{"id":166849,"date":"2019-02-07T08:34:06","date_gmt":"2019-02-07T00:34:06","guid":{"rendered":"\/\/m.iemloyee.com\/?p=166849"},"modified":"2019-02-07T12:07:35","modified_gmt":"2019-02-07T04:07:35","slug":"%e7%94%9f%e7%89%a9%e5%90%88%e6%88%90%e6%9c%80%e6%96%b0nature%e9%87%91%e5%b1%9e%e9%85%b6%e6%9e%84%e5%bb%ba%e5%8c%96%e7%96%97%e8%8d%af%e7%89%a9%e7%9a%84%e8%8d%af%e6%95%88%e5%9f%ba%e5%9b%a2","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=166849","title":{"rendered":"\u751f\u7269\u5408\u6210\u6700\u65b0Nature:\u91d1\u5c5e\u9176\u6784\u5efa\u5316\u7597\u836f\u7269\u7684\u836f\u6548\u57fa\u56e2"},"content":{"rendered":"<p><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n<p>\u94fe\u8132\u4f50\u83cc\u7d20\uff08SZN\/STZ\uff09\u662f\u4e00\u79cd\u5929\u7136\u7684\u6c28\u57fa\u8461\u8404\u7cd6-\u4e9a\u785d\u57fa\u8132\u7c7b\u5316\u5408\u7269\uff0c\u5b83\u4e0d\u4ec5\u662f\u4e00\u79cd\u6297\u764c\u7684\u5316\u7597\u836f\u7269\uff0c\u4e5f\u5e38\u5e38\u56e0\u4e3a\u5bf9\u80f0\u5c9b\u03b2\u7ec6\u80de\u5177\u6709\u6bd2\u6027\u800c\u88ab\u7528\u4e8e\u5f15\u53d1\u5efa\u7acb\u7cd6\u5c3f\u75c5\u52a8\u7269\u6a21\u578b\u3002\u76ee\u524d\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8fd9\u4e00\u836f\u7269\u4e3b\u8981\u901a\u8fc7\u4ea7\u751fDNA\u70f7\u57fa\u5316\u8bd5\u5242\u4ee5\u53ca\u6d3b\u6027\u6c27\u524d\u9a71\u4f53\u6765\u8868\u73b0\u51fa\u5bf9\u7ec6\u80de\u7684\u6bd2\u6027\uff0c\u4ece\u800c\u53d1\u6325\u7279\u5b9a\u7684\u6cbb\u7597\u4f5c\u7528\u3002\u7136\u800c\uff0c\u5173\u4e8e\u94fe\u8132\u4f50\u83cc\u7d20\u7684\u751f\u7269\u5408\u6210\u9014\u5f84\u4ee5\u53ca\u76f8\u5173\u9176\u7684\u4f5c\u7528\u4f9d\u7136\u672a\u88ab\u63ed\u793a\u3002<\/p>\n<p>\u3010<strong>\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n<p><strong>\u5bbe\u5915\u6cd5\u5c3c\u4e9a\u5dde\u7acb\u5927\u5b66\u5927\u5b66\u7684<\/strong><strong>A. K. Boal<\/strong><strong>\u4ee5\u53ca<\/strong><strong>\u54c8\u4f5b\u5927\u5b66\u7684<\/strong><strong>E. P. Balskus<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u53d1\u8868\u6587\u7ae0\uff0c\u7814\u7a76\u9610\u91ca\u4e86\u76f8\u5173\u91d1\u5c5e\u9176\u5728\u6784\u5efaSZN\u836f\u6548\u57fa\u56e2\u8fc7\u7a0b\u4e2d\u7684\u4f5c\u7528\u673a\u7406\u3002\u7814\u7a76\u4eba\u5458\u8ba4\u4e3a\u8fd9\u4e00\u88ab\u547d\u540d\u4e3aSznF\u7684\u91d1\u5c5e\u9176\u80fd\u591f\u53c2\u4e0e\u5230SZN\u7684\u751f\u7269\u5408\u6210\u8fc7\u7a0b\u4e2d\uff0c\u50ac\u5316\u7532\u57fa\u7cbe\u6c28\u9178\uff08L-NMA\uff09\u4e0a\u7684\u80cd\u57fa\u53d1\u751f\u6c27\u5316\u91cd\u6392\u53cd\u5e94\uff0c\u4ece\u800c\u751f\u6210\u4e9a\u785d\u57fa\u8132\u7c7b\u6700\u7ec8\u4ea7\u7269\u3002SznF\u7684\u7ed3\u6784\u8868\u5f81\u53ca\u7a81\u53d8\u73b0\u8c61\u8fd8\u63ed\u793a\u4e86\u8fd9\u4e00\u91d1\u5c5e\u9176\u4e2d\u5b58\u5728\u4e24\u79cd\u72ec\u7acb\u7684\u6d3b\u6027\u4f4d\u70b9\uff0c\u53ef\u5728\u542b\u94c1\u8f85\u9176\u56e0\u5b50\uff08Metallocofactors\uff09\u4f5c\u7528\u4e0b\u901a\u8fc7\u622a\u7136\u4e0d\u540c\u7684\u4e24\u4e2a\u8fc7\u7a0b\u4fc3\u8fdb\u4e0a\u8ff0\u91cd\u6392\u53cd\u5e94\u7684\u53d1\u751f\u3002\u8fd9\u4e00\u975e\u8840\u7ea2\u7d20\u94c1\u9176\u50ac\u5316\u5f62\u6210\u4e9a\u785d\u57fa\u8132\u7c7b\u7684\u751f\u7269\u5408\u6210\u53cd\u5e94\u5728\u9176\u5316\u5b66\u6216\u8005\u6709\u673a\u5408\u6210\u4e2d\u51e0\u4e4e\u627e\u4e0d\u5230\u5148\u4f8b\uff0c\u56e0\u6b64\u8be5\u7814\u7a76\u5145\u5b9e\u4e86\u5bf9\u975e\u8840\u7ea2\u7d20\u94c1\u9176\u5728\u5929\u7136\u4ea7\u7269\u751f\u7269\u5408\u6210\u8fc7\u7a0b\u4e2d\u6240\u626e\u6f14\u89d2\u8272\u7684\u8ba4\u77e5\u30022019\u5e7402\u670806\u65e5\uff0c\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201c<strong>An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin<\/strong>\u201d\u7684\u6587\u7ae0\u5728\u7ebf\u53d1\u8868\u5728<strong>Nature<\/strong>\u4e0a\u3002<\/p>\n<p>\u3010<strong>\u56fe\u6587\u5bfc\u8bfb<\/strong>\u3011<\/p>\n<p><strong>\u56fe1 <\/strong><strong>SZN\u751f\u7269\u5408\u6210\u57fa\u56e0\u7c07\u7f16\u7801\u4e9a\u785d\u57fa\u8132\u751f\u6210\u8def\u5f84<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-166850\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/1.png\" alt=\"\" width=\"600\" height=\"356\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/1.