{"id":179441,"date":"2019-07-10T06:30:12","date_gmt":"2019-07-09T22:30:12","guid":{"rendered":"\/\/m.iemloyee.com\/?p=179441"},"modified":"2019-07-09T11:33:47","modified_gmt":"2019-07-09T03:33:47","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e5%94%90%e6%9c%ac%e5%bf%a0%e9%99%a2%e5%a3%ab%e5%9b%a2%e9%98%9f-afm%e6%8a%a5%e9%81%93-%e6%b0%b4%e6%ba%b6%e6%80%a7aie%e6%8e%a2%e9%92%88%e7%94%a8%e4%ba%8e%e7%bc%ba","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=179441","title":{"rendered":"\u5510\u672c\u5fe0\u9662\u58eb\u56e2\u961f AFM\u62a5\u9053: \u6c34\u6eb6\u6027AIE\u63a2\u9488\u7528\u4e8e\u7f3a\u6c27\u68c0\u6d4b\u7684\u65b0\u7b56\u7565"},"content":{"rendered":"
\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n \u80bf\u7624\u7684\u65e9\u671f\u8bca\u65ad\u5bf9\u4e8e\u63d0\u9ad8\u764c\u75c7\u6cbb\u7597\u7684\u6210\u529f\u7387\u548c\u60a3\u8005\u7684\u751f\u5b58\u7387\u81f3\u5173\u91cd\u8981\u3002\u5bf9\u65e9\u671f\u80bf\u7624\u8fdb\u884c\u7075\u654f\u51c6\u786e\u7684\u65e0\u521b\u6210\u50cf\uff0c\u5c06\u6709\u52a9\u4e8e\u5916\u79d1\u533b\u751f\u91c7\u53d6\u53ca\u65f6\u6709\u6548\u7684\u9884\u9632\u548c\u6cbb\u7597\u63aa\u65bd\u3002\u4e0d\u540c\u4e8e\u4eba\u4f53\u6b63\u5e38\u7ec4\u7ec7\uff0c\u80bf\u7624\u75af\u72c2\u751f\u957f\u6d88\u8017\u7684\u6c27\u6c14\u5927\u5927\u8d85\u8fc7\u4e86\u5176\u8840\u7ba1\u4f9b\u7ed9\u80fd\u529b\uff0c\u4ece\u800c\u5bfc\u81f4\u80bf\u7624\u5fae\u73af\u5883\u5904\u4e8e\u7f3a\u6c27\u72b6\u6001\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u5bf9\u8fd9\u4e00\u7f3a\u6c27\u6027\u8d28\u7684\u68c0\u6d4b\u53ef\u4ee5\u5b9e\u73b0\u5bf9\u65e9\u671f\u5f62\u6210\u7684\u6216\u8005\u8f6c\u79fb\u6027\u80bf\u7624\u8fdb\u884c\u7cbe\u786e\u6210\u50cf\u3002\u5176\u4e2d\uff0c\u5f00\u53d1\u4f4e\u6c27\u54cd\u5e94\u6027\u7684\u5316\u5b66\u8367\u5149\u63a2\u9488\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u5f88\u6709\u524d\u666f\u7684\u5b9e\u73b0\u80bf\u7624\u65e9\u671f\u68c0\u6d4b\u7684\u65b9\u6cd5\u3002\u5177\u6709\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u7279\u6027\u7684\u8367\u5149\u5206\u5b50\uff08AIEgens\uff09\u662f\u4e00\u7c7b\u5916\u5f62\u4e3a\u87ba\u65cb\u6868\u72b6\u7684\u5206\u5b50\uff0cAIEgens\u5728\u805a\u96c6\u4f53\u6216\u56fa\u6001\u4e2d\u5177\u6709\u5f3a\u7684\u8367\u5149\uff0c\u800c\u5728\u6eb6\u6db2\u72b6\u6001\u4e0b\u7684\u8367\u5149\u5f3a\u5ea6\u5927\u5927\u51cf\u5f31\u3002\u57fa\u4e8eAIE\u7279\u6027\u8bbe\u8ba1\u7684\u8367\u5149\u63a2\u9488\u76ee\u524d\u5df2\u7ecf\u88ab\u591a\u4e2a\u8bfe\u9898\u7ec4\u62a5\u9053\uff0cAIE\u5206\u5b50\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\uff0c\u8f83\u597d\u7684\u6c34\u6eb6\u6027\u548c\u72ec\u7279\u7684\u8367\u5149\u70b9\u4eae\u673a\u5236\u4f7f\u5176\u8fd1\u5e74\u6765\u6210\u4e3a\u5206\u6790\u5316\u5b66\u9886\u57df\u7684\u4e00\u4e2a\u91cd\u8981\u5206\u652f\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7684\u5