{"id":165295,"date":"2019-01-23T06:30:00","date_gmt":"2019-01-22T22:30:00","guid":{"rendered":"\/\/m.iemloyee.com\/?p=165295"},"modified":"2019-01-22T18:13:19","modified_gmt":"2019-01-22T10:13:19","slug":"%e5%a4%8d%e6%97%a6%e5%a4%a7%e5%ad%a6-%e8%92%8b%e6%99%a8%e5%9b%a2%e9%98%9f-adv-funct-mater-%e9%9d%b6%e5%90%91%e6%bf%80%e6%b4%bb%e8%a1%80%e5%b0%8f%e6%9d%bf%e7%9a%84%e6%8e%a7%e9%87%8a%e8%83%b6","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=165295","title":{"rendered":"\u590d\u65e6\u5927\u5b66 \u848b\u6668\u56e2\u961f Adv. Funct. Mater.: \u9776\u5411\u6fc0\u6d3b\u8840\u5c0f\u677f\u7684\u63a7\u91ca\u80f6\u675f\u6709\u6548\u6cbb\u7597\u4e09\u9634\u6027\u4e73\u817a\u764c\u539f\u53d1\u80bf\u7624\u53ca\u5176\u8f6c\u79fb"},"content":{"rendered":"

\u3010\u80cc\u666f\u4ecb\u7ecd\u3011<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0\u4e09\u9634\u6027\u4e73\u817a\u764c (TNBC)\u662f\u6307\u96cc\u6fc0\u7d20\u53d7\u4f53 (ER)\u3001\u5b55\u6fc0\u7d20\u53d7\u4f53 (PR)\u548c\u4eba\u8868\u76ae\u751f\u957f\u56e0\u5b50\u53d7\u4f53 (HER2)\u5747\u4e3a\u9634\u6027\u7684\u4e00\u79cd\u7279\u6b8a\u7c7b\u578b\u4e73\u817a\u764c\uff0cTNBC\u7ea6\u5360\u6240\u6709\u4e73\u817a\u764c\u768415%\u3002TNBC\u662f\u4e00\u79cd\u6781\u96be\u6cbb\u7597\u7684\u4e73\u817a\u764c\u4e9a\u578b\uff0c\u4f20\u7edf\u7684\u5c0f\u5206\u5b50\u6291\u5236\u5242\u5728\u4e34\u5e8a\u4e0a\u5bf9TNBC\u60a3\u8005\u7684\u6cbb\u7597\u6548\u679c\u5f88\u5dee\u3002\u66f4\u4e25\u91cd\u7684\u662f\uff0cTNBC\u6613\u590d\u53d1\uff0c\u4e14\u6613\u8f6c\u79fb\u5230\u8fdc\u5904\u5668\u5b98\u7ec4\u7ec7 (\u80ba\u3001\u809d\uff0c\u9aa8\u548c\u8111)\uff0c\u4f7f\u5176\u6210\u4e3a\u975e\u5e38\u4e25\u91cd\u7684\u4e34\u5e8a\u95ee\u9898\u3002\u8f6c\u79fb\u6027\u80bf\u7624\u5728\u4e34\u5e8a\u4e0a\u5f88\u96be\u6cbb\u6108\uff0c\u4e5f\u662f\u5bfc\u81f4\u5927\u591a\u6570\u60a3\u8005\u6b7b\u4ea1\u7684\u4e3b\u8981\u539f\u56e0\u3002\u76ee\u524d\uff0c\u6cbb\u7597\u8f6c\u79fb\u6027TNBC\u7684\u7814\u7a76\u4e3b\u8981\u6709\u4e24\u79cd\u7b56\u7565\uff1a1\uff09\u3001\u5728\u4f20\u64ad\u524d\u963b\u6b62\u9ad8\u5ea6\u4fb5\u88ad\u6027\u7684\u5faa\u73af\u80bf\u7624\u7ec6\u80de (CTCs\uff0c\u8f6c\u79fb\u7684\u201c\u79cd\u5b50\u201d)\u4ee5\u9632\u6b62\u8f6c\u79fb\u7684\u5f62\u6210\uff1b2\uff09\u3001\u9776\u5411\u5df2\u5f62\u6210\u7684\u8f6c\u79fb\u7076\u4ee5\u6740\u6b7b\u8f6c\u79fb\u764c\u7ec6\u80de\u5e76\u6291\u5236\u80bf\u7624\u7684\u8fc7\u5ea6\u751f\u957f\u3002\u56e0\u6b64\uff0c\u9488\u5bf9\u8f6c\u79fb\u6027TNBC\u7684\u7406\u60f3\u5316\u7597\u5236\u5242\u5e94\u80fd\u6709\u6548\u9776\u5411\u5e76\u6e17\u900f\u5230TNBC\u548c\u5176\u8f6c\u79fb\u7076\u3002<\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u901a\u5e38\uff0c\u8f7d\u836f\u7eb3\u7c73\u9897\u7c92\u53ef\u4ee5\u901a\u8fc7\u8c03\u63a7\u5c3a\u5bf8\u5927\u5c0f\u548c\u9488\u5bf9\u80bf\u7624\u5904\u7279\u5f02\u6027\u8fc7\u8868\u8fbe\u53d7\u4f53\u6765\u8fdb\u884c\u8868\u9762\u4fee\u9970\u4ee5\u9776\u5411\u80bf\u7624\u90e8\u4f4d\u3002\u5728\u9776\u5411\u8fc7\u7a0b\u4e2d\uff0c\u7eb3\u7c73\u7c92\u5b50\u5bf9\u539f\u53d1\u6027\u6216\u8f6c\u79fb\u6027\u80bf\u7624\u90e8\u4f4d\u7684\u7279\u5f02\u6027\u5206\u5b50\u7684\u8bc6\u522b\u81f3\u5173\u91cd\u8981\u3002\u7136\u800c\uff0c\u7531\u4e8e\u80bf\u7624\u7684\u5f02\u8d28\u6027\uff0c\u9776\u5411\u80bf\u7624\u7ec6\u80de\u7684\u7eb3\u7c73\u9897\u7c92\u5bf9CTCs\u548c\u5df2\u5f62\u6210\u7684\u8f6c\u79fb\u7076\u7684\u7279\u5f02\u6027\u548c\u9776\u5411\u6548\u7387\u53ef\u80fd\u53d7\u5230\u6781\u5927\u6311\u6218\uff0c\u540c\u65f6\uff0c\u7531\u4e8eTNBC\u8fdb\u5c55\u8fc7\u7a0b\u4e2d\u5b58\u5728\u5206\u5b50\u8868\u578b\u7684\u6539\u53d8\uff0c\u5bb9\u6613\u53d1\u751f\u8131\u9776\u6548\u5e94\u3002\u7814\u7a76\u53d1\u73b0\uff0c\u5229\u7528\u80bf\u7624\u5f52\u5de2\u5206\u5b50\u6216\u4e0d\u53d7\u80bf\u7624\u5f02\u8d28\u6027\u9650\u5236\u7684\u201c\u5185\u6e90\u6027\u8f7d\u4f53\u201d\u662f\u53ef\u4ee5\u8ffd\u8e2aCTCs\u5e76\u9776\u5411\u8f6c\u79fb\u80bf\u7624\u3002\u6700\u8fd1\u7684\u7814\u7a76\u8868\u660e\uff0c\u8840\u5c0f\u677f\u53ef\u4ee5\u901a\u8fc7\u7ec6\u80de\u95f4\u7c98\u9644\u5206\u5b50(ICAM)\u76f8\u4e92\u4f5c\u7528\u88ab\u80bf\u7624\u7ec6\u80de\u52df\u96c6\u548c\u6fc0\u6d3b\uff0c\u5e2e\u52a9\u5176\u8fdb\u884c\u8840\u7ba1\u5185\u6e17\u5f62\u6210CTC\uff0c\u968f\u540e\u6fc0\u6d3b\u7684\u8840\u5c0f\u677f\u805a\u96c6\u5728CTC\u5468\u56f4\u5f62\u6210\u201c\u8840\u5c0f\u677f-CTC\u201d\u805a\u96c6\u4f53\u5e76\u5e2e\u52a9\u4fb5\u88ad\u6027CTCs\u64ad\u6563\u81f3\u8fdc\u7aef\u5668\u5b98\u3002\u56e0\u6b64\uff0c\u63a8\u6d4b\u6fc0\u6d3b\u7684\u8840\u5c0f\u677f\u5177\u6709\u80bf\u7624\u5f52\u5de2\u3001CTCs\u6355\u83b7\u548c\u9776\u5411\u8f6c\u79fb\u7624\u7684\u80fd\u529b\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u6700\u8fd1\uff0c\u590d\u65e6\u5927\u5b66\u7684\u848b\u6668\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u62a5\u9053\u4e86\u5728\u8d1f\u8f7d\u7d2b\u6749\u9187\u7684\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u578b\u80f6\u675f\u4e0a\u4fee\u9970P-\u9009\u62e9\u7d20\uff08\u5728\u6fc0\u6d3b\u7684\u8840\u5c0f\u677f\u8868\u9762\u4e0a\u8868\u8fbe\uff09\u9776\u5411\u80bd (PSN) \u5f62\u6210\u7684PSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u53ef\u4ee5\u5229\u7528\u6fc0\u6d3b\u7684\u8840\u5c0f\u677f\u4f5c\u4e3a\u201c\u6865\u6881\u201d\u4e0e\u764c\u7ec6\u80de\u76f8\u4e92\u4f5c\u7528\u3002PSN\u4fee\u9970\u7684\u80f6\u675f\u53ef\u4ee5\u901a\u8fc7\u7ed3\u5408P-\u9009\u62e9\u7d20\u5bb9\u6613\u5730\u7c98\u9644\u5230\u6fc0\u6d3b\u7684\u8840\u5c0f\u677f\u8868\u9762\uff0c\u5229\u7528\u8840\u5c0f\u677f\u5bf9\u80bf\u7624\u8f6c\u79fb\u8fc7\u7a0b\u7684\u8ffd\u8e2a\u4f5c\u7528\uff0c\u4e0d\u4ec5\u53ef\u4ee5\u5728\u8840\u6db2\u5faa\u73af\u4e2d\u6355\u83b7CTCs\uff0c\u8fd8\u53ef\u8ffd\u8e2a\u81f3\u8f6c\u79fb\u7076\u6216\u5f52\u5de2\u5230\u539f\u53d1\u7076\u3002\u4e0eTaxol\uff08\u7d2b\u6749\u9187\u6ce8\u5c04\u5242\uff0c\u4ee5\u805a\u6c27\u4e59\u70ef\u84d6\u9ebb\u6cb9\u548c\u4e59\u9187\u4e3a\u6eb6\u5242\uff09\u548c\u672a\u4fee\u9970\u7684PEG-SS-PTX4<\/sub>\u80f6\u675f\u76f8\u6bd4\uff0cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u4e0e\u80bf\u7624\u6d78\u6da6\u6027\u8840\u5c0f\u677f\u7684\u7ed3\u5408\u660e\u663e\u589e\u591a\uff0c\u5bf9\u539f\u53d1\u6027TNBC\u53ca\u5176\u8f6c\u79fb\u7684\u9776\u5411\u6027\u548c\u7a7f\u900f\u6027\u663e\u8457\u589e\u5f3a\uff0c\u5e76\u56e0\u6b64\u663e\u8457\u6539\u5584\u4e86\u6cbb\u7597\u6548\u679c\u3002\u66f4\u91cd\u8981\u7684\u662f\uff0cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u53ef\u4ee5\u6709\u6548\u5730\u6291\u5236TNBC\u7684\u80ba\u8f6c\u79fb\uff0c\u964d\u4f4e\u809d\u8f6c\u79fb\u7684\u53d1\u751f\u7387\u3002\u9776\u5411\u6fc0\u6d3b\u8840\u5c0f\u677f\u7684\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u80f6\u675f\u7cfb\u7edf\u4e3a\u8f6c\u79fb\u6027\u764c\u75c7\u7684\u5168\u65b9\u4f4d\u6cbb\u7597\u63d0\u4f9b\u4e86\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cActivated Platelets-Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Funct. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u89e3\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001PSN-PEG-SS-PTX4<\/sub>\u7684\u5236\u5907\u548c\u4f5c\u7528\u673a\u7406\u56fe<\/strong>
\n \"\"\uff08A\uff09 \u80f6\u675f\u5236\u5907\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

