{"id":167234,"date":"2019-02-17T06:17:05","date_gmt":"2019-02-16T22:17:05","guid":{"rendered":"\/\/m.iemloyee.com\/?p=167234"},"modified":"2019-02-16T20:51:17","modified_gmt":"2019-02-16T12:51:17","slug":"%e3%80%90%e5%ae%a1%e7%a8%bf%e5%b7%b2%e5%9b%9e%e5%a4%8d%e3%80%91%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6acs-nano-%e6%8f%90%e9%ab%98cu2-xse%e7%ba%b3%e7%b1%b3%e6%99%b6%e4%bd%93%e7%9a%84%e6%94%be%e5%b0%84","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=167234","title":{"rendered":"\u82cf\u5dde\u5927\u5b66ACS Nano: \u63d0\u9ad8Cu2-xSe\u7eb3\u7c73\u6676\u4f53\u7684\u653e\u5c04\u589e\u654f\u548c\u5149\u70ed\u6027\u80fd\uff0c\u7528\u4e8e\u653e\u5c04\u7597\u6cd5\u4e0e\u5149\u70ed\u7597\u6cd5\u534f\u540c\u6cbb\u7597\u539f\u4f4d\u4e73\u817a\u764c"},"content":{"rendered":"
\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n 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\u8fd1\u65e5\uff0c\u82cf\u5dde\u5927\u5b66\u674e\u6862\u6559\u6388\u8bfe\u9898\u7ec4<\/b><\/strong>\u62a5\u5bfc\u4e86\u54d1\u94c3\u578b\u5f02\u8d28\u7ed3\u6784\u7684\u7852\u5316\u94dc-\u91d1\u7eb3\u7c73\u63a2\u9488\u53ef\u4ee5\u4f5c\u4e3a\u4e00\u79cd\u9ad8\u6548\u7684\u653e\u5c04\u589e\u654f\u5242\uff0c\u7528\u4e8e\u589e\u5f3a\u653e\u5c04\u6cbb\u7597\u30024T1\u80bf\u7624\u7ec6\u80de\u541e\u566c\u5f02\u8d28\u7ed3\u6784\u7eb3\u7c73\u6676\u4f53\u540e\uff0c\u5176X\u5c04\u7ebf\u7684\u5e73\u5747\u81f4\u6b7b\u5242\u91cf\u8f83\u6ca1\u541e\u566c\u76844T1\u7ec6\u80de\u663e\u8457\u964d\u4f4e\u4e8640%\u3002\u7531\u4e8e\u5f02\u8d28\u7ed3\u6784\u7684\u534f\u540c\u4f5c\u7528\uff0c\u6240\u7528\u7684X\u5c04\u7ebf\u5242\u91cf\u4e5f\u8fdc\u4f4e\u4e8e\u76f8\u5e94\u7684Cu2-x<\/sub>Se\u7eb3\u7c73\u9897\u7c92\u3001Au\u7eb3\u7c73\u9897\u7c92\u53ca\u4e8c\u8005\u7684\u6df7\u5408\u7269\u3002Cu2-x<\/sub>Se-Au\uff08CSA\uff09\u5f02\u8d28\u7ed3\u6784\u7684\u653e\u5c04\u589e\u654f\u6548\u7387\u8f83 Cu2-x<\/sub>Se\u7eb3\u7c73\u9897\u7c92\u663e\u8457\u63d0\u9ad8\u4e8645%\uff08\u4ece1.1 Gy\u52301.6 Gy\uff09\u3002\u540c\u65f6\uff0c\u7531\u4e8e\u5c40\u90e8\u8868\u9762\u7b49\u79bb\u5b50\u5171\u632f\u7684\u534f\u540c\u4f5c\u7528\uff0c\u5f02\u8d28\u7ed3\u6784\u7eb3\u7c73\u63a2\u9488\u7684\u5149\u70ed\u8f6c\u5316\u6548\u7387\u4e5f\u663e\u8457\u63d0\u9ad8\u4e86\u3002\u8fd9\u4e9b\u7279\u6027\u4f7f\u5176\u6210\u4e3a\u591a\u6a21\u6001\u6210\u50cf\u9020\u5f71\u5242\u548c\u7528\u4e8e\u6210\u50cf\u5f15\u5bfc\u7684\u653e\u5c04\/\u5149\u70ed\u534f\u540c\u6cbb\u7597\u764c\u75c7\u7684\u8bd5\u5242\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a\u201dBoosting the Radiosensitizing and Photothermal Performance of Cu<\/b><\/strong>2-x<\/b><\/sub><\/strong>Se Nanocrystals for Synergetic Radiophotothermal Therapy of Orthotopic Breast Cancer<\/b><\/strong>\u201d\u53d1\u8868\u5728ACS Nano<\/b><\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n Scheme 1.