{"id":177774,"date":"2019-06-20T06:30:39","date_gmt":"2019-06-19T22:30:39","guid":{"rendered":"\/\/m.iemloyee.com\/?p=177774"},"modified":"2019-06-19T19:36:45","modified_gmt":"2019-06-19T11:36:45","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e4%b8%ad%e5%9b%bd%e7%a7%91%e5%ad%a6%e9%99%a2%e5%8c%96%e5%ad%a6%e7%a0%94%e7%a9%b6%e6%89%80%e4%b8%ad%e5%9b%bd%e5%86%9c%e5%a4%a7angew-chem-int-ed","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=177774","title":{"rendered":"\u4e2d\u79d1\u9662\u5316\u5b66\u6240&\u4e2d\u56fd\u519c\u5927Angew. Chem. Int. Ed.\uff1a\u4e0e\u8840\u7ea2\u86cb\u767d\u5171\u4ef7\u7ed3\u5408\u7684\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u81ea\u53d1\u5149\u3001\u81ea\u4f9b\u6c27\u7684\u5149\u52a8\u529b\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n

\u5149\u52a8\u529b\u7597\u6cd5\u88ab\u89c6\u4e3a\u6cbb\u7597\u5305\u62ec\u764c\u75c7\u5728\u5185\u7684\u4f17\u591a\u75be\u75c5\u7684\u65b0\u9896\u7684\u4e34\u5e8a\u65b9\u6cd5\uff0c\u7531\u4e8e\u5176\u65e0\u521b\u6027\u548c\u7a7a\u95f4\u9009\u62e9\u6027\u9ad8\u800c\u5438\u5f15\u4e86\u5927\u91cf\u7814\u7a76\u8005\u7684\u5174\u8da3\u3002\u5149\u654f\u5242\u3001\u5149\u6e90\u548c\u5206\u5b50\u6c27\u662f\u5149\u52a8\u529b\u7597\u6cd5\u7684\u4e09\u79cd\u4e3b\u8981\u7ec4\u5206\u3002\u5149\u654f\u5242\u5728\u5149\u7684\u7167\u5c04\u4e0b\u88ab\u6fc0\u6d3b\u5230\u6fc0\u53d1\u5355\u91cd\u6001\uff0c\u6fc0\u53d1\u5355\u91cd\u6001\u901a\u8fc7\u7cfb\u95f4\u7a9c\u8d8a\u88ab\u6fc0\u6d3b\u5230\u6fc0\u53d1\u4e09\u91cd\u6001\u3002\u63a5\u7740\uff0c\u5149\u654f\u5242\u5c06\u80fd\u91cf\u4f20\u9012\u7ed9\u5206\u5b50\u6c27\u7684\u4e09\u91cd\u6001\uff0c\u751f\u6210\u80fd\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u81ea\u7531\u57fa\u548c\/\u6216\u8005\u6d3b\u6027\u6c27\u3002\u5c3d\u7ba1\u5149\u52a8\u529b\u7597\u6cd5\u5728\u764c\u75c7\u6cbb\u7597\u4e0a\u9887\u5177\u524d\u666f\uff0c\u4f46\u5b83\u5728\u4e34\u5e8a\u7684\u5e94\u7528\u4e0a\u4f9d\u7136\u5177\u6709\u5c40\u9650\u6027\u3002\u4f8b\u5982\uff0c\u7531\u4e8e\u5149\u7684\u7a7f\u900f\u6df1\u5ea6\u548c\u4f20\u8f93\u6548\u7387\u6709\u9650\uff0c\u5149\u52a8\u529b\u7597\u6cd5\u5bf9\u5916\u90e8\u5149\u6e90\u7684\u9700\u6c42\u963b\u788d\u4e86\u5176\u5728\u6df1\u5c42\u7ec4\u7ec7\u6cbb\u7597\u7684\u5e94\u7528\uff0c\u4ee5\u53ca\u7531\u4e8e\u5b9e\u4f53\u80bf\u7624\u7684\u5fae\u73af\u5883\u901a\u5e38\u542b\u6c27\u