{"id":159987,"date":"2018-11-23T06:39:39","date_gmt":"2018-11-22T22:39:39","guid":{"rendered":"\/\/m.iemloyee.com\/?p=159987"},"modified":"2018-11-22T19:41:30","modified_gmt":"2018-11-22T11:41:30","slug":"%e6%8a%97%e7%99%8c%e5%8a%9f%e8%87%a3%ef%bc%9a%e6%a2%b3%e7%90%86%e5%8f%b6%e7%bb%bf%e7%b4%a0%e5%ae%b6%e6%97%8f%e7%9a%84%e5%85%ab%e7%a7%8d%e5%85%89%e6%95%8f%e5%89%82","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=159987","title":{"rendered":"\u6297\u764c\u529f\u81e3\uff1a\u68b3\u7406\u53f6\u7eff\u7d20\u5bb6\u65cf\u7684\u516b\u79cd\u5149\u654f\u5242"},"content":{"rendered":"

\u5149\u52a8\u529b\u7597\u6cd5(photodynamic therapy\uff0c\u7b80\u5199\u4e3a PDT)\u662f\u901a\u8fc7\u5149\u52a8\u529b\u4f5c\u7528<\/b><\/strong>\u5904\u7406\u764c\u75c7\u7684\u4e00\u79cd\u65b0\u7684\u6cbb\u7597\u6a21\u5f0f\u3002\u5176\u57fa\u672c\u8fd0\u4f5c\u8fc7\u7a0b\u662f\u5229\u7528\u5149\u654f\u5242(\u6297\u764c\u836f\u7269)\u548c\u5149\u7684\u5171\u540c\u4f5c\u7528\u800c\u5f62\u6210\u7ec6\u80de\u6bd2\u7d20\uff0c\u5e76\u5bf9\u75c5\u53d8\u7ec6\u80de(\u764c\u7ec6\u80de)\u6216\u8005\u5176\u4ed6\u75c5\u53d8\u7ec4\u7ec7\u5b9e\u65bd\u6740\u706d\u3002\u5f53\u5065\u5eb7\u548c\u75c5\u53d8\u7ec4\u7ec7\u4e0a\u7684\u836f\u7269\u96c6\u805a\u5230\u5408\u9002\u6d53\u5ea6\u65f6\uff0c\u4eba\u4e3a\u8c03\u8282\u7279\u5b9a\u6ce2\u957f\u7684\u5149\u5bf9\u76f8\u5e94\u7684\u7ec4\u7ec7\u533a\u57df\u8fdb\u884c\u7167\u5c04\uff0c\u7ecf\u5149\u6fc0\u53d1\u7684 PDT \u836f\u7269(\u4e00\u822c\u662f\u5177\u6709\u5149\u654f\u6d3b\u6027\u7684\u5316\u5408\u7269)\u5f15\u53d1\u5149\u6bd2\u6548\u5e94\u3002\u6709\u6548\u7684PDT\u6cbb\u7597\u8fc7\u7a0b\u5fc5\u987b\u5177\u59073\u4e2a\u8981\u7d20\uff0c\u5373\u5149\u654f\u5242\u3001\u5149\u3001\u6c27\u6c14<\/b><\/strong>\u3002[1<\/a>]<\/p>\n

\u5176\u4e2d\u4f5c\u4e3a\u4e0d\u53ef\u6216\u7f3a\u7684\u4e00\u73af\u7684\u5149\u654f\u5242\u53d1\u5c55\u81f3\u4eca\u5df2\u6709\u4e09\u4ee3\u3002<\/p>\n

\u7b2c\u4e00\u4ee3\u5149\u654f\u5242\uff1a\u53d1\u5c55\u4e8e\u4e8c\u5341\u4e16\u7eaa70\u5e74\u4ee3\u548c80\u5e74\u4ee3\u65e9\u671f\uff0c\u4e3b\u8981\u4e3a\u535f\u5549\u7c7b\u6df7\u5408\u7269\uff1b<\/p>\n

