{"id":177636,"date":"2019-06-17T06:30:56","date_gmt":"2019-06-16T22:30:56","guid":{"rendered":"\/\/m.iemloyee.com\/?p=177636"},"modified":"2019-06-16T19:48:33","modified_gmt":"2019-06-16T11:48:33","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e4%b8%ad%e5%9b%bd%e5%86%9c%e4%b8%9a%e5%a4%a7%e5%ad%a6%e8%b5%b5%e5%b9%bf%e5%8d%8e%e6%95%99%e6%8e%88nano-lett-%e7%94%b1%e6%b7%80%e7%b2%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=177636","title":{"rendered":"\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u8d75\u5e7f\u534e\u6559\u6388Nano Lett.:\u7531\u6dc0\u7c89\u6837\u86cb\u767d\u57fa\u5e8f\u63d0\u4f9b\u7684\u758f\u6c34\u4f5c\u7528\u9a71\u52a8\u7684\u4e8c\u7ef4\u548c\u4e09\u7ef4\u86cb\u767d\u8d28\u7eb3\u7c73\u7f51\u7edc"},"content":{"rendered":"
\u3010\u5f15\u8a00<\/strong>\u3011<\/p>\n \u86cb\u767d\u8d28\u5177\u6709\u81ea\u6211\u7ec4\u88c5\u7684\u80fd\u529b\uff0c\u5728\u8fdb\u5316\u8fc7\u7a0b\u4e2d\u8d4b\u4e88\u81ea\u8eab\u591a\u6837\u7684\u529f\u80fd\u3002\u86cb\u767d\u8d28\u7684\u5468\u671f\u6027\u7ec4\u88c5\u53ef\u4ee5\u5f62\u6210\u4e00\u7ef4\uff081D\uff09\u5fae\u7ba1\uff0c\u4e8c\u7ef4\uff082D\uff09\u7ec6\u83cc\u8868\u9762\u5c42\u548c\u4e09\u7ef4\uff083D\uff09\u75c5\u6bd2\u8863\u58f3\u3002\u7531\u4e8e\u5176\u590d\u6742\u7684\u62d3\u6251\u7ed3\u6784\u548c\u5e7f\u6cdb\u7684\u529f\u80fd\uff0c\u86cb\u767d\u8d28\u53ef\u6210\u4e3a\u5236\u5907\u53ef\u63a7\u81ea\u7ec4\u88c5\u6750\u6599\u7684\u6784\u5efa\u5355\u5143\u3002\u4e0eDNA\u548c\u80bd\u4f5c\u4e3a\u6784\u5efa\u5355\u5143\u76f8\u6bd4\uff0c\u7531\u4e8e\u86cb\u767d\u8d28\u8868\u9762\u53ca\u5176\u4f5c\u7528\u529b\u7684\u4e0d\u5747\u4e00\u6027\uff0c\u9020\u6210\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u8bbe\u8ba1\u7684\u56f0\u96be\u3002\u76ee\u524d\uff0c\u91c7\u7528\u4e86\u51e0\u79cd\u7b56\u7565\u6765\u5b9e\u73b0\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\uff0c\u5305\u62ec\u57fa\u4e8e\u5bf9\u79f0\u878d\u5408\u7684\u81ea\u7ec4\u88c5\uff0c\u5229\u7528\u91d1\u5c5e\u914d\u4f4d\uff0c\u5f15\u5165DNA\u6216\u80bd\u7684\u4ea4\u8054\u5be1\u805a\u4f53\uff0c\u57fa\u56e0\u878d\u5408\u65b9\u6cd5\u548c\u86cb\u767d\u8d28\u8ba1\u7b97\u673a\u8f85\u52a9\u8bbe\u8ba1\u3002\u4f17\u6240\u5468\u77e5\uff0c\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\u5982\u6c22\u952e\uff0c\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u548c\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u662f\u5929\u7136\u86cb\u767d\u8d28\u7ed3\u6784\u5f62\u6210\u7684\u4e3b\u8981\u539f\u56e0\u3002\u4f46\u8fc4\u4eca\u4e3a\u6b62\uff0c\u901a\u8fc7\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\uff0c\u7279\u522b\u662f\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u6784\u5efa\u4eba\u5de5\u5206\u5c42\u86cb\u767d\u8d28\u7eb3\u7c73\u7ed3\u6784\uff0c\u4e0e\u901a\u8fc7\u5171\u4ef7\u952e\uff08\u4e8c\u786b\u952e\u548c\u91d1\u5c5e\u914d\u4f4d\u952e\uff09\u76f8\u6bd4\uff0c\u6210\u529f\u7387\u8f83\u4f4e\uff0c\u4ecd\u6709\u5f85\u63a2\u7d22\u3002<\/p>\n \u4e3a\u4e86\u5efa\u7acb\u4e00\u79cd\u7531\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u9a71\u52a8\u7684\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u7684\u6709\u6548\u65b9\u6cd5\uff0c\u5927\u81ea\u7136\u63d0\u4f9b\u4e86\u8bb8\u591a\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u7684\u4f8b\u5b50\u3002\u4f8b\u5982\u96c6\u4e2d\u5728\u661f\u5f62\u80f6\u8d28\u7ec6\u80de\u672b\u7aef\u6c34\u901a\u9053\u86cb\u767d-4\u7684\u65b9\u9635\u6392\u5e03\uff0c\u4ee5\u53ca\u808c\u8089\u548c\u5fc3\u810f\u7ec4\u7ec7\u4e2d\u7684\u95f4\u9699\u7ed3\u6591\u5757\u3002\u9664\u4e86\u5728\u4e0a\u8ff0\u6b63\u5e38\u6761\u4ef6\u4e0b\u53d1\u751f\u7684\u81ea\u7ec4\u88c5\u5916\uff0c\u86cb\u767d\u8d28\u7ec4\u88c5\u8fd8\u51fa\u73b0\u5728\u75be\u75c5\u4e2d\uff0c\u4f8b\u5982\u9570\u72b6\u7ec6\u80de\u6027\u8d2b\u8840\u4e2d\u7684\u8840\u7ea2\u86cb\u767d\u53d8\u4f53\u7684\u7ea4\u7ef4\u675f\u548c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\u7684\u03b2\u6dc0\u7c89\u6837\u86cb\u767d42\uff08A\u03b242<\/sub>\uff09\u6c89\u79ef\u548ctau\u86cb\u767d\u7ea4\u7ef4\u7f20\u7ed3\u3002\u8fd9\u4e9b\u7ea4\u7ef4\u7f20\u7ed3\u7684\u5f62\u6210\u5f62\u6210\u901a\u5e38\u7531\u6dc0\u7c89\u6837\u86cb\u767d\u57fa\u5e8f\uff08AM\uff09\u9a71\u52a8\uff0c\u4f8b\u5982\u7531II\u578b\u7cd6\u5c3f\u75c5\u4e2d\u7684\u201cNFGAIL\u201d\u57fa\u5e8f\u8bf1\u5bfc\u7684\u80f0\u5c9b\u6dc0\u7c89\u6837\u86cb\u767d\u591a\u80bd\u7ea4\u7ef4\u7f20\u7ed3\uff0c\u963f\u5c14\u8328\u6d77\u9ed8\u75c5\u4e2d\u7684\u201cKLVFFAE\u201d\u548c\u201cGLMVG\u201d\u57fa\u5e8f\u8bf1\u5bfc\u7684A\u03b2\u6c89\u79ef\uff0c\u6162\u6027\u708e\u75c7\u6dc0\u7c89\u6837\u53d8\u6027\u75c5\u4e2d\u201cSFFSFLGEAFD\u201d\u57fa\u5e8f\u8bf1\u5bfc\u7684\u8840\u6e05\u6dc0\u7c89\u6837\u86cb\u767d\u7684\u5f62\u6210\uff0c\u4ee5\u53ca\u7532\u72b6\u817a\u764c\u4e2d\u201cDFNKF\u201d\u57fa\u5e8f\u8bf1\u5bfc\u7684\u964d\u9499\u7d20\u7ea4\u7ef4\u7f20\u7ed3\u3002 AM\u5df2\u88ab\u7528\u4e8e\u6784\u5efa\u80bd\u6216\u86cb\u767d\u8d28\u7684\u7ea4\u7ef4\u72b6\u81ea\u7ec4\u88c5\uff0c\u7eb3\u7c73\u7ebf\u7684\u5236\u9020\u548c\u5176\u4ed6\u7c7b\u578b\u7684\u5206\u5b50\u5de5\u7a0b\u3002\u7136\u800c\uff0c\u8fc4\u4eca\u4e3a\u6b62\uff0c\u5c1a\u672a\u63a2\u7d22\u4f7f\u7528AM\u6784\u5efa\u86cb\u767d\u8d28\u9ad8\u5ea6\u6709\u5e8f\u76842D\u81f33D\u81ea\u7ec4\u88c5\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n \u8fd1\u65e5\uff0c\u4e2d\u56fd\u519c\u4e1a\u5927\u5b66\u8d75\u5e7f\u534e\u6559\u6388\u8bfe\u9898\u7ec4<\/strong>\u901a\u8fc7\u5229\u7528\u201cGLMVG\u201d\u57fa\u5e8f\u8d21\u732e\u7684\u758f\u6c34\u529b\uff0c\u6211\u4eec\u5efa\u7acb\u4e86\u4e00\u79cd\u6709\u6548\u7684\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u7b56\u7565\u6765\u6784\u5efa\u4e8c\u7ef4\uff082D\uff09\u6216\u4e09\u7ef4\uff083D\uff09\u86cb\u767d\u8d28\u7eb3\u7c73\u7b3c\u9635\u5217\u3002\u94c1\u86cb\u767d\u5177\u6709\u9ad8\u5ea6\u7684\u5bf9\u79f0\u7ed3\u6784\uff0c\u5b83\u67096\u4e2a\u4e8c\u91cd\u5bf9\u79f0\u8f74\uff0c4\u4e2a\u4e09\u91cd\u5bf9\u79f0\u8f74\u548c3\u4e2a\u56db\u91cd\u5bf9\u79f0\u8f74\uff0c\u5c06A\u03b242<\/sub>\u4e2d\u7684\u201cGLMVG\u201d\u57fa\u5e8f\u5ac1\u63a5\u5230\u9760\u8fd1\u94c1\u86cb\u767d\u56db\u91cd\u8f74(C4<\/sub><\/em>) \u901a\u9053\u7684\u5916\u8868\u9762\u4e0a\uff0c\u94c1\u86cb\u767d\uff08HF-GMG\uff09\u9996\u5148\u81ea\u7ec4\u88c5\u5f62\u6210\u6709\u5e8f\u76842D\u6392\u5217\uff0c\u8fd9\u4e9b\u4e8c\u7ef4\u7ec4\u88c5\u518d\u76f8\u4e92\u4f5c\u7528\uff0c\u9010\u6b65\u53e0\u52a0\u6700\u7ec8\u4ea7\u751f\u9ad8\u5ea6\u6709\u5e8f\u76843D\u6392\u5217\u3002\u91cd\u8981\u7684\u662f\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u7ec4\u88c5\u4f53\u7684\u53ef\u9006\u6027\u548c\u5f62\u6210\u901f\u7387\u53ef\u4ee5\u901a\u8fc7pH\u8c03\u8282\u3002\u8fd9\u9879\u5de5\u4f5c\u4e3a\u7cbe\u786e\u63a7\u52362D\u62163D\u86cb\u767d\u8d28\u81ea\u81ea\u7ec4\u88c5\u63d0\u4f9b\u4e86\u4ece\u5934\u8bbe\u8ba1\u7684\u7b56\u7565\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201cDesigned Two- and Three-Dimensional Protein Nanocage Networks Driven by Hydrophobic Interactions Contributed by Amyloidogenic Motifs<\/strong>\u201d\u53d1\u8868\u5728Nano Lett.<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n Figure 1.<\/strong> \u6784\u5efa\u6dc0\u7c89\u6837\u86cb\u767d\u57fa\u5e8f\u4ecb\u5bfc\u7684<\/strong>HF-GMG<\/strong>\u81ea\u7ec4\u88c5\u793a\u610f\u56fe<\/strong><\/p>\n (a).\u94c1\u86cb\u767d\u56db\u91cd\u8f74\u901a\u9053\u7ed3\u6784\u793a\u610f\u56fe<\/p>\n (b).HF-GMG\u53ef\u9006\u81ea\u7ec4\u88c5\u7684\u793a\u610f\u56fe\uff0c\u5176\u4e2d\u6765\u81eaA\u03b242\u7684\u201c33<\/sub>GLMVG37<\/sub>\u201d\u57fa\u5e8f\u88ab\u5ac1\u63a5\u5230\u9760\u8fd1\u94c1\u86cb\u767d\u56db\u91cd\u8f74\u901a\u9053\u7684\u5916\u8868\u9762\u4e0a<\/p>\n Figure 2.HF-GMG 2D<\/strong>\u9635\u5217\u7684\u8868\u5f81<\/strong><\/p>\n (a).