\uff08B\uff09 PSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u7684\u4f5c\u7528\u793a\u610f\u56fe\u3002<\/p>\n

\u56fe\u4e8c\u3001PEG-PTX4<\/sub>\u3001PSN-PEG-PTX4<\/sub>\u3001PEG-SS-PTX4<\/sub>\u548cPSN-PEG-SS-PTX4<\/sub>\u7684\u5408\u6210\u8def\u7ebf<\/strong>
\n \"\"
\n \u56fe\u4e09\u3001\u805a\u5408\u7269-\u836f\u7269\u6750\u6599\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09 PEG-PTX4<\/sub>\u3001PSN-PEG-PTX4<\/sub>\u3001PEG-SS-PTX4<\/sub>\u548c PSN-PEG-SS-PTX4<\/sub>\u7684GPC\u5206\u6790\uff1b<\/p>\n

\uff08B\uff09 PEG-PTX4<\/sub>\u3001PSN-PEG-PTX4<\/sub>\u3001PEG-SS-PTX4<\/sub>\u548c PSN-PEG-SS-PTX4<\/sub>\u76841HNMR\u56fe\u3002<\/p>\n

\u56fe\u56db\u3001PEG-SS-PTX4<\/sub>\u80f6\u675f\u548cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u7684\u8868\u5f81<\/strong>
\n \"\"\uff08A\uff09 PEG-SS-PTX4<\/sub>\u80f6\u675f\u548cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u7684\u7c92\u5f84\u5206\u5e03\uff1b<\/p>\n

\uff08B\uff09 PEG-SS-PTX4<\/sub>\u80f6\u675f\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08C\uff09 PSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

\uff08D\uff09 \u7528\u542b10\u00d710-3<\/sup> M GSH \u7684PBS(pH = 7.4)\u5904\u74064 h\u540ePSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u89e3\u79bb\u7684TEM\u56fe;<\/p>\n

\uff08E\uff09 \u5728\u542b\u6709\u4e0d\u540c\u6d53\u5ea6GSH\u7684PBS (pH = 7.4)\u4e2d\u80f6\u675f\u7684\u836f\u7269\u91ca\u653e\u66f2\u7ebf\u3002<\/p>\n

\u56fe\u4e94\u3001MDA-MB-231\u7ec6\u80de\u4e0a\u80f6\u675f\u7684\u7ec6\u80de\u6444\u53d6\u548c\u7ec6\u80de\u6bd2\u6027\u7814\u7a76<\/strong>
\n \"\"\uff08A\uff09 \u5177\u6709\u4e0d\u540cPSN\u80bd\u4fee\u9970\u7a0b\u5ea6\u7684BODIPY\u6807\u8bb0\u80f6\u675f\u4e0e\u6fc0\u6d3b\u8840\u5c0f\u677f\u7684\u7ed3\u5408\u80fd\u529b\uff1b<\/p>\n

\uff08B\uff09 \u4e0e\u6fc0\u6d3b\u7684\u8840\u5c0f\u677f\u9884\u5b75\u80b20.5 h\u540e\uff0cBODIPY\u6807\u8bb0\u7684PEG-SS-PTX4<\/sub>\u80f6\u675f\u548cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f(40\uff05PSN\u4fee\u9970)\u7684\u7ec6\u80de\u6444\u53d6\uff1b<\/p>\n

