{"id":170633,"date":"2019-03-28T06:30:12","date_gmt":"2019-03-27T22:30:12","guid":{"rendered":"\/\/m.iemloyee.com\/?p=170633"},"modified":"2019-03-27T19:14:31","modified_gmt":"2019-03-27T11:14:31","slug":"%e5%ae%be%e5%a4%95%e6%b3%95%e5%b0%bc%e4%ba%9a%e5%a4%a7%e5%ad%a6nat-mater-%e5%b1%80%e9%83%a8%e6%96%b0%e7%94%9f%e8%9b%8b%e7%99%bd%e6%b2%89%e7%a7%af%e9%87%8d%e6%9e%84%e5%bc%95%e5%af%bc%e4%b8%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=170633","title":{"rendered":"\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66Nat. Mater.: \u5c40\u90e8\u65b0\u751f\u86cb\u767d\u6c89\u79ef\u91cd\u6784\u5f15\u5bfc\u4e09\u7ef4\u6c34\u51dd\u80f6\u4e2d\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de\u7684\u673a\u68b0\u654f\u611f\u548c\u884c\u4e3a\u529f\u80fd\u8c03\u63a7"},"content":{"rendered":"<p><strong>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n<p>\u751f\u7406\u80de\u5916\u5fae\u73af\u5883\u63d0\u4f9b\u4e86\u8c03\u8282\u7ec6\u80de\u884c\u4e3a\u548c\u529f\u80fd\u7684\u7269\u7406\u548c\u5316\u5b66\u4fe1\u53f7\uff0c\u800c\u6c34\u51dd\u80f6\u4f5c\u4e3a\u7814\u7a76\u7ec6\u80de-\u7ec6\u80de\u5916\u57fa\u8d28\u5728\u4e09\u7ef4\u73af\u5883\u4e2d\u76f8\u4e92\u4f5c\u7528\u7684\u91cd\u8981\u5de5\u5177\uff0c\u5b83\u53ef\u4ee5\u56ca\u62ec\u751f\u7406\u80de\u5916\u57fa\u8d28\u7684\u5404\u4e2a\u65b9\u9762\u3002\u73b0\u5982\u4eca\uff0c\u5408\u6210\u6c34\u51dd\u80f6\u5df2\u88ab\u5f00\u53d1\u6210\u6a21\u62df\u751f\u7406\u7ec6\u80de\u5fae\u73af\u5883\u7684\u4e09\u7ef4\uff083D\uff09\u57f9\u517b\u7cfb\u7edf\uff0c\u5e76\u5c06\u5176\u7528\u4e8e\u63a2\u7d22\u7ec6\u80de\u5982\u4f55\u611f\u77e5\u548c\u54cd\u5e94\u8fd9\u4e9b\u4fe1\u53f7\uff0c\u4ee5\u9488\u5bf9\u7ec4\u7ec7\u5de5\u7a0b\u4e09\u7ef4\u6c34\u51dd\u80f6\u7684\u5408\u7406\u8bbe\u8ba1\u3002\u867d\u7136\u57fa\u8d28\u521a\u5ea6\u662f\u8c03\u8282\u7ec6\u80de\u884c\u4e3a\u6240\u516c\u8ba4\u7684\u53c2\u6570\uff0c\u4f46\u6c34\u51dd\u80f6\u4e2d\u5176\u4ed6\u7ec4\u5206\u5982\u901a\u8fc7\u86cb\u767d\u6c34\u89e3\u964d\u89e3\u91cd\u6784\u6216\u6750\u6599\u5e94\u529b\u677e\u5f1b\uff0c\u5bf9\u8c03\u63a7\u7ec6\u80de\u884c\u4e3a\u529f\u80fd\u4e5f\u662f\u81f3\u5173\u91cd\u8981\u7684\u3002\u8fd9\u4e9b\u56e0\u7d20\u5bf9\u7ec6\u80de\u7684\u4e09\u7ef4\u7ed3\u6784\u7279\u522b\u91cd\u8981\uff0c\u56e0\u4e3a\u5728\u7ec6\u80de\u4e09\u7ef4\u7ed3\u6784\u4e2d\uff0c\u52a8\u6001\u6c34\u51dd\u80f6\u91cd\u7ec4\u53ef\u4ee5\u4f7f\u7ec6\u80de\u9aa8\u67b6\u5f20\u529b\u589e\u5927\u3001\u7ec6\u80de\u8fdb\u884c\u589e\u6b96\u548c\u5206\u5316\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u7ec6\u80de\u8fd8\u80fd\u5728\u6c34\u51dd\u80f6\u4e2