91cf\u4f4e\uff0c\u5206\u5b50\u6c27\u9650\u5236\u4e86\u5149\u52a8\u529b\u7597\u6cd5\u5bf9\u5b9e\u4f53\u80bf\u7624\u7684\u7597\u6548\u3002\u4ece\u8fd9\u4e2a\u89d2\u5ea6\u6765\u770b\uff0c\u5f00\u53d1\u65b0\u578b\u7684\u5149\u52a8\u529b\u7597\u6cd5\u4f53\u7cfb\u6765\u540c\u65f6\u9632\u6b62\u8fd9\u4e24\u4e2a\u95ee\u9898\u662f\u975e\u5e38\u6709\u610f\u4e49\u7684\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u4e2d\u56fd\u79d1\u5b66\u9662\u5316\u5b66\u7814\u7a76\u6240<\/strong>\u7684\u738b\u6811\u7814\u7a76\u5458<\/strong>\u3001\u5218\u793c\u5175\u7814\u7a76\u5458<\/strong>\u4ee5\u53ca\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66<\/strong>\u7684\u4efb\u96ea\u82b9\u6559\u6388<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u62a5\u9053\u4e86\u57fa\u4e8e\u8840\u7ea2\u86cb\u767d\uff08Hb\uff09\u5171\u4ef7\u7ed3\u5408\u7684\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\uff0c\u5e76\u7528\u4e8e\u9ad8\u6548\u7684\u5149\u52a8\u529b\u7597\u6cd5\u7684\u4f53\u7cfb\uff0c\u8fd9\u79cd\u4f53\u7cfb\u80fd\u540c\u65f6\u81ea\u53d1\u5149\u548c\u81ea\u4f9b\u6c27\u3002\u5728\u8fd9\u79cd\u4f53\u7cfb\u4e2d\uff0cHb\u4f5c\u4e3a\u50ac\u5316\u5242\uff0c\u540c\u65f6\u63d0\u4f9b\u6c27\u6c14\u3002\u5171\u8f6d\u805a\u5408\u7269MEH-PPV\u7eb3\u7c73\u9897\u7c92\u80fd\u901a\u8fc7\u5316\u5b66\u53d1\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\u5438\u6536\u9c81\u7c73\u8bfa\u7684\u5316\u5b66\u53d1\u5149\uff0c\u7136\u540e\u654f\u5316\u8840\u7ea2\u86cb\u767d\u63d0\u4f9b\u7684\u6c27\u6c14\u6765\u4ea7\u751f\u80fd\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u6d3b\u6027\u6c27\u3002\u800c\u4e14\uff0c\u8fd9\u79cd\u4f53\u7cfb\u80fd\u901a\u8fc7\u524d\u836f\u7b56\u7565\u7528\u4e8e\u6297\u764c\u836f\u7269\u7684\u53ef\u63a7\u91ca\u653e\u6765\u540c\u65f6\u8fdb\u884c\u5316\u7597\u3002\u8fd9\u79cd\u4f53\u7cfb\u4e0d\u9700\u8981\u7a7f\u900f\u6df1\u5ea6\u6709\u9650\u7684\u5916\u90e8\u5149\u6e90\uff0c\u4ee5\u53ca\u907f\u514d\u4e86\u5206\u5b50\u6c27\u5728\u542b\u6c27\u91cf\u4f4e\u7684\u73af\u5883\u7684\u4e0d\u8db3\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201cHemoglobin<\/strong>\u2010Linked Conjugated Polymer Nanoparticles for Self<\/strong>\u2010Luminescing and Oxygen Self<\/strong>\u2010Supplying Phototherapy<\/strong>\u201d\u4e3a\u9898\u4e8e\u8fd1\u65e5\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb<\/strong>\u3011<\/p>\n

