{"id":163760,"date":"2019-01-07T06:28:14","date_gmt":"2019-01-06T22:28:14","guid":{"rendered":"\/\/m.iemloyee.com\/?p=163760"},"modified":"2019-04-26T18:15:12","modified_gmt":"2019-04-26T10:15:12","slug":"%e6%a2%b3%e7%90%86%ef%bc%9a%e5%85%ab%e7%a7%8d%e7%94%9f%e7%89%a9%e6%88%90%e5%83%8f%e6%8a%80%e6%9c%af%ef%bc%8c%e5%90%84%e6%98%be%e7%a5%9e%e9%80%9a%ef%bc%8c%e4%bd%a0%e6%9c%80%e9%9d%92%e7%9d%90%e8%b0%81","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=163760","title":{"rendered":"\u68b3\u7406\uff1a\u516b\u79cd\u751f\u7269\u6210\u50cf\u6280\u672f\uff0c\u5404\u663e\u795e\u901a\uff0c\u4f60\u6700\u9752\u7750\u8c01\uff1f"},"content":{"rendered":"

\u3010\u5f15\u8bed\u3011<\/strong><\/p>\n

\u751f\u7269\u4e13\u680f\uff1a\u5b9a\u671f\u68b3\u7406\u751f\u7269\u9886\u57df\u53d1\u5e03\u8fc7\u7684\u597d\u6587\u7ae0\uff0c\u603b\u7ed3\u4e00\u4e9b\u4e13\u4e1a\u77e5\u8bc6\uff0c\u4e13\u4e1a\u6280\u80fd\u4f9b\u5927\u5bb6\u53c2\u8003\u3002<\/strong><\/p>\n

\u6750\u6599\u4eba\u73b0\u5728\u8bbe\u7acb\u5404\u79cd\u6587\u7ae0\u4e13\u680f\uff0c\u6240\u6d89\u53ca\u9886\u57df\u6b63\u5728\u6162\u6162\u5b8c\u5584\uff0c\u7531\u6b64\u4e5f\u9700\u8981\u66f4\u591a\u7684\u4e13\u680f\u4f5c\u8005\uff0c\u671f\u5f85\u4f60\u4eec\u7684\u52a0\u5165\uff0c\u6709\u610f\u5411\u7684\u5c0f\u4f19\u4f34\u76f4\u63a5\u5fae\u4fe1\u8054\u7cfbcailiaorenVIP\u3002\u4e0d\u8981\u518d\u72b9\u8c6b\uff0c\u4e0b\u4e00\u4e2a\u4e13\u680f\u521b\u59cb\u4eba\u5c31\u662f\u4f60\u3002\u8bf7\u8bb0\u4f4f\uff1a\u7eb5\u7136\u4f60\u79bb\u6211\u5343\u91cc\u4e07\u91cc\uff0c\u6211\u90fd\u5728\u6750\u6599\u4eba\u7b49\u4f60\uff01<\/strong><\/p>\n

<\/b><\/b>1.\u524d\u8a00<\/b><\/strong><\/p>\n

\u751f\u7269\u6210\u50cf\uff0c\u987e\u540d\u601d\u4e49\uff0c\u662f\u4e86\u89e3\u751f\u7269\u4f53\u7ec4\u7ec7\u7ed3\u6784\uff0c\u9610\u660e\u751f\u7269\u4f53\u5404\u79cd\u751f\u7406\u529f\u80fd\u7684\u4e00\u79cd\u91cd\u8981\u7814\u7a76\u624b\u6bb5\u3002\u5b83\u5229\u7528\u5149\u5b66\u6216\u7535\u5b50\u663e\u5fae\u955c\u83b7\u53d6\u751f\u7269\u7ec6\u80de\u548c\u7ec4\u7ec7\u7684\u5fae\u89c2\u7ed3\u6784\u56fe\u50cf\uff0c\u7528\u6765\u4e86\u89e3\u751f\u7269\u7ec6\u80de\u7684\u5404\u79cd\u751f\u7406\u8fc7\u7a0b\u3002\u4e00\u822c\u6765\u8bf4\uff0c\u751f\u7269\u6210\u50cf\u4ec5\u4ec5\u662f\u4e3a\u4e86\u521d\u6b65\u8bca\u65ad\uff0c\u540e\u7eed\u8fd8\u9700\u8981\u5229\u7528\u5404\u79cd\u6cbb\u7597\u65b9\u5f0f\u6765\u6cbb\u6108\u76f8\u5173\u75be\u75c5\uff0c\u8fd9\u4e2a\u8fc7\u7a0b\u4e5f\u5c31\u662f\u5927\u5bb6\u7ecf\u5e38\u542c\u5230\u7684\u201c\u8bca\u7597\u4e00\u4f53\u5316\u201d\u3002\u7531\u4e8e\u6587\u7ae0\u7bc7\u5e45\u6709\u9650\uff0c\u8fd9\u91cc\u5148\u4ecb\u7ecd\u751f\u7269\u6210\u50cf\uff0c\u4e0b\u6b21\u518d\u8bb2\u540e\u7eed\u751f\u7269\u6cbb\u7597\u624b\u6bb5\u3002\u90a3\u4e48\u76ee\u524d\u751f\u7269\u6210\u50cf\u65b9\u5f0f\u6709\u54ea\u4e9b\u5462\uff1f\u5b83\u4eec\u53c8\u5404\u81ea\u6709\u4ec0\u4e48\u4f18\u7f3a\u70b9\u5462\uff1f\u53c8\u6709\u54ea\u4e9b\u6750\u6599\u5df2\u7ecf\u5e7f\u6cdb\u5e94\u7528\u4e8e\u8be5\u6210\u50cf\u6a21\u5f0f\uff1f\u4e0b\u9762\u6211\u4eec\u4e00\u8d77\u6765\u770b\u770b\u3002<\/p>\n

2.\u8367\u5149\u6210\u50cf<\/b><\/strong>(Fluorescence imaging<\/b><\/strong>\uff0c<\/b><\/strong>FI)<\/b><\/strong><\/p>\n

2.1<\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

FI\u7684\u7406\u8bba\u57fa\u7840\u662f\u8367\u5149\u7269\u8d28\u88ab\u6fc0\u53d1\u540e\u6240\u53d1\u5c04\u7684\u8367\u5149\u4fe1\u53f7\u7684\u5f3a\u5ea6\u5728\u4e00\u5b9a\u7684\u8303\u56f4\u5185\u4e0e\u8367\u5149\u7d20\u7684\u91cf\u6210\u7ebf\u6027\u5173\u7cfb\u3002FI\u7cfb\u7edf\u5305\u62ec\u8367\u5149\u4fe1\u53f7\u6fc0\u53d1\u7cfb\u7edf\uff08\u6fc0\u53d1\u5149\u6e90\u3001\u5149\u8def\u4f20\u8f93\u7ec4\u4ef6\uff09\u3001\u8367\u5149\u4fe1\u53f7\u6536\u96c6\u7ec4\u4ef6\u3001\u4fe1\u53f7\u68c0\u6d4b\u4ee5\u53ca\u653e\u5927\u7cfb\u7edf\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u8367\u5149<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong><\/p>\n

\u8367\u5149\u5206\u5149\u5149\u5ea6\u8ba1\u2014\u2014\u4e3b\u8981\u7528\u4e8e\u5f97\u5230\u8367\u5149\u6fc0\u53d1\u548c\u53d1\u5c04\u5149\u8c31\uff0c\u8367\u5149\u5bff\u547d\uff0c\u91cf\u5b50\u4ea7\u7387\u7b49\u6570\u636e\uff1b<\/p>\n

\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u955c\u2014\u2014\u4e3b\u8981\u7528\u4e8e\u7ec6\u80de\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

\u6d3b\u4f53\u6210\u50cf\u7cfb\u7edf\u2014\u2014\u4e3b\u8981\u7528\u4e8e\u52a8\u7269\u4f53\u5185\u8367\u5149\u6210\u50cf\u3002<\/p>\n

