{"id":176142,"date":"2019-05-27T06:30:34","date_gmt":"2019-05-26T22:30:34","guid":{"rendered":"\/\/m.iemloyee.com\/?p=176142"},"modified":"2019-05-26T22:30:37","modified_gmt":"2019-05-26T14:30:37","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91%e4%b8%ad%e7%a7%91%e9%99%a2%e9%95%bf%e6%98%a5%e5%ba%94%e5%8c%96%e6%89%80%e5%a7%9c%e7%a7%80%e5%a8%a5%e7%a0%94%e7%a9%b6%e5%91%98angew-chem-int-ed","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=176142","title":{"rendered":"\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u59dc\u79c0\u5a25\u7814\u7a76\u5458Angew. Chem. Int. Ed.: \u901a\u8fc7Cu-TCPP \u7eb3\u7c73\u7247\u5728\u7f3a\u6c27\u80bf\u7624\u4e2d\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u5e76\u6d88\u8017GSH\u5b9e\u73b0\u764c\u75c7\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5149\u52a8\u529b\u7597\u6cd5\uff08PDT\uff09\u662f\u57fa\u4e8e\u7167\u5c04\u65f6\u7ec4\u7ec7\u6c27\u548c\u5149\u654f\u5242\uff08PS\uff09\u4e4b\u95f4\u53d1\u751f\u53cd\u5e94\u4ea7\u751f\u76841<\/sup>O2<\/sub>\u5b9e\u73b0\u7684\uff0c\u5176\u5177\u6709\u8f83\u5c0f\u4fb5\u5165\u6027\u548c\u9ad8\u9009\u62e9\u6027\uff0c\u56e0\u800c\u5728\u764c\u75c7\u6cbb\u7597\u4e2d\u5f15\u8d77\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u7136\u800c\uff0c\u6c27\u4f9d\u8d56\u6027\u3001\u5916\u6e90\u5149\u7a7f\u900f\u6df1\u5ea6\u6709\u9650\u3001\u6cbb\u7597\u6548\u7387\u8f83\u4f4e\u7b49\u51e0\u4e2a\u7f3a\u9677\u4ecd\u7136\u5b58\u5728\u3002\u4e3a\u4e86\u89e3\u51b3\u5173\u952e\u7684\u6291\u5236\u4f5c\u7528\uff0c\u5404\u79cd\u7eb3\u7c73\u7ea7O2<\/sub>\u91ca\u653e\u4ee5\u53caGSH\u6d88\u8017\u7684\u5149\u52a8\u529b\u8bd5\u5242\u4e0d\u65ad\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u4ee5\u7f13\u89e3\u80bf\u7624\u7f3a\u6c27\u6216\u964d\u4f4eGSH\u6d53\u5ea6\u3002\u6b64\u5916\uff0c\u5c3d\u7ba1\u5c40\u90e8\u5149\u6d3b\u5316\u589e\u5f3a\u4e86\u9009\u62e9\u6027\uff0c\u4f46\u5bf9\u5916\u90e8\u5149\u7684\u4f9d\u8d56\u4ecd\u7136\u6781\u5927\u9650\u5236\u4e86\u5149\u52a8\u529b\u7597\u6cd5\u7684\u53d1\u5c55\u3002\u4e3a\u4e86\u5b9e\u73b0\u9009\u62e9\u6027\u80bf\u7624\u6cbb\u7597\uff0c\u80bf\u7624\u5fae\u73af\u5883\uff08\u4ee5\u7f3a\u6c27\u3001\u9178\u6027\u3001\u9ad8\u6d53\u5ea6H2<\/sub>O2<\/sub>\u548cGSH\u4e3a\u7279\u5f81\uff09\u5df2\u7ecf\u5f97\u5230\u5e7f\u6cdb\u7814\u7a76\u3002\u7136\u800c\u76ee\u524d\u7684\u7b56\u7565\u7531\u4e8e\u6cbb\u7597\u6548\u7387\u4f4e\u6216\u6750\u6599\u5408\u6210\u590d\u6742\uff0c\u663e\u8457\u5f71\u54cd\u4e86\u5176\u4e34\u5e8a\u5e94\u7528\u3002\u4e8b\u5b9e\u4e0a\uff0c\u6839\u636eRussell\u673a\u5236\uff0c\u5728\u75d5\u91cf\u91d1\u5c5e\u79bb\u5b50\u6216\u9176\u5b58\u5728\u4e0b\u53ef\u4ee5\u8ddf\u751f\u7269\u6c22\u8fc7\u6c27\u5316\u7269\u53cd\u5e94\u6765\u4ea7\u751f1<\/sup>O2<\/sub>\uff0c\u800c\u4e14\u5927\u591a\u6570\u751f\u7269\u6c22\u8fc7\u6c27\u5316\u7269\u53ef\u4ee5\u5728\u6d3b\u6027\u6c27\u7684\u8fc7\u6c27\u5316\u53cd\u5e94\u4e2d\u4ea7\u751f\uff0c\u8fd9\u8868\u660e\u5176\u6709\u53ef\u80fd\u53d6\u4ee3\u4f9d\u8d56\u4e8e\u5149\u548c\u6c27\u6c14\u7684\u5149\u52a8\u529b\u8bd5\u5242\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u59dc\u79c0\u5a25\u7814\u7a76\u5458\u8bfe\u9898\u7ec4<\/strong>\u62a5\u9053\u4e86Cu-TCPP\u7eb3\u7c73\u7247\u8d85\u8584\u4e8c\u7ef4\u91d1\u5c5e\u6709\u673a\u9aa8\u67b6\u53ef\u4ee5\u5728\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9009\u62e9\u6027\u5730\u4ea7\u751f1<\/sup>O2<\/sub>\uff0c\u9996\u5148\u662f\u9178\u6027H2<\/sub>O2<\/sub>\u5c06TCPP\u914d\u4f53\u8fc7\u6c27\u5316\uff0c\u7136\u540e\u5728\u5177\u6709\u8fc7\u6c27\u5316\u7269\u9176\u6027\u8d28\u7684\u7eb3\u7c73\u7247\u548cCu2+<\/sup>\u7684\u4f5c\u7528\u4e0b\u88ab\u8fd8\u539f\u4e3a\u8fc7\u6c27\u81ea\u7531\u57fa\uff0c\u6700\u540e\u4f1a\u53d1\u751f\u57fa\u4e8eRussell\u673a\u5236\u7684\u81ea\u53d1\u91cd\u7ec4\u53cd\u5e94\u3002\u800c\u4e14\u7eb3\u7c73\u7247\u8fd8\u53ef\u4ee5\u6d88\u8017GSH\u3002\u56e0\u6b64\uff0cCu-TCPP\u7eb3\u7c73\u7247\u53ef\u4ee5\u9ad8\u6548\u5730\u9009\u62e9\u6027\u5730\u7834\u574f\u80bf\u7624\uff0c\u8bc1\u660e\u5176\u662f\u514b\u670d\u76ee\u524d\u5149\u52a8\u529b\u7597\u6cd5\u9650\u5236\u7684\u4e00\u79cd\u6709\u6548\u65b9\u5f0f\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a” Specifically Generation of Singlet Oxygen via Russell Mechanism in Hypoxic Tumor and GSH Depletion by Cu<\/strong>\u2010<\/strong>TCPP Nanosheets for Cancer Therapy <\/strong>“\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\uff08\u6587\u7ae0TOC\u56fe\u5982\u4e0b\uff09\u3002<\/p>\n

