1\u6d4b\u3002\u4f5c\u8005\u5229\u7528\u4e24\u6027\u591a\u5df4\u80fa\u78fa\u9178\u76d0\uff08ZDS\uff09\u529f\u80fd\u5316\u7684HPMO NPs\u4f5c\u4e3a\u4e00\u4e2a\u591a\u529f\u80fd\u5e73\u53f0\uff0c\u4ee5\u8d1f\u8f7d\u6709\u673a\u67d3\u6599\u6216\u9ad8\u8d1f\u8f7d\u7387\u7684\u5316\u7597\u836f\u7269\u3002\u5236\u5907\u7684\u836f\u7269@HPMO\u4f1a\u5206\u89e3\u6210\u987a\u78c1\u6027\u7684Mn2+<\/sup>\uff0c\u5e76\u5728\u80bf\u7624\u5fae\u73af\u5883\u548c\u6eb6\u9176\u4f53\u7684\u9178\u6027\u6761\u4ef6\u4e0b\u91ca\u653e\u836f\u7269\u3002\u91ca\u653e\u7684Mn2+\u53ef\u589e\u5f3aT1\u78c1\u5171\u632f\u4fe1\u53f7\uff0c\u5b9e\u65f6\u76d1\u6d4b\u4f53\u5185\u836f\u7269\u8fd0\u8f93\u3002\u8be5\u516b\u8db3\u5f62\u7684\u836f\u7269@HPMO\u4f5c\u4e3a\u4e00\u4e2a\u667a\u80fd\u578b\u591a\u529f\u80fd\u7eb3\u7c73\u5e73\u53f0\uff0c\u5177\u6709pH\u54cd\u5e94\u7684\u591a\u6a21\u5f0f\u6210\u50cf\u548c\u7279\u5b9a\u7684\u4f4d\u7f6e\u836f\u7269\u8f93\u9001\uff0c\u53ef\u4ee5\u51c6\u786e\u7684\u8bca\u65ad\u548c\u6709\u6548\u7684\u764c\u75c7\u6cbb\u7597\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cVersatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery\u201d<\/strong>\u53d1\u5e03\u5728\u8457\u540d\u671f\u520aNano Lett.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001pH\u54cd\u5e94\u5c0f\u578b\u516b\u8db3\u5f62HPMO NPs\u4f5c\u4e3aT1\u53ef\u6fc0\u6d3b\u7eb3\u7c73\u8f7d\u4f53\u4ee5\u5b9e\u65f6\u76d1\u6d4b\u836f\u7269\u9012\u9001<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001\u5c0f\u5c3a\u5bf8\u516b\u8db3\u5f62HPMO-NPs\u7684\u8868\u5f81\u53capH\u54cd\u5e94\u964d\u89e3<\/strong>
\n \"\"\uff08a-b\uff09\u516b\u8db3\u5f62MnO\u548cHPMO-NPs\u7684\u900f\u5c04\u7535\u955c\uff08TEM\uff09\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09HPMO NPs\u7684SAXS\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09\u4e0d\u540cpH\u503c\u7684PBS\u4e2d\u5b75\u80b2\u540eHPMO NPs\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u4e0d\u540cpH\u503c\u4e0b\u5b75\u80b2\u7684HPMO NPs\u7684UV-vis\u5438\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08f\uff09\u4e0d\u540cpH\u503c\u4e0b\uff0cHPMO NPs\u7684\u5f1b\u8c6b\u5ea6\u6d4b\u91cf\uff1b<\/p>\n

\uff08g\uff09HPMO NPs\u7684T1\u52a0\u6743\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e09\u3001\u836f\u7269\u91ca\u653e\u3001pH\u53ef\u6fc0\u6d3b\u7684T1\u52a0\u6743MR\u548c\u8367\u5149\u5206\u6790<\/strong>
\n \"\"\uff08a\uff09\u6e38\u79bbDOX\u548cDOX@HPMO\u5728\u4e0d\u540cpH\u503c\u4e0b\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08b\uff09\u4e0d\u540cpH\u503c\u4e0b\uff0c\u6e38\u79bbCPT\u548cCPT@HPMO\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09\u6e38\u79bbRh123\u548cRh123@HPMO\u5728\u4e0d\u540cpH\u503c\u4e0b\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08d-f\uff09DOX@HPMO\u3001CPT@HPMO\u548cRh123@HPMO\u5728\u4e0d\u540cpH\u503c\u4e0b\u7684\u836f\u7269\u91ca\u653e\u52a8\u529b\u5b66\u3002<\/p>\n