\u800c\u8fd9\u4e2a\u53d1\u5c04\u7684\u8367\u5149\u4fe1\u53f7\u7684\u6ce2\u957f\u8303\u56f4\u4e00\u822c\u5728\u53ef\u89c1\u5230\u7ea2\u5916\u533a\u57df\u7684\u5c45\u591a\u3002\u56e0\u4e3a\u5149\u7684\u6ce2\u957f\u8d8a\u957f\u5bf9\u7ec4\u7ec7\u7684\u7a7f\u900f\u529b\u8d8a\u5f3a\uff0c\u6240\u4ee5\u5bf9\u4e8e\u80fd\u591f\u53d1\u5c04\u51fa\u6ce2\u957f\u8f83\u957f\u7684\u8fd1\u7ea2\u5916\u8367\u5149\uff08NIRF\uff09\u7684\u6750\u6599\u662f\u6211\u4eec\u6240\u8ffd\u6c42\u7684\u3002\u76ee\u524d\u6709\u5f88\u591a\u8367\u5149\u67d3\u6599\u5df2\u7ecf\u5546\u4e1a\u5316\uff0c\u7528\u4e8e\u5bf9\u7ec6\u80de\u5185\u90e8\u7684\u5404\u4e2a\u7ec6\u80de\u5668\u8fdb\u884c\u67d3\u8272\uff0c\u5448\u73b0\u51fa\u4e0d\u540c\u6ce2\u957f\u7684\u53d1\u5c04\u5149\uff0c\u4ece\u800c\u6709\u5229\u4e8e\u5bf9\u5355\u4e2a\u751f\u7269\u529f\u80fd\u5206\u5b50\u7684\u4f53\u5185\u8fde\u7eed\u8ffd\u8e2a\uff0c\u8be6\u7ec6\u5730\u8bb0\u5f55\u5176\u751f\u7406\u8fc7\u7a0b\u3002<\/p>\n

\u56fe<\/b><\/strong>\u00a01 <\/b><\/strong>\u7ec6\u80de\u8367\u5149\u6210\u50cf\u56fe\u3002<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u7528100\u03bcg\/ mL\uff08A\uff09Au18<\/sub>SG14<\/sub>\u548c\uff08B\uff09Au18<\/sub>SG12<\/sub>MTPB2<\/sub>\u572837\u2103\u4e0b\u4e0e\u4e73\u817a\u764c\u7ec6\u80de\u5171\u5b75\u80b21h\u540e\u5e76\u5206\u522b\u4e0eLysotracker green\u548cMitotracker green\u5171\u67d3\u8272\u5f97\u5230\u7684\u5171\u805a\u7126\u6fc0\u5149\u626b\u63cf\u663e\u5fae\u955c\u56fe\u50cf\u3002\u5728\u5408\u5e76\u7684\u56fe\u7247\u4e2d\uff0c\u7531\u7ea2\u8272\u548c\u7eff\u8272\u4fe1\u53f7\u4ea7\u751f\u7684\u9ec4\u8272\u6591\u70b9\u8868\u793a\u7eb3\u7c73\u56e2\u7c07\u5728\u6eb6\u9176\u4f53\u6216\u7ebf\u7c92\u4f53\u5185\u7684\u5171\u5b9a\u4f4d\u60c5\u51b5\u3002\u56fe\u4e2d\u6240\u6709\u6bd4\u4f8b\u5c3a\u5747\u4e3a20\u03bcm\u3002[1] <\/b><\/sup><\/strong><\/p>\n

2.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u6210\u672c\u8f83\u4f4e\uff0c\u7075\u654f\u5ea6\u9ad8\uff0c\u53ef\u4ee5\u505a\u591a\u8272\u6210\u50cf\uff0c\u64cd\u4f5c\u8f83\u7b80\u5355\u3002<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u7a7a\u95f4\u5206\u8fa8\u7387\u8f83\u4f4e\uff0c\u7ec4\u7ec7\u6e17\u900f\u6027\u8f83\u5dee\uff0c\u4e00\u822c\u53ea\u80fd\u505a\u5230\u8868\u5c42\u3002<\/p>\n

2.3<\/b><\/strong>\u7ecf\u5178\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

\u91cf\u5b50\u70b9[2]<\/b><\/sup><\/strong>\uff0c\u6bd4\u5982\u7845\u91cf\u5b50\u70b9\uff0c\u9517\u91cf\u5b50\u70b9\uff0cCdS\u3001CdSe\u3001CdTe\u3001ZnS\u3001PbS\u3001ZnSe\u91cf\u5b50\u70b9\u7b49\u7b49\uff1b<\/p>\n

\u8367\u5149\u67d3\u6599[3]<\/b><\/sup><\/strong>\uff0c\u6bd4\u5982\u9999\u8c46\u7d20\uff0c\u8367\u5149\u7d20\uff0c\u787c\u4e8c\u5421\u54af\u7532\u57fa\u884d\u751f\u7269\uff08BODIPY\uff09\uff0c\u7f57\u4e39\u660e\u548c\u82b1\u9752\u67d3\u6599\uff08\u5432\u54da\u83c1\u7effICG\uff0ccy5\u7b49\u7b49\uff09\uff1b<\/p>\n

\u9567\u7cfb\u5143\u7d20\u63ba\u6742\u7684\u4e0a\u8f6c\u6362\u7eb3\u7c73\u9897\u7c92[4]<\/b><\/sup><\/strong>\uff0c\u6bd4\u5982NaYF4<\/sub>\uff0cY2<\/sub>O3<\/sub>\uff0cGd2<\/sub>O3<\/sub>\uff0cNaGdF4<\/sub>\uff0cGdF3<\/sub>\uff0cCaF2<\/sub>\uff0cLaPO4<\/sub>\uff1b<\/p>\n

\u00a0\u00a0\u00a0\u00a0\u8367\u5149\u91d1\u5c5e\u7eb3\u7c73\u56e2\u7c07[5]<\/b><\/sup><\/strong>\uff0c\u6bd4\u5982\u8c37\u80f1\u7518\u80bd\u6216\u8005\u725b\u8840\u6e05\u767d\u86cb\u767d\u4fdd\u62a4\u7684\u91d1\u7eb3\u7c73\u56e2\u7c07\u3002<\/p>\n

3.\u78c1\u5171\u632f\u6210\u50cf<\/b><\/strong>(Magnetic resonance imaging<\/b><\/strong>\uff0c<\/b><\/strong>MRI)<\/b><\/strong><\/p>\n

3.1<\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

MRI\u662f\u6839\u636e\u6709\u78c1\u8ddd\u7684\u539f\u5b50\u6838\u5728\u78c1\u573a\u4f5c\u7528\u4e0b\uff0c\u80fd\u4ea7\u751f\u80fd\u7ea7\u95f4\u7684\u8dc3\u8fc1\u7684\u539f\u7406\u800c\u91c7\u7528\u7684\u4e00\u9879\u65b0\u68c0\u67e5\u6280\u672f\uff0c\u5229\u7528\u5916\u78c1\u573a\u548c\u7269\u4f53\u7684\u76f8\u4e92\u4f5c\u7528\u6765\u6210\u50cf\u3002MRI\u7cfb\u7edf\u4e3b\u8981\u7531\u4e09\u5927\u57fa\u672c\u6784\u4ef6\u7ec4\u6210\uff0c\u5373\u78c1\u4f53\u90e8\u5206\u3001\u78c1\u5171\u632f\u6ce2\u8c31\u4eea\u90e8\u5206\u3001\u6570\u636e\u5904\u7406\u548c\u56fe\u50cf\u91cd\u5efa\u90e8\u5206\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u78c1\u573a\uff08\u65e0\u7ebf\u7535\u6ce2\uff09<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>\u78c1\u5171\u632f\u626b\u63cf\u4eea\u2014\u2014\u7528\u4e8e\u4f53\u5916\u6a21\u62df\u73af\u5883\u548c\u6d3b\u4f53\u6210\u50cf<\/p>\n

\u56fe<\/b><\/strong>\u00a02 <\/b><\/strong>Fe3+<\/sup>\u87af\u5408\u7684\u9ed1\u8272\u7d20\u7eb3\u7c73\u7c92\u5b50\uff08MNP\uff09\u7684\u4f53\u5916\u548c\u4f53\u5185MRI\u7814\u7a76[6]<\/b><\/sup><\/strong>\u3002<\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u5728\u743c\u8102\u7cd6\u51dd\u80f6\u4e2d\u4e0d\u540c\u6d53\u5ea6\u7684Fe-RGD-PEG-MNP\u5728\u78c1\u573a\u4e3a1.0T\uff0c\u6e29\u5ea625\u2103\u6761\u4ef6\u4e0b\u5f97\u5230\u7684T1\u5f1b\u8c6b\u7387\uff081\/T1<\/sub>\uff0cs-1<\/sup>\uff09\u3002\uff08B\uff09Fe-RGD-PEG-MNP\u5728\u6d3b\u5c0f\u9f20\u4f53\u5185\u6d4b\u5f97\u7684MRI\u4fe1\u53f7\u3002\u7528\u6d53\u5ea6\u4e3a0\uff0c1.25\uff0c2.5\uff08\u4e0a\u5c42\u4ece\u5de6\u5230\u53f3\uff09\u548c5\uff0c10\uff0c20\uff08\u4e0b\u5c42\u4ece\u5de6\u5230\u53f3\uff09\u03bcM\u7684Fe-RGD-PEG-MNP\u5bf9\u5c0f\u9f20\u8fdb\u884c\u76ae\u4e0b\u6ce8\u5c04\uff08\u7ea2\u8272\u865a\u7ebf\u5305\u56f4\u7684\u533a\u57df\uff09\u3002\uff08C\uff09\u5bf9\u5c0f\u9f20\u5c3e\u9759\u8109\u6ce8\u5c04RGD-PEG-MNP 4 h\u540e\u4e0e0h\u6bd4\u8f83\u5f97\u5230U87MG\u80bf\u7624\u589e\u5f3aMR\u4fe1\u53f7\u7684\u5b9a\u91cf\u5206\u6790\u3002\uff08D\uff09\u5bf9\u5c0f\u9f20\u5c3e\u90e8\u9759\u8109\u6ce8\u5c04250 \u03bcL\uff0c200 \u03bcM RGD-PEG-MNP\u524d\u540e\u6240\u5f97\u5230\u7684U87MG\u80bf\u7624\u7684MRI\u56fe\u50cf\uff08\u80bf\u7624\u90e8\u4f4d\u88ab\u9ec4\u8272\u865a\u7ebf\u5708\u51fa\uff09\u3002\u9876\u884c\u663e\u793a\u9ed1\u767d\u56fe\u50cf\uff0c\u5e95\u884c\u663e\u793a\u4f2a\u5f69\u8272\u56fe\u50cf\u3002<\/p>\n