\"\"<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 Cu-TCPP\u7eb3\u7c73\u7247\u7684\u5408\u6210\u53ca\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(A) Cu-TCPP\u7eb3\u7c73\u7247\u7684\u5408\u6210\u65b9\u6848\u548c\u6cbb\u7597\u673a\u7406\uff1b<\/p>\n

(B) Cu-TCPP\u7eb3\u7c73\u7247\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(C) Cu-TCPP\u7eb3\u7c73\u7247\u7684HRTEM\u56fe\u50cf\uff1b<\/p>\n

(D) Cu-TCPP\u7eb3\u7c73\u7247\u7684AFM\u56fe\u50cf\u53ca\u5176\u9ad8\u5ea6\u56fe\uff1b<\/p>\n

(E) TCPP\u548cCu-TCPP\u7eb3\u7c73\u7247\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

(F) Cu-TCPP\u7eb3\u7c73\u7247\u3001TMB\u548cH2<\/sub>O2<\/sub>\u6df7\u5408\u7269\u7684pH\u4f9d\u8d56\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\u53ca\u5176\u7167\u7247\uff08\u63d2\u56fe\uff09\uff1b<\/p>\n

(G) ICP\u6d4b\u5b9a\u7684Cu-TCPP\u7eb3\u7c73\u7247\u4e2dCu2+<\/sup>\u7684\u542b\u91cf\u548c\u91ca\u653e\u91cf\u3002<\/p>\n

\u56fe2 Cu-TCPP\u7eb3\u7c73\u7247\u5c06GSH\u8f6c\u5316\u4e3aGSSG<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u4e0a\uff0cCu-TCPP\u548cGSH\u6df7\u5408\u6eb6\u6db2\u7684\u4e0a\u6e05\u6db2\u4e2dGSH\u548cGSSG\u7684\u542b\u91cf\uff1b<\/p>\n

(B) \u4e0d\u540c\u6761\u4ef6\u4e0bHeLa\u7ec6\u80de\u4e2dGSH\/GSSG\u6bd4\u503c\u7684\u68c0\u6d4b\uff1b<\/p>\n

(C) \u52a0\u5165DMPO\u7684\u53cd\u5e94\u6df7\u5408\u7269\u7684ESR\u5149\u8c31\u4ee5\u6d4b\u91cfO\u2022- 2\u548c\u2022OH\u7684\u4fe1\u53f7\u3002<\/p>\n

\u56fe3 TCPP\u4e0e<\/strong> H2<\/sub>O2<\/sub>\u4ea7\u751f1<\/sup>O2<\/sub>\u7684\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u4ee5\u5355\u72ecSOSG\u6eb6\u6db2\u4e3a\u5bf9\u7167\uff0cSOSG\u4e0ePBS\u4e2d\u4e0d\u540c\u8bd5\u5242\u53cd\u5e94\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

(B) SOSG\u68c0\u6d4b\u5230\u5e38\u6c27\u548c\u7f3a\u6c27\u6761\u4ef6\u4e0bCu-TCPP\u7eb3\u7c73\u7247\u4e0eH2<\/sub>O2<\/sub>\u4ea7\u751f\u76841<\/sup>O2<\/sub>\uff1b<\/p>\n

(C) \u5305\u542bTCPP\u548cH2<\/sub>O2<\/sub>\u53cd\u5e94\u6eb6\u6db2\u7684MS\u8c31\u56fe\uff1b<\/p>\n

(D) SOSG\u68c0\u6d4b\u5230\u5305\u542bTCPP\uff0cHRP\u548cH2<\/sub>O2<\/sub>\u7684PBS\u4e2d\u4ea7\u751f\u76841<\/sup>O2<\/sub>\uff1b<\/p>\n

(E) \u52a0\u5165TEMP\u548cH2<\/sub>O2<\/sub>\u540e\uff0c\u6709\u65e0GSH\u6761\u4ef6\u4e0bCu-TCPP\u7684ESR\u8c31\uff1b<\/p>\n

(F) \u52a0\u5165TEMP\u548cH2<\/sub>O2<\/sub>\u540e\uff0c\u6709\u65e0GSH\u6761\u4ef6\u4e0bHRP+TCPP\u7684ESR\u8c31\u3002<\/p>\n

\u56fe4 Cu-TCPP\u7eb3\u7c73\u7247\u5904\u7406\u7ec6\u80de\u7684CLSM\u56fe\u50cf\u53ca\u5176\u7ec6\u80de\u6bd2\u6027\u6d4b\u8bd5<\/strong><\/p>\n

\"\"<\/p>\n

(A) Cu-TCPP\u7eb3\u7c73\u7247\u5904\u7406\u524d\u540eSOSG\u67d3\u8272\u7684HeLa\u548cL929\u7ec6\u80de\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

(B) Cu-TCPP\u7eb3\u7c73\u7247\u5904\u7406\u524d\u540e\uff0c\u5728\u5e38\u6c27\u548c\u7f3a\u6c27\u6761\u4ef6\u4e0b\u67d3\u8272\u7684HeLa\u7ec6\u80de\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

(C) \u4e0d\u540c\u5904\u7406\u6761\u4ef6\u4e0bHeLa\u7ec6\u80de\u4e2dDCFH-DA\u7684\u8367\u5149\uff1b<\/p>\n