d\u5408\u6210\u548c\u6c89\u79ef\u86cb\u767d\u8d28\uff0c\u5305\u62ec\u7ec6\u80de\u5916\u57fa\u8d28\uff08ECM\uff09\u86cb\u767d\u3002\u7136\u800c\uff0c\u5c3d\u7ba1\u8fd9\u4e9b\u65b0\u751f\u86cb\u767d\u5728\u7ec6\u80de\u5916\u57fa\u8d28\u5468\u56f4\u4e2d\u7684\u65e9\u671f\u6c89\u79ef\u5f88\u6709\u53ef\u80fd\u4ecb\u5bfc\u7ec6\u80de\u53d1\u51fa\u7269\u7406\u548c\u5316\u5b66\u4fe1\u53f7\uff0c\u4f46\u662f\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u5176\u5bf9\u7ec6\u80de-\u6c34\u51dd\u80f6\u76f8\u4e92\u4f5c\u7528\u7684\u5f71\u54cd\u5f80\u5f80\u88ab\u5ffd\u89c6\u4e86\u3002<\/p>\n<p><strong>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n<p>\u6700\u8fd1\uff0c<strong>\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5927\u5b66Jason A. Burdick\u6559\u6388<\/strong>\u56e2\u961f\u9996\u6b21\u62a5\u9053\u4e86\u5728\u590d\u5408\u6c34\u51dd\u80f6\u4e2d\u65b0\u751f\u57fa\u8d28\u7ec6\u80de\u7c98\u9644\u548c\u91cd\u6784\u7684\u673a\u68b0\u654f\u611f\u8c03\u8282\u3002\u5229\u7528\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u6280\u672f\uff0c\u7814\u7a76\u8005\u4eec\u89c2\u5bdf\u4e86\u5728\u591a\u79cd\u6c34\u51dd\u80f6\u4e2d\u57f9\u517b\u4e00\u5929\u540e\u7684\u65b0\u751f\u86cb\u767d\u3002\u800c\u5728\u53ef\u86cb\u767d\u964d\u89e3\u7684\u4e24\u79cd\u5171\u4ef7\u4ea4\u8054\u548c\u52a8\u6001\u7c98\u5f39\u6027\u900f\u660e\u8d28\u9178\u51dd\u80f6\u8fd9\u7528\u4e8e\u4e09\u7ef4\u751f\u7269\u529b\u5b66\u7814\u7a76\u7684\u5de5\u7a0b\u6c34\u51dd\u80f6\u4e2d\uff0c\u7814\u7a76\u8005\u4eec\u53c8\u89c2\u5bdf\u4e86\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de\u5206\u5316\u3001YAP\/TAZ\u6838\u8f6c\u4f4d\u548c\u6210\u9aa8\u5206\u5316\u3002\u7ed3\u679c\u8868\u660e\uff0c\u6291\u5236\u7ec6\u80de\u5bf9\u65b0\u751f\u86cb\u767d\u7684\u7c98\u9644\u6216\u65b0\u751f\u86cb\u767d\u91cd\u6784\uff0c\u4f1a\u51cf\u5c11\u95f4\u5145\u8d28\u57fa\u8d28\u7ec6\u80de\u7684\u5206\u6563\u548cYAP\/TAZ\u7684\u6838\u8f6c\u4f4d\uff0c\u4ece\u800c\u5bfc\u81f4\u57fa\u8d28\u7ec6\u80de\u5411\u8102\u80aa\u7ec6\u80de\u5206\u5316\u7684\u8f6c\u53d8\u3002\u8fd9\u9879\u7814\u7a76\u7740\u91cd\u4e8e\u65b0\u751f\u86cb\u767d\u5728\u7ec6\u80de\u5bf9\u5de5\u7a0b\u6750\u6599\u611f\u5e94\u4e2d\u7684\u4f5c\u7528\uff0c\u8fd9\u5bf9\u4e8e\u4f53\u5916\u7ec6\u80de\u4fe1\u53f7\u7814\u7a76\u548c\u7ec4\u7ec7\u4fee\u590d\u5e94\u7528\u5177\u6709\u91cd\u5927\u7684\u610f\u4e49\u3002\u76f8\u5173\u6210\u679c\u4ee5\u201c<strong>Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels<\/strong>\u201d\u53d1\u8868\u4e8e<strong>Nat. Mater.