3.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u7a7a\u95f4\u5206\u8fa8\u7387\u9ad8\uff0c\u4e0d\u53d7\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u7684\u9650\u5236\uff1b\u7531\u4e8e\u662f\u78c1\u573a\u6210\u50cf\uff0c\u65e0\u653e\u5c04\u6027\uff0c\u5bf9\u4eba\u4f53\u65e0\u5bb3\u3002<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u82b1\u8d39\u6210\u672c\u8f83\u9ad8\uff0c\u7075\u654f\u5ea6\u8f83\u4f4e\uff0c\u9700\u8981\u6210\u50cf\u68c0\u6d4b\u65f6\u95f4\u8f83\u957f\uff0c\u4e0d\u80fd\u5b9a\u91cf\u5206\u6790\uff0cT1\u3001T2\u4ee5\u53ca\u8d28\u5b50\u5bc6\u5ea6\u6d4b\u91cf\u8fd0\u7b97\u9ebb\u70e6\u3001\u53ef\u6bd4\u6027\u5dee\u3002<\/p>\n

3.3 <\/b><\/strong>\u7ecf\u5178\u9020\u5f71\u5242<\/b><\/strong>[7-8]<\/b><\/sup><\/strong><\/p>\n

\u8d85\u987a\u78c1\u6027\u9020\u5f71\u5242\uff1aFe3<\/sub>O4<\/sub>, MnFe2<\/sub>O4<\/sub>, FeCo<\/p>\n

\u987a\u78c1\u7eb3\u7c73\u7c92\u5b50\u9020\u5f71\u5242\uff1aGd2<\/sub>O3<\/sub>, MnO<\/p>\n

\u987a\u78c1\u6027\u91d1\u5c5e\u79bb\u5b50\u548c\u914d\u4f53\u7ec4\u6210\u7684\u9020\u5f71\u5242\uff1a\u91d1\u5c5e\u79bb\u5b50\u4e3b\u8981\u4e3a\u4e8c\u4ef7\u94c1Fe2+<\/sup>3d6<\/sup>\uff0c\u4e09\u4ef7\u94c1Fe3+<\/sup>3d5<\/sup>\uff0c\u4e8c\u4ef7\u9530Mn2+<\/sup>3d5<\/sup>\uff0c\u4e09\u4ef7\u9486Gd3+<\/sup>4f7<\/sup>\u9567\u7cfb\u5143\u7d20\uff0c\u4e09\u4ef7\u955dDy3+<\/sup>4f9<\/sup>\u9567\u7cfb\u5143\u7d20\uff0cGd3+<\/sup>\u67097\u4e2a\u672a\u6210\u5bf9\u7535\u5b50\uff0c\u81ea\u65cb\u78c1\u77e9\u5927\uff0c\u7535\u573a\u5bf9\u79f0\uff0c\u5f1b\u8c6b\u6548\u7387\u9ad8\uff0c\u6613\u4e0e\u6c34\u914d\u4f4d\uff0c\u4e14\u914d\u4f4d\u6c34\u5206\u5b50\u4e3a8-9\u4e2a\uff0c\u662f\u9020\u5f71\u5242\u7684\u8f83\u4f73\u9009\u62e9\u3002\u5f88\u591a\u6587\u732e\u90fd\u662f\u4f18\u5148\u91c7\u7528Gd3+<\/sup>\u4e0e\u5404\u79cd\u914d\u4f53\uff08\u53ea\u8981\u8be5\u914d\u4f53\u5bcc\u542b\u8d1f\u7535\u5b50\u57fa\u56e2\u5373\u53ef\uff09\u87af\u5408\u7528\u4e8eMRI\u5206\u6790\u3002<\/p>\n

4.\u7535\u5b50\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf<\/b><\/strong>(Computed tomography<\/b><\/strong>\uff0c<\/b><\/strong>CT)<\/b><\/strong><\/p>\n

4.1 <\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

CT\u662f\u7528X\u5c04\u7ebf\u675f\u5bf9\u4eba\u4f53\u67d0\u90e8\u4e00\u5b9a\u539a\u5ea6\u7684\u5c42\u9762\u8fdb\u884c\u626b\u63cf\uff0c\u7531\u63a2\u6d4b\u5668\u63a5\u6536\u900f\u8fc7\u8be5\u5c42\u9762\u7684X\u5c04\u7ebf\uff0c\u8f6c\u53d8\u4e3a\u53ef\u89c1\u5149\u540e\uff0c\u7531\u5149\u7535\u8f6c\u6362\u53d8\u4e3a\u7535\u4fe1\u53f7\uff0c\u518d\u7ecf\u6a21\u62df\/\u6570\u5b57\u8f6c\u6362\u5668\u8f6c\u4e3a\u6570\u5b57\uff0c\u8f93\u5165\u8ba1\u7b97\u673a\u5904\u7406\u3002CT\u56fe\u50cf\u662f\u5c42\u9762\u56fe\u50cf\uff0c\u5e38\u7528\u7684\u662f\u6a2a\u65ad\u9762\u3002\u4e3a\u4e86\u663e\u793a\u6574\u4e2a\u5668\u5b98\uff0c\u9700\u8981\u591a\u4e2a\u8fde\u7eed\u7684\u5c42\u9762\u56fe\u50cf\u3002\u901a\u8fc7CT\u8bbe\u5907\u4e0a\u56fe\u50cf\u7684\u91cd\u5efa\u7a0b\u5e8f\u7684\u4f7f\u7528\uff0c\u8fd8\u53ef\u91cd\u5efa\u51a0\u72b6\u9762\u548c\u77e2\u72b6\u9762\u7684\u5c42\u9762\u56fe\u50cf\uff0c\u53ef\u4ee5\u591a\u89d2\u5ea6\u67e5\u770b\u5668\u5b98\u548c\u75c5\u53d8\u7684\u5173\u7cfb\u3002CT\u7cfb\u7edf\u4e3b\u8981\u7531\u626b\u63cf\u90e8\u5206\uff08X\u7ebf\u7ba1\u3001\u63a2\u6d4b\u5668\u548c\u626b\u63cf\u67b6\uff09\uff0c\u8ba1\u7b97\u673a\u7cfb\u7edf\uff0c\u56fe\u50cf\u663e\u793a\u548c\u5b58\u50a8\u7cfb\u7edf\u4e09\u90e8\u5206\u7ec4\u6210\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>X\u7ebf\u675f<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>CT\u626b\u63cf\u4eea\u2014\u2014\u7528\u4e8e\u4f53\u5916\u6a21\u62df\u73af\u5883\u548c\u6d3b\u4f53\u6210\u50cf<\/p>\n

\u56fe<\/b><\/strong>\u00a03<\/b><\/strong>\u00a0\u7ecf\u8fc7TAP-SiO2 <\/sub>@ AuNPs\u5904\u7406\u7684\u8840\u6813\u548c\u975e\u8840\u6813\u5f62\u6210\u6a21\u578b\u7684\u5fae\u578bCT\u8f74\u5411\u5207\u7247\uff0c\u77e2\u72b6\u5207\u7247\u548c\u8840\u6813\u75c5\u53d8\u90e8\u4f4d\u76843D\u91cd\u5efa\u56fe\u50cf\u3002\u9ec4\u8272\u77e9\u5f62\u8868\u793a\u5c0f\u9f20\u539f\u4f4d\u8840\u6813\u6a21\u578b\u4e2d\u5f62\u6210\u7684\u9888\u603b\u52a8\u8109[9]<\/b><\/sup><\/strong>\u3002<\/p>\n

