{"id":173286,"date":"2019-04-23T06:30:16","date_gmt":"2019-04-22T22:30:16","guid":{"rendered":"\/\/m.iemloyee.com\/?p=173286"},"modified":"2019-04-22T19:57:20","modified_gmt":"2019-04-22T11:57:20","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91angew-chem-int-ed-%e7%bb%bc%e8%bf%b0%ef%bc%9a%e4%bb%bf%e7%94%9fdna%e7%ba%b3%e7%b1%b3%e7%ae%a1%e7%9a%84%e7%ba%b3%e7%b1%b3%e7%ba%a7%e9%80%9a%e9%81%93","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=173286","title":{"rendered":"\u5357\u5f00\u5927\u5b66Angew. Chem. Int. Ed.\u7efc\u8ff0\uff1a\u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u7684\u7eb3\u7c73\u7ea7\u901a\u9053\u8bbe\u8ba1\u548c\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u81ea\u7136\u8fdb\u5316\u7684\u751f\u7269\u5927\u5206\u5b50\u7eb3\u7c73\u7ba1\u5305\u62ec\u819c\u901a\u9053\u5bf9\u4e8e\u7ec6\u80de\u800c\u8a00\u662f\u81f3\u5173\u91cd\u8981\uff0c\u5176\u80fd\u591f\u4e3a\u8de8\u819c\u79bb\u5b50\/\u5206\u5b50\u901a\u9053\u3001\u7ec6\u80de\u5185\u8f6c\u8fd0\u548c\u7ec6\u80de\u95f4\u901a\u4fe1\u63d0\u4f9b\u7ed3\u6784\u652f\u6301\uff0c\u800c\u4e14\u8fd9\u4e9b\u901a\u9053\u5f80\u5f80\u663e\u793a\u51fa\u57fa\u4e8e\u7535\u8377\u3001\u5927\u5c0f\u3001\u6da6\u6e7f\u6027\u548c\u9009\u62e9\u6027\u8bc6\u522b\u7684\u7279\u5f81\u95e8\u63a7\u884c\u4e3a\u3002\u5728\u6d3b\u7ec6\u80de\u4e2d\uff0c\u8fd9\u4e9b\u86cb\u767d\u8d28\u7eb3\u7c73\u7ba1\u7684\u5f62\u6210\u662f\u5728\u4e25\u683c\u7684\u65f6\u7a7a\u63a7\u5236\u4e0b\u7ecf\u7531\u9057\u4f20\u7f16\u7801\u5f97\u5230\u7684\uff0c\u96be\u4ee5\u5728\u5b9e\u9a8c\u4e2d\u5b9e\u73b0\u590d\u5236\u3002\u8fd1\u5e74\u6765\uff0c\u968f\u7740\u7eb3\u7c73\u6280\u672f\u7684\u84ec\u52c3\u53d1\u5c55\uff0c\u5404\u79cd\u4eba\u5de5\u8bbe\u8ba1\u7684\u6709\u673a\u6216\u65e0\u673a\u7eb3\u7c73\u7ba1\u5728\u751f\u7269\u7269\u7406\u5b66\u3001\u5149\u5b50\u5b66\u548c\u7535\u5b50\u5b66\u7b49\u9886\u57df\u4e2d\u5c55\u73b0\u51fa\u5de8\u5927\u7684\u5e94\u7528\u6f5c\u529b\u3002\u5176\u4e2d\uff0c\u690d\u6839\u4e8e\u7ed3\u6784DNA\u7eb3\u7c73\u6280\u672f\u7684\u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u7531\u4e8e\u5176\u751f\u7269\u5b66\u6027\u8d28\u548c\u8bbe\u8ba1\u7075\u6d3b\u6027\u800c\u5f15\u8d77\u4e86\u4eba\u4eec\u7684\u6d53\u539a\u5174\u8da3\u3002\u76ee\u524dDNA\u7684\u5206\u5b50\u7ef4\u5ea6\u5df2\u88ab\u5f88\u597d\u5730\u7406\u89e3\uff0c\u56e0\u800cDNA\u7eb3\u7c73\u7ba1\u7684\u51e0\u4f55\u53c2\u6570\u53ef\u4ee5\u5b9e\u73b0\u7cbe\u786e\u7f16\u7a0b\uff0c\u53e6\u4e00\u65b9\u9762\uff0c\u590d\u6742\u8f6f\u4ef6\u7684\u4f7f\u7528\u8ba9\u7ed3\u6784\u8bbe\u8ba1\u53d8\u5f97\u66f4\u52a0\u5bb9\u6613\u3002\u6b64\u5916\uff0cDNA\u5408\u6210\u7684\u653e\u5927\u7b56\u7565\u4e5f\u4f7f\u5f97\u5927\u89c4\u6a21\u751f\u4ea7DNA\u7eb3\u7c73\u7ba1\u6210\u4e3a\u53ef\u80fd\u3002\u53d7\u76ca\u4e8e\u8fd9\u4e9b\u72ec\u7279\u7684\u6027\u8d28\u548c\u7814\u7a76\u6210\u679c\uff0c\u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u5df2\u7ecf\u4ece\u7b80\u5355\u7684\u7ed3\u6784\u6f14\u53d8\u4e3a\u590d\u6742\u7684\u7ed3\u6784\uff0c\u5e76\u4e14\u5176\u5728\u4eba\u5de5\u819c\u901a\u9053\u3001\u8d27\u7269\u8f93\u9001\u548c\u751f\u7269\u53cd\u5e94\u5668\u7b49\u65b9\u9762\u7684\u5e94\u7528\u6b63\u5728\u8fc5\u901f\u51fa\u73b0\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5357\u5f00\u5927\u5b66\u6797\u5efa\u5e73\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u4e0e\u4e0a\u6d77\u4ea4\u901a\u5927\u5b66\u6a0a\u6625\u6d77\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5728Angew. Chem. Int. Ed. <\/strong>\u4e0a\u53d1\u8868\u4e86\u9898\u4e3a\u201c<\/strong>Biomimetic DNA Nanotubes: Nanoscale Channel Design and Applications<\/strong>\u201d<\/strong>\u7684\u7efc\u8ff0\u3002\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u4e13\u6ce8\u4e8e\u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u7684\u7ed3\u6784\u8bbe\u8ba1\u3001\u8868\u5f81\u548c\u5e94\u7528\u7684\u603b\u7ed3\uff0c\u5e76\u6307\u51faDNA\u7eb3\u7c73\u7ba1\u7684\u901a\u9053\u80fd\u591f\u4e3a\u836f\u7269\u6301\u7eed\u91ca\u653e\u3001\u751f\u7269\u53cd\u5e94\u5668\u548c\u8de8\u819c\u901a\u9053\u63d0\u4f9b\u7cbe\u786e\u7684\u7eb3\u7c73\u7ea7\u7a7a\u8154\uff0c\u800c\u5916\u8868\u9762\u7684\u521a\u6027\u652f\u67b6\u548c\u591a\u4e2a\u6709\u5e8f\u8fde\u63a5\u4f4d\u70b9\u53ef\u7528\u4f5c\u8d27\u7269\u8fd0\u8f93\u8f7d\u4f53\u548c\u6a21\u677f\u3002\u6b64\u5916\uff0c\u7531\u4e8e\u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u7684\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u53ef\u7f16\u5740\u6027\uff0c\u5b83\u4eec\u5728\u751f\u7269\u6210\u50cf\u548c\u6cbb\u7597\u65b9\u9762\u4e5f\u663e\u793a\u51fa\u5de8\u5927\u7684\u6f5c\u529b\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u5177\u6709\u786e\u5b9a\u548c\u672a\u5b9a\u957f\u5ea6\u7684DNA\u7eb3\u7c73\u7ba1\u7684\u8bbe\u8ba1\u7b56\u7565<\/strong><\/p>\n

