{"id":177345,"date":"2019-06-11T06:30:56","date_gmt":"2019-06-10T22:30:56","guid":{"rendered":"\/\/m.iemloyee.com\/?p=177345"},"modified":"2019-06-10T19:39:14","modified_gmt":"2019-06-10T11:39:14","slug":"%e5%b7%b2%e6%a0%a1%e7%a8%bf%e4%bb%b6-%e6%ad%a6%e6%b1%89%e5%a4%a7%e5%ad%a6-acs-nano-%e6%8a%a5%e9%81%93-%e5%88%a9%e7%94%a8%e7%89%b9%e5%bc%82%e6%80%a7%e5%93%8d%e5%ba%94%e7%9a%84mniii%e5%b0%81%e5%8d%b0","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=177345","title":{"rendered":"\u6b66\u6c49\u5927\u5b66 ACS Nano \u62a5\u9053: \u5229\u7528\u7279\u5f02\u6027\u54cd\u5e94\u7684Mn(III)\u5c01\u5370\u7684MOFs\u7eb3\u7c73\u7cfb\u7edf\u5bf9\u80bf\u7624\u8fdb\u884c\u8bca\u65ad\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u76ee\u524d\uff0c\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u901a\u8fc7\u5c06\u5149\u6fc0\u53d1\u5149\u654f\u5242\uff08PS\uff09\u7684\u80fd\u91cf\u8f6c\u79fb\u81f3\u6c27\u6c14\u4ee5\u4ea7\u751f\u9ad8\u6bd2\u6027\u7684\u6d3b\u6027\u6c27\u7269\u8d28\uff08ROS\uff09\u8bf1\u5bfc\u80bf\u7624\u7ec6\u80de\u6b7b\u4ea1\uff0c\u5df2\u7ecf\u88ab\u5e7f\u6cdb\u7814\u7a76\u7528\u4e8e\u80bf\u7624\u6cbb\u7597\u3002\u4f46\u662fPDT\u7684\u8fdb\u4e00\u6b65\u4e34\u5e8a\u5e94\u7528\u4ecd\u7136\u9762\u4e34\u7740\u8bb8\u591a\u95ee\u9898\u3002\u4f8b\u5982\u5e38\u7528\u7684PS\u901a\u5e38\u5177\u6709\u6c34\u6eb6\u6027\u5dee\u3001\u5408\u6210\u4fee\u9970\u590d\u6742\u3001\u6709\u6548\u8f7d\u8377\u4f4e\u3001\u6613\u805a\u96c6\u7b49\u7f3a\u70b9\uff0c\u4e14\u5bf9\u80bf\u7624\u7684\u9776\u5411\u548c\u79ef\u7d2f\u80fd\u529b\u8f83\u5dee\u3002\u6b64\u5916\uff0c\u5728\u80bf\u7624\u7ec6\u80de\u4e2d\u8fc7\u91cf\u8868\u8fbe\u7684\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u4e0d\u4ec5\u53ef\u4ee5\u62b5\u6297\u5316\u5b66\u3001\u653e\u5c04\u548c\u5149\u52a8\u529b\u6cbb\u7597\uff0c\u800c\u4e14\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u6297\u6c27\u5316\u5242\u6765\u6e05\u9664\u80de\u5185\u7684ROS\u3002\u5e76\u4e14\u8fc7\u91cf\u7684ROS\u4e5f\u4f1a\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u6709\u6bd2\u526f\u4f5c\u7528\u5e76\u5728\u80bf\u7624\u533a\u57df\u5f15\u53d1\u708e\u75c7\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u4e00\u79cd\u53ef\u540c\u65f6\u5b9e\u73b0\u53ef\u63a7ROS\u4ea7\u751f\u548c\u80de\u5185GSH\u6d88\u9664\u7684\u667a\u80fd\u9012\u9001\u7cfb\u7edf\u6765\u6539\u5584\u80bf\u7624\u90e8\u4f4d\u7684PDT\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u6b66\u6c49\u5927\u5b66\u7684\u5f20\u5148\u6b63\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u4e00\u79cd\u7531Mn(III)\u548c\u535f\u5549\uff08TCPP\uff09\u901a\u8fc7\u201c\u4e00\u9505\u6cd5\u201d\u8bbe\u8ba1\u5408\u6210\u7684Mn(III)\u5c01\u5370\u7684\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\uff08MOFs\uff09\u7eb3\u7c73\u7cfb\u7edf\u3002\u5176\u4e2d\uff0cMn(III)\u4f5c\u4e3a\u5c01\u5370\u5242\u4e0d\u4ec5\u53ef\u4ee5\u6dec\u706d\u57fa\u4e8eTCPP\u7684\u8367\u5149\uff0c\u800c\u4e14\u8fd8\u4f1a\u6291\u5236\u5176\u4ecb\u5bfc\u7684\u6d3b\u6027\u6c27\uff08ROS\uff09\u4ea7\u751f\uff0c\u4f7f\u5f97MOFs\u6210\u4e3a\u4e00\u79cd\u60f0\u6027\u8bca\u7597\u7eb3\u7c73\u9897\u7c92\u3002\u5728\u88ab\u80bf\u7624\u7ec6\u80de\u5185\u541e\u540e\uff0c\u7531\u4e8eMn(III)\u4f1a\u4e0e\u80de\u5185\u7684\u8c37\u80f1\u7518\u80bd\uff08GSH\uff09\u53d1\u751f\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\uff0c\u4f7f\u5f97MOFs\u88abGSH\u5206\u89e3\u6210Mn(II)\u548c\u6e38\u79bbTCPP\uff0c\u4ece\u800c\u5b9e\u73b0\u6297\u6c27\u5316\u5242GSH\u7684\u6d88\u8017\u548c\u6fc0\u6d3b\u7684\u57fa\u4e8eMn(II)\u7684\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u4ee5\u53ca\u57fa\u4e8eTCPP\u7684\u8367\u5149\u6210\u50cf\u3002\u66f4\u91cd\u8981\u7684\u662f\u901a\u8fc7GSH\u63a7\u91caTCPP\u53ef\u5728\u5149\u7167\u4e0b\u5b9e\u73b0\u53ef\u63a7\u7684ROS\u4ea7\u751f\uff0c\u6709\u6548\u907f\u514d\u526f\u4f5c\u7528\u3002\u56e0\u6b64\uff0c\u8fd9\u79cdGSH\u7279\u5f02\u6027\u54cd\u5e94\u7684\u53ef\u540c\u65f6\u5b9e\u73b0GSH\u6d88\u8017\u548c\u53ef\u63a7ROS\u4ea7\u751f\u7684Mn(III)\u5c01\u5370\u7684MOFs\u53ef\u663e\u8457\u7684\u63d0\u5347\u5149\u52a8\u529b\u7597\u6cd5\u7684\u6cbb\u7597\u6548\u7387\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cA Mn(III)-Sealed Metal\u2212Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001\u5185\u541e\u540eMn(III)\u5c01\u5370\u7684MOFs\u7eb3\u7c73\u7cfb\u7edf\u7528\u4e8eMRI\u548cOI\u4ecb\u5bfc\u7684PDT\u4f5c\u7528\u793a\u610f\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u56fe\u4e8c\u3001Mn(III)-TCPP MOFs\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09MOFs\u7684SEM\u56fe\uff1b<\/p>\n