\"\"<\/p>\n

4.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u7a7a\u95f4\u5206\u8fa8\u7387\u8f83\u9ad8\uff0c\u4e0d\u53d7\u7ec4\u7ec7\u7a7f\u900f\u529b\u7684\u9650\u5236<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u8f90\u5c04\u98ce\u9669\u5927\uff0c\u4e0d\u80fd\u5b9a\u91cf\u5206\u6790<\/p>\n

4.3 <\/b><\/strong>\u7ecf\u5178\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

\u5df2\u7ecf\u7528\u4e8e\u4e34\u5e8a\u7684\uff08\u4e3b\u8981\u57fa\u4e8e\u7898\u5316\u5316\u5408\u7269\uff09<\/b><\/strong><\/p>\n

\u79bb\u5b50\u578b\u9020\u5f71\u5242<\/b><\/strong>: <\/b><\/strong>\u6cdb\u5f71\u8461\u80fa\uff08Angiografin\uff09\uff0c\u590d\u65b9\u6cdb\u5f71\u8461\u80fa\uff08Urografin\uff09\u6216\u6cdb\u5f71\u94a0\uff08Hapaque\uff09\uff1b<\/p>\n

\u975e\u79bb\u5b50\u578b\u9020\u5f71\u5242\uff1a<\/b><\/strong>\u76ee\u524d\u56fd\u5185\u5916\u5747\u666e\u904d\u5efa\u8bae\u4f7f\u7528\u975e\u79bb\u5b50\u578b\u9020\u5f71\u5242\uff0c\u5b83\u4e0e\u79bb\u5b50\u578b\u9020\u5f71\u5242\u76f8\u6bd4\u5177\u6709\u6bd2\u6027\u5c0f\uff0c\u542b\u7898\u9ad8\uff0c\u526f\u4f5c\u7528\u5c0f\u548c\u589e\u5f3a\u6548\u679c\u597d\u7b49\u4f18\u70b9\uff0c\u4f46\u4ef7\u683c\u8f83\u6602\u8d35\u3002<\/p>\n

\u7898\u666e\u7f57\u80fa\u7c7b\uff1a\u4f18\u7ef4\u5148\uff08Ultravist\uff09<\/p>\n

\u7898\u6d77\u9187\u7c7b\uff1a\u6b27\u5185\u6d3e\u514b\uff08Omnipaque\uff09<\/p>\n

\u7898\u5e15\u9187\u7c7b\uff1a\u7898\u6bd4\u4e50\uff08lopamiro\uff09<\/p>\n

\u76ee\u524d\u5904\u4e8e\u7814\u7a76\u9636\u6bb5\u7684\u65b0\u4e00\u4ee3<\/b><\/strong>CT<\/b><\/strong>\u9020\u5f71\u5242\uff1a<\/b><\/strong><\/p>\n

\u91d1\u7eb3\u7c73\u7c92\u5b50[9]<\/b><\/sup><\/strong>\uff0c\u94cb\uff08Bi\uff09\uff0c\u9571\uff08Yb\uff09\u6216\u91d1\uff08Au\uff09\u57fa\u7eb3\u7c73\u9897\u7c92[10-12]<\/b><\/sup><\/strong>\uff0c\u751f\u7269\u5c0f\u5206\u5b50\u4fdd\u62a4\u7684\u8d85\u5c0f\u91d1\u7eb3\u7c73\u56e2\u7c07[13]<\/b><\/sup><\/strong><\/p>\n

5.\u53d1\u5c04\u578b\u8ba1\u7b97\u673a\u65ad\u5c42\u6210\u50cf\u672f<\/b><\/strong>(Emission Computed Tomography<\/b><\/strong>\uff0c<\/b><\/strong>ECT)<\/b><\/strong><\/p>\n

5.1 <\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

ECT\u5305\u62ec\u5355\u5149\u5b50\u53d1\u5c04\u8ba1\u7b97\u673a\u65ad\u5c42\u6210\u50cf\u672f(Single-Photon Emission Computed Tomography\uff0cSPECT)\u548c\u6b63\u7535\u5b50\u53d1\u5c04\u65ad\u5c42\u6210\u50cf\u672f(Positron Emission Tomography\uff0cPET)\u4e24\u79cd\uff0c\u5c5e\u4e8e\u6838\u533b\u5b66\u7684\u4e24\u79cdCT\u6280\u672f\u3002\u987e\u540d\u601d\u4e49\uff0c\u4e8c\u8005\u533a\u522b\u5728\u4e8e\u4e00\u4e2a\u662f\u5355\u5149\u5b50\u53d1\u5c04\uff0c\u4e00\u4e2a\u662f\u6b63\u7535\u5b50\u53d1\u5c04\u3002\u8fd9\u4fbf\u6d89\u53ca\u5230\u6210\u50cf\u539f\u7406<\/b><\/strong>\uff1aSPECT\u6210\u50cf\u6240\u9700\u8981\u7684\u653e\u5c04\u6027\u6838\u7d20\u5927\u591a\u662f\u8870\u53d8\u4ea7\u751f\u5355\u4e00\u80fd\u91cf\u7684\u03b3\u5149\u5b50\u5373\u5355\u5149\u5b50\uff0c\u53d1\u5c04140KeV\u7684\u4f4e\u80fd\u03b3\u5149\u5b50\uff1b\u800cPET\u6210\u50cf\u6240\u4f7f\u7528\u7684\u662f\u53d1\u5c04\u6b63\u7535\u5b50\u7684\u653e\u5c04\u6027\u6838\u7d20\uff0c\u6b63\u7535\u5b50\u662f\u8d1f\u7535\u5b50\u7684\u53cd\u7269\u8d28\uff0c\u672c\u8eab\u7a7f\u900f\u6027\u8f83\u5f31\uff0c\u4eba\u4f53\u5185\u6b63\u7535\u5b50\u6838\u7d20\u663e\u50cf\u6240\u53d1\u5c04\u7684\u6b63\u7535\u5b50\u4e0d\u80fd\u88ab\u4f53\u5916\u7684\u8bbe\u5907\u63a2\u6d4b\u5230\uff0c\u8bbe\u5907\u63a2\u6d4b\u7684\u662f\u6b63\u7535\u5b50\u4e0e\u8d1f\u7535\u5b50\u76f8\u4e92\u4f5c\u7528\u540e\u6240\u4ea7\u751f\u7684\u6e6e\u706d\u8f90\u5c04\u8fc7\u7a0b\u7684\u9ad8\u80fd\u03b3\u5149\u5b50\u3002<\/p>\n

ECT\u7cfb\u7edf\u7684\u57fa\u672c\u7ed3\u6784\u52063\u90e8\u5206\uff0c\u5373\u65cb\u8f6c\u63a2\u5934\u88c5\u7f6e\uff08\u4e13\u95e8\u63a2\u6d4b\u03b3\u5c04\u7ebf\uff09\u3001\u7535\u5b50\u7ebf\u8def\u3001\u6570\u636e\u5904\u7406\u548c\u56fe\u50cf\u91cd\u5efa\u7684\u8ba1\u7b97\u673a\u7cfb\u7edf\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u03b3\u5c04\u7ebf<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>ECT\u626b\u63cf\u4eea<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>\u00a064<\/sup>Cu\u6807\u8bb0\u7684\u9ed1\u8272\u7d20\u7eb3\u7c73\u7c92\u5b50\uff08MNP\uff09\u7684\u4f53\u5916\u548c\u4f53\u5185PET\u7814\u7a76\u3002<\/p>\n

\"\"<\/p>\n

\uff08A\uff0964<\/sup>Cu-RGD-PEG-MNP\u5206\u522b\u4e0e\u7ecf\u8fc7\u548c\u672a\u7ecf\u8fc7RGD\u9884\u5904\u7406\u7684U87MG\u7ec6\u80de\u572837\u2103\u4e0b\u5b75\u80b21\uff0c2\u548c4\u5c0f\u65f6\u540e\u6240\u5f97\u7684\u7ec6\u80de\u6444\u53d6\u7387\u3002\uff08B\uff09\u5728\u5c3e\u9759\u8109\u6ce8\u5c0464<\/sup>Cu-RGD-PEG-MNP 2\uff0c4\u548c24\u5c0f\u65f6\u540e\u83b7\u5f97\u7684\u7ecf\u8fc7\u8870\u53d8\u6821\u6b63\u7684\u51a0\u72b6\uff08\u9876\u90e8\uff09\u548c\u6a2a\u8f74\uff08\u5e95\u90e8\uff09\u5c0f\u52a8\u7269PET\u56fe\u50cf\uff08\u5de6\u4e09\u4e2a\u56fe\u50cf\uff09\u548cU87MG\u80bf\u7624\u7684CT\uff08\u7070\u8272\uff09\u548cPET\uff08\u5f69\u8272\uff09\uff08\u53f3\u4e09\u4e2a\u56fe\u50cf\uff09\u7684\u91cd\u53e0\u56fe\u50cf\uff08\u9ec4\u8272\u865a\u7ebf\u5708\u51fa\u7684\u533a\u57df\uff09\u3002\uff08C\uff09\u5728\u5c3e\u9759\u8109\u6ce8\u5c0464<\/sup>Cu-RGD-PEG-MNP 2\uff0c4\u548c24\u5c0f\u65f6\u540e\u5728\u5c0f\u9f20\u4f53\u5185\u7684\u751f\u7269\u5206\u5e03\u3002\u4f7f\u7528\u5728\u6574\u4e2a\u5668\u5b98\u533a\u57df\u4e0a\u7ed8\u5236\u7684\u611f\u5174\u8da3\u533a\u57df\u8ba1\u7b97\u6765\u81ea\u6bcf\u4e2a\u5668\u5b98\u7684\u653e\u5c04\u6027\u4fe1\u53f7[6]<\/b><\/sup><\/strong>\u3002<\/p>\n

