{"id":179619,"date":"2019-07-11T06:30:15","date_gmt":"2019-07-10T22:30:15","guid":{"rendered":"\/\/m.iemloyee.com\/?p=179619"},"modified":"2019-07-11T07:04:33","modified_gmt":"2019-07-10T23:04:33","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e5%8d%97%e4%ba%ac%e5%a4%a7%e5%ad%a6j-am-chem-soc-%e9%80%9a%e8%bf%87%e9%85%b6%e4%bb%8b%e5%af%bc%e7%9a%84%e8%8d%a7%e5%85%89%e5%8f%8d%e5%ba%94%e5%92%8c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=179619","title":{"rendered":"\u5357\u4eac\u5927\u5b66J. Am. Chem. Soc.:\u901a\u8fc7\u9176\u4ecb\u5bfc\u7684\u8367\u5149\u53cd\u5e94\u548c\u81ea\u7ec4\u88c5\u5b9e\u73b0\u53ef\u6fc0\u6d3bNIR\u8367\u5149\/ MRI\u53cc\u6a21\u6001\u63a2\u9488\u7528\u4e8e\u4f53\u5185\u6210\u50cf"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u591a\u6a21\u6001\u5206\u5b50\u6210\u50cf\u63a2\u9488\u5bf9\u4e8e\u751f\u7269\u533b\u5b66\u548c\u4e34\u5e8a\u7814\u7a76\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\u4f8b\u5982\uff0c\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u548c\u8fd1\u7ea2\u5916\uff08NIR\uff09\u8367\u5149\u534f\u540c\u7ec4\u5408\u7684\u53cc\u6a21\u6001\u6210\u50cf\u63a2\u9488\uff0c\u5176\u4e2dMRI\u53ef\u4ee5\u4ea7\u751f\u5177\u6709\u65e0\u9650\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u548c\u9ad8\u7a7a\u95f4\u5206\u8fa8\u7387\u7684\u89e3\u5256\u56fe\u50cf\uff0c\u800cNIR\u8367\u5149\u80fd\u591f\u4ea7\u751f\u9ad8\u7075\u654f\u5ea6\u7684\u56fe\u50cf\u3002\u7136\u800c\uff0c\u5927\u591a\u6570\u63a2\u9488\u663e\u793a\u201c\u59cb\u7ec8\u5728\u7ebf\u201d\u4fe1\u53f7\uff0c\u53ef\u80fd\u5bfc\u81f4\u80bf\u7624-\u80cc\u666f\u6bd4(TBR)\u8f83\u5dee\uff0c\u8fd8\u4e0d\u80fd\u6709\u6548\u5730\u6ee1\u8db3\u65e9\u671f\u8bca\u65ad\u6076\u6027\u80bf\u7624\u7684\u9700\u6c42\u3002\u5c0f\u5206\u5b50\u57fa\u53ef\u6fc0\u6d3b\u63a2\u9488\u5177\u6709\u660e\u786e\u7684\u5316\u5b66\u7ed3\u6784\u4ee5\u53ca\u8f83\u5c0f\u7684\u5c3a\u5bf8\uff0c\u4f7f\u5f97\u5b83\u4eec\u80fd\u591f\u6e17\u900f\u5e76\u6269\u6563\u5230\u80bf\u7624\u7ec4\u7ec7\u4e2d\u4ee5\u8fbe\u5230\u5206\u5b50\u9776\u5e76\u88ab\u6fc0\u6d3b\u3002\u4f46\u662f\uff0c\u8bbe\u8ba1\u80fd\u591f\u4e0e\u80bf\u7624\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u4e14\u53ef\u4ee5\u540c\u65f6\u5207\u6362NIR\u8367\u5149\u548cMRI\u4fe1\u53f7\u7684\u5c0f\u5206\u5b50\u63a2\u9488\u4ecd\u7136\u5177\u6709\u6311\u6218\u6027\u3002\u6b64\u5916\uff0c\u5c0f\u5c3a\u5bf8\u63a2\u9488\u53ef\u5bfc\u81f4\u4ece\u9776\u4f4d\u5feb\u901f\u51b2\u6d17\u8fdb\u800c\u964d\u4f4e\u80bf\u7624\u7d2f\u79ef\u548cTBR\uff0c\u5bf9\u957f\u671f\u5206\u5b50\u6210\u50cf\u662f\u4e0d\u5229\u7684\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u4e00\u79cd\u65b0\u7684\u7b56\u7565\u6765\u8bbe\u8ba1\u53ef\u6fc0\u6d3b\u8367\u5149\/MR\u53cc\u6a21\u6001\u6210\u50cf\u63a2\u9488\u4ee5\u63d0\u9ad8\u5176\u80bf\u7624\u6e17\u900f\u6027\u548c\u80bf\u7624\u79ef\u7d2f\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5357\u4eac\u5927\u5b66\u53f6\u5fb7\u4e3e\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u4e00\u79cd\u5c0f\u5206\u5b50\u57fa\u53ef\u6fc0\u6d3bNIR\u8367\u5149\/ MRI\u53cc\u6a21\u6001\u63a2\u9488\uff0c\u5e76\u901a\u8fc7\u9176\u4ecb\u5bfc\u8367\u5149\u53cd\u5e94\u548c\u539f\u4f4d\u81ea\u7ec4\u88c5\u5c06\u5176\u7528\u4e8e\u4f53\u5185\u6210\u50cf\u3002\u8be5\u7b56\u7565\u5229\u7528\u9176\u7684\u50ac\u5316\u6d3b\u6027\u589e\u5f3a\u4e86MR\u7279\u6027\u5e76\u589e\u52a0\u4e86\u9776\u7ec4\u7ec7\u4e2d\u7684\u63a2\u9488\u79ef\u7d2f\u3002\u4f7f\u7528\u78b1\u6027\u78f7\u9178\u9176\uff08ALP\uff09\u4f5c\u4e3a\u6a21\u578b\u9176\uff0c\u7814\u7a76\u8868\u660e\uff0c\u53ef\u6fc0\u6d3b\u53cc\u6a21\u6001\u63a2\u9488\u80fd\u591f\u5b9e\u73b0\u76ae\u4e0bALP\u9633\u6027\u80bf\u7624\u7684\u975e\u4fb5\u5165\u3001\u9ad8\u654f\u611f\u548c\u7a7a\u95f4\u5206\u8fa8\u6210\u50cf\u4ee5\u53caNIR\u8367\u5149\u5f15\u5bfc\u7684\u539f\u4f4d\u809d\u810f\u80bf\u7624\u7684\u5b9e\u65f6\u624b\u672f\u5207\u9664\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a” Activatable NIR Fluorescence\/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly<\/strong>“\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aJ. Am. Chem. Soc.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 ALP\u6fc0\u6d3b\u7684NIR\u8367\u5149\/MR\u53cc\u6a21\u6001\u63a2\u9488\u7528\u4e8e\u4f53\u5185\u6210\u50cf\u7684\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a) P-CyFF-Gd\u7684\u5316\u5b66\u7ed3\u6784\u3001ALP\u4ecb\u5bfc\u7684\u8367\u5149\u53cd\u5e94\u548cP-CyFF-Gd\u539f\u4f4d\u81ea\u7ec4\u88c5\u6210NPs\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(b) \u63d0\u51fa\u7684P-CyFF-Gd\u7528\u4e8e\u4f53\u5185ALP\u9633\u6027\u80bf\u7624\u7ec6\u80de\u7684NIR\u8367\u5149\/MR\u53cc\u6a21\u6001\u6210\u50cf\u7684\u673a\u5236\uff1b<\/p>\n