Scheme 1.<\/p>\n

\"\"<\/p>\n

a)Hb-NPs@liposome\u7684\u5236\u5907\u793a\u610f\u56fe<\/p>\n

b)\u7528\u4e8e\u5149\u52a8\u529b\u7597\u6cd5\u7684\u81ea\u53d1\u5149\u548c\u81ea\u4f9b\u6c27\u7684\u4f53\u7cfb\u7684\u793a\u610f\u56fe<\/p>\n

Figure 1. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0\"\"a)MEH-PPV\u7684\u6807\u51c6\u5316\u5438\u6536\u5149\u8c31\u548c\u9c81\u7c73\u8bfa\u7684\u53d1\u5149\u5149\u8c31<\/p>\n

b)MEH-PPV\u7eb3\u7c73\u9897\u7c92\u7684\u5c3a\u5bf8\u5206\u5e03; \u63d2\u56fe\u662fMEH-PPV\u7eb3\u7c73\u9897\u7c92\u7684\u4ee3\u8868\u6027\u7684TEM\u56fe<\/p>\n

c) \u3001d)\u7eb3\u7c73\u9897\u7c92\u548cHb\u5171\u4ef7\u7ed3\u5408\u524d\u540e\u7684\u6d41\u4f53\u529b\u5b66\u76f4\u5f84\uff08\u56fec\uff09\u548c ZETA\u7535\u4f4d\uff08\u56fed\uff09<\/p>\n

e)Hb-NPs@liposome\u7684\u5c3a\u5bf8\u5206\u5e03; \u63d2\u56fe\u662f Hb-NPs@liposome\u7684\u4ee3\u8868\u6027\u7684TEM\u56fe
\n f)oxy-Hb-NPs@liposome\u548c oxy-Hb-NPs\u7684\u6c27\u89e3\u79bb\u66f2\u7ebf<\/p>\n

Figure 2.<\/p>\n

\"\"<\/p>\n

a)\u9c81\u7c73\u8bfa\u5728\u5206\u522b\u540c\u65f6\u5b58\u5728Hb\u3001Hb\u548c\u7eb3\u7c73\u9897\u7c92\u7684\u6df7\u5408\u7269\u4ee5\u53caHb-NPs\u7684\u6761\u4ef6\u4e0b\u7684\u53d1\u5149\u5149\u8c31\uff1b\u63d2\u56fe\u662f MEH-PPV\u7eb3\u7c73\u9897\u7c92\u7684\u8367\u5149\u5f3a\u5ea6\u56fe\u7684\u653e\u5927\u56fe<\/p>\n

b)\u6d3b\u6027\u6c27\u4ea7\u7387\u7684\u8bc4\u4ef7<\/p>\n

c)\u6d3b\u6027\u6c27\u4ea7\u7387\u7684\u8bc4\u4ef7<\/p>\n

Figure 3.<\/p>\n

\"\"<\/p>\n

a)Hb-NPs@liposome\u6cbb\u75976h\u548c12h\u540e\u7684\u6d77\u62c9\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe<\/p>\n

b)Hb-NPs@liposome\u6f5c\u4f0f12h\u540e\u7684\u6d77\u62c9\u7ec6\u80de\u7684\u5171\u805a\u7126\u8367\u5149\u56fe\u00a0 \u00a0 \u00a0<\/p>\n

c)\u6d77\u62c9\u7ec6\u80de\u5b58\u6d3b\u7387<\/p>\n

Figure 4.<\/p>\n

\"\"a)\u524d\u836f\u7684\u91ca\u653e\u673a\u7406<\/p>\n

b)\u524d\u836f\uff08\u9ed1\u7ebf\uff09\u3001\u52a0\u4e86S(luminol, H2<\/sub>O2<\/sub>)\u540e\u7684\u524d\u836f\uff08\u84dd\u7ebf\uff09\u3001\u52a0\u4e86S(luminol, H2<\/sub>O2<\/sub>)\/oxy-Hb-NPs\u540e\u7684\u524d\u836f\uff08\u7ea2\u7ebf\uff09\u3001\u6c2e\u82a5\uff08\u7eff\u7ebf\uff09\u76841<\/sup>H NMR\u56fe<\/p>\n