5.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

SPECT<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u7075\u654f\u5ea6\u9ad8\uff0c\u4e0d\u53d7\u7ec4\u7ec7\u7a7f\u900f\u529b\u9650\u5236<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u6709\u4e00\u5b9a\u8f90\u5c04\u98ce\u9669\uff0c\u7a7a\u95f4\u5206\u8fa8\u7387\u8f83\u4f4e<\/p>\n

PET<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u7075\u654f\u5ea6\u9ad8\uff0c\u7279\u5f02\u6027\u9ad8\uff0c\u53ef\u4e00\u6b21\u6027\u5168\u8eab\u626b\u63cf\u663e\u50cf\uff0c\u4e0d\u53d7\u7ec4\u7ec7\u7a7f\u900f\u529b\u9650\u5236\uff0c\u53ef\u4ee5\u5b9a\u91cf\u5206\u6790\u3002<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u6709\u4e00\u5b9a\u8f90\u5c04\u98ce\u9669\uff08\u6bd5\u7adf\u6838\u7d20\u8fd8\u662f\u6709\u4e00\u5b9a\u653e\u5c04\u6027\u7684\uff0c\u4f46\u6240\u7528\u5242\u91cf\u5f88\u5c11\uff0c\u8fdc\u8fdc\u5c0f\u4e8e\u5e38\u89c4CT\u68c0\u67e5\uff09\uff0c\u82b1\u8d39\u6210\u672c\u9ad8\uff0c\u7a7a\u95f4\u5206\u8fa8\u7387\u8f83\u4f4e\u3002<\/p>\n

5.3 <\/b><\/strong>\u5178\u578b\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

\u653e\u5c04\u6027\u6838\u7d20\uff1a<\/b><\/strong><\/p>\n

SPECT\u5e38\u752899mTc\u3001133I\u300167Ga\u3001153Sm<\/p>\n

PET\u5e38\u752818F\u300111C\u300113N\u300115O<\/p>\n

6.\u5149\u70ed\u6210\u50cf\uff08<\/b><\/strong>Photothermal imaging<\/b><\/strong>\uff0c<\/b><\/strong>PTI<\/b><\/strong>\uff09<\/b><\/strong><\/p>\n

6.1 <\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u7ea2\u5916\u8f90\u5c04\u80fd\u91cf<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>\u7ea2\u5916\u70ed\u6210\u50cf\u4eea<\/p>\n

\u7ea2\u5916\u70ed\u50cf\u4eea\u4e3b\u8981\u7531\u7ea2\u5916\u63a2\u6d4b\u5668\u3001\u5149\u5b66\u6210\u50cf\u7269\u955c\u3001\u5149\u673a\u626b\u63cf\u7cfb\u7edf\u4e09\u5927\u90e8\u5206\u6784\u6210\u3002\u70ed\u6210\u50cf\u4eea\u5229\u7528\u5149\u5b66\u5668\u4ef6\u5c06\u573a\u666f\u4e2d\u7684\u7269\u4f53\u53d1\u51fa\u7684\u7ea2\u5916\u80fd\u91cf\u805a\u7126\u5728\u7ea2\u5916\u63a2\u6d4b\u5668\u4e0a\uff0c\u7136\u540e\u5c06\u6bcf\u4e2a\u63a2\u6d4b\u5668\u5143\u4ef6\u7684\u7ea2\u5916\u6570\u636e\u8f6c\u6362\u6210\u6807\u51c6\u7684\u56fe\u7247\u6216\u8005\u89c6\u9891\u683c\u5f0f\uff0c\u53ef\u4ee5\u5728\u6807\u51c6\u7684\u89c6\u9891\u76d1\u89c6\u5668\u4e0a\u663e\u793a\u51fa\u6765\uff0c\u6216\u8bb0\u5f55\u5728\u5f55\u50cf\u5e26\u4e0a\u3002<\/p>\n

\u56fe<\/b><\/strong>5<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\uff08A\uff09\u7528\u6c19\u706f\u7167\u5c04\u5c3e\u9759\u8109\u6ce8\u5c04IABDP NPs\u540e\uff0c\u4f53\u5185\u542b\u6709HeLa\u80bf\u7624\u7684\u88f8\u9f20\u7684PT\u56fe\u50cf\u3002\uff08B\uff09\u6c19\u706f\u7167\u5c04\u4e0b\u7684\u80bf\u7624\u6e29\u5ea6\u66f2\u7ebf[14]<\/b><\/sup><\/strong>\u3002<\/p>\n

6.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u826f\u597d\u7684\u6e29\u5ea6\u7075\u654f\u5ea6\uff0c\u53ef\u5b9e\u65f6\u76d1\u6d4b\u00a0<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u7a7a\u95f4\u5206\u8fa8\u7387\u8f83\u5dee<\/p>\n

6.3 <\/b><\/strong>\u5178\u578b\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

\u57fa\u672c\u4e0a\u5177\u6709\u5149\u70ed\u8f6c\u6362\u7279\u6027\u7684\u6750\u6599\u90fd\u53ef\u4ee5\u5b9e\u73b0\u5149\u70ed\u6210\u50cf\u3002\u6bd4\u5982\uff0c\u91d1\u7eb3\u7c73\u9897\u7c92\uff08\u91d1\u7eb3\u7c73\u68d2\uff0c\u91d1\u7eb3\u7c73\u7403\uff0c\u91d1\u7eb3\u7c73\u661f\u7b49\u7b49\uff09\uff0c\u77f3\u58a8\u70ef\u4ee5\u53ca\u884d\u751f\u7269\uff0c\u805a\u5421\u54af\u7b49\u6709\u673a\u7269\u3002<\/p>\n

7.\u62c9\u66fc\u6210\u50cf\uff08<\/b><\/strong>Raman imaging<\/b><\/strong>\uff0c<\/b><\/strong>RI<\/b><\/strong>\uff09<\/b><\/strong><\/p>\n

7.1 <\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

\u62c9\u66fc\u6210\u50cf\u6280\u672f\u662f\u65b0\u4e00\u4ee3\u5feb\u901f\u3001\u9ad8\u7cbe\u5ea6\u3001\u9762\u626b\u63cf\u6fc0\u5149\u62c9\u66fc\u6280\u672f\uff0c\u5b83\u5c06\u5171\u805a\u7126\u663e\u5fae\u955c\u6280\u672f\u4e0e\u6fc0\u5149\u62c9\u66fc\u5149\u8c31\u6280\u672f\u5b8c\u7f8e\u7ed3\u5408\uff0c\u4f5c\u4e3a\u7b2c\u4e09\u4ee3Raman\u6280\u672f\uff0c\u62c9\u66fc\u5149\u8c31\u6210\u50cf\u4e0a\u7684\u6bcf\u4e00\u4e2a\u50cf\u5143\uff0c\u90fd\u5bf9\u5e94\u4e8e\u4e00\u6761\u5b8c\u6574\u7684\u62c9\u66fc\u5149\u8c31\uff0c\u8fd9\u4e9b\u6570\u767e\u3001\u6570\u5343\u751a\u81f3\u6570\u767e\u4e07\u6761\u5149\u8c31\u7efc\u5408\u5728\u4e00\u8d77\uff0c\u5c31\u4ea7\u751f\u4e86\u4e00\u5e45\u53cd\u6620\u6750\u6599\u7684\u6210\u5206\u548c\u7ed3\u6784\u7684\u4f2a\u5f69\u56fe\u50cf\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u62c9\u66fc\u6563\u5c04\u5149<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>\u6fc0\u5149\u5171\u805a\u7126\u663e\u5fae\u62c9\u66fc\u5149\u8c31\u6210\u50cf\u7cfb\u7edf<\/p>\n