\u7b2c\u4e8c\u4ee3\u5149\u654f\u5242\uff1a\u6307\u4e8c\u5341\u4e16\u7eaa80\u5e74\u4ee3\u540e\u671f\u5f00\u53d1\u7684\u5177\u6709\u4e0d\u540c\u7ed3\u6784\u7c7b\u578b\u7684\u535f\u5549\u884d\u751f\u7269\u5355\u4f53\u548c\u76f8\u5173\u5408\u6210\u5316\u5408\u7269\uff1b<\/p>\n

\u7b2c\u4e09\u4ee3\u5149\u654f\u5242\uff1a\u5c06\u5149\u654f\u5242\u4e0e\u5355\u514b\u9686\u6297\u4f53\u6216\u5176\u4ed6\u5c0f\u7684\u751f\u7269\u6d3b\u6027\u5206\u5b50\u5982\u7c7b\u56fa\u9187\u3001\u7c7b\u8102\u3001\u80bd\u3001\u6838\u82f7\u548c\u6838\u82f7\u9178\u8fde\u63a5\uff0c\u4ee5\u5f97\u5230\u5177\u6709\u9776\u5411\u529f\u80fd\u7684\u5149\u654f\u5242\u3002[2<\/a>]<\/p>\n

\u672c\u6587\u5c31\u53f6\u7eff\u7d20\u76f8\u5173\u7684\u5149\u654f\u5242\u53ca\u5176\u5728\u6297\u80bf\u7624\u7eb3\u7c73\u6750\u6599\u4e2d\u7684\u5e94\u7528\u505a\u4e00\u4e2a\u6574\u7406\u3002<\/b><\/strong><\/p>\n

1\u3001mTHPC<\/b><\/strong><\/p>\n

mTHPC(\u5546\u54c1\u540d\u4e3aFoscan)\uff0c\u4f5c\u4e3a\u7b2c\u4e8c\u4ee3\u5149\u654f\u5242\u5c55\u73b0\u51fa\u4e86\u591a\u79cd\u5149\u52a8\u529b\u6cbb\u7597\u65b9\u9762\u7684\u4f18\u826f\u7279\u6027\uff0c\u5728\u6b27\u6d32\u53ca\u65e5\u672c\u5df2\u88ab\u7528\u4e8e\u6cbb\u7597\u5934\u9888\u764c\u3002\u8fd9\u79cd\u5149\u654f\u5242\u5728\u751f\u7406pH\u6761\u4ef6\u4e0b\u662f\u4e00\u79cd\u758f\u6c34\u7684\u5e26\u4e2d\u6027\u7535\u8377\u7684\u5206\u5b50\uff0c\u53ef\u7a7f\u900f7mm\u7684\u6df1\u5ea6\uff0c\u5728652nm\u5904\u88ab\u6fc0\u53d1\u4ee5\u53d1\u6325\u5149\u52a8\u529b\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n

\u56fe\u4e3amTHPC\u7ed3\u6784\u5f0f<\/p>\n

\"\"<\/p>\n

Fabrice P. Navarro\u7b49[3<\/a>]\u5236\u5907\u4e86mTHPC\u56fa\u4f53\u8102\u8d28\u4f53\u7528\u4e8e\u5149\u52a8\u529b\u6cbb\u7597\uff0c\u5e76\u8bc1\u660e\u5b83\u5177\u6709\u826f\u597d\u7684\u7a33\u5b9a\u6027\u548c\u91cd\u73b0\u6027\uff0c\u4ee5\u53ca\u8f83\u5c0f\u7684\u7c92\u5f84\u5206\u5e03\u3002\u6b64\u5916\u8fd8\u8bc4\u4ef7\u4e86\u5b83\u7684\u5149\u7269\u7406\u3001\u7269\u7406\u5316\u5b66\u6027\u8d28\u3001\u5149\u8c31\u5438\u6536\u3001\u5355\u7ebf\u6001\u6c27\u3001\u80f6\u4f53\u7a33\u5b9a\u6027\u3001\u7c92\u5f84\u4ee5\u53ca\u7535\u4f4d\u3002\u5e76\u9009\u7528\u4e86MCF-7\u7ec6\u80de\u6765\u8bc4\u4ef7\u8be5\u7eb3\u7c73\u7c92\u7684\u5149\u6bd2\u6027\uff0c\u6700\u7ec8\u8bc1\u660emTHPC\u56fa\u4f53\u8102\u8d28\u4f53\u662f\u4e00\u79cd\u5f88\u6709\u524d\u9014\u7684\u836f\u7269\u9012\u9001\u7cfb\u7edf\u3002<\/p>\n