\"\"<\/p>\n

(a1<\/sub>) \u4eceDNA\u201c\u74f7\u7816\u201d\u8bbe\u8ba1\u76846HB\u7ed3\u6784\uff1b<\/p>\n

(a2-4<\/sub>) \u7531\u8702\u7a9d\u72b6\u3001\u65b9\u5f62\u548c\u516d\u89d2\u5f62\u87ba\u65cb\u6392\u5217\u7684DNA\u6298\u7eb8\u7ec4\u88c5\u7684DNA\u7eb3\u7c73\u7ba1\uff1b<\/p>\n

(b1<\/sub>) \u7531\u5355\u94fe\u201c\u74f7\u7816\u201d\u7ec4\u88c5\u800c\u6210\u7684\u5177\u6709\u53ef\u7f16\u7a0b\u5706\u5468\u7684DNA\u7eb3\u7c73\u7ba1\uff1b<\/p>\n

(b2<\/sub>) \u7531DNA\u8fde\u63a5\u5668\u63a7\u5236\u7684DNA\u7eb3\u7c73\u7ba1\u7684\u5305\u88f9\uff1b<\/p>\n

(b3<\/sub>) \u7ec4\u88c5\u4e92\u8fde\u5206\u5b50\u6807\u5fd7\u548cDNA\u7eb3\u7c73\u7ba1\u7684\u66f2\u7387\uff1b<\/p>\n

