{"id":177377,"date":"2019-06-13T06:30:22","date_gmt":"2019-06-12T22:30:22","guid":{"rendered":"\/\/m.iemloyee.com\/?p=177377"},"modified":"2019-06-12T09:54:16","modified_gmt":"2019-06-12T01:54:16","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91-acc-chem-res-%ef%bc%9a%e4%ba%86%e8%a7%a3%e7%ba%b3%e7%b1%b3%e8%8d%af%e7%89%a9%e4%b8%8e%e7%94%9f%e7%89%a9%e7%95%8c%e9%9d%a2%e7%9a%84%e7%9b%b8%e4%ba%92","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=177377","title":{"rendered":"Acc. Chem. Res.\uff1a\u4e86\u89e3\u7eb3\u7c73\u836f\u7269\u4e0e\u751f\u7269\u754c\u9762\u7684\u76f8\u4e92\u4f5c\u7528"},"content":{"rendered":"

\u3010\u7814\u7a76\u80cc\u666f\u3011<\/strong><\/p>\n

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\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u671f\uff0c\u56fd\u5bb6\u7eb3\u7c73\u79d1\u5b66\u4e2d\u5fc3\u9648\u6625\u82f1\u7814\u7a76\u5458\u56e2\u961f<\/strong>\u5168\u9762\u7efc\u8ff0\u4e86\u8fd1\u5e74\u6765\u7eb3\u7c73\u836f\u7269\u7eb3\u7c73-\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u7814\u7a76\u8fdb\u5c55\uff0c\u91cd\u70b9\u4ecb\u7ecd\u4e86\u7eb3\u7c73\u836f\u7269-\u751f\u7269\u754c\u9762\u7684\u9a71\u52a8\u529b\u548c\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\uff0c\u8fd9\u5df2\u88ab\u516c\u8ba4\u4e3a\u8c03\u63a7\u7eb3\u7c73\u836f\u7269\u529f\u80fd\u548c\u6bd2\u6027\u7684\u4e3b\u8981\u56e0\u7d20\u3002\u9996\u5148\uff0c\u4f5c\u8005\u6df1\u5165\u4e86\u89e3\u5851\u9020\u4e0d\u540c\u7eb3\u7c73\u751f\u7269\u754c\u9762\uff08\u5305\u62ec\u86cb\u767d\u8d28\uff0c\u7ec6\u80de\u819c\u548c\u751f\u7269\u6d41\u4f53\uff09\u7684\u9a71\u52a8\u529b\uff0c\u4f8b\u5982\u758f\u6c34\u3001\u9759\u7535\u3001\u6c22\u952e\u3001\u5206\u5b50\u8bc6\u522b\u3001\u91d1\u5c5e\u914d\u4f4d\u548c\u7acb\u4f53\u9009\u62e9\u6027\u76f8\u4e92\u4f5c\u7528\u3002\u7eb3\u7c73\u9897\u7c92\u548c\u751f\u7269\u5206\u5b50\u7684\u7406\u5316\u6027\u8d28\u5404\u4e0d\u76f8\u540c\uff0c\u5bfc\u81f4\u86cb\u767d\u8d28\u7684\u7ed3\u6784\u91cd\u7ec4\u3001\u529f\u80fd\u969c\u788d\u548c\u751f\u7269\u6d3b\u6027\u4e27\u5931\uff1b\u76