(D) MTT\u6d4b\u5b9a\u6cd5\u6d4b\u8bd5\u7eb3\u7c73\u7247\u7684\u7ec6\u80de\u6bd2\u6027\uff1b<\/p>\n

(E) Calcein AM \u548c PI\u5171\u67d3\u8272\u6d4b\u5b9a\u6cd5\u6d4b\u8bd5\u7eb3\u7c73\u7247\u7684\u7ec6\u80de\u6bd2\u6027\u3002<\/p>\n

\u56fe5 Cu-TCPP\u7eb3\u7c73\u7247\u7684\u4f53\u5185\u80bf\u7624\u6cbb\u7597\u6548\u679c<\/strong><\/p>\n

\"\"<\/p>\n

(A) \u6cbb\u7597\u540e\u5c0f\u9f20\u548c\u80bf\u7624\u7684\u5178\u578b\u7167\u7247\uff1b<\/p>\n

(B) \u6bcf\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u91cd\u91cf\uff1b<\/p>\n

(C) \u6bcf\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff1b<\/p>\n

(D) \u6bcf\u7ec4\u5c0f\u9f20\u7684\u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n

(E) \u6bcf\u7ec4\u5c0f\u9f20\u7684\u6b63\u5e38\u7ec4\u7ec7\u548c\u80bf\u7624\u7ec4\u7ec7\u7684H&E\u67d3\u8272\u56fe\u50cf\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cdCu-TCPP\u7eb3\u7c73\u7247\u7684\u4e8c\u7ef4MOF\uff0c\u5176\u80fd\u591f\u901a\u8fc7\u4e0e\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u9ad8\u6d53\u5ea6\u7684H2<\/sub>O2<\/sub>\u53cd\u5e94\u4ea7\u751f1<\/sup>O2<\/sub>\u5e76\u901a\u8fc7\u5faa\u73af\u53cd\u5e94\u6d88\u8017GSH\u3002\u56e0\u6b64\uff0cCu-TCPP\u7eb3\u7c73\u7247\u80fd\u591f\u9009\u62e9\u6027\u4ea7\u751f1<\/sup>O2<\/sub>\u548c\u6291\u5236GSH\u5bf91<\/sup>O2<\/sub>\u7684\u6e05\u9664\uff0c\u4ece\u800c\u5b9e\u73b0\u4f53\u5916\u548c\u4f53\u5185\u8bf1\u5bfc\u80bf\u7624\u51cb\u4ea1\u5e76\u4e14\u6ca1\u6709\u526f\u4f5c\u7528\u3002\u663e\u7136\uff0c\u8fd9\u79cd\u65b9\u6cd5\u6709\u6548\u907f\u514d\u4e86PDT\u5fc5\u4e0d\u53ef\u5c11\u5730\u5bf9\u6c27\u6c14\u548c\u5916\u90e8\u5149\u523a\u6fc0\u7684\u4f9d\u8d56\uff0c\u5c06\u4e3a\u764c\u75c7\u6cbb\u7597\u7b56\u7565\u7684\u53d1\u5c55\u63d0\u4f9b\u6709\u610f\u4e49\u7684\u542f\u53d1\u548c\u6307\u5bfc\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aSpecifically Generation of Singlet Oxygen via Russell Mechanism in Hypoxic Tumor and GSH Depletion by Cu-TCPP Nanosheets for Cancer Therapy<\/a>\u00a0(Angew. Chem. Int. Ed., 2019, DOI: 10.1002\/anie.201903981)<\/strong><\/p>\n

