{"id":178467,"date":"2019-06-21T08:29:03","date_gmt":"2019-06-21T00:29:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=178467"},"modified":"2019-06-21T08:29:03","modified_gmt":"2019-06-21T00:29:03","slug":"%e6%83%b3%e5%8f%91science%e5%90%97%ef%bc%9f%ef%bc%9a%e4%b8%8d%e5%a6%a8%e8%af%95%e8%af%95%e4%ba%b2%e6%a0%b8%e8%8a%b3%e7%83%83%e6%b0%9f%e5%8c%96%e7%ad%96%e7%95%a5","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=178467","title":{"rendered":"\u60f3\u53d1Science\u5417\uff1f\uff1a\u4e0d\u59a8\u8bd5\u8bd5\u4eb2\u6838\u82b3\u70c3\u6c1f\u5316\u7b56\u7565"},"content":{"rendered":"<p><strong><b>\u3010\u5f15\u8a00\u3011<\/b><\/strong><\/p>\n<p>\u6c1f-18\uff08<sup>18<\/sup>F\uff09\u662f\u653e\u5c04\u6027\u836f\u7269\u5de5\u4e1a\u4e2d\u6700\u91cd\u8981\u7684\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u4e4b\u4e00\uff0c\u56e0\u4e3a\u5b83\u5177\u6709\u76f8\u5bf9\u957f\u7684\u534a\u8870\u671f\uff08t<sub>1\/2<\/sub>\u00a0= 110 min\uff09\uff0c\u548c\u9ad8\u6548\u7684\u6b63\u7535\u5b50\u53d1\u5c04\u8870\u53d8\uff0897\uff05\uff09\u3002\u8fd9\u79cd\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u7684\u4e3b\u8981\u5e94\u7528\u5f62\u5f0f\u662f2-[<sup>18<\/sup>F]\u6c1f\u8131\u6c27\u8461\u8404\u7cd6\uff08[<sup>18<\/sup>F] FDG\uff09\uff0c\u7528\u4e8e\u80bf\u7624\u8bca\u65ad\u3001\u795e\u7ecf\u6210\u50cf\u548c\u7814\u7a76\u8461\u8404\u7cd6\u4ee3\u8c22\u3002\u8bb8\u591a\u5c0f\u5206\u5b50\u836f\u7269\u548c\u6cbb\u7597\u5242\u542b\u6709\u82b3\u9999\u65cf\u6216\u6742\u82b3\u65cf\u7cfb\u7edf\uff0c\u4ece\u800c\u4e3a\u5b89\u88c5\u7684\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u63d0\u4f9b\u4e86\u4e00\u4e2a\u5171\u540c\u7684\u6709\u673a\u4e9a\u57fa\uff0c\u4ee5\u4ea7\u751f\u5177\u6709\u6210\u50cf\u529f\u80fd\u7684\u653e\u5c04\u6027\u793a\u8e2a\u5242\u3002\u7279\u522b\u662f\uff0c\u7531\u4e8e\u82b3\u9999\u65cfC-H\u952e\u7684\u666e\u904d\u5b58\u5728\uff0c\u4ee5\u53caC(sp<sup>2<\/sup>) -F\u952e\u5728\u5c0f\u5206\u5b50\u6cbb\u7597\u5242\u548c\u63a2\u9488\u4e2d\u7684\u91cd\u8981\u6027\u65e5\u76ca\u589e\u52a0\uff0c\u4f7f\u5f97\u82b3\u70c3C-H\u76f4\u63a5\u8f6c\u5316\u4e3aC-18F\u952e\u662f\u7406\u60f3\u7684\u3002\u76ee\u524d\uff0c\u82b3\u70c3\u76f4\u63a5<sup>18<\/sup>F\u6c1f\u5316\u9700\u8981\u4f7f\u7528\u4eb2\u7535\u6c1f\u6e90\uff0c\u5176\u4e2d\u6700\u7b80\u5355\u7684\u662f[<sup>18<\/sup>F]F<sub>2<\/sub>\uff1b\u7136\u800c\uff0c\u8fd9\u79cd\u6c14\u4f53\u8bd5\u5242\u4e0e\u8bb8\u591a\u5e38\u89c1\u7684\u6709\u673a\u5b98\u80fd\u56e2\u4e0d\u76f8\u5bb9\u3002\u5927\u591a\u6570C-H\u5230C-F\u952e\u7684\u8f6c\u5316\u9700\u8981\u4eb2\u7535\u6c1f\u5316\u8bd5\u5242\uff0c\u5982N-\u6c1f\u82ef\u78fa\u9170\u4e9a\u80fa\uff08NFSI\uff09\u3002\u7136\u800c\uff0c\u7531\u4e8e[<sup>18<\/sup>F]F<sub>2<\/sub>\u5236\u5907\u4e86[<sup>18<\/sup>F]NFSI\uff0c\u4f7f\u5f97<sup>18<\/sup>F\u653e\u5c04\u6027\u6807\u8bb0\u7684\u6548\u7528\u964d\u4f4e\u3002\u56e0\u6b64\uff0c\