\uff08C\uff09 \u5171\u5b75\u80b248 h\u540e\u4e0d\u540c\u5236\u5242\u5bf9MDA-MB-231\u7ec6\u80de\u7684\u6740\u4f24\u4f5c\u7528\uff1b<\/p>\n

\uff08D\uff09 \u7528\u4e0d\u540cPTX\u5236\u5242 (PTX\u5f53\u91cf1 \u03bcg\/mL) \u5904\u7406\u7684MDA-MB-231\u7ec6\u80de\u4e2d\u5fae\u7ba1\u86cb\u767d\u67d3\u8272\u3002<\/p>\n

\u56fe\u516d\u3001\u4f53\u5185\u8003\u5bdfBODIPY\u6807\u8bb0\u7684PSN\u4fee\u9970\u80f6\u675f\u5728TNBC\u539f\u53d1\u80bf\u7624\u548c\u80ba\u8f6c\u79fb\u5c0f\u9f20\u6a21\u578b\u4e2d\u4e0e\u8840\u5c0f\u677f\u7684\u7ed3\u5408<\/strong>
\n \"\"\uff08A\uff09 \u6ce8\u5c04BODIPY\u6807\u8bb0PEG-SS-PTX4<\/sub>\u80f6\u675f\u548cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f0.5 h\u540e\uff0cTNBC\u539f\u53d1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u7684\u80bf\u7624\u7ec4\u7ec7\u51b7\u51bb\u5207\u7247\u7684\u4ee3\u8868\u6027\u514d\u75ab\u67d3\u8272\u8367\u5149\u56fe\uff1b<\/p>\n

\uff08B\uff09 \u6ce8\u5c04BODIPY\u6807\u8bb0PEG-SS-PTX4<\/sub>\u80f6\u675f\u548cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f0.5 h\u540e\uff0cTNBC\u80ba\u8f6c\u79fb\u6a21\u578b\u5c0f\u9f20\u7684\u80ba\u7ec4\u7ec7\u51b7\u51bb\u5207\u7247\u7684\u4ee3\u8868\u6027\u514d\u75ab\u67d3\u8272\u8367\u5149\u56fe\u3002\u84dd\u8272\uff1aDAPI\uff08\u67d3\u7ec6\u80de\u6838\uff09\uff1b\u7eff\u8272\uff1aCD41\uff08\u8840\u5c0f\u677f\u8868\u9762\u6807\u5fd7\u7269\uff09\uff1b\u7ea2\u8272\uff1aBODIPY\u6807\u8bb0\u7684\u80f6\u675f\u3002<\/p>\n

\u56fe\u4e03\u3001PSN\u4fee\u9970\u80f6\u675f\u5bf9TNBC\u539f\u53d1\u80bf\u7624\u7684\u9776\u5411\u548c\u7a7f\u900f\u4f5c\u7528<\/strong>
\n \"\"\uff08A\uff09 TNBC\u539f\u53d1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u7ecf\u5c3e\u9759\u8109\u6ce8\u5c04BODIPY\u6807\u8bb0\u7684\u672a\u4fee\u9970\u80f6\u675f\uff08\u5de6\uff09\u548cPSN\u4fee\u9970\u7684\u80f6\u675f\uff08\u53f3\uff09\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5728\u4f53\u8367\u5149\u56fe\u50cf\uff0c3D\u8367\u5149\u56fe\u50cf\u53ca\u79bb\u4f53\u7ec4\u7ec7\u8367\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08B\uff09 TNBC\u539f\u53d1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u7684\u80bf\u7624\u7ec4\u7ec7\u51b7\u51bb\u5207\u7247\u7684\u4ee3\u8868\u6027\u8367\u5149\u56fe\u50cf\uff08\u84dd\u8272\uff1a\u7ec6\u80de\u6838\uff1b\u7eff\u8272\uff1a\u80bf\u7624\u65b0\u751f\u8840\u7ba1\uff1b\u7ea2\u8272\uff1aBODIPY\u6807\u8bb0\u7684\u80f6\u675f\uff09\u3002<\/p>\n