(b4<\/sub>) \u7531\u5782\u76f4\u6392\u5217\u7684\u68af\u7ea7\u6784\u6210\u7684\u4e09\u89d2\u5f62DNA\u7eb3\u7c73\u7ba1\u3002<\/p>\n

\u56fe2 \u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u4f5c\u4e3a\u836f\u7269\u9012\u9001\u8f7d\u4f53<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u8d1f\u8f7d\u572830HB DNA\u7eb3\u7c73\u7ba1\u4e0a\u768462\u4e2aCpG\u5e8f\u5217\uff1b<\/p>\n

(b) Dox\u8d1f\u8f7d\u5230\u5e73\u76f4\u548c\u626d\u66f2\u7684DNA\u7eb3\u7c73\u7ba1\u4e2d\uff1b<\/p>\n

(c) \u75c5\u6bd2\u8863\u58f3\u86cb\u767d\u8d1f\u8f7d\u5728DNA\u7eb3\u7c73\u7ba1\u4e0a\uff0c\u7531\u77e9\u5f62DNA\u6298\u7eb8\u5305\u88f9\u3002<\/p>\n

\u56fe3 DNA\u7eb3\u7c73\u7ba1\u4f5c\u4e3a\u7eb3\u7c73\u6a21\u677f<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u901a\u8fc7\u5c06AuNP\u9644\u7740\u572824\u87ba\u65cbDNA\u7eb3\u7c73\u7ba1\u4e0a\u5f62\u6210\u7684\u624b\u6027\u7b49\u79bb\u5b50\u4f53\u7eb3\u7c73\u7ed3\u6784\uff1b<\/p>\n

(b) \u4e0a\u56fe\uff1a\u808c\u7403\u86cb\u767d\u951a\u5b9a\u5728DNA\u7eb3\u7c73\u7ba1\u4e0a\u589e\u5f3a\u4e86\u808c\u52a8\u86cb\u767d\u4e1d\u7684\u6d41\u52a8\u6027\uff1b\u4e0b\u56fe\uff1a\u6cbf\u808c\u7403\u86cb\u767d\u7eb3\u7c73\u7ba1\uff08\u7ea2\u8272\uff09\u79fb\u52a8\u7684\u4e24\u6761\u808c\u52a8\u86cb\u767d\u4e1d\uff08\u7eff\u8272\uff09\u7684\u8fde\u7eed\u56fe\u50cf\uff1b<\/p>\n

(c) \u4e0a\u56fe\uff1a\u7528\u4e8e\u9ad8\u5206\u8fa8\u7387\u6210\u50cf\u7684\u8fde\u63a5\u5728DNA\u7eb3\u7c73\u7ba1\u4e0a\u7684\u6210\u50cf\u94fe\uff1b\u4e0b\u56fe\uff1aDNA\u7eb3\u7c73\u7ba1\u7684\u8d85\u5206\u8fa8\u7387\u56fe\u50cf\uff1b<\/p>\n

(d) \u8f6c\u5f55\u524d\u540e\u5728\u516d\u87ba\u65cb\u675f\u8def\u5f84\u4e0a\u79fb\u52a8DNA\u884c\u8d70\u673a\u5668\u4eba\u3002<\/p>\n

\u56fe4 \u57fa\u4e8eDNA\u7eb3\u7c73\u7ba1\u7684\u8de8\u819c\u901a\u9053<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u516d\u87ba\u65cb\u675f\u643a\u5e26\u7531\u786b\u4ee3\u78f7\u9178\u916f\u4fee\u9970\u5f62\u6210\u7684\u8de8\u819c\u758f\u6c34\u5e26\uff1b<\/p>\n

(b) \u7531\u8de8\u819c\u830e\u548c\u80c6\u56fa\u9187\u4fee\u9970\u7684\u5e3d\u7ec4\u6210\u7684DNA\u5b54\uff1b<\/p>\n

(c) \u5728\u535f\u5549\u7684\u5e2e\u52a9\u4e0b\u53cc\u94feDNA\u5f62\u6210\u7684\u79bb\u5b50\u901a\u9053\uff1b<\/p>\n

(d) \u8de8\u8d8a\u5177\u6709\u80c6\u56fa\u9187\u4fee\u9970\u7684\u8102\u8d28\u53cc\u5c42\u7684DNA\u5b54\u86cb\u767d\u3002<\/p>\n