f8\u5e94\u7684\uff0cENMs\u7684\u8868\u9762\u6027\u8d28\u3001\u751f\u7269\u5b66\u529f\u80fd\u3001\u7ec6\u80de\u5185\u6444\u53d6\u9014\u5f84\u548c\u547d\u8fd0\u4e5f\u53d7\u5230\u5f71\u54cd\u3002\u5176\u6b21\uff0c\u5728\u8fd9\u4e9b\u9a71\u52a8\u529b\u7684\u4f5c\u7528\u4e0b\uff0c\u5229\u7528\u4e0e\u6d3b\u6027\u6c27(ROS)\u3001\u6297\u6c27\u5316\u5242\u3001\u8868\u9762\u5438\u9644\u5206\u5b50\u548c\u6c27\u5316\u8fd8\u539f\u9176\u5173\u952e\u6d3b\u6027\u57fa\u56e2\u7684\u56db\u79cd\u6c27\u5316\u8fd8\u539f\u76f8\u4e92\u4f5c\u7528\uff0c\u6765\u8c03\u8282\u7ec6\u80de\u5185\u6c27\u5316\u8fd8\u539f\u5e73\u8861\u5e76\u6784\u5efa\u534f\u540c\u7eb3\u7c73\u836f\u7269\u4ee5\u5bf9\u6297\u7ec6\u83cc\u548c\u764c\u75c7\u3002\u7eb3\u7c73\u836f\u7269\u8bbe\u8ba1\u6d89\u53ca\u4e09\u79cd\u7535\u5b50\u4f20\u9012\u673a\u5236\uff0c\u5305\u62ec\u76f4\u63a5\u7535\u5b50\u6ce8\u5165\u3001\u8868\u9762\u5438\u9644\u5206\u5b50\u4ecb\u5bfc\u548c\u8f90\u5c04\u8bf1\u5bfc\u8fc7\u7a0b\u3002\u6700\u540e\uff0c\u4f5c\u8005\u8ba8\u8bba\u4e86\u5f71\u54cd\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u56e0\u7d20\uff0c\u5e76\u63d0\u51fa\u4e86\u76f8\u5e94\u7684\u7b56\u7565\u6765\u64cd\u7eb5\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u63a8\u8fdb\u7eb3\u7c73\u533b\u5b66\u8bbe\u8ba1\u3002\u8be5\u6210\u679c\u8fd1\u65e5\u4ee5\u9898\u4e3a\u201cThe Nano\u2212Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions<\/strong>\u201d\u53d1\u8868\u5728\u77e5\u540d\u7efc\u8ff0Acc. Chem. Res.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\uff1aENMs\u4e0e\u751f\u7269\u5206\u5b50\u7684\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n ENMs\u5728\u751f\u7269\u5206\u5b50\u5b58\u5728\u4e0b\u4f1a\u9047\u5230\u591a\u79cd\u76f8\u4e92\u4f5c\u7528\uff0c\u5305\u62ec\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u3001\u6c22\u952e\u3001\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\u3001\u914d\u4f53-\u53d7\u4f53\u76f8\u4e92\u4f5c\u7528\u3001\u7acb\u4f53\u9009\u62e9\u6027\u76f8\u4e92\u4f5c\u7528\u3001\u914d\u4f4d\u548c\u819c\u66f2\u7387\u6548\u5e94\u3002<\/p>\n