\u56fe<\/b><\/strong>6 <\/b><\/strong>C12-\u5355\u58c1\u78b3\u7eb3\u7c73\u7ba1SWNT-\u6297\u4f53Her2\u4e0eBT474\u7ec6\u80de\u5171\u5b75\u80b2\u540e\u7684\u5171\u805a\u7126\u62c9\u66fc\u5149\u8c31\u56fe\u50cf\uff08\u5de6\uff09\uff08\u4e2d\u95f4\u7684\u662f\u5149\u5b66\u56fe\u50cf\uff0c\u53f3\u4fa7\u7684\u662f\u91cd\u53e0\u56fe\u50cf\uff09[15]<\/b><\/sup><\/strong>\u3002<\/p>\n

\"\"<\/p>\n

7.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u5206\u8fa8\u7387\u9ad8\uff0c\u626b\u63cf\u901f\u5ea6\u5feb\uff0c\u53ef\u907f\u514d\u7ec4\u7ec7\u81ea\u53d1\u8367\u5149\u95ee\u9898\uff0c\u53ef\u5b9a\u6027\u5b9a\u91cf\u5b9a\u4f4d\u5206\u6790\uff0c\u53ef\u63d0\u4f9b\u6837\u54c1\u7684\u5316\u5b66\u6210\u5206\u3001\u5206\u5b50\u7ed3\u6784\u3001\u7ed3\u6676\u5ea6\u548c\u5e94\u53d8\u5e94\u529b\u7b49\u91cd\u8981\u7684\u751f\u5316\u4fe1\u606f<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u53d7\u5149\u5b66\u6210\u50cf\u7a7f\u900f\u6df1\u5ea6\u7684\u9650\u5236\uff0c\u62c9\u66fc\u6210\u50cf\u65b9\u6cd5\u4e3b\u8981\u9002\u7528\u4e8e\u6d3b\u4f53\u6d45\u8868\u4ee5\u53ca\u79bb\u4f53\u7ec4\u7ec7\u68c0\u6d4b\uff1b\u6570\u636e\u91c7\u96c6\u4ee5\u53ca\u5904\u7406\u65f6\u95f4\u8f83\u957f<\/p>\n

7.3 <\/b><\/strong>\u5178\u578b\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

\u5177\u6709\u5171\u632f\u62c9\u66fc\u6563\u5c04\u7279\u6027\u7684\u6750\u6599\uff1a\u78b3\u57fa\u7eb3\u7c73\u6750\u6599\uff0c\u6bd4\u5982\u5355\u58c1\u78b3\u7eb3\u7c73\u7ba1\uff0c\u77f3\u58a8\u70ef\uff1b\u8d35\u91d1\u5c5e\u7eb3\u7c73\u9897\u7c92\uff0c\u6bd4\u5982\u91d1\u7eb3\u7c73\u9897\u7c92<\/p>\n

8.\u8d85\u58f0\u6210\u50cf<\/b><\/strong>(Ultrasound imaging<\/b><\/strong>\uff0c<\/b><\/strong>USI)<\/b><\/strong><\/p>\n

8.1 <\/b><\/strong>\u6210\u50cf\u539f\u7406<\/b><\/strong><\/p>\n

\u8d85\u58f0\u6210\u50cf\u662f\u5229\u7528\u8d85\u58f0\u58f0\u675f\u626b\u63cf\u4eba\u4f53\uff0c\u901a\u8fc7\u5bf9\u53cd\u5c04\u4fe1\u53f7\u7684\u63a5\u6536\u3001\u5904\u7406\uff0c\u4ee5\u83b7\u5f97\u4f53\u5185\u5668\u5b98\u7684\u56fe\u8c61\u3002\u4e0d\u540c\u7ec4\u7ec7\u5668\u5b98\u7684\u53cd\u5c04\u89c4\u5f8b\u4e0d\u540c\u3002\u9635\u5217\u58f0\u573a\u5ef6\u65f6\u53e0\u52a0\u6210\u50cf\u662f\u8d85\u58f0\u6210\u50cf\u4e2d\u6700\u4f20\u7edf\uff0c\u6700\u7b80\u5355\u7684\uff0c\u4e5f\u662f\u76ee\u524d\u5b9e\u9645\u5f53\u4e2d\u5e94\u7528\u6700\u4e3a\u5e7f\u6cdb\u7684\u6210\u50cf\u65b9\u5f0f\u3002\u5728\u8fd9\u79cd\u65b9\u5f0f\u4e2d\uff0c\u901a\u8fc7\u5bf9\u9635\u5217\u7684\u5404\u4e2a\u5355\u5143\u5f15\u5165\u4e0d\u540c\u7684\u5ef6\u65f6\uff0c\u800c\u540e\u5408\u6210\u4e3a\u4e00\u805a\u7126\u6ce2\u675f\uff0c\u4ee5\u5b9e\u73b0\u5bf9\u58f0\u573a\u5404\u70b9\u7684\u6210\u50cf\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u8d85\u58f0\u6ce2<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>\u8d85\u58f0\u6210\u50cf\u4eea\uff0c\u6700\u5e38\u7528\u7684\u4e3aB\u8d85<\/p>\n

\u56fe<\/b><\/strong>7 <\/b><\/strong>\u624b\u5de5\u5236\u4f5c\u7684\u743c\u8102\u51dd\u80f6\u4f53\u6a21\u7528\u4e8e\u4f53\u5916US\u6210\u50cf\u3002\u572837\u2103\u7684\u76d0\u6c34\u4e2dGas-NPs\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u4f53\u5916US\u56fe\u50cf\u3002\u901a\u8fc7\u4ece\u5e7b\u8c61\u4fe1\u53f7\u4e2d\u51cf\u53bb\u6c34\u5f3a\u5ea6\u6765\u5bf9US\u56fe\u50cf\u8fdb\u884c\u5f52\u4e00\u5316\u5904\u7406[16]<\/b><\/sup><\/strong>\u3002\u00a0<\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>8 <\/b><\/strong>Gas-NPs\u7684\u957f\u671f\u548c\u6301\u7eed\u7684\u4f53\u5185US\u80bf\u7624\u6210\u50cf\u80fd\u529b[16]<\/b><\/sup><\/strong>\u3002<\/p>\n

\"\"<\/p>\n

8.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u4ef7\u5ec9\uff0c\u7b80\u4fbf\uff0c\u65e0\u7535\u79bb\u8f90\u5c04\u6027\uff0c\u6210\u50cf\u901f\u5ea6\u5feb\uff0c\u5bf9\u8f6f\u7ec4\u7ec7\u7ed3\u6784\u5206\u8fa8\u7387\u9ad8\uff0c\u5bf9\u6bd4\u6027\u5f3a\uff0c\u5b9e\u65f6\u6210\u50cf\uff0c\u65e0\u75db\u82e6\uff0c\u6613\u88ab\u591a\u6570\u60a3\u8005\u4f7f\u7528\u3002<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>\u53d7\u6c14\u4f53\u4e0e\u9aa8\u9abc\u7684\u963b\u788d\uff0c\u4e0d\u9002\u5408\u4e8e\u542b\u6c14\u810f\u5668\u7684\u68c0\u67e5\uff1b\u8bca\u65ad\u51c6\u786e\u6027\u5f71\u54cd\u56e0\u7d20\u8f83\u591a\uff0c\u53d7\u64cd\u4f5c\u8005\u7ecf\u9a8c\u6280\u5de7\u5f71\u54cd\uff0c\u6bd4\u5982\u8d85\u58f0\u4f2a\u50cf\u662f\u58f0\u50cf\u56fe\u7578\u53d8\uff0c\u6613\u5bfc\u81f4\u8bef\u8bca\u3002<\/p>\n

8.3 <\/b><\/strong>\u5178\u578b\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

\u8d85\u58f0\u9020\u5f71\u5242\u662f\u4e00\u79cd\u542b\u6709\u76f4\u5f84\u4e3a\u51e0\u5fae\u7c73\u6c14\u6ce1\u7684\u6db2\u4f53\u3002\u5229\u7528\u542b\u6709\u6c14\u6ce1\u7684\u6db2\u4f53\u5bf9\u8d85\u58f0\u6ce2\u6709\u5f3a\u6563\u5c04\u7684\u7279\u6027\uff0c\u4e34\u5e8a\u5c06\u8d85\u58f0\u9020\u5f71\u5242\u6ce8\u5c04\u5230\u4eba\u4f53\u8840\u7ba1\u4e2d\u7528\u4ee5\u589e\u5f3a\u8840\u6d41\u7684\u8d85\u58f0\u591a\u666e\u52d2\u4fe1\u53f7\u548c\u63d0\u9ad8\u8d85\u58f0\u56fe\u50cf\u7684\u6e05\u6670\u5ea6\u548c\u5206\u8fa8\u7387\u3002<\/p>\n