\u3010\u56e2\u961f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u59dc\u79c0\u5a25\uff0c\u4e2d\u56fd\u79d1\u5b66\u9662\u957f\u6625\u5e94\u7528\u5316\u5b66\u7814\u7a76\u6240\u7814\u7a76\u5458\u3001\u535a\u58eb\u751f\u5bfc\u5e08\u30022005\u5e74\u535a\u58eb\u6bd5\u4e1a\u4e8e\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u30022006\u5e74~2010\u5e74\u5148\u540e\u5728\u5fb7\u56fdBielefeld\u5927\u5b66\u3001\u5fb7\u56fdULM\u5927\u5b66\u53ca\u5fb7\u56fdKarlsruhe\u6280\u672f\u7814\u7a76\u6240\u4ece\u4e8b\u6d2a\u5821\u5b66\u8005\u53ca\u535a\u58eb\u540e\u7814\u7a76\u30022010\u5e74\u52a0\u5165\u4e2d\u79d1\u9662\u957f\u6625\u5e94\u5316\u6240\u7535\u5206\u6790\u5316\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4\uff0c\u7ec4\u5efa\u72ec\u7acb\u79d1\u7814\u56e2\u961f\u30022013\u5e74\u83b7\u201c\u4f18\u79c0\u9752\u5e74\u57fa\u91d1\u201d\u8d44\u52a9\u3002\u4e3b\u8981\u4ece\u4e8b\u7eb3\u7c73\u5c3a\u5ea6\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u673a\u5236\u53ca\u6548\u5e94\u7684\u7814\u7a76\u3002\u81f3\u4eca\uff0c\u4ee5\u7b2c\u4e00\u4f5c\u8005\u548c\u901a\u8baf\u8054\u7cfb\u4eba\u5728Proc. Natl. Acad. Sci. USA, J. Am. Chem. Soc., Angew. Chem. Int. Ed. , ACS Nano, Adv. Funct. Mater., Anal. Chem.<\/em>\u7b49\u8457\u540d\u520a\u7269\u53d1\u8868\u6587\u7ae066\u7bc7\uff0c\u76f8\u5173\u8bba\u6587\u88abSCI\u8bba\u6587\u5f15\u75282900\u4f59\u6b21\u3002\u6388\u6743\u53d1\u660e\u4e13\u52294\u9879\uff0c\u64b0\u5199\u82f1\u6587\u4e13\u84572\u7ae0\u3002\u8363\u83b7\u5409\u6797\u7701\u4e09\u516b\u7ea2\u65d7\u624b\uff082013\u5e74\uff09\u53ca\u5168\u56fd\u4e94\u4e00\u5dfe\u5e3c\u6807\u5175\uff082015\u5e74\uff09\u79f0\u53f7\u3002<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u59dc\u79c0\u5a25\u7814\u7a76\u5458\u56e2\u961f\u56f4\u7ed5\u7eb3\u7c73\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u7684\u52a8\u6001\u54cd\u5e94\u673a\u5236\u5f00\u5c55\u4e86\u7cfb\u7edf\u7814\u7a76\u3002\u57fa\u4e8e\u8868\u9762\u589e\u5f3a\u7ea2\u5916\u5149\u8c31\u63ed\u793a\u4e86\u7eb3\u7c73\u6750\u6599\u4e0e\u7ec6\u80de\u819c\u7684\u5f31\u76f8\u4e92\u4f5c\u7528\u53ca\u6750\u6599\u7684\u52a8\u6001\u7ed3\u6784\u53d8\u5316\u4e0e\u751f\u7269\u6548\u5e94\u7684\u6784\u6548\u5173\u7cfb\uff08J. Am. Chem. Soc., 2015, 137, 