{"id":164462,"date":"2019-01-16T06:30:53","date_gmt":"2019-01-15T22:30:53","guid":{"rendered":"\/\/m.iemloyee.com\/?p=164462"},"modified":"2019-01-15T17:05:23","modified_gmt":"2019-01-15T09:05:23","slug":"%e3%80%90%e5%b7%b2%e6%a0%a1%e7%a8%bf%e3%80%91adv-mater-%ef%bc%9a%e4%b8%80%e7%a7%8d%e6%b6%88%e9%99%a4%e8%80%90%e8%8d%af%e6%80%a7%e6%84%9f%e6%9f%93%e7%9a%84%e4%bb%bf%e7%94%9f%e9%9d%9e%e6%8a%97%e7%94%9f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=164462","title":{"rendered":"Adv. Mater.\uff1a\u4e00\u79cd\u6d88\u9664\u8010\u836f\u6027\u611f\u67d3\u7684\u4eff\u751f\u975e\u6297\u751f\u7d20\u65b9\u6cd5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u94dc\u7eff\u5047\u5355\u80de\u83cc(P. aeruginosa)\u662f\u9769\u5170\u6c0f\u9634\u6027\u5fae\u751f\u7269\uff0c\u5360\u5168\u4e16\u754c\u533b\u9662\u611f\u67d310-20%\u3002\u901a\u5e38\u7528\u4e8e\u6d88\u9664P. aeruginosa\u611f\u67d3\u7684\u6297\u751f\u7d20\u5242\u5305\u62ec\u03b2-\u5185\u9170\u80fa\u7c7b\u3001\u6c28\u57fa\u7cd6\u82f7\u7c7b\u548c\u6c1f\u55b9\u8bfa\u916e\u7c7b\u3002\u6b64\u5916\uff0c\u591a\u7c98\u83cc\u7d20\u4e5f\u53ef\u4ee5\u7528\u4e8e\u6cbb\u7597\u591a\u836f\u8010\u836f\u83cc\u682a\uff0c\u4f46\u662f\u5b83\u4eec\u5177\u6709\u9ad8\u6bd2\u6027\u3002\u7531\u4e8e\u7ec6\u83cc\u751f\u7269\u88ab\u819c\u7684\u4f4e\u6e17\u900f\u6027\u548c\u5bf9\u836f\u7269\u7684\u5916\u6392\u4f5c\u7528\uff0c\u4ee5\u53caP. aeruginosa\u5bf9\u5e38\u89c4\u6297\u751f\u7d20\u5242\u5177\u6709\u7684\u81ea\u8eab\u6297\u6027\uff0c\u4f1a\u5bfc\u81f4\u591a\u79cd\u5e76\u53d1\u75c7\u3001\u6cbb\u7597\u5931\u8d25\u751a\u81f3\u6b7b\u4ea1\u3002\u56e0\u6b64\uff0c\u8feb\u5207\u9700\u8981\u53d1\u5c55\u4e00\u79cd\u9488\u5bf9P. aeruginosa\u7684\u975e\u6297\u751f\u7d20\u7b56\u7565\u7528\u4e8e\u6cbb\u7597\u5176\u611f\u67d3\u3002\u4f17\u6240\u5468\u77e5\uff0c\u7ec6\u83cc\u7b49\u5fae\u751f\u7269\u4f7f\u7528\u5176\u51dd\u96c6\u7d20\u4e0e\u5bbf\u4e3b\u7ec4\u7ec7\u4e0a\u7684\u7cd6\u57fa\u53d1\u751f\u7279\u5f02\u6027\u4f5c\u7528\uff0c\u5df2\u6709\u7814\u7a76\u8868\u660eP. aeruginosa\u8868\u9762\u51dd\u96c6\u7d20LecA\u548cLecB\u80fd\u591f\u4ecb\u5bfc\u5176\u751f\u7269\u819c\u7684\u5f62\u6210\u3002\u56e0\u6b64\uff0c\u8fd9\u4e24\u79cd\u51dd\u96c6\u7d20\u662f\u9884\u9632\u7ec6\u83cc\u5b9a\u690d\u548c\u6f5c\u5728\u751f\u7269\u819c\u5f62\u6210\u7684\u9776\u6807\u3002\u4e8b\u5b9e\u4e0a\uff0c\u51dd\u96c6\u7d20\u4e0e\u86cb\u767d\u8d28\u76f8\u4e92\u4f5c\u7528\u7684\u4e09\u7ef4\u7684\u591a\u4ef7\u5f02\u8d28\u5bf9\u4e8e\u751f\u7269\u819c\u7684\u8c03\u63a7\u81f3\u5173\u91cd\u8981\uff0c\u4f46\u76ee\u524d\u5728\u8bbe\u8ba1\u7ec6\u83cc\u6291\u5236\u5242\u65f6\u5374\u5f88\u5c11\u8003\u8651\u5230\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u5357\u5f00\u5927\u5b66\u5f20\u65b0\u6b4c\u526f\u6559\u6388\u4e0e\u7f8e\u56fd\u97e6\u6069\u5dde\u7acb\u5927\u5b66\u66f9\u667a\u5f3a\u526f\u6559\u6388<\/strong>\u5408\u4f5c\u5f00\u53d1\u4e86\u4e00\u79cd\u65b0\u578b\u7eb3\u7c73\u6297\u83cc\u5242\uff0c\u5176\u663e\u793a\u51fa\u9ad8\u6548\u7684\u751f\u7269\u819c\u6291\u5236\u80fd\u529b\uff08\u9ad8\u8fbe90%\uff09\u4ee5\u53ca\u5bf9P. aeruginosa\u6740\u706d\u80fd\u529b\uff08\u63a5\u8fd1100%\uff09\u3002\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u6027\u80fd\u4f18\u5f02\u7684\u7ec6\u83cc\u6291\u5236\u4f5c\u7528\u4e3b\u8981\u662f\u5f52\u56e0\u4e8e50-100\u7eb3\u7c73\u5c3a\u5ea6\u7ed3\u6784\u4e0a\u4e24\u79cd\u7c7b\u578b\u7cd6\u6a21\u62df\u81ea\u7136\u754c\u7684\u591a\u4ef7\u5f02\u8d28\u4f5c\u7528\u548c\u7279\u5f02\u6027\u9776\u5411P. aeruginosa\u4e0a\u7684LecA\u548cLecB\u51dd\u96c6\u7d20\u3002\u8fd9\u79cd\u65b0\u7684\u963b\u65ad\u65b9\u6cd5\u80fd\u591f\u6a21\u62df\u78b3\u6c34\u5316\u5408\u7269-\u51dd\u96c6\u7d20\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u81ea\u7136\u5f3a\u5316\u673a\u5236\uff0c\u800c\u663e\u8457\u7684\u6740\u83cc\u6548\u679c\u5219\u6765\u6e90\u4e8e\u91d1\u7eb3\u7c73\u68d2\u826f\u597d\u7684\u5149\u70ed\u8f6c\u5316\u80fd\u529b\u3002\u8be5\u8bbe\u8ba1\u7b56\u7565\u8fd8\u53ef\u7528\u4e8e\u8fdb\u4e00\u6b65\u6784\u5efa\u6297\u5176\u4ed6\u75c5\u539f\u83cc\u611f\u67d3\u7684\u6297\u83cc\u5242\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a” A Biomimetic Non-Antibiotic Approach to Eradicate Drug-Resistant Infections <\/strong>“\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u7eb3\u7c73\u6297\u83cc\u5242\u7684\u5236\u5907\u4e0e\u6027\u80fd<\/strong><\/p>\n