u901a\u8fc7\u4eb2\u6838\u82b3\u70c3\u6c1f\u5316\u7b56\u7565\u5c06C-H\u76f4\u63a5\u8f6c\u5316\u4e3aC-<sup>18<\/sup>F\u952e\u7684\u65b9\u6cd5\u5177\u6709\u5f88\u9ad8\u7684\u5438\u5f15\u529b\uff0c\u56e0\u4e3a\u53ef\u4ee5\u7528\u9ad8\u6469\u5c14\u6d3b\u6027\u6c1f\u5316\u7269([<sup>18<\/sup>F]F<sup>\u2212<\/sup>)\u5408\u6210<sup>18<\/sup>F<sup>\u2212<\/sup>\u653e\u5c04\u6027\u6807\u8bb0\u7684\u836f\u7269\u3002<\/p>\n<p><strong><b>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/b><\/strong><\/p>\n<p>\u4eca\u65e5\uff0c\u5728<strong><b>\u5317\u5361\u7f57\u6765\u7eb3\u5927\u5b66\u6559\u5802\u5c71\u5206\u6821<\/b><\/strong><strong><b>David A. Nicewicz\u6559\u6388<\/b><\/strong>\u548c<strong><b>\u674e\u5b50\u535a<\/b><\/strong><strong><b>\u6559\u6388<\/b><\/strong><strong><b>\u56e2\u961f\uff08<\/b><\/strong><strong><b>\u5171\u540c<\/b><\/strong><strong><b>\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u5e26\u9886\u4e0b\uff0c\u5f00\u53d1\u4e86\u4e00\u79cd\u6e29\u548c\u7684\u65b9\u6cd5\uff0c\u5728\u84dd\u5149\u7167\u5c04\u4e0b\uff0c\u4f7f\u7528[<sup>18<\/sup>F]F-\u76d0\u548c\u6709\u673a\u5149\u81f4\u6c27\u5316\u8fd8\u539f\u50ac\u5316\u82b3\u9999\u65cfC-H\u952e\u8fdb\u884c\u6c1f-18(<sup>18<\/sup>F)-\u6c1f\u5316\u3002\u8be5\u7b56\u7565\u88ab\u5e7f\u6cdb\u5e94\u7528\u4e8e\u5408\u6210\u591a\u79cd<sup>18<\/sup>F\u6807\u8bb0\u7684\u82b3\u70c3\u548c\u6742\u82b3\u70c3\uff0c\u5305\u62ec\u836f\u7269\u5316\u5408\u7269\u3002\u8fd9\u4e9b\u4ea7\u54c1\u53ef\u4ee5\u4f5c\u4e3a\u8bca\u65ad\u5242\u6216\u63d0\u4f9b\u6709\u5173\u6807\u8bb0\u5e95\u7269\u5728\u4f53\u5185\u7684\u5173\u952e\u4fe1\u606f\uff0c\u5982\u5728\u5c0f\u9f20\u7684\u521d\u6b65\u793a\u8e2a\u7814\u7a76\u3002\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a<strong><b>\u201c<\/b><\/strong><strong><b>Direct arene C\u2013H fluorination with <\/b><\/strong><strong><sup><b>18<\/b><\/sup><\/strong><strong><b>F<\/b><\/strong><strong><sup><b>\u2212<\/b><\/sup><\/strong><strong><b>\u00a0via organic photoredox catalysis<\/b><\/strong><strong><b>\u201d<\/b><\/strong>\u53d1\u8868\u5728\u4e86<strong><b>Science<\/b><\/strong>\u4e0a\u3002<\/p>\n<p><strong><b>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n<p><strong><b>\u56fe1<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u7528\u4e8ePET\u7814\u7a76\u7684<\/b><\/strong><strong><sup><b>18<\/b><\/sup><\/strong><strong><b>F\u6807\u8bb0\u82b3\u70c3\u7684\u6709\u673a\u5149\u81f4\u6c27\u5316\u8fd8\u539f\u6cd5<\/b><\/strong><strong><b><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178468\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F1.large_.jpg\" alt=\"\" width=\"600\" height=\"112\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F1.large_.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F1.large_-300x56.