\u9610\u8ff0LNP\u4e0d\u540c\u7ec4\u6210\u7684\u793a\u610f\u56fe\uff0cmTHPC\u4f4d\u4e8e\u8102\u8d28\u4f53\u7684\u4e2d\u90e8\u3002<\/p>\n

\"\"<\/p>\n

2\u3001\u53f6\u7eff\u7d20-a(Chl-a)<\/b><\/strong><\/p>\n

\u5929\u7136\u5b58\u5728\u7684Chl-a\u4f5c\u4e3a\u5149\u654f\u5242\u5177\u6709\u5982\u4e0b\u4f18\u52bf\uff1a\u7ec4\u6210\u5355\u4e00\u4e14\u7a33\u5b9a\uff0c\u5355\u7ebf\u6001\u6c27\u4ea7\u7387\u53ca\u8f6c\u5316\u6548\u7387\u9ad8\u3002\u4f46\u7531\u4e8e\u53f6\u7eff\u7d20-a\u6c34\u6eb6\u6027\u4e0d\u597d\u5e76\u4e14\u5bb9\u6613\u56e2\u805a\uff0c\u5bfc\u81f4\u5b83\u7684\u4f7f\u7528\u53d7\u5230\u9650\u5236\u3002<\/p>\n

\"\"<\/p>\n

\u4e3a\u4e86\u6539\u5584Chl-a\u7684\u6c34\u6eb6\u6027\uff0cPaola Semeraro[4<\/a>]\u7b49\u5728Chl-a\u7684\u5916\u8fb9\u4fee\u9970\u4e0a\u7ecf\u8fc7\u4e0d\u540c\u6539\u9020\u7684\u73af\u7cca\u7cbe\uff0c\u5206\u522b\u4e3a2-HP-trin (2-HP-\u03b2-CD)\uff0c2-Hydroxypropyl-\u03b3-cyclodextrin (2-HP-\u03b3-CD)\uff0c\u00a0Heptakis(2,6-di-o-methyl)-\u03b2-cyclodextrin(DIMEB)\u00a0\u548cHeptakis(2,3,6-tri-o-methyl)-\u03b2-cyclodextrin (TRIMEB)\uff0c\u6700\u7ec8\u901a\u8fc7\u4e00\u7cfb\u5217\u4f53\u5916\u8bc4\u4f30\u8bc1\u660eChl a\/2-HP-\u03b2-CD\u8d85\u5206\u5b50\u590d\u5408\u7269\u6709\u671b\u6210\u4e3a\u4e00\u4e2a\u6709\u6f5c\u529b\u7684\u5149\u52a8\u529b\u6cbb\u7597\u5242\u3002<\/p>\n

3\u3001<\/b><\/strong>p-bromo-phenylhydrazone-methyl pyropheophorbide-a (BPMppa) <\/b><\/strong><\/p>\n