\u56fe\u4e8c\uff1aENMs\u4e0e\u86cb\u767d\u8d28\u6216\u7ec6\u80de\u819c\u754c\u9762\u7684\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n \u63a7\u5236ENM\u4e0e\u86cb\u767d\u8d28\u6216\u7ec6\u80de\u819c\u4e4b\u95f4\u754c\u9762\u76f8\u4e92\u4f5c\u7528\u7684\u4e3b\u8981\u9a71\u52a8\u529b\uff0c\u5305\u62ec\uff08A\uff09\u758f\u6c34\u76f8\u4e92\u4f5c\u7528\uff0c\uff08B\uff09\u76d0\u6865\uff0c\uff08C\uff09\u7acb\u4f53\u9009\u62e9\u6027\u76f8\u4e92\u4f5c\u7528\uff0c\uff08D\uff09\u91d1\u5c5e-\u914d\u4f53\u914d\u4f4d\uff0c\uff08E\uff09\u9759\u7535\u76f8\u4e92\u4f5c\u7528\u548c\uff08F\uff09\u6c22\u952e\u3002<\/p>\n

\u56fe\u4e09\uff1a\u7ec6\u80de\u5185ENMs\u4ea7\u751f\u548c\u6e05\u9664ROS\u7684\u673a\u5236<\/strong>
\n \"\"
\n \u4e3b\u8981\u8fc7\u7a0b\u4e3a\uff1a\uff081\uff09\u7ec6\u80de\u5185\u8d85\u6c27\u9634\u79bb\u5b50\u7684\u4ea7\u751f\u3002\uff082\uff09\u901a\u8fc7SOD\u5c06\u8d85\u6c27\u5316\u7269\u8f6c\u5316\u4e3aH2O2\u548c\uff083\uff09\u901a\u8fc7\u8fd8\u539f\u5242\u548c\u6c27\u5316\u8fd8\u539f\u9176\uff08\u4f8b\u5982\uff1a\u8fc7\u6c27\u5316\u6c22\u9176\uff09\u6e05\u9664\u7ec6\u80de\u5185ROS\u3002\uff084\uff09\u901a\u8fc7\u8f90\u5c04\u3001\u7f3a\u6c27\u6216\u5176\u4ed6\u7269\u8d28\u7684\u523a\u6fc0\u4ea7\u751fROS\u3002\uff085\uff09\u901a\u8fc7ENMs\u6e05\u9664ROS\u6216\u6291\u5236ROS\u4ea7\u751f\u3002\uff086\uff09ENMs\u4e0e\u8fd8\u539f\u7269\u8d28\u7684\u53cd\u5e94\u6216\u901a\u8fc7H2O2\u50ac\u5316\u751f\u6210ROS\u3002<\/p>\n

\u56fe\u56db\uff1a\u5316\u5b66\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u5f71\u54cd\u7eb3\u7c73\u2014\u751f\u7269\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n \uff08A\uff09\u7ec6\u80de\u5185ROS\u8f6c\u5316\u548c\u91d1\u5c5e\u9176\u50ac\u5316\u7684ROS\u6c27\u5316\u8fd8\u539f\u5173\u7cfb\u3002
\n \uff08B\uff09ENM\u901a\u8fc7\u4e0e\u6c27\u5316\u8fd8\u539f\u5242\u6216\u5206\u5b50\u7684\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u4f5c\u4e3aROS \/ RNS\u4fc3\u6c27\u5316\u5242\u6216\u6297\u6c27\u5316\u5242\u7684\u56db\u79cd\u9014\u5f84\u7684\u793a\u610f\u56fe\uff1a\uff08i\uff09\u81ea\u7531\u57fa\u6d3b\u6027\u7269\u8d28\uff1b\uff08ii\uff09\u6e38\u79bb\u4e2d\u6027\u5206\u5b50\uff1b\uff08iii\uff09\u6297\u6c27\u5316\u751f\u7269\u5206\u5b50\u548c\uff08iv\uff09\u6c27\u5316\u8fd8\u539f\u9176\u7684\u5173\u952e\u6d3b\u6027\u57fa\u56e2\u3002<\/p>\n

\u56fe\u4e94\uff1a\u76f4\u63a5\u7535\u5b50\u6ce8\u5165\u7684\u7eb3\u7c73\u751f\u7269\u754c\u9762\u6c27\u5316\u8fd8\u539f\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n \uff08A\uff09ENMs\u7528\u4f5cROS\/RNS\u6e05\u9664\u5242\u7684\u793a\u610f\u56fe\u3002
\n \uff08B\uff09Pd\u7eb3\u7c73\u9897\u7c92\u7684TEM\u56fe\u50cf\u3002
\n \uff08C\uff09\u663e\u793aCAT \/ SOD\u9176\u6d3b\u6027\u7684Pd\u7eb3\u7c73\u9897\u7c92\u7684ESR\u5149\u8c31\u3002
\n \uff08D\uff09Pd\u7eb3\u7c73\u6676\u4f53\u51cf\u5c11\u5bf9\u751f\u7269\u5206\u5b50\uff08a\uff0c\u8102\u8d28; b\uff0c\u86cb\u767d\u8d28; c\uff0cDNA\uff09\u7684\u635f\u5bb3\u3002
\n \uff08E\uff09Pd\u7eb3\u7c73\u6676\u4f53\u964d\u4f4e\u4e86\u6c27\u5316\u5e94\u6fc0\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