\u56fe\u516b\u3001PSN\u4fee\u9970\u80f6\u675f\u5728\u4f53\u5185\u5bf9CTC\u7684\u7cbe\u51c6\u6355\u83b7<\/strong>
\n \"\"\u7eff\u8272\uff1aCTC\u4fe1\u53f7\uff1b\u7ea2\u8272\uff1a\u80f6\u675f\u4fe1\u53f7<\/p>\n

\u56fe\u4e5d\u3001PSN\u4fee\u9970\u80f6\u675f\u5bf9TNBC (MDA-MB-231\/luci<\/em>)\u80ba\u8f6c\u79fb\u7684\u9776\u5411\u548c\u7a7f\u900f\u4f5c\u7528<\/strong>
\n \"\"\uff08A\uff09\u5c3e\u9759\u8109\u6ce8\u5c04BODIPY\u6807\u8bb0\u7684\u672a\u4fee\u9970\u7684\u80f6\u675f\uff08\u5de6\uff09\u548cPSN\u4fee\u9970\u7684\u80f6\u675f\uff08\u53f3\uff09\u540ea). 2 h\u65f6\u5728\u4f53\u8367\u5149\u56fe\u50cf\uff1bb). \u5728\u4f53\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff1bc).\u00a0 24 h\u65f6\u79bb\u4f53\u8367\u5149\u56fe\u50cf\uff1bd).\u79bb\u4f53\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff1b<\/p>\n

\uff08B\uff09TNBC\u80ba\u8f6c\u79fb\u6a21\u578b\u5c0f\u9f20\u7684\u80ba\u7ec4\u7ec7\u51b7\u51bb\u5207\u7247\u7684\u4ee3\u8868\u6027\u8367\u5149\u56fe\u50cf\uff08\u84dd\u8272\uff1a\u7ec6\u80de\u6838\uff1b\u7eff\u8272\uff1a\u80bf\u7624\u65b0\u751f\u8840\u7ba1\uff1b\u7ea2\u8272\uff1aBODIPY\u6807\u8bb0\u7684\u80f6\u675f\uff09\u3002<\/p>\n

\u56fe\u5341\u3001PSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u5bf9TNBC\u539f\u53d1\u80bf\u7624\u7684\u6291\u5236\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09 \u7ed9\u4e88\u4e0d\u540c\u5236\u5242\u540eTNBC\u539f\u53d1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\uff1b<\/p>\n

\uff08B\uff09 TNBC\u539f\u53d1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u7684\u4f53\u91cd\u53d8\u5316\uff1b<\/p>\n

\uff08C\uff09 TNBC\u539f\u53d1\u80bf\u7624\u6a21\u578b\u5c0f\u9f20\u7684\u80bf\u7624\u7ec4\u7ec7\u51b0\u51bb\u5207\u7247\u7684\u514d\u75ab\u8367\u5149\u67d3\u8272\u56fe\u50cf (\u7eff\u8272\uff1a\u51cb\u4ea1\u7ec6\u80de\uff1b\u84dd\u8272\uff1a\u7ec6\u80de\u6838)\u3002<\/p>\n

\u56fe\u5341\u4e00\u3001PSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u5bf9TNBC\u80ba\u8f6c\u79fb\u7684\u6291\u5236\u6548\u679c<\/strong>
\n \"\"\uff08A\uff09 \u7ed9\u4e88\u4e0d\u540c\u5236\u5242\u540eTNBC\u80ba\u8f6c\u79fb\u6a21\u578b\u5c0f\u9f20\u5728\u4f53\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff08\u7b2c17\uff0c21\uff0c25\u5929\u7ed9\u836f\uff09\uff1b<\/p>\n

\uff08B\uff09 \u80ba\u8f6c\u79fb\u751f\u7269\u53d1\u5149\u4fe1\u53f7\u7684\u534a\u5b9a\u91cf\u7ed3\u679c\uff1b<\/p>\n