\u5f02\u8d28\u7ed3\u6784\u7684\u7852\u5316\u94dc-\u91d1\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u591a\u6a21\u6001\u6210\u50cf\u548c\u653e\u7597\u4e0e\u5149\u70ed\u534f\u540c\u6cbb\u7597\u764c\u75c7\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n Figure 1.\u7eb3\u7c73\u9897\u7c92\u7684\u8868\u5f81<\/b><\/strong><\/p>\n (a,b).CS\u7eb3\u7c73\u9897\u7c92\u548cCSA\u7eb3\u7c73\u9897\u7c92\u7684TEM\u56fe<\/p>\n (c). CSA\u7eb3\u7c73\u9897\u7c92\u7684HRTEM\u56fe<\/p>\n (d).CSA\u7eb3\u7c73\u9897\u7c92\u7684\u9ad8\u89d2\u5ea6\u73af\u5f62\u6697\u573a\u626b\u63cfTEM<\/p>\n (e).CS\u7eb3\u7c73\u9897\u7c92\u548cCSA\u7eb3\u7c73\u9897\u7c92\u7684XRD\u8868\u5f81<\/p>\n (f). CS\u7eb3\u7c73\u9897\u7c92\u548cCSA\u7eb3\u7c73\u9897\u7c92\u7684\u7d2b\u5916\u5438\u6536\u8c31\u56fe<\/p>\n Figure 2.\u7eb3\u7c73\u9897\u7c92\u4f53\u5916\u6210\u50cf\u4e0e\u6cbb\u7597\u8868\u5f81<\/b><\/strong><\/p>\n (a).CSA\u7eb3\u7c73\u9897\u7c92\u6eb6\u6db2\u7684\u5149\u70ed\u7a33\u5b9a\u6027<\/p>\n (b,c).\u4e0d\u540c\u6d53\u5ea6\u7684CSA\u6eb6\u6db2\u5728808 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u7684\u5347\u6e29\u7167\u7247\u548c\u5149\u70ed\u66f2\u7ebf<\/p>\n (d).\u4e0d\u540c\u6d53\u5ea6\u7684CSA\u6eb6\u6db2\u7684\u5149\u58f0\u6210\u50cf\u56fe\u50cf\u548c\u4fe1\u53f7\u5f3a\u5ea6<\/p>\n (e).\u4e0d\u540c\u6d53\u5ea6CSA\u7eb3\u7c73\u9897\u7c92\u6eb6\u6db2\u7684\u7ec6\u80de\u6bd2\u6027<\/p>\n (f).\u4e0d\u540c\u6d53\u5ea6CSA\u7eb3\u7c73\u63a2\u9488\u5728\u4e0d\u540c\u6fc0\u5149\u5f3a\u5ea6\u7167\u5c04\u4e0b\u5bf94T1\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528<\/p>\n \u56fe3.\u534f\u540c\u653e\u5c04\u70ed\u6cbb\u7597<\/b><\/strong>\u00a0<\/b><\/strong> (a).\u4e0e\u4e0d\u540c\u6d53\u5ea6\u7684CS\uff0cAu\u548cCS+Au\u7eb3\u7c73\u9897\u7c92\u4ee5\u53ca\u4e34\u5e8a\u4f7f\u7528\u7684\u7898\u666e\u7f57\u80fa\u76f8\u6bd4\uff0cCSA\u7eb3\u7c73\u9897\u7c92\u7684\u4f53\u5916CT\u6210\u50cf\u548c\u4fe1\u53f7\u5f3a\u5ea6<\/p>\n (b).\u00a04T1\u7ec6\u80de\u5206\u522b\u4e0eCS\uff0cAu\uff0cCS+Au\u548cCSA\u7eb3\u7c73\u9897\u7c92\u5171\u57f9\u517b\u540e\uff0c\u5728\u4e0d\u540c\u5242\u91cfX\u5c04\u7ebf\u7167\u5c04\u4e0b\u7684\u5b58\u6d3b\u7387<\/p>\n (c). 4T1\u7ec6\u80de\u5206\u522b\u4e0eCS\uff0cAu\uff0cCS+Au\u548cCSA\u7eb3\u7c73\u9897\u7c92\u5171\u57f9\u517b\u540e\uff0c 6 Gy X\u5c04\u7ebf\u7167\u5c04\u540e\u7684\u7ec6\u80deDNA\u635f\u4f24<\/p>\n (d). 