\u4f5c\u4e3a\u53f6\u7eff\u7d20-a\u7684\u884d\u751f\u7269\uff0cBPMppa\u5177\u6709\u957f\u5438\u6536\uff08683nm\uff09\u4ee5\u53ca\u8f83\u5927\u6469\u5c14\u6d88\u5149\u7cfb\u6570\uff087.03\u00d7104<\/sup>\u00a0M-1<\/sup>cm-1<\/sup>\uff09\u7b49\u4f18\u70b9\uff0c\u56e0\u6b64\u66f4\u4e3a\u9002\u5408\u7528\u4e8e\u6df1\u5c42\u764c\u75c7\u7684\u6cbb\u7597\u3002Hongyue Zhang[5<\/a>]\u7b49\u5229\u7528\u03c0-\u03c0\u5806\u53e0\u5c06\u5b83\u4e0e\u77f3\u58a8\u70ef\u5171\u7ec4\u88c5\u3002\u5b9e\u9a8c\u8bc1\u660e\uff0c\u7ec4\u88c5\u540e\u7684\u5316\u5408\u7269\uff08G-BPMppa\uff09\u5728\u6c34\u3001PBS\u4ee5\u53ca\u57f9\u517b\u57fa\u4e2d\u7684\u6eb6\u89e3\u6027\u53ca\u5206\u6563\u6027\u826f\u597d\u3002\u6b64\u5916DMF\u73af\u5883\u4e0b\u7684\u5355\u7ebf\u6001\u6c27\u4ea7\u7387\u4e5f\u8f83\u5355\u72ec\u7684BPMppa\u6709\u6240\u63d0\u5347\uff0c\u7ec6\u80de\u5b9e\u9a8c\u4e5f\u8bc1\u660e\u4e86G-BPMppa\u663e\u8457\u63d0\u9ad8\u4e86BPMppa\u7684PDT\u6548\u5e94\u3002<\/p>\n

\"\"<\/p>\n

 <\/p>\n

4\u3001\u8131\u9541\u53f6\u7eff\u9178 a\uff08<\/b><\/strong>Pheophorbide A<\/b><\/strong>\uff09<\/b><\/strong><\/p>\n

\u8131\u9541\u53f6\u7eff\u9178a\u662f\u7531\u53f6\u7eff\u7d20\u5206\u5b50\u8131\u53bb\u9541\u79bb\u5b50\u540e\u8fdb\u4e00\u6b65\u6c34\u89e3\u800c\u5f62\u6210\u7684\u5316\u5408\u7269\uff0c\u5728600~700nm\u548c400~500nm\u5904\u5747\u6709\u8f83\u5f3a\u7684\u5438\u6536\u5149\u8c31\uff0c\u4e14\u5728Q-band\u7684\u5438\u6536\u8f83\u5176\u4ed6\u535f\u5549\u66f4\u9ad8\uff0c\u4f7f\u5f97\u5176\u5728\u91c7\u7528\u66f4\u957f\u6ce2\u957f\u7684\u6fc0\u5149\u7167\u5c04\u5149\u654f\u5242\u4e2d\u5360\u6709\u4f18\u52bf\u3002\u7814\u7a76\u8868\u660e\uff0c\u8131\u9541\u53f6\u7eff\u9178a\u7684\u6fc0\u53d1\u6ce2\u957f\u548c\u53d1\u5c04\u6ce2\u957f\u5206\u522b\u4e3a665\u548c675nm\uff0c\u7531\u4e8e\u5176\u8f83\u9ad8\u7684\u80bf\u7624\u9009\u62e9\u6027\u6444\u5165\u3001\u8f83\u5f3a\u7684\u5149\u654f\u5316\u6c27\u5316\u7279\u6027\u548c\u8f83\u4f4e\u6bd2\u6027\u800c\u88ab\u7528\u4e8e\u80bf\u7624\u7684\u8367\u5149\u5b9a\u4f4d\u548c\u5149\u654f\u6cbb\u7597\u3002Xiangdong Xue[6<\/a>]\u7b49\u901a\u8fc7\u8159\u952e\u8fde\u63a5\u8131\u9541\u53f6\u7eff\u9178a\u548c\u963f\u9709\u7d20\uff0c\u518d\u901a\u8fc7\u81ea\u7ec4\u88c5\u6784\u5efaPa-Hyd-DOX\uff08PhD\uff09\u7eb3\u7c73\u7c92\uff0c\u5b9e\u73b0\u5149\u52a8\u529b\u3001\u5149\u70ed\u4ee5\u53ca\u5316\u7597\u7684\u8054\u5408\u6cbb\u7597\u3002<\/p>\n