\uff08B\uff09MOFs\u7684TEM\u548cHR-TEM\u56fe\uff1b<\/p>\n

\uff08C\uff09MOFs\u7684AFM\u56fe\uff1b<\/p>\n

\uff08D\uff09MOFs\u7684TEM\u56fe\uff1b<\/p>\n

\uff08E\uff09XRD\u56fe\uff1b<\/p>\n

\uff08F\uff09MOFs\u7684\u70ed\u91cd\u5206\u6790\uff1b<\/p>\n

\uff08G\uff09TCPP\u3001MOFs\u548cTCPP(Mn)\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

\uff08H\uff09Mn 3s\u7684XPS\u5149\u8c31\uff1b<\/p>\n

\uff08I\uff09Mn\u5143\u7d20\u7684ESR\u8c31\u3002<\/p>\n

\uff08J\uff09\u4e0d\u540cGSH\u6d53\u5ea6\u4e0b\u7684MOFs\u7684SEM\u56fe\u3002<\/p>\n

\u56fe\u4e09\u3001MOFs\u7684\u6027\u80fd\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09GSH\u89e6\u53d1\u7684MOFs\u89e3\u4f53\u673a\u5236\uff1b<\/p>\n

\uff08B\uff09\u7528DTNB\u68c0\u6d4bGSH\u6d88\u8017\uff1b<\/p>\n

\uff08C\uff09GSH\u54cd\u5e94\u6027TCPP\u7684\u91ca\u653e\uff1b<\/p>\n

\uff08D\uff09\u6709\u6216\u65e0GSH\uff082.5 mM\uff09\u4e0b\u7684MOFs\u7684T1<\/sub><\/em>\u52a0\u6743\u6210\u50cf\uff1b<\/p>\n

\uff08E\uff09Mn(OAc)3<\/sub>\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\u4ee5\u53caMOFs\u548cTCPP\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08F\uff09MOFs\u8367\u5149\u968fGSH\u6d53\u5ea6\u53d8\u5316\uff1b<\/p>\n