\u56fe\u516d\uff1a\u8868\u9762\u5438\u9644\u5206\u5b50\u4ecb\u5bfc\u7535\u5b50\u8f6c\u79fb\u7684\u7eb3\u7c73\u751f\u7269\u754c\u9762\u6c27\u5316\u8fd8\u539f\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n \uff08A\uff09ENMs\u7528\u4f5cROS\/RNS\u53d1\u751f\u5668\u7684\u793a\u610f\u56fe\u3002
\n \uff08B\uff09Pd\u7eb3\u7c73\u9897\u7c92\u76f8\u5e94\u5904\u7406\u540e\u7684ROS\u6c34\u5e73\u3002
\n \uff08C\uff09\u76f8\u5e94\u5904\u7406\u540e\u7ec6\u83cc\u5b58\u6d3b\u7684\u767e\u5206\u6bd4\u3002
\n \uff08D\uff09\u901a\u8fc7SEM\u89c2\u5bdfPd\u7eb3\u7c73\u9897\u7c92\u5904\u7406\u7684\u7ec6\u83cc\u5f62\u6001\u53d8\u5316\u3002<\/p>\n

\u56fe\u4e03\uff1a\u8f90\u5c04\u8bf1\u5bfc\u7535\u5b50\u8f6c\u79fb\u7684\u7eb3\u7c73\u751f\u7269\u754c\u9762\u6c27\u5316\u8fd8\u539f\u76f8\u4e92\u4f5c\u7528<\/strong>
\n \"\"
\n \uff08A\uff09\u7eb3\u7c73\u751f\u7269\u754c\u9762\u5904\u8f90\u5c04\u8bf1\u5bfc\u7684\u7535\u5b50\u8f6c\u79fb\u8fc7\u7a0b\u793a\u610f\u56fe\u3002
\n \uff08B\uff09\u8bbe\u8ba1\u7528\u4e8e\u88c5\u8f7dDOX\u4f5c\u4e3aMCF-7\/ADR\u7ec6\u80de\u5904\u7406\u7684\u534f\u540c\u5e73\u53f0\u7684HCSs\u3002
\n \uff08C\uff09HCSs\u7684DOX\u8d1f\u8f7d\u80fd\u529b\u548cTEM\u6210\u50cf\u3002
\n \uff08D\uff09\u6240\u793a\u5236\u5242\u7684ESR\u5149\u8c31\u3002
\n \uff08E\uff09\u901a\u8fc7NIR\u7167\u5c04\u7684\u7ec6\u80de\u5185\u5206\u5e03\u548cDOX\u91ca\u653e\u3002
\n \uff08F\uff09\u7ec6\u80de\u4e2dHCSs\u7684\u5206\u5e03\uff08a\uff09\u7ec6\u80de\u5185\u79ef\u7d2f\uff0c\uff08b\uff09\u5171\u805a\u7126\u6210\u50cf\uff0c\u548c\uff08c\u548cd\uff09TEM\u6210\u50cf\u3002<\/p>\n

\u56fe\u516b\uff1a\u5f71\u54cdENMs\u6c27\u5316\u8fd8\u539f\u6027\u8d28\u7684\u56e0\u7d20<\/strong>
\n \"\"
\n \uff08A\uff09ENMs\u7684\u6c27\u5316\u8fd8\u539f\u76f8\u5173\u539f\u5b50\u7684\u4f4d\u7f6e\u793a\u610f\u56fe\u548c\u751f\u7269\u6d3b\u6027\u6c27\u5316\u8fd8\u539f\u5bf9\u7684\u6c27\u5316\u8fd8\u539f\u7535\u4f4d\u3002
\n \uff08B-F\uff09\u5f62\u72b6\u3001\u6676\u9762\u3001\u7f3a\u9677\u3001\u7167\u5c04\u548cpH\u5bf9\u6c27\u5316\u8fd8\u539f\u6027\u8d28\u7684\u5f71\u54cd\u3002<\/p>\n