\"\"<\/p>\n

5\u3001\u4e8c\u6c22\u535f\u5429e6 (Chlorin e6\uff0cCe6)<\/b><\/strong><\/p>\n

Ce6\u901a\u5e38\u53ef\u7531\u8131\u9541\u53f6\u7eff\u9178 a \u5408\u6210\u800c\u5f97\uff0c\u662f\u4e00\u79cd\u826f\u597d\u7684\u5149\u654f\u5242\uff0c\u751f\u7269\u6d3b\u6027\u4e0e\u8131\u9541\u53f6\u7eff\u9178 a \u76f8\u8fd1\u3002Ce6\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u7684\u6548\u7387\u5f88\u9ad8\uff0c\u56e0\u4e3a\u9002\u5408\u5f00\u53d1\u7528\u4e8e\u80bf\u7624\u7684\u5149\u52a8\u529b\u6cbb\u7597\u3002\u4f46\u540c\u8fc4\u4eca\u4e3a\u6b62\u7684\u5927\u90e8\u5206\u5149\u654f\u5242\u4e00\u6837\uff0cCe6\u8868\u73b0\u4e3a\u758f\u6c34\u6027\uff0c\u5e76\u5728\u6eb6\u6db2\u4e2d\u5bb9\u6613\u805a\u96c6\uff0c\u56e0\u6b64\u5728\u5b9e\u9645\u5e94\u7528\u4e2d\u6709\u4e00\u5b9a\u56f0\u96be\u3002\u4e3a\u6b64\uff0cJingping Wei[7<\/a>]\u7b49\u6784\u5efa\u4e86Pd@Pt-PEG-Ce6\u7eb3\u7c73\u7c92\uff0c\u4fdd\u62a4\u5149\u654f\u5242\u4e4b\u4f59\u53c8\u589e\u5f3a\u4e86\u5b83\u7684\u5149\u52a8\u529b\u6548\u679c\u3002<\/p>\n

\"\"<\/p>\n

6\u3001\u7126\u8131\u9541\u53f6\u7eff\u9178-a\uff08<\/b><\/strong>Pyropheophorbide <\/b><\/strong>A\uff0cPpa\uff09<\/b><\/strong><\/p>\n

\u7126\u8131\u9541\u53f6\u7eff\u7d20-a\u662f\u5929\u7136\u4ea7\u7269\u53f6\u7eff\u7d20a\u901a\u8fc7\u8131\u7532\u6c27\u7fb0\u57fa\u3001\u53bb\u690d\u7269\u9187\u3001\u53bbMg\u540e\u7684\u4ea7\u7269\u3002\u8be5\u7c7b\u7269\u8d28\u5177\u6709\u5149\u654f\u6027\uff0c\u5728\u4e00\u5b9a\u6ce2\u957f\u7684\u5149\u6fc0\u53d1\u4e0b\u80fd\u4ea7\u751f\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u7684\u6d3b\u6027\u6c27\uff0c\u4e14\u5bf9\u80bf\u7624\u7ec6\u80de\u5177\u6709\u4e00\u5b9a\u9009\u62e9\u6027\uff0c\u56e0\u6b64\u53ef\u4f5c\u4e3a\u5149\u52a8\u529b\u6cbb\u7597\u836f\u7269\u6216\u5176\u524d\u4f53\u836f\u7269\u3002Souad Adriouach, MS[8<\/a>]\u7b49\u901a\u8fc7\u4fee\u9970PEG\u7684\u9ca8\u70ef\uff08SQ-PEG\uff09\u81ea\u7ec4\u88c5\u5305\u8f7dPpa\u5f97\u5230SQ-PEG\uff1aPpa\u7eb3\u7c73\u7c92\uff0c\u5b9e\u73b0\u8bca\u7597\u4e00\u4f53\u5316\u3002<\/p>\n

\"\"<\/p>\n

7\u3001\u7126\u8131\u9541\u53f6\u7eff\u9178a\u5df1\u919a\uff08HPPH\uff09<\/b><\/strong><\/p>\n