\uff08G\uff09\u7528SOSG\u68c0\u6d4bROS\u7684\u4ea7\u751f\uff1b<\/p>\n

\uff08H\uff09\u9ad8\u6d53\u5ea6GSH\u6eb6\u6db2\u4e2dMOFs\u5728660 nm\u7167\u5c04\u540eSOSG\u7684\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08I\uff09\u572810 mM GSH\u4e0b\u4e0d\u540c\u7684\u6750\u6599\u4ecb\u5bfc\u7684ROS\u4ea7\u751f\u3002<\/p>\n

\u56fe\u56db\u3001MOFs\u7684\u4f53\u5916\u89e3\u79bb\u53ca\u5176\u5bf9\u7ec6\u80de\u6c27\u5316\u538b\u7684\u5f71\u54cd<\/strong>
\n \"\"\uff08A\uff09\u5b75\u80b24 h\u540e\uff0cCLSM\u68c0\u6d4b\u7684\u80de\u5185MOFs\u8367\u5149\u968f\u65f6\u95f4\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08B, C\uff09\u5728\u5b75\u80b24 h\u540e\uff0c0 min\uff08\u7ea2\u8272\uff09\u300120 min\uff08\u6a59\u8272\uff09\u548c40 min\uff08\u7eff\u8272\uff09\u540e\u80de\u5185MOFs\u7684\u8367\u5149\u4fe1\u53f7\uff0c\u6d41\u5f0f\u5206\u6790\u548c\u76f8\u5e94\u7684\u7edf\u8ba1\u5206\u6790\u7ed3\u679c\uff1b<\/p>\n

\uff08D\uff09\u7528\u4e0d\u540c\u6837\u54c1\u5904\u7406\u540e\u7684\u7ec6\u80de\u5185GSH\u6c34\u5e73\uff1b<\/p>\n

\uff08E, F\uff09\u7528PBS + hv\uff08\u7ea2\u8272\uff09\u3001Mn(OAc)2<\/sub> + hv\uff08\u84dd\u8272\uff09\u3001TCPP + hv\uff08\u6a59\u8272\uff09\u3001MOFs\uff08\u7eff\u8272\uff09\u548cMOFs + hv\uff08\u6df1\u7eff\u8272\uff09\u5904\u7406\u540e\u6d41\u5f0f\u68c0\u6d4b\u76f8\u5e94\u7ec6\u80de\u5185ROS\u542b\u91cf\u53ca\u5176\u7edf\u8ba1\u5206\u6790\u7ed3\u679c\uff1b<\/p>\n

\uff08G\uff09\u901a\u8fc7CLSM\u68c0\u6d4b\u7ec6\u80deROS\u4ea7\u751f\u3002<\/p>\n

\u56fe\u4e94\u3001\u8bc4\u4f30MOFs\u4ecb\u5bfc\u7684\u7ec6\u80de\u6bd2\u6027<\/strong>
\n \"\"\uff08A\uff09MOFs\u5904\u7406\u7684\u4e0d\u540c\u7ec6\u80de\u7cfb\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

\uff08B\uff09TCPP + hv\u548cTCPP + L-BSO + hv\u5b75\u80b2\u540e\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

\uff08C\uff09\u4e0d\u540c\u6750\u6599\u5904\u7406\u540e\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

\uff08D\uff09\u4e0d\u540c\u6750\u6599\u5904\u7406\u540e\u68c0\u6d4b\u6d3b\u7ec6\u80de\/\u6b7b\u7ec6\u80de\u6bd4\u4f8b\uff1b<\/p>\n

\uff08E\uff09\u901a\u8fc7\u6d41\u5f0f\u7528\u819c\u8054\u86cb\u767dV-FITC\/PI\u6765\u8bc4\u4f30\u7ec6\u80de\u6b7b\u4ea1\u7684\u673a\u5236\u3002<\/p>\n

\u56fe\u516d\u3001MOFs\u5728\u4f53\u5185\u7684\u6210\u50cf\u6548\u679c<\/strong>
\n \"\"\uff08A, B\uff09\u7624\u5185\u6ce8\u5c0430 min\u540e\uff0c\u5728\u80bf\u7624\u90e8\u4f4d\u7684\u8367\u5149\u548cT1<\/sub><\/em>\u9020\u5f71\u4fe1\u53f7\uff1b<\/p>\n

\uff08C\uff09\u9759\u8109\u6ce8\u5c04MOFs\u540e\u7684\u4f53\u5185MRI\u4fe1\u53f7\uff1b<\/p>\n