(c) \u8bbe\u8ba1\u7684\u975e\u7ec4\u88c5\u5bf9\u7167\u63a2\u9488P-Cy-Gd\u7684\u5316\u5b66\u7ed3\u6784\u3002<\/p>\n

\u56fe2 P-CyFF-Gd\u7684\u4f53\u5916\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0eALP\uff082 U\/mL\uff09\u572837 \u00b0C\u5b75\u5316\u6307\u5b9a\u65f6\u95f4\u540e\uff0cP-CyFF-Gd\uff08200 \u03bcM\uff09\u7684HPLC\u5206\u6790\uff1b<\/p>\n

(b) \u4e0eALP\uff082 U\/mL\uff09\u572837 \u00b0C\u5b75\u5316\u6307\u5b9a\u65f6\u95f4\u540e\uff0cP-CyFF-Gd\uff08200 \u03bcM\uff09\u7684DLS\u5206\u6790\uff1b<\/p>\n

(c) \u5c06P-CyFF-Gd\uff08200 \u03bcM\uff09\u4e0eALP\uff082 U\/mL\uff0c37 \u00b0C\uff09\u4e00\u8d77\u5b75\u531630\u5206\u949f\u540e\u5f62\u6210\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u548cAFM\u56fe\u50cf\uff1b<\/p>\n