\u3010\u603b\u7ed3\u5c55\u671b\u3011<\/strong><\/p>\n

ENMs\u662f\u975e\u5e38\u6709\u524d\u666f\u7684\u751f\u7269\u533b\u5b66\u6750\u6599\uff0c\u5176\u4e2d\u4e34\u5e8a\u5b89\u5168\u6709\u6548\u7684\u7eb3\u7c73\u836f\u7269\u7684\u7cbe\u786e\u8bbe\u8ba1\u4ecd\u7136\u975e\u5e38\u9700\u8981\u3002\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u603b\u7ed3\u4e86\u4ece\u9a71\u52a8\u529b\u548c\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u7684\u89d2\u5ea6\u63a2\u8ba8\u7eb3\u7c73\u836f\u7269\u4e0e\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u6700\u65b0\u6210\u679c\uff0c\u589e\u52a0\u4e86\u5bf9\u5f3a\u5f31\u7684\u975e\u5171\u4ef7\u76f8\u4e92\u4f5c\u7528\u4ee5\u53ca\u7eb3\u7c73\u751f\u7269\u754c\u9762\u4e0a\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\u7684\u7406\u89e3\u548c\u8ba4\u8bc6\uff0c\u63d0\u4f9b\u4e86\u64cd\u7eb5\u8868\u9762\u5316\u5b66\u548c\u7eb3\u7c73\u86cb\u767d\u51a0\u76f8\u5173\u9a71\u52a8\u529b\u7684\u6709\u4ef7\u503c\u7684\u4fe1\u606f\uff0c\u5e2e\u52a9\u7406\u89e3ROS\u751f\u6210\u6240\u4ea7\u751f\u7684\u6bd2\u6027\u673a\u5236\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8fd8\u8ba8\u8bba\u4e86\u5f71\u54cd\u7eb3\u7c73-\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u56e0\u7d20\uff0c\u5e76\u63d0\u51fa\u4e86\u76f8\u5e94\u7684\u7b56\u7565\u6765\u64cd\u7eb5\u7eb3\u7c73-\u751f\u7269\u76f8\u4e92\u4f5c\u7528\uff0c\u4ee5\u5b9e\u73b0\u5b89\u5168\u8bbe\u8ba1\u7684\u7eb3\u7c73\u836f\u7269\u3002\u867d\u7136\u5728\u5f00\u53d1\u7528\u4e8e\u5bf9\u6297\u764c\u75c7\u548c\u7ec6\u83cc\u7684\u667a\u80fd\u7eb3\u7c73\u836f\u7269\u65b9\u9762\u53d6\u5f97\u4e86\u663e\u7740\u8fdb\u5c55\uff0c\u4f46\u8fd9\u4e00\u65b0\u5174\u9886\u57df\u4ecd\u5728\u56f4\u7ed5\u8bb8\u591a\u6311\u6218\u53d1\u5c55\uff1a
\n \uff081\uff09\u5355\u4e2a\u7eb3\u7c73\u9897\u7c92\u8868\u9762\u7279\u6027\uff08\u4f8b\u5982\uff0c\u7535\u5b50\u7ed3\u6784\u3001\u6d3b\u6027\u90e8\u4f4d\u3001\u5206\u5e03\u548c\u8868\u9762\u63a5\u679d\u65b9\u5411\uff09\u662f\u5f02\u8d28\u7684\uff0c\u9700\u8981\u5728\u4f7f\u7528\u524d\u6e05\u695a\u5730\u8fdb\u884c\u5206\u6790\u548c\u8868\u5f81\u3002