\"\"(a) AuNRs@pLAMA\/pFEMA\u7684\u5408\u6210\uff1b<\/p>\n

(b) AuNRs@pLAMA\/pFEMA\u7684TEM\u56fe\u50cf\uff1b<\/p>\n

(c) AuNRs\u548cAuNRs@pLAMA\/pFEMA\u7684\u7d2b\u5916-\u53ef\u89c1\u5149\u8c31\uff1b<\/p>\n

(d) AuNRs @ pLAMA\/pFEMA\u6eb6\u6db2\u7684\u6e29\u5ea6\u53d8\u5316\u4e0eNIR\u7167\u5c04\u65f6\u95f4\u7684\u51fd\u6570\u5173\u7cfb\u56fe\u3002<\/p>\n

\u56fe2<\/strong> \u6750\u6599\u6d53\u5ea6\u548c\u7c98\u9644\u65f6\u95f4\u5bf9\u7ec6\u83cc\u7684\u7c98\u9644\u6548\u679c\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u4e0eAuNRs@pLAMA\u3001AuNRs@pFEMA\u548cAuNRs@pLAMA\/pFEMA\u5b75\u5316\u540eP. aeruginosa \u548c E. coli\u7684CLSM\u56fe\u50cf\uff1b<\/p>\n

(b) \u4e0a\u6e05\u6db2\u7684OD600<\/sub>\u503c\u540cAuNRs@pLAMA\/pFEMA\u7eb3\u7c73\u7f00\u5408\u7269\u4e0eP. aeruginosa\u5b75\u5316\u540e\u7684\u6d53\u5ea6(b)\u7684\u51fd\u6570\u5173\u7cfb\uff1b<\/p>\n