4T1\u7ec6\u80de\u4e0eCSA\u7eb3\u7c73\u9897\u7c92\u57f9\u80b2\u540e\uff0c\u5728\u4e0d\u540c\u6fc0\u5149\u548c\u5c04\u7ebf\u5f3a\u5ea6\u7167\u5c04\u4e0b\u7684\u534f\u540c\u6cbb\u7597\u5206\u6790<\/p>\n \u56fe4.\u8840\u5e38\u89c4\u68c0\u67e5\u548c\u8840\u751f\u5316\u5206\u6790<\/b><\/strong><\/p>\n \u56fe5.\u6d3b\u4f53\u6210\u50cf<\/b><\/strong><\/p>\n (b).\u6ce8\u5c0499m<\/sup>Tc\u6807\u8bb0\u7684CSA\u7eb3\u7c73\u9897\u7c92\u6eb6\u6db2\u540e\uff0c4T1\u539f\u4f4d\u8377\u7624\u5c0f\u9f20\u7684SPECT\/CT\u56fe\u50cf<\/p>\n (c,d).\u7624\u5185\u5206\u522b\u6ce8\u5c04CSA\u7eb3\u7c73\u9897\u7c92\u548c\u7898\u666e\u7f57\u80fa\u6eb6\u6db2\u540e\uff0c\u80bf\u7624\u7684CT\u56fe\u50cf\u548c\u4fe1\u53f7\u5f3a\u5ea6\u5bf9\u6bd4<\/p>\n \u56fe6.\u6d3b\u4f53\u6cbb\u7597\u6548\u679c<\/b><\/strong><\/p>\n (a,b). 4T1\u539f\u4f4d\u8377\u7624\u5c0f\u9f20\u5728\u6ce8\u5c04CSA\u7eb3\u7c73\u9897\u7c92\u6eb6\u6db2\u548cPBS\u6eb6\u6db2\u540e\u5149\u70ed\u6cbb\u7597\u65f6\u7684\u7ea2\u5916\u70ed\u6210\u50cf\u56fe\u50cf\u548c\u80bf\u7624\u90e8\u4f4d\u5347\u6e29\u66f2\u7ebf<\/p>\n (c,d,e,f). 4T1\u539f\u4f4d\u8377\u7624\u5c0f\u9f20\u5728\u4e0d\u540c\u6761\u4ef6\u6cbb\u7597\u540e\u7684\u4f53\u91cd\u3001\u80bf\u7624\u4f53\u79ef\u3001\u5b58\u6d3b\u7387\u53d8\u5316\u548c\u80ba\u90e8\u5207\u7247\u56fe<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n \u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u901a\u8fc7\u5ba4\u6e29\u4e0b\u7852\u5316\u94dc\u7eb3\u7c73\u9897\u7c92\u4e0eHAuCl4<\/sub>\u6eb6\u6db2\u4e4b\u95f4\u7684\u81ea\u53d1\u6c27\u5316\u8fd8\u539f\u53cd\u5e94\uff0c\u6210\u529f\u5236\u5907\u4e86\u7852\u5316\u94dc-\u91d1\u5f02\u8d28\u7ed3\u7eb3\u7c73\u9897\u7c92\u6676\u4f53\u3002\u7531\u4e8e\u534f\u540c\u6548\u5e94\uff0c\u6240\u5f97\u7684\u5f02\u8d28\u7ed3\u6784\u5728\u5149\u70ed\u8f6c\u5316\u6548\u7387\u548cX\u5c04\u7ebf\u8870\u51cf\u65b9\u9762\u6bd4\u5355\u72ec\u7684\u7852\u5316\u94dc\u7eb3\u7c73\u9897\u7c92\u3001\u91d1\u7eb3\u7c73\u9897\u7c92\u53ca\u4e24\u8005\u6df7\u5408\u7269\u5177\u6709\u66f4\u597d\u7684\u6027\u80fd\u3002\u8fd9\u4e9b\u7279\u6027\u786e\u4fdd\u4e86\u7852\u5316\u94dc-\u91d1\u5f02\u8d28\u7ed3\u7eb3\u7c73\u6676\u4f53\u5728\u591a\u6a21\u6001\u6210\u50cf\u3001\u653e\u7597\u4e0e\u70ed\u7597\u534f\u540c\u6cbb\u7597\u539f\u4f4d\u4e73\u817a\u764c\u65f6\u7684\u826f\u597d\u6027\u80fd\u3002<\/p>\n<\/p>\n
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\u00a0<\/b><\/strong>(a).\u00a04T1\u539f\u4f4d\u8377\u7624\u5c0f\u9f20\u6ce8\u5c04CSA\u6eb6\u6db2\u524d\u540e\u7684\u80bf\u7624\u5149\u58f0\u6210\u50cf<\/p>\n
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