\n \uff082\uff09\u7eb3\u7c73\u6750\u6599\u7684\u7406\u5316\u6027\u8d28\u4e0e\u529f\u80fd\u548c\u6bd2\u6027\u4e4b\u95f4\u7684\u5b9a\u91cf\u5173\u7cfb\u5c1a\u4e0d\u5b8c\u5168\u6e05\u695a\u3002
\n \uff083\uff09\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u8fc7\u7a0b\u7684\u52a8\u6001\u3001\u539f\u4f4d\u3001\u5b9e\u65f6\u3001\u8d85\u9ad8\u901f\u548c\u9ad8\u5206\u8fa8\u7387\u534f\u540c\u7814\u7a76\uff0c\u6240\u9700\u7684\u5148\u8fdb\u6280\u672f\u548c\u8bbe\u5907\u4ecd\u7136\u7f3a\u4e4f\u3002
\n \uff084\uff09\u4e0e\u7eb3\u7c73\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u76f8\u5173\u7684\u5404\u79cd\u7269\u7406\u5316\u5b66\u56e0\u7d20\u7684\u7ec4\u5408\uff0c\u5728\u7eb3\u7c73\u533b\u5b66\u8bbe\u8ba1\u4e2d\u4ea7\u751f\u4e86\u5927\u91cf\u7684\u53ef\u80fd\u6027\u3002
\n \u56e0\u6b64\uff0c\u901a\u8fc7\u4e86\u89e3\u548c\u9884\u6d4b\u7eb3\u7c73-\u751f\u7269\u76f8\u4e92\u4f5c\u7528\u7684\u57fa\u672c\u673a\u5236\uff0c\u4ee5\u53ca\u7eb3\u7c73\u5b9a\u91cf\u7ed3\u6784-\u6d3b\u6027\u5173\u7cfb(nanoQSAR)\u65b9\u6cd5\u548c\u7eb3\u7c73\u4fe1\u606f\u5b66\uff0c\u9ad8\u901a\u91cf\u7b5b\u9009\u548c\u8ba1\u7b97\u673a\u6a21\u62df\u65b9\u6cd5\u5c06\u4fc3\u8fdb\u7eb3\u7c73\u836f\u7269\u7684\u53d1\u5c55\uff0c\u4ece\u800c\u52a0\u901f\u6f5c\u5728\u7684\u5b89\u5168\u6709\u6548\u914d\u65b9\u7684\u9009\u62e9\u3002\u4f5c\u8005\u8ba4\u4e3a\u8fd9\u4e9b\u969c\u788d\u5c06\u5f88\u5feb\u88ab\u514b\u670d\uff0c\u4ece\u800c\u66f4\u5168\u9762\u5730\u63cf\u8ff0\u7eb3\u7c73- \u751f\u7269\u4e4b\u95f4\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u5e76\u5c06\u7eb3\u7c73\u533b\u5b66\u5e26\u5165\u4e0b\u4e00\u4e2a\u9636\u6bb5\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aThe Nano\u2013Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions<\/a> (Acc. Chem. Res.<\/em>, 2019<\/strong>, DOI: 10.1021\/acs.accounts.9b00126)<\/p>\n