(c) \u4e0a\u6e05\u6db2\u7684OD600<\/sub>\u503c\u540cAuNRs@pLAMA\/pFEMA\u7eb3\u7c73\u7f00\u5408\u7269\u4e0eP. aeruginosa\u5b75\u5316\u7684\u65f6\u95f4(c)\u7684\u51fd\u6570\u5173\u7cfb\u3002<\/p>\n

\u56fe3 \u7cd6\u805a\u5408\u7269\u94fe\u957f\u548c\u7c7b\u578b\u5bf9\u751f\u7269\u88ab\u819c\u6291\u5236\u6548\u679c\u7684\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

(a) AuNRs\u6291\u5236\u751f\u7269\u819c\u5f62\u6210\uff1b<\/p>\n

(b) \u542b\u6709\u4e0d\u540c\u957f\u5ea6\u7684\u7cd6\u805a\u5408\u7269\u914d\u4f53\u7684AuNRs@pLAMA\/pFEMA\u6291\u5236\u751f\u7269\u819c\u5f62\u6210\u3002<\/p>\n

\u56fe4 \u542b\u7cd6\u805a\u5408\u7269\u94fe\u957f\u548c\u7cd6\u7c7b\u578b\u5bf9\u751f\u7269\u88ab\u819c\u5f62\u6210\u5f71\u54cd\u7684CLSM\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6709\u65e0AuNRs\u548cAuNRs@ pLAMA\/pFEMA\u5904\u7406\u7684P. aeruginosa\u751f\u7269\u819c\uff1b<\/p>\n

(b) \u7528\u4e0d\u540c\u6d53\u5ea6\u7684AuNRs@pLAMA-50\u3001AuNRs@pFEMA-50\u6216AuNRs@pLAMA\/pFEMA-50\u5904\u7406\u7684P. aeruginosa\u751f\u7269\u819c\u3002<\/p>\n

\u56fe5 \u7eb3\u7c73\u7f00\u5408\u7269\u5bf9P. aeruginosa\u7684\u4f53\u5916\u6297\u7c98\u9644\u6d3b\u6027<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6750\u6599\u6291\u5236\u7ec6\u83cc\u7c98\u9644A549\u7ec6\u80de\u7684CLSM\u56fe\uff1b<\/p>\n

(b) \u5b9a\u91cf\u6d4b\u91cf\u6750\u6599\u6291\u5236\u7ec6\u83cc\u5bf9\u7ec6\u80de\u7684\u7c98\u9644\u4f5c\u7528\uff1b<\/p>\n

(c) AuNRs@pLAMA\/pFEMA\u4e0eA549\u7ec6\u80de\u5171\u57f9\u517b\u540e\u5b58\u6d3b\u7387\u3002<\/p>\n

\u56fe6 AuNRs@pLAMA\/pFEMA\u5149\u70ed\u6740\u83cc\u7684CLSM\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5728\u4e0d\u540cNIR\u7167\u5c04\u65f6\u95f4\u4e0b\uff0c\u7528AuNRs@pLAMA\/pFEMA\u5904\u7406\u540eP. aeruginosa\u7684CLSM\u6d3b\/\u6b7b\u56fe\u50cf\uff08\u6d3b\u7ec6\u80de\u4e3a\u7eff\u8272\uff0c\u6b7b\u7ec6\u80de\u4e3a\u7ea2\u8272\uff09\uff1b<\/p>\n

(b) \u5728\u6709\u65e0\u8fd1\u7ea2\u5916\u6fc0\u5149\u7167\u5c04\u6761\u4ef6\u4e0b\uff0c\u7528PBS\u3001AuNRs\u548cAuNRs@ pLAMA\/pFEMA-50\u5904\u7406\u540eP. aeruginosa\u7684SEM\u56fe\u50cf\u3002<\/p>\n

\u56fe7 \u4f53\u5185\u5c40\u7076\u6027\u611f\u67d3\u7684\u5149\u70ed\u7597\u6cd5\u6cbb\u7597<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5c0f\u9f20\u7684\u76ae\u4e0b\u8113\u80bf\u9020\u6a21\uff1b<\/p>\n

(b) \u6ce8\u5c04\u6750\u6599\u5149\u7167\u540e\u5c0f\u9f20\u70ed\u6210\u50cf\u56fe\u50cf\uff1b<\/p>\n

(c) \u5c0f\u9f20\u7684\u76ae\u4e0b\u7ec4\u7ec7\u7ec6\u83cc\u8ba1\u6570\uff1b<\/p>\n