c)HCT-8\u7ec6\u80de\u7684\u5b58\u6d3b\u7387<\/p>\n

\u3010\u603b\u7ed3<\/strong>\u3011\u00a0 \u00a0<\/p>\n

\u7814\u7a76\u56e2\u961f\u6210\u529f\u5730\u57fa\u4e8e\u80fd\u81ea\u53d1\u5149\u548c\u81ea\u4f9b\u6c27\u3001\u4e0e\u8840\u7ea2\u86cb\u767d\u5171\u4ef7\u7ed3\u5408\u7684\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u6784\u5efa\u4e86\u7528\u4e8e\u9ad8\u6548\u7684\u5149\u52a8\u529b\u7597\u6cd5\u7684\u65b0\u4f53\u7cfb\u3002\u8840\u7ea2\u86cb\u767d\u662f\u8fd9\u4e2a\u4f53\u7cfb\u7684\u50ac\u5316\u5242\uff0c\u540c\u65f6\u4f9b\u5e94\u5206\u5b50\u6c27\u3002\u901a\u8fc7\u5c06\u8840\u7ea2\u86cb\u767d\u4e0e\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u5171\u4ef7\u7ed3\u5408\uff0c\u8fd9\u4e2a\u4f53\u7cfb\u4ea7\u751f\u4e86\u66f4\u591a\u7684\u6d3b\u6027\u6c27\uff0c\u63d0\u9ad8\u5bf9\u764c\u7ec6\u80de\u7684\u6740\u4f24\u6548\u679c\u3002\u8be5\u4f53\u7cfb\u901a\u8fc7\u5c06\u5316\u5b66\u53d1\u5149\u548c\u81ea\u4f9b\u6c27\u76f8\u7ed3\u5408\u6765\u7528\u4e8e\u9ad8\u6548\u7684\u5149\u52a8\u529b\u7597\u6cd5\u3002\u800c\u4e14\uff0c\u8be5\u4f53\u7cfb\u80fd\u901a\u8fc7\u524d\u836f\u7b56\u7565\u7528\u4e8e\u6297\u764c\u836f\u7269\u7684\u53ef\u63a7\u91ca\u653e\u6765\u540c\u65f6\u8fdb\u884c\u5316\u7597\u3002\u53e6\u5916\uff0c\u8be5\u4f53\u7cfb\u4e0d\u9700\u8981\u7a7f\u900f\u6df1\u5ea6\u6709\u9650\u7684\u5916\u90e8\u5149\u6e90\uff0c\u4ee5\u53ca\u907f\u514d\u4e86\u5206\u5b50\u6c27\u5728\u542b\u6c27\u91cf\u4f4e\u7684\u73af\u5883\u7684\u4e0d\u8db3\u3002\u8fd9\u9879\u5de5\u4f5c\u4e3a\u667a\u80fd\u7684\u3001\u591a\u529f\u80fd\u7684\u7eb3\u7c73\u5e73\u53f0\u7528\u4e8e\u9ad8\u6548\u7684\u5149\u7597\u6cd5\u63d0\u4f9b\u4e86\u65b0\u7b56\u7565\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aHemoglobin\u2010Linked Conjugated Polymer Nanoparticles for Self\u2010Luminescing and Oxygen Self\u2010Supplying Phototherapy<\/a>\uff08<\/strong>An<\/em>gew. Chem. Int. Ed.\uff0c2019\uff0c<\/em>DOI\uff1a10.1002\/anie.201905884\uff09<\/strong>\u00a0 \u00a0<\/p>\n

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