 <\/p>\n

1. \u56e2\u961f\u4ecb\u7ecd\uff1b2.\u56e2\u961f\u5728\u8be5\u9886\u57df\u7684\u5de5\u4f5c\u6c47\u603b\uff1b3.\u76f8\u5173\u4f18\u8d28\u6587\u732e\u63a8\u8350\uff1a<\/strong><\/p>\n

1. \u56e2\u961f\u4ecb\u7ecd<\/p>\n

\u672c\u8bfe\u9898\u7ec4\u5efa\u4e8e2006\u5e746\u6708\uff0c\u96b6\u5c5e\u4e8e\u4e2d\u79d1\u9662\u7eb3\u7c73\u751f\u7269\u6548\u5e94\u4e0e\u5b89\u5168\u6027\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff0c\u7531\u7814\u7a76\u5458\u3001\u526f\u7814\u7a76\u5458\uff0c\u9ad8\u7ea7\u5de5\u7a0b\u5e08\u3001\u52a9\u7406\u7814\u7a76\u5458\u53ca\u535a\u58eb\u540e\u3001\u535a\u58eb\u751f\u3001\u7855\u58eb\u751f\u3001\u8054\u5408\u57f9\u517b\u5b66\u751f\u6784\u6210\u3002
\n \u672c\u8bfe\u9898\u7ec4\u5148\u540e\u627f\u62c5\u79d1\u6280\u90e8\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u7eb3\u7c73\u4e13\u9879\u3001973\u9879\u76ee\u8bfe\u9898\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6b27\u76df\u5730\u5e73\u7ebf2020\u9879\u76ee\u3001\u6b27\u76df\u7b2c\u516d\u3001\u7b2c\u4e03\u6846\u67b6\u8ba1\u5212(EU-FP6&FP7)\u3001\u56fd\u9645\u539f\u5b50\u80fd\u673a\u6784\u534f\u8c03\u7814\u7a76\u8ba1\u5212(IAEA)\u7b49\u591a\u9879\u56fd\u5185\u4e0e\u56fd\u9645\u5408\u4f5c\u9879\u76ee\u3002\u5728\u56fd\u9645\u91cd\u8981\u671f\u520a\u53d1\u8868\u8bba\u6587200\u4f59\u7bc7\uff0c\u4e2d\u56fd\u6388\u6743\u4e13\u522918\u9879\uff0c\u56fd\u9645\u6388\u6743\u4e13\u52291\u9879\u3002\u8bfe\u9898\u7ec4\u957f\u9648\u6625\u82f1\u7814\u7a76\u5458\u4e8e2018\u5e74\u83b7\u201c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u4e8c\u7b49\u5956\u201d\uff0c2017\u5e74\u88ab\u8bc4\u4e3a\u4e2d\u56fd\u79d1\u5b66\u9662\u7b2c\u4e94\u5c4a\u201c\u5341\u5927\u6770\u51fa\u5987\u5973\u201d \uff0c2014\u5e74\u83b7\u4e2d\u56fd\u9752\u5e74\u5973\u79d1\u5b66\u5bb6\u5956\uff0c\u591a\u6b21\u5165\u9009\u5168\u7403\u9ad8\u5f15\u7528\u79d1\u5b66\u5bb6\uff0c2011\u5e74\u83b7\u201c\u4e2d\u56fd\u6807\u51c6\u5316\u6770\u51fa\u4eba\u7269\u2014\u521b\u65b0\u4eba\u7269\u5956\u201d\uff0c2012\u5e74\u83b7\u201c\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u4e8c\u7b49\u5956(2)\u201d\u30022018\u5e74\u5f53\u9009\u4e9a\u6d32\u6bd2\u7406\u5b66\u4f1a\u79d8\u4e66\u957f\u3002\u8bfe\u9898\u7ec4\u5185\u4f18\u97521\u4eba\uff0c\u5b66\u751f\u8363\u83b7\u56fd\u5bb6\u5956\u5b66\u91d15\u4eba\uff0c\u6731\u674e\u6708\u534e\u59561\u4eba\uff0c\u4f18\u79c0\u6bd5\u4e1a\u751f1\u4eba\uff0c\u4f18\u79c0\u5b66\u751f\u6807\u51753\u4eba\uff0c2017\u5e74\u8bfa\u8d1d\u5c14\u5956\u83b7\u5f97\u8005\u5927\u4f1a\u4e2d\u56fd\u53c2\u4f1a\u4ee3\u88681\u4eba\u3002
\n 2. \u56e2\u961f\u5728\u8be5\u9886\u57df\u7684\u5de5\u4f5c\u6c47\u603b<\/p>\n

\u56e2\u961f\u9488\u5bf9\u7eb3\u7c73\u6750\u6599\u751f\u7269\u6548\u5e94\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u7684\u7814\u7a76\u3002\u6211\u4eec\u53d1\u73b0\u8840\u6db2\u86cb\u767d\u5206\u5b50\u5728\u7eb3\u7c73\u6750\u6599\u8868\u9762\u7684\u5438\u9644\u548c\u8c03\u7406\u4f5c\u7528\uff0c\u662f\u8c03\u63a7\u5176\u751f\u7269\u533b\u5b66\u7279\u6027\u4e0e\u529f\u80fd\u7684\u5173\u952e\u4e4b\u4e00\u3002\u7eb3\u7c73\u86cb\u767d\u51a0\u5f62\u6210\u53ca\u4e0e\u751f\u7269\u5206\u5b50\u76f8\u4e92\u4f5c\u7528\u53d7\u5230\u7eb3\u7c73\u6750\u6599\u3001\u751f\u7269\u5206\u5b50\u7406\u5316\u7279\u6027\u7684\u5f71\u54cd1\u3002\u540c\u65f6\uff0c\u6211\u4eec\u5229\u7528\u540c\u6b65\u8f90\u5c04\u6280\u672f\u53ca\u7406\u8bba\u6a21\u62df\u7814\u7a76\u4e86\u7eb3\u7c73\u6750\u6599\u4e0e\u751f\u7269\u5206\u5b50\u4f5c\u7528\u7684\u673a\u5236\u3001\u65b9\u5f0f\u53ca\u5f71\u54cd\u56e0\u7d202\u3002<\/p>\n