510\u672c\u5fe0\u9662\u58eb\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u7684\u7528\u4e8e\u7f3a\u6c27\u6210\u50cf\u7684AIE\u63a2\u9488\u3002\u7531\u4e8e\u6c2e\u6c27\u57fa\u56e2\u7684\u4e24\u6027\u79bb\u5b50\u6027\u8d28\uff0c\u6240\u8bbe\u8ba1\u7684\u56db\u82ef\u57fa\u4e59\u70ef\uff08TPE\uff09\u6c2e\u6c27\u5316\u7269\u5177\u6709\u826f\u597d\u7684\u6c34\u6eb6\u6027\u3002\u8fd9\u7c7b\u5206\u5b50\u5c55\u73b0\u51fa\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u7279\u6027\uff0c\u7531\u4e8e\u5206\u5b50\u8f6c\u5b50\u7684\u5267\u70c8\u8fd0\u52a8\uff0c\u5b83\u4eec\u5728\u6c34\u6eb6\u6db2\u4e2d\u5e76\u4e0d\u53d1\u5149\u3002\u5206\u5b50\u7684\u7535\u4e2d\u6027\u548c\u6c34\u5408\u4f5c\u7528\u4e5f\u8fdb\u4e00\u6b65\u907f\u514d\u4e86\u5176\u5728\u751f\u7269\u73af\u5883\u4e2d\u4e0e\u5e26\u7535\u6027\u7269\u8d28\uff08\u5c24\u5176\u662f\u86cb\u767d\uff09\u53d1\u751f\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u4ea7\u751f\u80cc\u666f\u8367\u5149\u4fe1\u53f7\u3002\u6240\u5408\u6210\u7684\u4e09\u79cd\u6c2e\u6c27\u5316\u7269\u53ef\u4ee5\u88ab\u4e9a\u94c1\u79bb\u5b50\u8fd8\u539f\u540c\u65f6\u5b8c\u6210\u4ece\u4eb2\u6c34\u5230\u758f\u6c34\u7684\u8f6c\u6362\uff0c\u7531\u6b64\u4ea7\u751f\u7684\u758f\u6c34\u6027\u805a\u96c6\u4f53\u9650\u5236\u4e86\u5206\u5b50\u5185\u8fd0\u52a8\uff0c\u4ece\u800c\u5f00\u542f\u4e86\u5b83\u4eec\u7684\u8367\u5149\u3002\u5728\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0c\u7ec6\u80de\u8fd8\u539f\u9176\uff08CYP450\uff09\u53ef\u4ee5\u9009\u62e9\u6027\u5730\u5207\u65adTPE-2E\u6c2e\u6c27\u5316\u7269\u4e2d\u7684N-O\u952e\uff0c\u4ece\u800c\u5b9e\u73b0\u70b9\u4eae\u578b\u7684\u7f3a\u6c27\u6210\u50cf\u3002\u603b\u4e4b\uff0c\u8be5\u7f3a\u6c27\u6210\u50cf\u7684\u65b0\u7b56\u7565\u5728\u80bf\u7624\u65e9\u671f\u8bca\u65ad\u4e2d\u5177\u6709\u5f88\u9ad8\u7684\u5e94\u7528\u4ef7\u503c\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cA New Strategy toward \u201cSimple\u201d Water-Soluble AIE Probes for Hypoxia Detection\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Funct. Mater.<\/strong>\u4e0a\u3002 \u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001\u6c2e\u6c27\u5316\u7269\u7684\u8bbe\u8ba1\u4e0e\u5408\u6210<\/strong> \uff08B\uff09TPE-2M\u548cTPE-2M\u6c2e\u6c27\u5316\u7269\u76841<\/sup>H NMR\u5149\u8c31\uff1b<\/p>\n \uff08C\uff09TPE-2M\u6c2e\u6c27\u5316\u7269\u7684\u5355\u6676\u7ed3\u6784\u3002<\/p>\n \u56fe\u4e8c\u3001\u6c2e\u6c27\u5316\u7269\u7684\u5149\u7269\u7406\u6027\u8d28<\/strong> \uff08D\uff09\u4e09\u79cd\u6c2e\u6c27\u5316\u7269\u76f8\u5bf9\u8367\u5149\u5f3a\u5ea6\uff08I\/I0<\/sub>\uff09\u4e0e\u6b63\u5df1\u70f7\u542b\u91cf\u7684\u5173\u7cfb\u56fe\uff1b<\/p>\n \uff08E\uff09TPE-2M\u6c2e\u6c27\u5316\u7269\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u548cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u5728\u4e8c\u6c2f\u7532\u70f7\u4e2d\u7684\u5438\u6536\u5149\u8c31\uff1b<\/p>\n \uff08F\uff09\u5728\u65e5\u5149\uff08\u9876\u90e8\uff09\u548c\u7d2b\u5916\u5149\uff08\u5e95\u90e8\uff09\u4e0b\u62cd\u6444\u7684\u56fa\u6001TPE-2E\u548cTPE-2E\u6c2e\u6c27\u5316\u7269\u7684\u7167\u7247\u3002<\/p>\n \u56fe\u4e09\u3001\u5bf9\u4e9a\u94c1\u79bb\u5b50\u7684\u8367\u5149\u54cd\u5e94<\/strong> \uff08B\uff09\u52a0\u5165\u4e9a\u94c1\u79bb\u5b50\u540e\uff0cTPE-2M\u6c2e\u6c27\u5316\u7269\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u548cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u7684\u8367\u5149\u53d8\u5316\u52a8\u529b\u5b66\u66f2\u7ebf\uff1b<\/p>\n \uff08C\uff09\u5728\u4e0d\u540c\u4e9a\u94c1\u79bb\u5b50\u6d53\u5ea6\u4e0b,TPE-2E\u6c2e\u6c27\u5316\u7269\u7684\u8367\u5149\u53d8\u5316\u52a8\u529b\u5b66\u66f2\u7ebf\uff1b<\/p>\n \uff08D\uff09\u6c2e\u6c27\u5316\u7269\u8fd8\u539f\u548cTMB\u6c27\u5316\u8fc7\u7a0b\u7684\u793a\u610f\u56fe\uff1b<\/p>\n \uff08E\uff09\u52a0\u51652\u00d710-3<\/sup> M (NH4<\/sub>)2<\/sub>Fe(SO4<\/sub>)2<\/sub>\u548c200\u00d710-6<\/sup> M TMB\u6216\u8005\u5355\u72ec\u52a0\u5165200\u00d710-6<\/sup> M TMB\u5b75\u80b2\u540e\uff0c200\u00d710-6<\/sup> M TPE-2M2F \u6c2e\u6c27\u5316\u7269\u7684\u5438\u5149\u5ea6\u53d8\u5316\uff1b<\/p>\n \uff08F\uff09\u52a0\u5165200\u00d710-6<\/sup> M TMB\u548c2\u00d710-3<\/sup> M (NH4<\/sub>)2<\/sub>Fe(SO4<\/sub>)2<\/sub>\u5171\u5b75\u80b2\u7684TPE-2M \u6c2e\u6c27\u5316\u7269\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u548cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u5728652 nm\u5904\u7684\u5438\u5149\u5ea6\u53d8\u5316\u52a8\u529b\u5b66\u66f2\u7ebf\u3002<\/p>\n \u56fe\u56db\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u7684\u8fd8\u539f\u4ea7\u7269\u5206\u6790<\/strong> \uff08B\uff09\u52a0\u516520\u00d710-3<\/sup> M\u7684(NH4<\/sub>)2<\/sub>Fe(SO4<\/sub>)2<\/sub>\u524d\u540e\uff0c\u5206\u6563\u5728\u6c34\u4e2d\u7684TPE-2E\u6c2e\u6c27\u5316\u7269\u53ca\u5176\u8fd8\u539f\u4ea7\u7269\u7684\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n \uff08C\uff09\u52a0\u516520\u00d710-3<\/sup> M (NH4<\/sub>)2<\/sub>Fe(SO4<\/sub>)2<\/sub>\u524d\u540e\uff0c2\u00d710-3<\/sup> M TPE-2E\u6c2e\u6c27\u5316\u7269\u6c34\u6eb6\u6db2\u53ca\u5176\u8fd8\u539f\u4ea7\u7269\u7684\u8367\u5149\u56fe\u7247\u3002<\/p>\n \u56fe\u4e94\u3001\u4f53\u5916\u7f3a\u6c27\u6210\u50cf<\/strong> \u56fe\u516d\u3001\u4e8c\u82ef\u57fa\u6c2f\u5316\u7898\u76d0\uff08DPI\uff09\u5bf9CYP450\u8fd8\u539f\u9176\u7684\u6291\u5236\u5b9e\u9a8c<\/strong> \u56fe\u4e03\u3001\u4e0e\u5c3c\u7f57\u7ea2\u7684\u5171\u67d3\u5b9e\u9a8c<\/strong> \u3010\u603b\u7ed3\u3011<\/strong><\/p>\n \u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u63d0\u51fa\u4e86\u4e00\u79cd\u5168\u65b0\u7684\u7b56\u7565\u7528\u4e8e\u8bbe\u8ba1\u6c34\u6eb6\u6027\u63a2\u9488\u8fdb\u800c\u5b9e\u73b0\u4f4e\u6c27\u8367\u5149\u6210\u50cf\u3002\u9996\u5148\uff0c\u672c\u6587\u4ee5\u4e00\u6761\u7b80\u5355\u7684\u5408\u6210\u8def\u7ebf\u83b7\u5f97\u4e86TPE-2M\u6c2e\u6c27\u5316\u7269\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u548cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u4e09\u79cd\u63a2\u9488\u5206\u5b50\u3002\u5177\u6709AIE\u6d3b\u6027\u7684TPE\u57fa\u56e2\u4e0e\u4e24\u6027\u6c2e\u6c27\u5b98\u80fd\u56e2\u7684\u7ed3\u5408\u4f7f\u8fd9\u4e9b\u6c2e\u6c27\u5316\u7269\u5728\u6eb6\u6db2\u72b6\u6001\u4e0b\u4e0d\u53d1\u5149\u3002\u52a0\u5165Fe2+<\/sup>\u540e\uff0c\u7531\u4e8e\u53d6\u4ee3\u57fa\u7684\u4e0d\u540c\uff0c\u8fd9\u7c7b\u6c2e\u6c27\u5316\u7269\u5448\u73b0\u4e0d\u540c\u901f\u7387\u7684\u8367\u5149\u54cd\u5e94\u3002\u901a\u8fc7\u7ec6\u80de\u6210\u50cf\u7814\u7a76\uff0c\u4f5c\u8005\u53d1\u73b0TPE-2E\u6c2e\u6c27\u5316\u7269\u5728HeLa\u7ec6\u80de\u4e2d\u8868\u73b0\u51fa\u968f\u6c27\u6c14\u6d53\u5ea6\u964d\u4f4e\u8367\u5149\u70b9\u4eae\u4e14\u4e0d\u65ad\u589e\u5f3a\u7684\u884c\u4e3a\u3002\u758f\u6c34\u7684TPE-2E\u6c2e\u6c27\u5316\u7269\u8fd8\u539f\u4ea7\u7269\u9009\u62e9\u6027\u5730\u805a\u96c6\u5728\u8102\u6ef4\u4e2d\u3002\u7531\u4e8eTPE\u6c2e\u6c27\u5316\u7269\u7684\u4f18\u5f02\u6027\u80fd\uff0c\u8be5\u5de5\u4f5c\u4e3a\u8bbe\u8ba1\u548c\u5408\u6210\u57fa\u4e8eAIEgens\u7684\u8bca\u65ad\u4f53\u7cfb\u63d0\u4f9b\u4e86\u4e00\u79cd\u65b0\u7684\u9014\u5f84\u3002<\/p>\n
\n \u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u4e3a\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u5316\u5b66\u7cfb\u7684\u535a\u58eb\u751f\u5f90\u660c\u6d3b\u548c\u5357\u65b9\u533b\u79d1\u5927\u5b66\u7684\u90b9\u822a\u535a\u58eb\u3002<\/strong><\/p>\n
<\/p>\n
\n
\uff08A\uff09\u6c2e\u6c27\u5316\u7269\u7684\u5408\u6210\u8def\u7ebf\uff1b<\/p>\n
\n
\uff08A-C\uff09TPE-2M\u6c2e\u6c27\u5316\u7269\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u548cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u5728\u4e0d\u540c\u4e8c\u6c2f\u7532\u70f7\/\u6b63\u5df1\u70f7\u6df7\u5408\u7269\u4e2d\u7684PL\u5149\u8c31\uff1b<\/p>\n
\n
\uff08A\uff09\u52a0\u5165100\u00d710-6<\/sup>M\u00a0 (NH4<\/sub>)2<\/sub>Fe(SO4<\/sub>)2<\/sub>\u540e\uff0cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u7684PL\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff1b<\/p>\n
\n
\uff08A\uff09\u52a0\u516520\u00d710-3<\/sup> M (NH4<\/sub>)2<\/sub>Fe(SO4<\/sub>)2<\/sub>\u540e\uff0c\u4eb2\u6c34\u6027\u7684TPE-2E\u6c2e\u6c27\u5316\u7269\u8f6c\u5316\u4e3a\u758f\u6c34\u6027\u7684TPE-2E\uff1b<\/p>\n
\n
TPE-2M\u6c2e\u6c27\u5316\u7269\u3001TPE-2E\u6c2e\u6c27\u5316\u7269\u548cTPE-2M2F\u6c2e\u6c27\u5316\u7269\u5728HeLa\u7ec6\u80de\u4e2d\u4e0d\u540c\u6c27\u6c14\u6761\u4ef6\u4e0b\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n
\n
\u5728\u4f4e\u6c27\u6761\u4ef6\u4e0b\uff0c\u7528TPE-2E\u6c2e\u6c27\u5316\u7269\u548c\u4e0d\u540cDPI\u6d53\u5ea6\u5b75\u80b23 h\u7684HeLa\u7ec6\u80de\u7684\u8367\u5149\u56fe\u50cf\u3002<\/p>\n
\n
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