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/1-300x178.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe2 SznF\u50ac\u5316L-NMA\u7684\u6c27\u5316\u91cd\u6392\u53cd\u5e94<\/strong> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-166851\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/2.png\" alt=\"\" width=\"600\" height=\"491\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/2.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/2-300x246.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe3 SznF\u50ac\u5316\u91cd\u6392\u53cd\u5e94\u53c2\u4e0eSZN\u4f53\u5185\u5408\u6210\u7684\u53ef\u80fd\u9014\u5f84<\/strong> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-166852\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/3.png\" alt=\"\" width=\"600\" height=\"640\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/3.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/3-281x300.png 281w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe4 SznF\u7684X\u5c04\u7ebf\u6676\u4f53\u7ed3\u6784<\/strong> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-166853\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/4.png\" alt=\"\" width=\"600\" height=\"596\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/4.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/4-150x150.png 150w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/4-300x298.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u56fe5 SznF\u4e0a\u7684\u91d1\u5c5e\u8f85\u9176\u56e0\u5b50\u4f4d\u70b9\u53ca\u5176\u529f\u80fd<\/strong> <img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-166854\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/5.png\" alt=\"\" width=\"600\" height=\"409\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/5.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2019\/02\/5-300x205.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41586-019-0894-z\" target=\"_blank\" rel=\"noopener\">An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin<\/a>\uff08Nature, 2018, DOI: 10.1038\/s41586-019-0894-z\uff09<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4NanoCJ\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n<p>\u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 \u94fe\u8132\u4f50\u83cc\u7d20\uff08SZN\/STZ\uff09\u662f\u4e00\u79cd\u5929\u7136\u7684\u6c28\u57fa\u8461\u8404\u7cd6-\u4e9a\u785d\u57fa\u8132\u7c7b\u5316\u5408\u7269\uff0c\u5b83\u4e0d\u4ec5\u662f\u4e00\u79cd\u6297\u764c\u7684\u5316\u7597\u836f\u7269\uff0c\u4e5f\u5e38\u5e38\u56e0\u4e3a\u5bf9\u80f0\u5c9b\u03b2\u7ec6\u80de\u5177\u6709\u6bd2\u6027\u800c\u88ab\u7528\u4e8e\u5f15\u53d1\u5efa\u7acb\u7cd6\u5c3f\u75c5&#8230;<\/p>\n","protected":false},"author":1076,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[],"class_list":["post-166849","post","type-post","status-publish","format-standard","hentry","category-jiedu"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/166849"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/1076"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=166849"}],"version-history":[{"count":1,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/166849\/revisions"}],"predecessor-version":[{"id":166855,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/166849\/revisions\/166855"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=166849"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=166849"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=166849"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}