\uff08C\uff09 TNBC\u80ba\u8f6c\u79fb\u6a21\u578b\u9f20\u7684\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\u3002<\/p>\n

\u3010\u603b\u7ed3\u3011<\/strong><\/p>\n

\u7efc\u4e0a\u6240\u8ff0\uff0c\u672c\u7814\u7a76\u6210\u529f\u5f00\u53d1\u4e86\u4e00\u79cd\u5177\u6709\u6c27\u5316\u8fd8\u539f\u54cd\u5e94\u578b\u836f\u7269\u91ca\u653e\u7279\u6027\u7684\u6fc0\u6d3b\u8840\u5c0f\u677f\u9776\u5411\u80f6\u675f\uff0c\u8be5\u80f6\u675f\u53ef\u901a\u8fc7\u201c\u8840\u5c0f\u677f\u6865\u6881\u201d\u6709\u6548\u9776\u5411\u539f\u53d1\u6027TNBC\uff0cCTCs\u548c\u8f6c\u79fb\u7076\u3002PSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u53ef\u4ee5\u5728\u5faa\u73af\u4e2d\u4e0e\u8868\u8fbeP-\u9009\u62e9\u7d20\u7684\u8840\u5c0f\u677f\u7ed3\u5408\uff0c\u5e76\u4e14\u8be5\u590d\u5408\u7269\u53ef\u6355\u83b7CTCs\u6216\u5f52\u5de2\u5230\u80bf\u7624\u7ec4\u7ec7\u53ca\u8f6c\u79fb\u7076\u3002\u968f\u540e\uff0c\u80f6\u675f\u88ab\u764c\u7ec6\u80de\u5185\u541e\uff0c\u5728\u80de\u6d46\u8fd8\u539f\u6027\u6761\u4ef6\u4e0b\u89e3\u79bb\u91ca\u653e\u836f\u7269\u6740\u4f24\u80bf\u7624\u7ec6\u80de\u3002\u56e0\u6b64\uff0cPSN-PEG-SS-PTX4<\/sub>\u80f6\u675f\u5177\u6709\u8f83\u5f3a\u7684\u6297\u80bf\u7624\u548c\u6297\u8f6c\u79fb\u6548\u679c\uff0c\u4e14\u5177\u6709\u826f\u597d\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3002\u603b\u4e4b\uff0c\u5177\u6709\u63a7\u91ca\u7279\u6027\u7684\u6fc0\u6d3b\u8840\u5c0f\u677f\u9776\u5411\u80f6\u675f\u4e3a\u8f6c\u79fb\u6027\u764c\u75c7\u7684\u5168\u65b9\u4f4d\u6cbb\u7597\u63d0\u4f9b\u4e86\u6709\u826f\u597d\u524d\u666f\u7684\u7b56\u7565\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aActivated Platelets-Targeting Micelles with Controlled Drug Release for Effective Treatment of Primary and Metastatic Triple Negative Breast Cancer<\/a><\/strong>\uff08Adv. Funct. Mater., 2019<\/strong>, DOI: 10.1002\/adfm.201806620\uff09<\/p>\n