(d) \u4e0eALP\uff080.1 U\/mL\uff0c37 \u00b0C\uff09\u5b75\u53160-40\u5206\u949f\uff0cP-CyFF-Gd\uff085 \u03bcM\uff09\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

(e) \u4e0eALP\uff080.1 U\/mL\uff0c37 \u00b0C\uff09\u5b75\u53160-40\u5206\u949f\uff0cP-CyFF-Gd\uff085 \u03bcM\uff09\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

(f) \u5728Tris\u7f13\u51b2\u6db2\u4e2d\u4e0eALP\uff082 U\/mL\uff09\u5b75\u53160-40\u5206\u949f\u540e\uff0cP-CyFF-Gd (200 \u03bcM)\u7684T<\/em>1<\/sub>\u52a0\u6743MR\u56fe\u50cf\u548cT<\/em>1<\/sub>\u503c\uff080.5 T\uff09\uff1b<\/p>\n

(g) \u7528\u4e0d\u540c\u6d53\u5ea6\u7684ALP\u5b75\u531630\u5206\u949f\u540eP-CyFF-Gd\uff085 \u03bcM\uff09\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

(h) \u4e0e\u80f0\u86cb\u767d\u9176\u3001BSA\u3001\u6eb6\u83cc\u9176\u3001ACP\u3001ALP\u6216ALP\u4ee5\u53caP-CyFF-Gd\u7684\u6291\u5236\u5242Na3<\/sub>VO4<\/sub>\u4e00\u8d77\u5728Tris\u7f13\u51b2\u6db2\u4e2d\u5b75\u5316\u540e\uff0cP-CyFF-Gd\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

(i) \u4e0e\u80f0\u86cb\u767d\u9176\u3001BSA\u3001\u6eb6\u83cc\u9176\u3001ACP\u3001ALP\u6216ALP\u4ee5\u53caP-CyFF-Gd\u7684\u6291\u5236\u5242Na3<\/sub>VO4<\/sub>\u4e00\u8d77\u5728Tris\u7f13\u51b2\u6db2\u4e2d\u5b75\u5316\u540e\uff0cP-CyFF-Gd\u7684T<\/em>1<\/sub>\u52a0\u6743MR\u56fe\u50cf\u3002<\/p>\n

\u56fe3 \u80bf\u7624\u7ec6\u80de\u4e2dALP\u6d3b\u6027\u7684\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0eP-CyFF-Gd\uff08100 \u03bcM\uff09\u5b75\u531610-60\u5206\u949f\u7684HeLa\u7ec6\u80de\u7684NIR\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

(b) \u4e0eP-CyFF-Gd\uff08100 \u03bcM\uff09\u5b75\u53161\u5c0f\u65f6\u540e\uff0c\u56fa\u5b9a\u5728HeLa\u7ec6\u80de\u819c\u4e0a\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7c92\u5b50\u7684\u5178\u578b\u51b7\u51bbSEM\u56fe\u50cf\uff1b<\/p>\n

(c) \uff08b\uff09\u56fe\u4e2d\u7ea2\u6846\u533a\u57df\u653e\u5927\u7684\u51b7\u51bbSEM\u56fe\u50cf\uff1b<\/p>\n

(d) \uff08c\uff09\u56fe\u4e2d\u7ea2\u6846\u533a\u57df\u653e\u5927\u7684\u51b7\u51bbSEM\u56fe\u50cf\uff1b<\/p>\n

(e) \u4e0eP-CyFF-Gd\uff08100 \u03bcM\uff09\u5b75\u53161\u5c0f\u65f6\u540e\uff0c\u4ece\u6d3bHeLa\u7ec6\u80de\u819c\u4e0a\u6536\u96c6\u7684\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7c92\u5b50\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(f) \u7ec6\u80de\u6c89\u6dc0\u7684\u8367\u5149\uff08\u4e0a\uff09\u548cT<\/em>1<\/sub>\u52a0\u6743MR\uff08\u4e0b\uff09\u56fe\u50cf\uff1b<\/p>\n

(g) \uff08f\uff09\u56fe\u4e2d\u7ec6\u80de\u6c89\u6dc0\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff08\u7ea2\u8272\uff09\u548cT<\/em>1<\/sub>\u503c\uff080.5T\uff0c\u9ed1\u8272\uff09\u7684\u6bd4\u8f83\uff1b<\/p>\n