\u56fe\u56db\u3001\u7ec6\u80de\u6444\u53d6\u540e\uff0cT1 MRI\u548c\u8367\u5149\u4fe1\u53f7\u5747\u201c\u5f00\u542f\u201d<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09HPMO NPs\u5b75\u80b2\u4e0d\u540c\u65f6\u95f4\u540eSMMC-7721\u7ec6\u80de\u7684T1\u52a0\u6743MR\u56fe\uff1b<\/p>\n

\uff08b\uff09\uff08a\uff09\u7684\u5b9a\u91cfMR\u4fe1\u53f7\u5206\u6790\uff1b<\/p>\n

\uff08c\uff09\u7528Rh123@HPMO\u5904\u7406\u4e0d\u540c\u65f6\u95f4\u7684SMMC-7721\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e94\u3001\u53ef\u6fc0\u6d3b\u7684T1 MR\u548c\u8367\u5149\u6210\u50cf\u7528\u4e8e\u76d1\u6d4b\u7ec6\u80de\u4e2dpH\u54cd\u5e94\u6027\u7684\u836f\u7269\u91ca\u653e<\/strong>
\n \"\"\uff08a\uff09\u7528DOX@HPMO\u3001\u6e38\u79bbDOX\u5904\u74064 h\u7684SMMC-7721\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08b\uff09\u4e0eDOX HPMO\u5b75\u80b24 h\u540e\uff0cSMMC-7721\u7ec6\u80de\u7684T1\u52a0\u6743MR\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09\uff08b\uff09\u7684\u5b9a\u91cfMR\u4fe1\u53f7\u5206\u6790\uff1b<\/p>\n

\uff08d\uff09ICP-MS\u6d4b\u91cf\u7684\uff08b\uff09\u4e2dSMMC-7721\u7ec6\u80de\u4e2dMn\u7684\u603b\u91cf\uff1b<\/p>\n

\uff08e\uff09\u4e0d\u540c\u57f9\u517b\u6761\u4ef6\u4e0b\uff0c\u7528\u6e38\u79bbDOX\u548cDOX@HPMO\u5904\u740624 h\u7684SMMC-7721\u7ec6\u80de\u7684\u7ec6\u80de\u6d3b\u529b\uff1b<\/p>\n

\uff08f\uff09\uff08e\uff09\u4e2dIC50<\/sub>\u503c\u7684\u6bd4\u8f83\u3002<\/p>\n

\u56fe\u516d\u3001\u6d3b\u4f53T1\u78c1\u5171\u632f\u6210\u50cf\u548c\u8367\u5149\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

\uff08a\uff09\u5c40\u90e8\u6ce8\u5c04DOX@HPMO\u8fdb\u5165\u80bf\u7624\u548c\u808c\u8089\u7ec4\u7ec7\u524d\u540e\uff0c\u643a\u5e26H22\u80bf\u7624\u7684\u5c0f\u9f20\u7684T1\u52a0\u6743MR\u6210\u50cf\uff1b<\/p>\n

\uff08b\uff09\uff08a\uff09\u4e2d\u7684\u76f8\u5173SNR\uff1b<\/p>\n

\uff08c\uff09\u9759\u8109\u6ce8\u5c04\u524d\u540e\u5c0f\u9f20\u7684T1\u52a0\u6743MR\u56fe\u50cf\uff1b<\/p>\n

\uff08d\uff09\uff08c\uff09\u4e2dSNR\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

\uff08e\uff09\u9759\u8109\u6ce8\u5c04DOX@HPMO\u524d\u540e\uff0c\u5c0f\u9f20\u7684\u4e3b\u8981\u5668\u5b98\u548c\u80bf\u7624\u7684\u79bb\u4f53\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

\uff08f\uff09\uff08e\uff09\u4e2d\u80bf\u7624\u7684\u8367\u5149\u5f3a\u5ea6\u5206\u6790\u3002<\/p>\n

\u56fe\u4e03\u3001\u4ee5HPMO NPs\u4e3a\u836f\u7269\u8f7d\u4f53\u7684\u4f53\u5185\u764c\u75c7\u6cbb\u7597\u7814\u7a76<\/strong>
\n \"\"\uff08a\uff09\u7528DOX@HPMO\u3001\u6e38\u79bbDOX\u3001HPMO NPs\u6216PBS\u6cbb\u7597\u671f\u95f4\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

\uff08b\uff09\u6cbb\u759720\u5929\u540e\uff0c\u4ece\u5c0f\u9f20\u6536\u96c6\u7684\u80bf\u7624\u7684\u5e73\u5747\u91cd\u91cf\uff1b<\/p>\n

\uff08c\uff09\u7528DOX@HPMO\u3001\u6e38\u79bbDOX\u3001HPMO NPs\u6216PBS\u6cbb\u7597\u671f\u95f4\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n