10052-10055<\/em>\uff09\u3002\u8fdb\u4e00\u6b65\u4e0e\u6210\u50cf\u5206\u6790\u7ed3\u5408\uff0c\u63ed\u793a\u4e86\u91d1\u5c5e-\u6709\u673a\u914d\u4f4d\u805a\u5408\u7269\u53ca\u6c27\u5316\u7269\u4e0e\u7ec6\u80de\u5185\u6c27\u5316\u8fd8\u539f\u5c0f\u5206\u5b50\u7684\u52a8\u6001\u4f5c\u7528\u673a\u5236\uff0c\u6784\u5efa\u80bf\u7624\u6cbb\u7597\u65b0\u7b56\u7565\u3002\u4f8b\u5982\uff0c\u901a\u8fc7\u7814\u7a76\u94c1\u79bb\u5b50\u63ba\u6742\u7684\u805a\u4e8c\u6c28\u57fa\u5421\u5576\u7eb3\u7c73\u7247\uff08Fe-PDAP\uff09\u53ca\u8d85\u8584\u4e8c\u7ef4\u91d1\u5c5e\u6709\u673a\u6846\u67b6\uff08Cu-TCPP\uff09\u4e0e\u7ec6\u80de\u5185\u8fc7\u6c27\u5316\u6c22\u548c\u8c37\u80f1\u7518\u80bd\u76f8\u4e92\u4f5c\u7528\uff0c\u6784\u5efa\u4e86\u5149\u52a8\u529b\u53ca\u5316\u7597\u534f\u540c\u589e\u5f3a\u7684\u65b0\u7b56\u7565\uff08J. Am. Chem. Soc.<\/em>, 2018, 140, 106\uff09\uff0c\u63d0\u51faRussell\u673a\u5236\u6cbb\u7597\u80bf\u7624\u7684\u65b0\u601d\u8def\uff1b\u91c7\u7528\u5ba4\u6e29\u8fd8\u539f\u65b9\u6cd5\u5728SiO2<\/sub>-MB\u5185\u6838\u8868\u9762\u5f62\u6210\u667a\u80fdMnO2<\/sub>\u58f3\uff0c\u5b9e\u73b0\u8fc7\u6c27\u5316\u6c22\u6fc0\u6d3b\u7684\u6c27\u6c14\u751f\u6210\u53ca\u5149\u654f\u5242\u91ca\u653e\uff0c\u6709\u6548\u63d0\u9ad8\u80bf\u7624\u5fae\u73af\u5883\u54cd\u5e94\u7684\u80bf\u7624\u8bca\u65ad\u53ca\u6cbb\u7597\uff08Adv. Funct. Mater.<\/em>, 2017, 27, 1604258\uff09\uff1b\u901a\u8fc7\u4e00\u6b65\u751f\u7269\u77ff\u5316\u6cd5\u5236\u5907\u4e86\u5177\u6709\u8d85\u5f3a\u7684\u5149\u70ed\u8f6c\u6362\u6548\u7387\uff0c\u826f\u597d\u7684\u5149\u50ac\u5316\u6d3b\u6027\u4ee5\u53ca\u9ad8X\u5c04\u7ebf\u5438\u6536\u7cfb\u6570\u7684\u6c27\u5316\u94f1\u7eb3\u7c73\u7c92\u5b50\uff08BSA-IrO2<\/sub> NPs\uff09\uff0c\u5b9e\u73b0\u4e86\u5149\u58f0\u548cCT\u53cc\u91cd\u6210\u50cf\u6307\u5bfc\u7684\u5149\u70ed\u5149\u52a8\u529b\u7cbe\u51c6\u6cbb\u7597\u3002\u8fdb\u4e00\u6b65\u5229\u7528\u5176\u8fc7\u6c27\u5316\u6c22\u6a21\u62df\u9176\u7279\u6027\uff0c\u4fdd\u62a4\u6b63\u5e38\u7ec6\u80de\u514d\u53d7H2<\/sub>O2<\/sub>\u8bf1\u5bfc\u7684\u6d3b\u6027\u6c27\u538b\u529b\u53ca\u708e\u75c7\uff0c\u5e76\u57fa\u4e8e\u5fae\u6ce1\u7684\u7a7a\u5316\u4f5c\u7528\u663e\u8457\u589e\u5f3a\u5149\u58f0\u6210\u50cf\uff08Angew. Chem. Int. Ed.<\/em>, 2018, 57, 10309\uff09\u3002<\/p>\n