\u86cb\u767d\u8d28\u7eb3\u7c73\u7b3c2D\u9635\u5217\u7684TEM\u89c6\u56fe<\/p>\n (b,c).2D\u9635\u5217\u7684\u9ad8\u500d\u653e\u5927TEM\u89c6\u56fe<\/p>\n (d).\u5feb\u901f\u5085\u91cc\u53f6\u53d8\u6362\uff08FFT\uff09\u56fe\u50cf<\/p>\n (e). FFT\u8f6c\u6362\u56fe\u50cf<\/p>\n (f).\u57fa\u4e8e\u56fee\u7684\u7ed3\u6784\u91cd\u5efa\u56fe<\/p>\n Figure 3.<\/strong>\u901a\u8fc7\u539f\u5b50\u529b\u663e\u5fae\u955c\uff08<\/strong>AFM<\/strong>\uff09\u8868\u5f81<\/strong>2D<\/strong>\u9635\u5217<\/strong><\/p>\n Figure 4.HF-GMG 3D<\/strong>\u7684\u548c\u5f62\u6210\u8fc7\u7a0b<\/strong><\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u5728\u8fd9\u9879\u5de5\u4f5c\u4e2d\uff0c\u53d7A\u03b242<\/sub>\u805a\u96c6\u7684\u542f\u53d1\uff0c\u4f5c\u8005\u5229\u7528\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u4f5c\u4e3a\u9a71\u52a8\u529b\u4e0e\u86cb\u767d\u8d28\u5bf9\u79f0\u6027\u76f8\u7ed3\u5408\u6765\u6784\u5efa\u86cb\u767d\u8d28\u7eb3\u7c73\u7b3c\u9635\u5217\uff0c\u63d0\u4f9b\u4e86\u8c03\u63a7\u86cb\u767d\u8d28\u81ea\u7ec4\u88c5\u7684\u6709\u6548\u3001\u7b80\u4fbf\u65b9\u6848\u3002\u6839\u636e\u8fd9\u4e2a\u7b56\u7565\uff0c\u53ef\u4ee5\u901a\u8fc7\u201c\u81ea\u4e0b\u800c\u4e0a\u201d\u7684\u7b56\u7565\u4ee5\u53ef\u9884\u6d4b\u7684\u65b9\u5f0f\u751f\u6210\u9ad8\u5ea6\u6709\u5e8f\u76842D\u548c3D\u86cb\u767d\u8d28\u7eb3\u7c73\u7b3c\u9635\u5217\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0c\u901a\u8fc7\u6539\u53d8\u6eb6\u6db2pH\u6216\u53cd\u5e94\u65f6\u95f4\uff0c\u53ef\u4ee5\u5bb9\u6613\u5730\u8c03\u8282\u8fd9\u79cd\u9ad8\u5ea6\u6709\u5e8f\u76842D\u548c3D\u94c1\u86cb\u767d\u7eb3\u7c73\u7b3c\u9635\u5217\u7684\u5f62\u6210\u4ee5\u53ca\u8fd9\u4e24\u79cd\u4e0d\u540c\u9635\u5217\u4e4b\u95f4\u7684\u8f6c\u6362\u3002\u9664\u4e86\u6765\u81eaA\u03b242<\/sub>\u7684\u201cGLMVG\u201d\u57fa\u5e8f\u4e4b\u5916\uff0c\u6b63\u5e38\u6216\u75be\u75c5\u53d1\u751f\u6761\u4ef6\u4e0b\u7684\u5176\u4ed6AM\u4e5f\u53ef\u4ee5\u5ac1\u63a5\u5230\u86cb\u767d\u8d28\u7684\u5916\u8868\u9762\u4e0a\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u86cb\u767d\u8d28\u5de5\u7a0b\u7b56\u7565\u539f\u5219\u4e0a\u53ef\u4ee5\u5e94\u7528\u4e8e\u5177\u6709\u9ad8\u5bf9\u79f0\u6027\u7684\u5176\u4ed6\u86cb\u767d\u8d28\uff0c\u4f8b\u5982Dps\uff0c\u75c5\u6bd2\u8863\u58f3\u548c\u5176\u4ed6\u4eba\u5de5\u86cb\u767d\u8d28\u7eb3\u7c73\u7b3c\u6216\u7eb3\u7c73\u73af\uff0c\u4ece\u800c\u4ea7\u751f\u5404\u79cd\u5177\u6709\u4e0d\u540c\u7279\u6027\u7684\u9ad8\u5ea6\u6709\u5e8f\u7684\u81ea\u7ec4\u88c5\u3002<\/p>\n<\/p>\n
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