\u00a0\"\"<\/b><\/strong><\/p>\n

\u6297\u80bf\u7624\u5149\u654f\u5242 HPPH \u5c5e\u4e8e\u7b2c\u4e8c\u4ee3\u5149\u654f\u5242\uff0c\u5176\u57fa\u672c\u7ed3\u6784\u4e3a\u4e8c\u6c22\u535f\u5429\u7c7b\u5316\u5408\u7269\u3002\u7f8e\u56fd Roswell Park \u80bf\u7624\u7814\u7a76\u6240\u7684\u7814\u7a76\u4eba\u5458\u4ece\u7eff\u8272\u690d\u7269\u4e2d\u63d0\u53d6\u3001\u7eaf\u5316\uff0c\u534a\u5408\u6210\u4e86\u4e00\u7cfb\u5217\u7684\u4e8c\u6c22\u535f\u5429\u7c7b\u5316\u5408\u7269\uff0c\u901a\u8fc7\u68c0\u6d4b\u8fd9\u4e9b\u5316\u5408\u7269\u7684\u5149\u8c31\u5b66\u7279\u6027\u3001\u5149\u6bd2\u6027\u3001\u6697\u6bd2\u6027\uff0c\u8fdb\u884c\u4f53\u5916\u6291\u764c\u8bd5\u9a8c\u4ee5\u53ca\u6784\u6548\u5173\u7cfb\u7684\u7814\u7a76\u4ee5\u540e\uff0c\u7b5b\u9009\u51fa\u7ed3\u6784\u5355\u4e00\u3001\u957f\u6fc0\u53d1\u6ce2\u957f\u3001\u6697\u6bd2\u6027\u5c0f\u7684\u4e8c\u6c22\u535f\u5429\u884d\u751f\u7269 HPPH \u4f5c\u4e3a PDT \u5149\u654f\u5242\u3002HPPH \u5177\u6709\u826f\u597d\u7684\u5149\u52a8\u529b\u6d3b\u6027\uff0c\u7406\u60f3\u7684\u4f5c\u7528\u5149\u8c31\u4ee5\u53ca\u51c6\u786e\u7684\u9776\u5411\u6027\uff0c\u5bf9\u80bf\u7624\u7ec4\u7ec7\u7684\u7a7f\u900f\u7387\u9ad8\uff0c\u4e34\u5e8a\u7528\u4e8e\u80ba\u764c\u3001\u98df\u7ba1\u764c\u3001\u5934\u9762\u9888\u764c\u3001\u8180\u80f1\u764c\u3001\u80c3\u764c\u7b49\u591a\u79cd\u5b9e\u4f53\u80bf\u7624\u7684\u6cbb\u7597;\u4e0e\u7b2c\u4e00\u4ee3\u76f8\u5e94\u7684\u5149\u654f\u5242\u76f8\u6bd4\uff0c\u5176\u5149\u6bd2\u6027\u660e\u663e\u964d\u4f4e\uff0c\u57fa\u672c\u4e0d\u9700\u8981\u907f\u5149\uff0c\u7528\u91cf\u5c0f\uff0c\u4f7f\u7528\u65b9\u4fbf\uff0c\u662f\u4e00\u79cd\u6781\u5bcc\u5e02\u573a\u6f5c\u529b\u7684 PDT \u6cbb\u7597\u764c\u75c7\u7528\u5149\u654f\u5242\u3002Fuwu Zhang[9<\/a>]\u7b49\u6784\u5efa\u4e86CPT-ss-HPPH\u81ea\u7ec4\u88c5\u7eb3\u7c73\u7c92\uff0c\u8054\u5408\u5316\u7597\u53ca\u5149\u52a8\u529b\u6cbb\u7597\uff0c\u5177\u6709\u8c37\u80f1\u7518\u80bd\u654f\u611f\u7279\u6027\u4ee5\u53ca\u5149\u52a8\u529b\u6548\u5e94\u3002<\/p>\n

8\u3001\u5355-\u5929\u51ac\u9170\u80fa\u57fa\u4e8c\u6c22\u535f\u5429-e6\uff08<\/b><\/strong>N-aspartyl chlorin e6<\/b><\/strong>\uff0c<\/b><\/strong>NPe6<\/b><\/strong>\uff09<\/b><\/strong><\/p>\n