\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n

\u848b\u6668\uff0c\u590d\u65e6\u5927\u5b66\u836f\u5b66\u9662\u6559\u6388\uff0c\u535a\u58eb\u751f\u5bfc\u5e08\uff0c\u6770\u9752\uff0c\u6559\u80b2\u90e8\u65b0\u4e16\u7eaa\u4eba\u624d\uff0c\u4e0a\u6d77\u5e02\u4f18\u79c0\u5b66\u79d1\u5e26\u5934\u4eba\u3002<\/strong>\u8bfe\u9898\u7ec4\u6210\u7acb\u4e8e2003\u5e74\uff0c\u76ee\u524d\u7ec4\u5185\u6709\u6559\u6388\u4e00\u540d\uff0c\u526f\u6559\u6388\u4e00\u540d\uff0c\u5728\u8bfb\u535a\u58eb\u7814\u7a76\u751f9\u540d\uff0c\u7855\u58eb\u7814\u7a76\u751f2\u540d\u3002\u8bfe\u9898\u7ec4\u8fd1\u5e74\u6765\u7814\u7a76\u65b9\u5411\u4e3b\u8981\u96c6\u4e2d\u5728\u8111\u9776\u5411\u3001\u80bf\u7624\u9776\u5411\u53ca\u5fae\u73af\u5883\u89e6\u53d1\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u7684\u7814\u7a76\u5f00\u53d1\uff0c\u81f4\u529b\u4e8e\u9488\u5bf9\u7ecf\u9000\u884c\u6027\u75be\u75c5\u7b49\u8111\u90e8\u75be\u75c5\u548c\u6076\u6027\u80bf\u7624\u53ca\u5176\u8f6c\u79fb\u7684\u6709\u6548\u6cbb\u7597\u7b56\u7565\u7814\u7a76\u3002<\/strong>\u5df2\u5728\u56fd\u9645\u77e5\u540d\u5b66\u672f\u671f\u520a\u4e0a\u5982Adv Mater, ACS Nano, Adv Funct Mater\uff0cAdv Sci\uff0cBiomaterials\uff0cTheranostics\u7b49\u53d1\u8868\u8bba\u658780\u4f59\u7bc7\u3002<\/p>\n

\u8bfe\u9898\u7ec4\u4e3b\u9875<\/strong>\uff1ahttp:\/\/smartdds.fudan.edu.cn\/jiangchen\/index.aspx<\/a><\/strong><\/p>\n

\u7814\u7a76\u8bba\u6587\u6c47\u603b\u8be6\u89c1Researchgate\u7f51\u5740\u94fe\u63a5\uff1ahttps:\/\/www.researchgate.net\/profile\/Chen_Jiang3<\/a><\/strong><\/p>\n

\u672c\u6587\u76f8\u5173\u4f18\u8d28\u6587\u732e\u63a8\u8350\uff1a<\/strong><\/p>\n

1. L. J. Gay, B. Feldinghabermann, Contribution of platelets to tumour metastasis. Nature Reviews Cancer<\/em><\/strong>,\u00a02011<\/strong>, 11, 123.<\/p>\n

2. Q. Hu, W. Sun, C. Qian, C. Wang, H. N. Bomba, Z. Gu, Anticancer platelet-mimicking nanovehicles. Adv. Mater.<\/strong>,<\/em>\u00a02015<\/strong>, 27, 7043.<\/p>\n

3. Chen, X.; Wang, Q.; Liu, L.; Sun, T.; Zhou, W.; Chen, Q.; Lu, Y.; He, X.; Zhang, Y.; Zhang, Y.; Ruan, C.; Guo, Q.; Li, C.; Jiang, C., Double-sided effect of tumor microenvironment on platelets targeting nanoparticles. Biomaterials,<\/strong> 2018<\/strong>, 183, 258.<\/p>\n

4. M. Haemmerle, R. L. Stone, D. G. Menter, V. A. Kharghan, A. K. Sood, The platelet lifeline to cancer: challenges and opportunities. Cancer Cell,<\/strong> 2018<\/strong>, 33, 965.<\/p>\n

5. Y. Lu, A. A. Aimetti, R. Langer, Z. Gu, Bioresponsive materials. Nat. Rev. Mater.,<\/strong> 2016<\/strong>, 1, 16075.<\/p>\n

6. Y. Zhang, Z. Guo, Z. Cao, W. Zhou, Y. Zhang, Q. Chen, Y. Lu, X. Chen, Q. Guo, C. Li, Endogenous albumin-mediated delivery of redox-responsive paclitaxel-loaded micelles for targeted cancer therapy. Biomaterials,<\/strong> 2018<\/strong>, 183, 243.<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7684\u9ad8\u751f\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\uff0c\u6750\u6599\u4eba\u6574\u7406\u3002<\/strong><\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com.<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n","protected":false},"excerpt":{"rendered":"

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