\uff08D\uff09\u9759\u8109\u6ce8\u5c04\u6750\u6599\u7684\u8367\u5149\u6210\u50cf\u548c\u7ed9\u836f36 h\u540e\u7ec4\u7ec7\u8367\u5149\uff1b<\/p>\n

\uff08E\uff09\u6ce8\u5c0436 h\u540e\u7684\u5c0f\u9f20\u7ec4\u7ec7\u7684MFI\u503c\uff1b<\/p>\n

\uff08F\uff09MOFs\u548cTCPP\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u7684\u836f\u4ee3\u52a8\u529b\u5b66\uff1b<\/p>\n

\uff08G\uff09\u8840\u751f\u5316\u548c\u8840\u5e38\u89c4\u5206\u6790\u4e3b\u8981\u53c2\u6570\u7684\u70ed\u56fe\uff1b<\/p>\n

\uff08H\uff09\u7528DCFH-DA\uff08\u7eff\u8272\uff09\u68c0\u6d4b\u7684\u80bf\u7624\u7ec4\u7ec7\u7684\u6c27\u5316\u538b\u3002<\/p>\n

\u56fe\u4e03\u3001\u751f\u7269\u5b89\u5168\u6027\u548c\u6cbb\u7597\u6548\u7387\u7684\u8bc4\u4f30<\/strong>
\n \"\"\uff08A, B\uff0914\u5929\u6cbb\u7597\u671f\u95f4\u5404\u79cd\u5904\u7406\u540e\u5c0f\u9f20\u4f53\u91cd\u548c\u80bf\u7624\u4f53\u79ef\u7684\u53d8\u5316\uff1b<\/p>\n

\uff08C, D\uff09\u79bb\u4f53\u80bf\u7624\u7ec4\u7ec7\u7684\u91cd\u91cf\u548c\u7167\u7247\uff1b<\/p>\n

\uff08E\uff0914\u5929\u540e\u80bf\u7624\u7684H\uff06E\u5207\u7247\u5206\u6790\u3001TUNEL\uff08\u7eff\u8272\uff09\u548cKi67\uff08\u7eff\u8272\uff09\u514d\u75ab\u8367\u5149\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u4f5c\u8005\u901a\u8fc7\u201c\u4e00\u9505\u6cd5\u201d\u6210\u529f\u6784\u5efa\u4e86Mn(III)\u5c01\u5370\u7684MOFs\u7eb3\u7c73\u7cfb\u7edf\u3002\u4f53\u5916\u548c\u4f53\u5185\u5b9e\u9a8c\u8bc1\u660eMOFs\u4f1a\u7279\u5f02\u6027\u54cd\u5e94\u80bf\u7624\u7ec6\u80de\u4e2d\u8fc7\u8868\u8fbe\u7684GSH\u800c\u53d1\u751f\u89e3\u4f53\uff0c\u4ea7\u751fGSSG\u3001Mn(II)\u548c\u6e38\u79bbTCPP\u3002\u5728\u8fd9\u4e2a\u8fc7\u7a0b\u4e2d\uff0c\u7ec6\u80de\u5185\u7684GSH\u88ab\u6d88\u8017\uff0c\u57fa\u4e8eMn(II)\u7684MRI\u548c\u57fa\u4e8eTCPP\u7684OI\u88ab\u6fc0\u6d3b\u3002\u540c\u65f6GSH\u8fd8\u53ef\u4ee5\u901a\u8fc7\u8c03\u63a7MOFs\u4e2dTCPP\u7684\u91ca\u653e\u6765\u6709\u6548\u5730\u63a7\u5236ROS\u4ea7\u751f\uff0c\u4ee5\u907f\u514d\u8fc7\u91cfROS\u5e26\u6765\u7684\u526f\u4f5c\u7528\u3002\u501f\u52a9\u4e8e\u6fc0\u6d3b\u7684MRI\u548cOI\u6210\u50cf\u8bca\u65ad\u6280\u672f\uff0c\u5177\u6709\u53ef\u63a7ROS\u4ea7\u751f\u53caGSH\u6d88\u8017\u7684MOFs\u7eb3\u7c73\u9897\u7c92\u80fd\u663e\u8457\u589e\u5f3aPDT\u7684\u6cbb\u7597\u6548\u679c\uff0c\u8fdb\u800c\u5b9e\u73b0\u80bf\u7624\u7684\u5168\u9762\u538b\u5236\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aA Mn(III)-Sealed Metal\u2212Organic Framework Nanosystem for Redox-Unlocked Tumor Theranostics<\/a><\/strong>\u00a0(ACS Nano, 2019<\/strong>, DOI: 10.1021\/acsnano.9b00300)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4ebaCQR\u7f16\u8bd1\u3002<\/p>\n

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