<\/strong>\u671f\u520a\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001\u5305\u57cbhMsCs\u53d1\u751f\u4e8e\u65e9\u671f\u7684\u65b0\u751f\u86cb\u767d\u6c89\u79ef\uff0c\u4e0e\u6c34\u51dd\u80f6\u7c7b\u578b\u65e0\u5173<\/strong><br \/>\n <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-170635\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/03\/Fig1.jpg\" alt=\"\" width=\"600\" height=\"484\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/03\/Fig1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/03\/Fig1-300x242.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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\/>\u7ec6\u80de\u4e0e\u4e09\u7ef4\u6c34\u51dd\u80f6\u76f8\u4e92\u4f5c\u7528\uff0c\u5728\u65b0\u751f\u86cb\u767d\u6c89\u79ef\u5f62\u6210\u7ec6\u80de\u5916\u57fa\u8d28\u4e4b\u524d\uff0c\u77ed\u65f6\u95f4\u5185\u4e0e\u5176\u914d\u5408\u8fde\u63a5\u3002\u6c34\u51dd\u80f6\u7684\u6027\u8d28\u51b3\u5b9a\u4e86\u88ab\u5305\u88f9\u7684\u7ec6\u80de\u662f\u5426\u80fd\u591f\u5206\u5316\uff0c\u4f46\u5206\u5316\u9700\u8981\u7c98\u9644\u86cb\u767d\u548c\u65b0\u751f\u86cb\u767d\u7684\u6d3b\u6027\u91cd\u6784\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u7efc\u4e0a\u6240\u8ff0\uff0c\u8be5\u7814\u7a76\u56e2\u961f\u5728\u7814\u7a76\u5408\u6210\u6c34\u51dd\u80f6\u7528\u4e8e\u8c03\u63a7\u57fa\u8d28\u7ec6\u80de\u884c\u4e3a\u529f\u80fd\u65f6\uff0c\u53d1\u73b0\u7ec6\u80de\u884c\u4e3a\u529f\u80fd\u4e0d\u4ec5\u53d7\u6700\u521d\u8bbe\u8ba1\u7684\u7ec6\u80de-\u6c34\u51dd\u80f6\u754c\u9762\u7684\u5f71\u54cd\uff0c\u8fd8\u53d7\u5230\u5728\u57f9\u517b\u5f00\u59cb\u4e0d\u4e45\u540e\u7ec6\u80de\u5c40\u90e8\u6c89\u79ef\u7684\u65b0\u751f\u86cb\u767d\u7c98\u9644\u548c\u91cd\u6784\u7684\u5f71\u54cd\u3002\u5bf9\u4e8e\u4ee5\u524d\u76f8\u5173\u7814\u7a76\u62a5\u9053\u5e38\u5ffd\u7565\u7684\u8fd9\u4e00\u70b9\uff0c\u4ed6\u4eec\u901a\u8fc7\u91c7\u7528\u65b0\u5174\u7684\u80de\u5916\u86cb\u767d\u6807\u8bb0\u65b9\u6cd5\uff0c\u6df1\u5165\u63a2\u7a76\u4e86\u7ec6\u80de-\u6c34\u51dd\u80f6\u754c\u9762\u7684\u52a8\u6001\u7279\u6027\uff0c\u4ee5\u53ca\u8be5\u754c\u9762\u5728\u4ecb\u5bfc\u7ec6\u80de\u884c\u4e3a\u529f\u80fd\u65b9\u9762\u65f6\u6240\u53d1\u6325\u7684\u534f\u540c\u4f5c\u7528\u3002\u7814\u7a76\u7ed3\u679c\u8868\u660e\uff0c\u5728\u8bb8\u591a\u6c34\u51dd\u80f6\u7cfb\u7edf\u4e2d\uff0c\u65b0\u751f\u86cb\u767d\u5f62\u6210\u5e76\u91cd\u65b0\u5f71\u54cd\u7ec6\u80de\u5916\u5fae\u73af\u5883\uff0c\u5f53\u7279\u5b9a\u7684\u65b0\u751f\u86cb\u767d\u7c98\u9644\u6216\u91cd\u6784\u88ab\u963b\u65ad\u65f6\uff0c\u5176\u57fa\u8d28\u7ec6\u80de\u884c\u4e3a\u529f\u80fd\u4f1a\u53d1\u751f\u7279\u5b9a\u7684\u53d8\u5316\u3002\u6b64\u5916\uff0c\u4f5c\u8005\u8ba