\u56fe5 \u57fa\u4e8eDNA\u7eb3\u7c73\u7ba1\u7684\u591a\u9176\u751f\u7269\u53cd\u5e94\u5668<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5305\u542bG6pDH\u548c\u7ec4\u88c5\u5728DNA\u201c\u74f7\u7816\u201d\u7eb3\u7c73\u7ba1\u4e0aMDH\u7684\u591a\u9176\u590d\u5408\u7269\uff1b<\/p>\n

(b) DNA\u6298\u7eb8\u6784\u6210\u7684DNA\u7eb3\u7c73\u7ba1\u4e2d\u53d1\u751f\u7684GOx\u548cHRP\u7ea7\u8054\u53cd\u5e94\uff1b<\/p>\n

(c) \u57fa\u4e8e\u7ba1\u72b6DNA\u6298\u7eb8\u7684GOx\u548cHRP\u53cd\u5e94\u3002<\/p>\n

\u56fe6 \u57fa\u4e8eDNA\u7eb3\u7c73\u7ba1\u7684DNA\u7eb3\u7c73\u673a\u5668\u4eba<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u901a\u8fc7\u6dfb\u52a0\u201c\u94a5\u5319\u201d\u94fe\uff08\u7eff\u8272\uff09\u4ee5\u79fb\u9664\u201c\u9501\u201d\u94fe\uff08\u7ea2\u8272\uff09\u6765\u6253\u5f00\u79bb\u5b50\u901a\u9053\uff1b<\/p>\n

(b) \u6dfb\u52a0\u94fe\u6765\u91ca\u653eAuNP\u4ee5\u9009\u62e9\u6027\u5730\u6253\u5f00DNA\u7eb3\u7c73\u7ba1\uff1b<\/p>\n

(c) \u6838\u4ec1\u7d20\u523a\u6fc0\u7ba1\u72b6\u7eb3\u7c73\u673a\u5668\u4eba\u8c03\u6574\u6784\u8c61\u5f62\u6210\u77e9\u5f62DNA\u6298\u7eb8\uff1b<\/p>\n

(d) \u7531\u7535\u573a\u63a7\u5236\u7684\u7eb3\u7c73\u7ea7\u673a\u5668\u4eba\u624b\u81c2\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u5728\u8fd9\u7bc7\u7efc\u8ff0\u4e2d\uff0c\u4f5c\u8005\u7b80\u8981\u603b\u7ed3\u4e86DNA\u7eb3\u7c73\u7ba1\u7684\u8bbe\u8ba1\u7b56\u7565\u4ee5\u53ca\u5229\u7528\u5176\u7ed3\u6784\u7279\u5f81\u5b9e\u73b0\u7684\u5e94\u7528\u3002\u540c\u65f6\uff0c\u5bf9\u4e8e\u73b0\u5b9e\u4e16\u754c\u7684\u751f\u7269\u5b66\u5e94\u7528\u4ecd\u7136\u5b58\u5728\u6311\u6218\uff0c\u6bd4\u5982\u7cbe\u786e\u63a7\u5236\u7ec6\u80de\u4e2d\u7684\u8d27\u7269\u91ca\u653e\u4ecd\u7136\u5f88\u56f0\u96be\u3002\u6700\u540e\uff0c\u4f5c\u8005\u4e5f\u6307\u51faDNA\u7eb3\u7c73\u7ba1\u7684\u5408\u6210\u4ea7\u7387\u3001\u7eaf\u5ea6\u548c\u89c4\u6a21\u7684\u63d0\u5347\u5bf9\u4e8e\u8bf8\u591a\u5e94\u7528\u7684\u6539\u5584\u5177\u6709\u91cd\u8981\u4f5c\u7528\u3002\u603b\u4e4b\uff0c\u867d\u7136\u76ee\u524d\u6311\u6218\u4ecd\u7136\u5b58\u5728\uff0cDNA\u7eb3\u7c73\u6280\u672f\u7684\u663e\u8457\u7814\u7a76\u8fdb\u5c55\u8fd8\u662f\u4f7f\u5f97\u6211\u4eec\u53ef\u4ee5\u5c55\u671b\u4eff\u751fDNA\u7eb3\u7c73\u7ba1\u5c06\u5bf9\u57fa\u7840\u751f\u7269\u5b66\u7814\u7a76\u548c\u73b0\u5b9e\u4e16\u754c\u7684\u533b\u7597\u4fdd\u5065\u4ea7\u751f\u91cd\u5927\u5f71\u54cd\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aBiomimetic DNA Nanotubes: Nanoscale Channel Design and Applications<\/a>\u00a0<\/strong>\u00a0(Angew. Chem. Int. Ed. 2019, DOI: 10.1002\/anie.201807779)<\/p>\n

\u672c\u6587\u7531biotech\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002<\/p>\n

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