1. Rong Cai, Chunying Chen*. The Crown and the Scepter: Roles of the Protein Corona in Nanomedicine. Advanced Materials, 2018, 1805740.
\n 2. Xinyi Wang, Xiaofeng Wang, Xuan Bai , Liang Yan, Tao Liu, Mingzhe Wang, Youtao Song, Guoqing Hu, Zhanjun Gu, Qing Miao, Chunying Chen*. Nanoparticle ligand exchange and its effects at the nanoparticle-cell membrane interface. Nano Letters, 2019, 19 (1): 8-18.
\n 3. Ge Fang#, Weifeng Li#, Xiaomei Shen, Jose Manuel Perez-Aguilar, Yu Chong, Xingfa Gao, Zhifang Chai, Chunying Chen*, Cuicui Ge*, Ruhong Zhou*. Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria. Nature Communications, 2018, 9: 129.
\n 4. Yu Chong#, Xing Dai#, Ge Fang, Renfei Wu, Lin Zhao, Xiaochuan Ma, Xin Tian, Sangyun Lee, Chao Zhang, Chunying Chen, Zhifang Chai, Cuicui Ge*, Ruhong Zhou*. Palladium Concave Nanocrystals with High-Index Facets Accelerate Ascorbate Oxidation in Cancer Treatment. Nature Communications, 2018, 9: 4861.<\/p>\n

\u76f8\u5173\u4f18\u8d28\u6587\u732e\u63a8\u8350<\/p>\n

1. Peng, F.; Setyawati, M. I.; Tee, J. K.; Ding, X.; Wang, J.; Nga, M. E.; Ho, H. K.; Leong, D. T. Nanoparticles Promote In Vivo Breast Cancer Cell Intravasation and Extravasation by Inducing Endothelial Leakiness. Nat. Nanotechnol. 2019, 14, 279\u2212286.
\n 2. Tsoi, K. M.; MacParland, S. A.; Ma, X.-Z.; Spetzler, V. N.; Echeverri, J.; Ouyang, B.; Fadel, S. M.; Sykes, E. A.; Goldaracena, N.; Kaths, J. M.; Conneely, J. B.; Alman, B. A.; Selzner, M.; Ostrowski, M. A.; Adeyi, O. A.; Zilman, A.; McGilvray, I. D.; Chan, W. C. W. Mechanism of Hard-Nanomaterial Clearance by the Liver. Nat. Mater. 2016, 15, 1212.
\n 3. Yu, M.; Song, W.; Tian, F.; Dai, Z.; Zhu, Q.; Ahmad, E.; Guo, S.; Zhu, C.; Zhong, H.; Yuan, Y.; Zhang, T.; Yi, X.; Shi, X.; Gan, Y.; Gao, H. Temperature- and Rigidity-Mediated Rapid Transport of Lipid Nanovesicles in Hydrogels. Proc. Natl. Acad. Sci. U. S. A. 2019, 116, 5362\u22125369.
\n 4. Mirshafiee, V.; Sun, B.; Chang, C. H.; Liao, Y.-P.; Jiang, W.; Jiang, J.; Liu, X.; Wang, X.; Xia, T.; Nel, A. E. Toxicological Profiling of Metal Oxide Nanoparticles in Liver Context Reveals Pyroptosis in Kupffer Cells and Macrophages versus Apoptosis in Hepatocytes. ACS Nano 2018, 12, 3836\u22123852.<\/p>\n

\u672c\u6587\u7531\u5927\u5175\u54e5\u4f9b\u7a3f\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com<\/a>\u3002<\/p>\n

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