\u7b2c\u4e00\u4ee3\u8d85\u58f0\u9020\u5f71\u5242<\/b><\/strong>\u5fae\u6ce1\u5185\u542b\u7a7a\u6c14<\/b><\/strong>\uff0c\u5305\u819c\u4e00\u822c\u4e3a\u767d\u86cb\u767d\u6216\u534a\u4e73\u7cd6\u7b49\u805a\u5408\u4f53\u3002<\/p>\n

\u7b2c\u4e8c\u4ee3\u8d85\u58f0\u9020\u5f71\u5242<\/b><\/strong>\u4e3a\u5305\u88f9\u9ad8\u5bc6\u5ea6<\/b><\/strong>\u60f0\u6027\u6c14\u4f53<\/b><\/strong>\uff08\u4e0d\u6613\u6eb6\u4e8e\u6c34\u6216\u8840\u6db2\uff09\u4e3a\u4e3b\u7684\u5916\u819c\u8584\u800c\u67d4\u8f6f\u7684\u6c14\u6ce1\uff0c\u6bd4\u5982\u5168\u6c1f\u4e19\u70f7\u8102\u8d28\u5fae\u6ce1\u3002<\/p>\n

9.\u5149\u58f0\u6210\u50cf<\/b><\/strong>(Photoacoustic imaging<\/b><\/strong>\uff0c<\/b><\/strong>PAI)<\/b><\/strong><\/p>\n

9.1 <\/b><\/strong>\u5178\u578b\u9020\u5f71\u5242<\/b><\/strong><\/p>\n

PAI\u662f\u8fd1\u5e74\u6765\u53d1\u5c55\u8d77\u6765\u7684\u4e00\u79cd\u975e\u5165\u4fb5\u5f0f\u548c\u975e\u7535\u79bb\u5f0f\u7684\u65b0\u578b\u751f\u7269\u533b\u5b66\u6210\u50cf\u65b9\u6cd5\u3002\u5f53\u8109\u51b2\u6fc0\u5149\u7167\u5c04\u5230\u751f\u7269\u7ec4\u7ec7\u4e2d\u65f6\uff0c\u7ec4\u7ec7\u7684\u5149\u5438\u6536\u57df\u5c06\u4ea7\u751f\u8d85\u58f0\u4fe1\u53f7\uff0c\u6211\u4eec\u79f0\u8fd9\u79cd\u7531\u5149\u6fc0\u53d1\u4ea7\u751f\u7684\u8d85\u58f0\u4fe1\u53f7\u4e3a\u5149\u58f0\u4fe1\u53f7\u3002\u751f\u7269\u7ec4\u7ec7\u4ea7\u751f\u7684\u5149\u58f0\u4fe1\u53f7\u643a\u5e26\u4e86\u7ec4\u7ec7\u7684\u5149\u5438\u6536\u7279\u5f81\u4fe1\u606f\uff0c\u901a\u8fc7\u63a2\u6d4b\u5149\u58f0\u4fe1\u53f7\u80fd\u91cd\u5efa\u51fa\u7ec4\u7ec7\u4e2d\u7684\u5149\u5438\u6536\u5206\u5e03\u56fe\u50cf\u3002<\/p>\n

\u6210\u50cf\u5a92\u4ecb\uff1a<\/b><\/strong>\u8d85\u58f0\u6ce2<\/p>\n

\u5e38\u7528\u4eea\u5668\uff1a<\/b><\/strong>\u5149\u58f0\u8ba1\u7b97\u673a\u65ad\u5c42\u626b\u63cf\u548c\u5149\u58f0\u663e\u5fae\u955c<\/p>\n

\u56fe<\/b><\/strong>9<\/b><\/strong>\u4e0d\u540c\u9020\u5f71\u5242\u5bf9\u5c0f\u9f20\u8111PA\u6210\u50cf\u7684\u5f71\u54cd\u7684\u6bd4\u8f83[17]<\/b><\/sup><\/strong>\u3002<\/p>\n

\"\"<\/p>\n

9.2 <\/b><\/strong>\u4f18\u7f3a\u70b9<\/b><\/strong><\/p>\n

\u4f18\u70b9\uff1a<\/b><\/strong>\u6bd4\u7eaf\u5149\u5b66\u6210\u50cf\u7a7f\u900f\u66f4\u6df1\uff08\u53ef\u5b9e\u73b070 mm\u7684\u6df1\u5c42\u6d3b\u4f53\u5185\u7ec4\u7ec7\u6210\u50cf\uff09\uff0c\u6bd4\u4f20\u7edfMRI\u4ee5\u53caPET\u6210\u50cf\u7684\u5206\u8fa8\u7387\u66f4\u9ad8\uff0c\u5bf9\u4eba\u4f53\u65e0\u5bb3\uff0c\u975e\u5e38\u5b89\u5168\uff0c\u53ef\u5e94\u7528\u4e8e\u4e34\u5e8a\u3002<\/p>\n

\u7f3a\u70b9\uff1a<\/b><\/strong>PAI\u7ed3\u5408\u4e86\u8d85\u58f0\u6210\u50cf\u548c\u5149\u5b66\u6210\u50cf\u5404\u81ea\u7684\u4f18\u70b9\uff0c\u6210\u4e3a\u8fd1\u5e74\u6765\u6700\u6709\u5e0c\u671b\u53d1\u5c55\u7684\u4e00\u79cd\u6210\u50cf\u6280\u672f\uff0c\u4e0d\u8fc7\u4e5f\u6709\u5b83\u9700\u8981\u514b\u670d\u7684\u96be\u9898\uff0c\u6bd4\u5982\uff0c\u5728\u5149\u58f0\u663e\u5fae\u6210\u50cf\u65b9\u9762\uff0c\u5982\u4f55\u63d0\u9ad8\u5149\u58f0\u663e\u5fae\u6210\u50cf\u7684\u901f\u5ea6\u4f7f\u5176\u66f4\u52a0\u9002\u5e94\u4e34\u5e8a\u8bca\u65ad\u4ee5\u53ca\u68c0\u6d4b\u7b49\u7b49\u3002<\/p>\n

9.3 <\/b><\/strong>\u5178\u578b\u9020\u5f71\u5242<\/b><\/strong>[18]<\/b><\/sup><\/strong><\/p>\n

\u91d1\u5c5e\u57fa\u7eb3\u7c73\u6750\u6599\uff0c\u78b3\u57fa\u7eb3\u7c73\u6750\u6599\uff0c\u8fc7\u6e21\u91d1\u5c5e\u786b\u5c5e\u5143\u7d20\u5316\u7269\/\u57fa\u4e8eMXene\u7684\u7eb3\u7c73\u6750\u6599\uff0c\u6709\u673a\u5c0f\u5206\u5b50\uff0c\u534a\u5bfc\u4f53\u805a\u5408\u7269\u7eb3\u7c73\u7c92\u5b50<\/p>\n

10.\u603b\u7ed3\u4e0e\u5c55\u671b<\/b><\/strong><\/p>\n

10.1 \u591a\u6a21\u6001\u6210\u50cf\u2014\u2014\u4f18\u5316\u7ec4\u5408\uff0c\u626c\u957f\u907f\u77ed<\/b><\/strong><\/p>\n

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10.2 \u4e0d\u540c\u9020\u5f71\u5242\u7684\u9009\u62e9\u4e0e\u7ec4\u5408<\/b><\/strong><\/p>\n

\u5c3d\u7ba1\u4e0d\u540c\u7684\u6210\u50cf\u6280\u672f\u76f8\u4e92\u8865\u507f\uff0c\u4f46\u4ecd\u7136\u5b58\u5728\u5bf9\u6bcf\u79cd\u6a21\u6001\u7684\u4e0d\u540c\u7075\u654f\u5ea6\u7684\u62c5\u5fe7\u3002\u4f8b\u5982\uff0cPET\u6216NIRF\u8bd5\u5242\u53ef\u4ee5\u4ee5\u6781\u4f4e\u6d53\u5ea6\u4f7f\u7528\uff0c\u800cMRI\u548cCT\u8bd5\u5242\u5219\u9700\u8981\u76f8\u5bf9\u9ad8\u7684\u6d53\u5ea6\u3002\u56e0\u6b64\uff0c\u6709\u5fc5\u8981\u66f4\u591a\u5730\u5173\u6ce8\u7ec4\u5408\u6210\u50cf\u5242\u5230\u7eb3\u7c73\u9897\u7c92\u4e2d\u7684\u91cf\u3002<\/p>\n

10.3 \u6210\u50cf\u4eea\u5668\u7684\u6539\u5584\u4e0e\u4f18\u5316<\/b><\/strong><\/p>\n