\uff08d\uff09\u5904\u740620\u5929\u540e\uff0c\u5c0f\u9f20\u7684\u80bf\u7624\u548c\u809d\u810f\u7684H\uff06E\u7ec4\u7ec7\u5b66\u56fe\u50cf\uff1b<\/p>\n

\uff08e\uff09\u5904\u740620\u5929\u540e\uff0c\u5bf9\u5c0f\u9f20\u7684\u751f\u5316\u6307\u6807\u8fdb\u884c\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u53d1\u5c55\u4e86\u4e00\u79cd\u65b0\u578b\u516b\u8db3\u5f62HPMO\u7eb3\u7c73\u5e73\u53f0\uff0c\u5177\u6709\u9ad8\u6548\u7684\u836f\u7269\u8d1f\u8f7d\u548cpH\u6fc0\u6d3bT1 MR\u6210\u50cf\u3002HPMO NPs\u7eb3\u7c73\u8f7d\u4f53\u53ef\u4ee5\u5206\u89e3\u6210Mn2+<\/sup>\u5e76\u91ca\u653e\u836f\u7269\u4ee5\u54cd\u5e94\u6e29\u548c\u7684\u9178\u6027\u73af\u5883\u3002\u6fc0\u6d3b\u7684T1 MR\u548c\u8367\u5149\u4fe1\u53f7\u7528\u4e8e\u53ef\u89c6\u5730\u76d1\u63a7\u836f\u7269\u7684\u9012\u9001\u3002T1 MR\u4fe1\u53f7\u6539\u53d8\u80fd\u591f\u5b9e\u65f6\u76d1\u6d4b\u6d3b\u4f53\u5185\u836f\u7269\u91ca\u653e\u3002DOX@HPMO\u51cf\u5c11\u4e86DOX\u7684\u526f\u4f5c\u7528\uff0c\u540c\u65f6\u6709\u6548\u6291\u5236\u4e86\u80bf\u7624\u751f\u957f\u3002\u8fd9\u79cd\u901a\u8fc7pH\u54cd\u5e94\u6027T1 MR\u548c\u8367\u5149\u6210\u50cf\u5b9e\u73b0\u836f\u7269\u91ca\u653e\u7684\u5b9e\u65f6\u591a\u6a21\u5f0f\u76d1\u6d4b\u7684\u7b56\u7565\u5bf9\u4e8e\u751f\u7269\u533b\u5b66\u5e94\u7528\u4e2d\u7684\u51c6\u786e\u8bca\u65ad\u548c\u7cbe\u786e\u6cbb\u7597\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u5177\u6709\u53ef\u63a7\u91ca\u653e\u548cT1\u4fe1\u53f7\u653e\u5927\u7684\u591a\u529f\u80fd\u836f\u7269\u8f7d\u4f53\u5728\u764c\u75c7\u6cbb\u7597\u65b9\u9762\u5177\u6709\u76f8\u5f53\u5927\u7684\u5e94\u7528\u6f5c\u529b\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aVersatile Octapod-Shaped Hollow Porous Manganese(II) Oxide Nanoplatform for Real-Time Visualization of Cargo Delivery<\/strong>\uff08Nano Lett., 2019<\/strong>, DOI: 10.1021\/acs.nanolett.9b01900\uff09<\/p>\n

\u672c\u6587\u7531CQR\u7f16\u8bd1\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u4f17\u6240\u5468\u77e5\uff0c\u5bf9\u764c\u75c7\u8fdb\u884c\u51c6\u786e\u8bca\u65ad\u548c\u53ca\u65f6\u6cbb\u7597\u5728\u4e34\u5e8a\u4e0a\u5177\u6709\u91cd\u8981\u610f\u4e49\u3002\u5728\u8fc7\u53bb\u51e0\u5341\u5e74\u4e2d\uff0c\u4eba\u4eec\u81f4\u529b\u4e8e\u5f00\u53d1\u5177\u6709\u54cd\u5e94\u4e8e\u80bf\u7624\u5fae\u73af\u5883\u7684\u8bca\u7597\u591a\u529f\u80fd\u7684\u667a\u80fd\u7eb3\u7c73\u6750\u6599\u3002\u57fa\u4e8e\u65e0\u673a…<\/p>\n","protected":false},"author":7770,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215,2],"tags":[4101],"class_list":["post-180848","post","type-post","status-publish","format-standard","hentry","category-jiedu","category-keji","tag-hpmo"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/180848"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7770"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=180848"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/180848\/revisions"}],"predecessor-version":[{"id":181058,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/180848\/revisions\/181058"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=180848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=180848"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=180848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}