4\u4e3a\u65b0\u751f\u7684\u7ec6\u80de\u57fa\u8d28\u86cb\u767d\u7c98\u9644\u548c\u7ec4\u88c5\u5f71\u54cd\u7ec6\u80de\u611f\u77e5\uff0c\u8fd9\u80fd\u89e3\u91ca\u5176\u5fae\u73af\u5883\u8bf1\u5bfc\u539f\u56e0\uff1b\u4f46\u5355\u4e2a\u86cb\u767d\u7684\u529f\u80fd\u7ec4\u88c5\uff0c\u4ee5\u53ca\u5982\u4f55\u88ab\u521d\u59cb\u6750\u6599\u5bfc\u81f4\u7684\u4e00\u4e9b\u56e0\u7d20\u6240\u8c03\u63a7\uff0c\u8fd9\u4e2a\u590d\u6742\u7684\u53cd\u9988\u673a\u5236\u4ecd\u6709\u5f85\u8fdb\u4e00\u6b65\u7684\u7814\u7a76\u9610\u660e\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41563-019-0307-6\" target=\"_blank\" rel=\"noopener\">Local nascent protein deposition and remodelling guide mesenchymal stromal cell mechanosensing and fate in three-dimensional hydrogels<\/a>\uff08<em>Nat. Mater.<\/em> <strong>2019.<\/strong> DOI\uff1ahttps:\/\/doi.org\/10.1038\/s41563-019-0307-6\uff09<\/p>\n<p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u751f\u7ec4\u6211\u4ea6\u662f\u884c\u4eba\u7f16\u8bd1\uff0c\u6750\u6599\u4eba\u6574\u7406\u3002<\/p>\n<p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1a<a href=\"mailto:tougao@cailiaoren.com.\" target=\"_blank\" rel=\"noopener\">tougao@cailiaoren.com.<\/a><\/p>\n<p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u80cc\u666f\u4ecb\u7ecd\u3011 \u751f\u7406\u80de\u5916\u5fae\u73af\u5883\u63d0\u4f9b\u4e86\u8c03\u8282\u7ec6\u80de\u884c\u4e3a\u548c\u529f\u80fd\u7684\u7269\u7406\u548c\u5316\u5b66\u4fe1\u53f7\uff0c\u800c\u6c34\u51dd\u80f6\u4f5c\u4e3a\u7814\u7a76\u7ec6\u80de-\u7ec6\u80de\u5916\u57fa\u8d28\u5728\u4e09\u7ef4\u73af\u5883\u4e2d\u76f8\u4e92\u4f5c\u7528\u7684\u91cd\u8981\u5de5\u5177\uff0c\u5b83\u53ef\u4ee5\u56ca\u62ec\u751f\u7406\u80de\u5916\u57fa\u8d28\u7684\u5404&#8230;<\/p>\n","protected":false},"author":11455,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[3952],"class_list":["post-170633","post","type-post","status-publish","format-standard","hentry","category-jiedu","tag-3952"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/170633"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/11455"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=170633"}],"version-history":[{"count":3,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/170633\/revisions"}],"predecessor-version":[{"id":170653,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/170633\/revisions\/170653"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=170633"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=170633"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=170633"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}