\u5927\u90e8\u5206\u60c5\u51b5\u4e0b\uff0c\u4e0d\u540c\u6210\u50cf\u6a21\u5f0f\u662f\u9700\u8981\u4e0d\u540c\u6210\u50cf\u4eea\u5668\u6765\u5b9e\u73b0\u7684\u3002\u5f53\u9700\u8981\u5bf9\u6837\u54c1\u8fdb\u884c\u591a\u79cd\u6d4b\u91cf\u65f6\uff0c\u5c31\u5f97\u79fb\u52a8\u6837\u54c1\u5230\u591a\u53f0\u8bbe\u5907\u4e0a\u6d4b\u91cf\uff0c\u8fd9\u6837\u4e0d\u4ec5\u4f1a\u8017\u65f6\u8017\u529b\uff0c\u8fd8\u4f1a\u5f71\u54cd\u6d4b\u91cf\u51c6\u786e\u5ea6\u3002\u56e0\u6b64\uff0c\u6210\u50cf\u4eea\u5668\u7684\u6539\u5584\u4e0e\u8fdb\u6b65\u4e5f\u662f\u6211\u4eec\u9700\u8981\u52aa\u529b\u7684\u4e00\u65b9\u9762\uff0c\u6709\u671b\u901a\u8fc7\u63d0\u4f9b\u5c11\u91cf\u63a2\u9488\u7684\u7cbe\u7ec6\u56fe\u50cf\u6765\u5e2e\u52a9\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\u3002\u6bd4\u5982\uff0c\u62c9\u66fc-\u8367\u5149\u5149\u8c31\u6d4b\u91cf\u7cfb\u7edf\uff0c<\/b><\/strong>\u4e00\u53f0\u8bbe\u5907\u5373\u53ef\u5b9e\u73b0\u62c9\u66fc\u6210\u50cf\uff0c\u8367\u5149\u6210\u50cf\uff0c\u5149\u7535\u6d41\u6210\u50cf\uff0c\u8367\u5149\u5bff\u547d\u6210\u50cf\u7b49\u591a\u79cd\u529f\u80fd\u3002\u65e0\u9700\u79fb\u52a8\u6837\u54c1\u5230\u591a\u53f0\u8bbe\u5907\u4e0a\u6d4b\u91cf\uff0c\u53ef\u4ee5\u5bf9\u6837\u54c1\u540c\u4e00\u4f4d\u7f6e\u8fdb\u884c\u62c9\u66fc\uff0c\u8367\u5149\uff0c\u8367\u5149\u5bff\u547d\uff0c\u5149\u7535\u6d41\u591a\u79cd\u6d4b\u91cf\uff0c\u6d88\u9664\u6837\u54c1\u79fb\u52a8\u9020\u6210\u7684\u4f4d\u7f6e\u8bef\u5dee\u3002<\/p>\n

\u7efc\u4e0a\uff0c\u516b\u79cd\u6210\u50cf\u6280\u672f\uff0c\u4f60\u6700\u9752\u7750\u54ea\u4e00\u79cd\uff0c\u6216\u8005\u8ba4\u4e3a\u54ea\u51e0\u79cd\u662f\u6700\u4f73\u642d\u6863\uff1f\u6b22\u8fce\u5728\u7559\u8a00\u533a\u8ba8\u8bba\uff0c\u5e0c\u671b\u4e0e\u5404\u4f4d\u8001\u5e08\u540c\u5b66\u4e92\u76f8\u6307\u6559\uff0c\u5171\u540c\u8fdb\u6b65\u3002\u4f5c\u8005\u6c34\u5e73\u6709\u9650\uff0c\u5982\u6709\u4e0d\u59a5\uff0c\u8bf7\u6279\u8bc4\u6307\u6b63\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a\uff08\u9644\u4e0a<\/b><\/strong>Sci-hub<\/b><\/strong>\u4e0b\u8f7d\u7f51\u5740\uff1a<\/b><\/strong>http:\/\/sci-hub.tw\/<\/b><\/strong>\uff09<\/b><\/strong><\/p>\n

[1]\u00a0Ying Y, Shuxin W, Shuang C, et al. Switching the subcellular organelle targeting of atomically precise gold nanoclusters by modifying the capping ligands[J]. Chemical Communications,\u00a0<\/i><\/em>2018,\u00a054, 9222-9225.<\/p>\n

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[3]\u00a0Kowada T, Maeda H, Kikuchi K. BODIPY-based probes for the fluorescence imaging of biomolecules in living cells[J]. Chemical Society Reviews, 2015, 46(35):4953-4972.<\/p>\n

[4]\u00a0Gnach A, Bednarkiewicz A. Lanthanide-doped up-converting nanoparticles: Merits and challenges[J]. Nano Today, 2012, 7(6):532-563.<\/p>\n

[5]\u00a0Zhang L, Wang E. Metal nanoclusters: New fluorescent probes for sensors and bioimaging[J]. Nano Today, 2014, 9(1):132-157.<\/p>\n

[6]\u00a0Fan Q, Cheng K, Hu X, et al. Transferring Biomarker into Molecular Probe: Melanin Nanoparticle as a Naturally Active Platform for Multimodality Imaging[J]. Journal of the American Chemical Society, 2014, 136(43):15185-15194.<\/p>\n

[7]\u00a0Lin L S, Cong Z X, Cao J B, et al. Multifunctional Fe3<\/sub>O4<\/sub>@Polydopamine Core-Shell Nanocomposites for Intracellular mRNA Detection and Imaging-Guided Photothermal Therapy[J]. ACS Nano, 2014, 8(4):3876-3883.<\/p>\n

[8]\u00a0Hongmin C, Wang G D, Wei T, et al. Gd-encapsulated carbonaceous dots with efficient renal clearance for magnetic resonance imaging[J]. Advanced Materials, 2014, 26(39):6761-6.<\/p>\n

[9]\u00a0Kwon S P, Jeon S, Lee S H, et al. Thrombin-activatable fluorescent peptide incorporated gold nanoparticles for dual optical\/computed tomography thrombus imaging[J]. Biomaterials, 2018, 150:125-136.<\/p>\n

[10] Pan D, Schirra C O, Senpan A, et al. An Early Investigation of Ytterbium Nanocolloids for Selective and Quantitative \u201cMulticolor\u201d Spectral CT Imaging[J]. ACS Nano, 2012, 6(4):3364-3370.<\/p>\n

[11] Pan D, Roessl E, Schlomka J P, et al. Computed Tomography in Color: NanoK-Enhanced Spectral CT Molecular Imaging[J]. Angewandte Chemie International Edition, 2010, 49(50):9635-9639.\u00a0<\/p>\n

[12] Jeong-Yeon K, Hee R J, Dawid S, et al. Direct Imaging of Cerebral Thromboemboli Using Computed Tomography and Fibrin-targeted Gold Nanoparticles[J]. Theranostics, 2015, 5(10):1098-1114.\u00a0<\/p>\n

[13]\u00a0Wu X, Li C, Liao S, et al. Silica-encapsulated Gd3+<\/sup>-aggregated gold nanoclusters for in vitro and in vivo multimodal cancer imaging[J]. Chemistry, 2014, 20(29):8876-8882.<\/p>\n

[14] Tang Q, Si W, Huang C, et al. An aza-BODIPY photosensitizer for photoacoustic and photothermal imaging guided dual modal cancer phototherapy[J]. Journal of Materials Chemistry B, 2017, 5, 1566-1573.<\/p>\n

[15]\u00a0Liu Z, Li X, Tabakman S M, et al. Multiplexed Multicolor Raman Imaging of Live Cells with Isotopically Modified Single Walled Carbon Nanotubes[J]. Journal of the American Chemical Society, 2008, 130(41):13540-13541.<\/p>\n

[16]\u00a0Min H S, Son S, You D G, et al. Chemical gas-generating nanoparticles for tumor-targeted ultrasound imaging and ultrasound-triggered drug delivery[J]. Biomaterials, 2016, 108, 57-70.<\/p>\n

[17]\u00a0Kang J, Kim D, Wang J, et al. Enhanced Performance of a Molecular Photoacoustic Imaging Agent by Encapsulation in Mesoporous Silicon Nanoparticles[J]. Advanced Materials, 2018, 30(27):1800512.<\/p>\n

[18]\u00a0Fu Q, Zhu R,\u00a0Song\u00a0J, et al.\u00a0Photoacoustic Imaging: Contrast Agents and Their Biomedical Applications[J]. Advanced Materials,\u00a02018, 1805875.<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u79d1\u6280\u4e13\u680f\u4f5c\u8005\u6768\u4e66\u51dd<\/strong>\u4f9b\u7a3f\uff0c\u7f16\u8f91\u90e8\u7f16\u8f91\u3002<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1: tougao@cailiaoren.com.<\/p>\n

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