(h) ICP-MS\u5206\u6790Gd\u542b\u91cf\u3002<\/p>\n

\u56fe4 \u643aHeLa\u80bf\u7624\u7684\u6d3b\u4f53\u5c0f\u9f20\u5185\u6e90\u6027ALP\u7684\u53cc\u6a21\u6001\u6210\u50cf<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5c0f\u9f20\u63a5\u53d7P-CyFF-Gd\uff08I\uff09\u3001P-Cy-Gd\uff08II\uff09\u6216P-CyFF-Gd + Na3<\/sub>VO4<\/sub>\uff08III\uff09\u6ce8\u5c04\u57280\u30011\u30012\u30014\u548c8\u5c0f\u65f6\u5c0f\u9f20\u7684\u7eb5\u5411\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

(b) \u5c0f\u9f20\u63a5\u53d7P-CyFF-Gd\uff08I\uff09\u3001P-Cy-Gd\uff08II\uff09\u6216P-CyFF-Gd + Na3<\/sub>VO4<\/sub>\uff08III\uff09\u6ce8\u5c04\u540e\uff0c\u643aHeLa\u80bf\u7624\u5c0f\u9f20\u7684T<\/em>1<\/sub>\u52a0\u6743MR\u56fe\u50cf\uff1b<\/p>\n

(c) \u5c0f\u9f20\u63a5\u53d7P-CyFF-Gd\uff08I\uff09\u3001P-Cy-Gd\uff08II\uff09\u6216P-CyFF-Gd + Na3<\/sub>VO4<\/sub>\uff08III\uff09\u6ce8\u5c04\u57280\u30011\u30012\u30014\u548c8\u5c0f\u65f6\u5c0f\u9f20\u7684\u5f52\u4e00\u5316\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

(d) \u5c0f\u9f20\u63a5\u53d7P-CyFF-Gd\uff08I\uff09\u3001P-Cy-Gd\uff08II\uff09\u6216P-CyFF-Gd + Na3<\/sub>VO4<\/sub>\uff08III\uff09\u6ce8\u5c04\u540e\uff0c\u643aHeLa\u80bf\u7624\u5c0f\u9f20\u7684\u6700\u5927\u4fe1\u53f7\u589e\u5f3a\uff08% SE\uff09\uff1b<\/p>\n

(e) P-CyFF-Gd\uff08\u9ed1\u8272\uff09\u3001CyFF-Gd\uff08\u84dd\u8272\uff09\u548c\u80bf\u7624\u88c2\u89e3\u7269\uff08\u7ea2\u8272\uff09\u7684HPLC\u8ddf\u8e2a\uff1b<\/p>\n

(f) \u5728\u6ce8\u5c04\u5230\u5c0f\u9f20\u4f53\u51854\u5c0f\u65f6\u540e\uff0cHeLa\u80bf\u7624\u548c\u4e3b\u8981\u5668\u5b98\u4e2dP-CyFF-Gd\uff08\u7ea2\u8272\uff09\u6216P-Cy-Gd\uff08\u84dd\u8272\uff09\u7684\u751f\u7269\u5206\u5e03\u3002<\/p>\n

\u56fe5 \u539f\u4f4d\u809d\u80bf\u7624\u7684\u53cc\u6a21\u6001\u6210\u50cf\u548c\u8367\u5149\u5f15\u5bfc\u624b\u672f<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6b63\u5e38\u5c0f\u9f20\u548c\u539f\u4f4dHepG2\/Luc\u809d\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u7684\u5168\u8eab\u8367\u5149\uff08\u4e0b\uff09\u548c\u751f\u7269\u53d1\u5149\uff08\u4e0a\uff09\u6210\u50cf\uff1b<\/p>\n

(b) \u539f\u4f4dHepG2\/Luc\u809d\u80bf\u7624\u5f02\u79cd\u79fb\u690d\u5c0f\u9f20\u7684T<\/em>1<\/sub>\u52a0\u6743MR\u6210\u50cf\uff1b<\/p>\n

(c) \u5728\u809d\u810f\u76f4\u63a5\u55b7\u6d12P-CyFF-Gd\uff0810 \u03bcM\uff0930\u5206\u949f\u540e\uff0c\u6210\u50cf\u5f15\u5bfc\u624b\u672f\u5207\u9664\u539f\u4f4dHepG2\/Luc\u809d\u80bf\u7624\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aActivatable NIR Fluorescence\/MRI Bimodal Probes for in Vivo Imaging by Enzyme-Mediated Fluorogenic Reaction and Self-Assembly<\/a>\u00a0\u00a0(J. Am. Chem. Soc., 2019, DOI: 10.1021\/jacs.9b03649)<\/strong><\/p>\n

 <\/p>\n

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