\u3010\u76f8\u5173\u4f18\u8d28\u6587\u732e\u63a8\u8350\u3011<\/strong><\/p>\n

1. BSA-IrO2<\/sub>: catalase-like nanoparticles with high photothermal conversion efficiency and X-ray absorption coefficient for anti-inflammation and tumor theranostics, Angew.<\/em> Chem. Int. Ed.<\/em>, 2018, 57, 10309\u201310313.<\/p>\n

2. A facile ion-doping strategy to regulate tumor microenvironments for enhanced multimodal tumor theranostics,\u00a0J.<\/em> Am. Chem. Soc.<\/em>, 2018, 140, 106\u2013109.<\/p>\n

3. MnO2<\/sub> gatekeeper: an intelligent and O2<\/sub>-evolving shell for preventing premature release of high cargo payload core, overcoming tumor hypoxia, and acidic H2<\/sub>O2<\/sub>-sensitive MRI,\u00a0Adv.<\/em> Funct. Mater.<\/em>, 2017, 27, 1604258.<\/p>\n

4. Revealing the nature of interaction between graphene oxide and lipid membrane by surface-enhanced infrared absorption spectroscopy, J. Am. Chem. Soc.<\/em>, 2015, 137, 10052-10055.<\/p>\n

 <\/p>\n

\u672c\u6587\u7531biotech\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

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