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/b><\/strong><\/p>\n<p><strong><b>\u56fe2<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u82b3\u70c318F-\u6c1f\u5316<\/b><\/strong><strong><b>\u7684<\/b><\/strong><strong><b>\u53cd\u5e94\u8303\u56f4<\/b><\/strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178469\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F2.large_.jpg\" alt=\"\" width=\"600\" height=\"698\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F2.large_.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F2.large_-258x300.jpg 258w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u56fe3<\/b><\/strong><strong><b>\u00a0<\/b><\/strong><strong><b>\u901a\u8fc7\u82b3\u70c3C-H\u653e\u5c04\u6027\u6c1f\u5316\u5408\u6210\u7684PET\u793a\u8e2a\u5242<\/b><\/strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-178470\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F3.large_.jpg\" alt=\"\" width=\"600\" height=\"230\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F3.large_.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/06\/F3.large_-300x115.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong><b>\u6587\u732e\u94fe\u63a5\uff1a<\/b><\/strong><a href=\"https:\/\/science.sciencemag.org\/content\/364\/6446\/1170?tdsourcetag=s_pcqq_aiomsg\" target=\"_blank\" rel=\"noopener\"><u>Direct arene C\u2013H fluorination with <\/u><u><sup>18<\/sup><\/u><u>F<\/u><u><sup>\u2212<\/sup><\/u><u>\u00a0via organic photoredox catalysis<\/u><\/a>\uff08Science\uff0c2019\uff0cDOI:10.1126\/science.aav7019\uff09<\/p>\n<p>\u672c\u6587\u7531<strong><b>\u6728\u6587\u97ec<\/b><\/strong>\u7ffb\u8bd1\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u6c1f-18\uff0818F\uff09\u662f\u653e\u5c04\u6027\u836f\u7269\u5de5\u4e1a\u4e2d\u6700\u91cd\u8981\u7684\u653e\u5c04\u6027\u540c\u4f4d\u7d20\u4e4b\u4e00\uff0c\u56e0\u4e3a\u5b83\u5177\u6709\u76f8\u5bf9\u957f\u7684\u534a\u8870\u671f\uff08t1\/2\u00a0= 110 min\uff09\uff0c\u548c\u9ad8\u6548\u7684\u6b63\u7535\u5b50\u53d1\u5c04\u8870\u53d8\uff0897\uff05&#8230;<\/p>\n","protected":false},"author":2109,"featured_media":178468,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2704,4062,4063],"class_list":["post-178467","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-2704","tag-4062","tag-4063"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/178467"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/2109"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=178467"}],"version-history":[{"count":4,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/178467\/revisions"}],"predecessor-version":[{"id":178474,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/178467\/revisions\/178474"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/178468"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=178467"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=178467"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=178467"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}