(d) \u62cd\u7167\u8bb0\u5f55\u6750\u6599\u7ecf\u5149\u7167\u5904\u7406\u5c0f\u9f20\u611f\u67d3\u90e8\u4f4d\u7167\u7247\u3002<\/p>\n

\u56fe8 \u7eb3\u7c73\u7f00\u5408\u7269\u6cbb\u7597\u540e\u76ae\u4e0b\u8113\u80bf\u7684\u708e\u75c7\u53cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5404\u7ec4\u611f\u67d3\u7ec4\u7ec7\u7684H&E\u67d3\u8272\u3001BAG3\u548cTNF-\u03b1<\/em>\u514d\u75ab\u7ec4\u5316\u67d3\u8272\u663e\u5fae\u7167\u7247\uff1b<\/p>\n

(b) \u57fa\u4e8e\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u4ea7\u751f\u7684\u5149\u5bc6\u5ea6\u5bf9BAG3\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(c) \u57fa\u4e8e\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u67d3\u8272\u4ea7\u751f\u7684\u5149\u5bc6\u5ea6\u5bf9TNF-\u03b1\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u56fe9 \u4f53\u5185\u6297\u751f\u7d20\u8010\u836f\u7ec6\u83cc\u6027\u80ba\u708e\u7684\u708e\u75c7\u53cd\u5e94<\/strong><\/p>\n

\"\"<\/p>\n

(a) P. aeruginosa\u8bf1\u5bfc\u7684\u80ba\u708e\u5c0f\u9f20\u4e2d\u7ec6\u83ccCFU\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(b) P. aeruginosa\u8bf1\u5bfc\u7684\u80ba\u708e\u5c0f\u9f20\u4e2d\u767d\u7ec6\u80de\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(c) P. aeruginosa\u8bf1\u5bfc\u7684\u80ba\u708e\u5c0f\u9f20\u4e2d\u603b\u86cb\u767d\u8d28\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(d) P. aeruginosa\u8bf1\u5bfc\u7684\u80ba\u708e\u5c0f\u9f20\u4e2dIL-1\u03b2\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(e) P. aeruginosa\u8bf1\u5bfc\u7684\u80ba\u708e\u5c0f\u9f20\u4e2dIL-6\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n

(f) P. aeruginosa\u8bf1\u5bfc\u7684\u80ba\u708e\u5c0f\u9f20\u4e2dTNF-\u03b1\u7684\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u56fe10 \u80ba\u90e8\u7ec6\u83cc\u7559\u5b58\u548c\u80ba\u90e8\u708e\u75c7\u611f\u67d3\u75c5\u7406\u56fe<\/strong><\/p>\n

\"\"<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u5728\u672c\u6587\u4e2d\uff0c\u4f5c\u8005\u5f00\u53d1\u4e86\u4e00\u79cd\u975e\u6297\u751f\u7d20\u57fa\u7684\u7eb3\u7c73\u5236\u5242\uff0c\u8be5\u5236\u5242\u901a\u8fc7\u4e24\u79cd\u7c7b\u578b\u7684\u7cd6\u805a\u5408\u7269\u4fee\u9970\u4e09\u7ef4\u7ed3\u6784\u7684\u91d1\u7eb3\u7c73\u68d2\u3002\u8fd9\u79cd\u65b0\u578b\u5236\u5242\u5206\u522b\u901a\u8fc7\u51dd\u96c6\u7d20\u963b\u65ad\u548c\u91d1\u7eb3\u7c73\u68d2\u7684\u8fd1\u7ea2\u5916\u5149\u8bf1\u5bfc\u7684\u5149\u70ed\u6548\u5e94\uff0c\u5b9e\u73b0\u5bf9\u8010\u836f\u6027\u80ba\u708e\u7684\u663e\u8457\u7597\u6548\u3002\u603b\u4e4b\uff0c\u65b0\u578b\u4eff\u751f\u8bbe\u8ba1\u4e0e\u5149\u70ed\u6740\u706d\u80fd\u529b\u7684\u6709\u6548\u7ed3\u5408\uff0c\u6709\u671b\u6210\u4e3a\u4e00\u79cd\u66ff\u4ee3\u6cbb\u7597\u7b56\u7565\u4ee5\u5bf9\u6297\u5a01\u80c1\u6027\u6781\u5f3a\u7684\u6297\u836f\u6027\u4f20\u67d3\u75c5\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aA Biomimetic Non-Antibiotic Approach to Eradicate Drug-Resistant Infections<\/a>\u00a0(Adv. Mater. 2018, DOI: 10.1002\/adma.201806024)<\/strong><\/p>\n

 <\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u5b66\u672f\u7ec4biotech\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaorenkefu\u3002<\/strong>\u00a0<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

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