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\"\"<\/p>\n

\u8fd1\u5e74\u6765\uff0c\u4eba\u4eec\u628a\u5149\u52a8\u529b\u7597\u6cd5\u7684\u7814\u7a76\u96c6\u4e2d\u5728\u7b2c\u4e8c\u4ee3\u5149\u654f\u5242\uff0c\u4f7fPDT\u7684\u7814\u7a76\u8fdb\u5165\u5230\u4e00\u4e2a\u5d2d\u65b0\u7684\u9636\u6bb5\uff0c\u8bb8\u591a\u7528\u4e8e\u6cbb\u7597\u591a\u79cd\u9002\u5e94\u75c7\u7684\u4e0d\u540c\u7c7b\u578b\u7684\u5149\u654f\u5242\u6b63\u5904\u4e8e\u2160\u671f\u3001\u2161\u671f\u6216\u2162\u671f\u4e34\u5e8a\u8bd5\u9a8c\u9636\u6bb5\uff0c\u76f8\u4fe1\u5728\u4e0d\u8fdc\u7684\u5c06\u6765\uff0c\u5149\u52a8\u529b\u7597\u6cd5\u5c06\u4f1a\u6210\u4e3a\u653e\u7597\u3001\u5316\u7597\u548c\u624b\u672f\u4e4b\u5916\u7684\u7b2c\u56db\u79cd\u6cbb\u7597\u6076\u6027\u80bf\u7624\u7684\u91cd\u8981\u624b\u6bb5\u3002<\/p>\n

\u53c2\u8003\u6587\u732e\uff1a<\/strong><\/p>\n

[1] \u738b\u8fdb\u519b, \u90ac\u65ed\u7136. \u5149\u52a8\u529b\u7597\u6cd5\u6240\u7528\u53f6\u7eff\u7d20\u7c7b\u5149\u654f\u5242\u7684\u7814\u7a76\u8fdb\u5c55. \u5927\u5b66\u5316\u5b66 2012;27:42.<\/p>\n

[2] Allison RR, Downie GH, Cuenca R, Hu XH, Childs CJH, Sibata CH. Photosensitizers in clinical PDT. Photodiagnosis Photodyn Ther 2004;1:27.<\/p>\n

[3] Navarro FP, Creusat G, Frochot C, Moussaron A, Verhille M, Vanderesse R, et al. Preparation and characterization of mTHPC-loaded solid lipid nanoparticles for photodynamic therapy. J Photochem Photobiol B-Biol 2014;130:161.<\/p>\n

[4] Semeraro P, Chimienti G, Altamura E, Fini P, Rizzi V, Cosma P. Chlorophyll a in cyclodextrin supramolecular complexes as a natural photosensitizer for photodynamic therapy (PDT) applications. Mater Sci Eng C-Mater Biol Appl 2018;85:47.<\/p>\n

[5] Zhang HY, Cheng JJ, Li WT, Tan GH, Wang ZQ, Jin YX. Facile synthesis of a highly water-soluble graphene conjugated chlorophyll-a photosensitizer composite for improved photodynamic therapy in vitro. New J Chem 2017;41:10069.<\/p>\n

[6] Xue XD, Huang Y, Bo RN, Jia B, Wu H, Yuan Y, et al. Trojan Horse nanotheranostics with dual transformability and multifunctionality for highly effective cancer treatment. Nat Commun 2018;9:15.<\/p>\n

[7] Wei J, Li J, Sun D, Li Q, Ma J, Chen X, et al. A Novel Theranostic Nanoplatform Based on Pd@Pt-PEG-Ce6 for Enhanced Photodynamic Therapy by Modulating Tumor Hypoxia Microenvironment. Advanced Functional Materials 2018:1706310.<\/p>\n

[8] Adriouach S, Vorobiev V, Trefalt G, Allemann E, Lange N, Babic A. Squalene-PEG: Pyropheophorbide-a nanoconstructs for tumor theranostics. Nanomedicine : nanotechnology, biology, and medicine 2018.<\/p>\n

[9] Zhang FW, Ni QQ, Jacobson O, Cheng SY, Liao A, Wang ZT, et al. Polymeric Nanoparticles with a Glutathione-Sensitive Heterodimeric Multifunctional Prodrug for In Vivo Drug Monitoring and Synergistic Cancer Therapy. Angew Chem-Int Edit 2018;57:7066.<\/p>\n

[10] Ishizumi T, Aizawa K, Tsuchida T, Okunaka T, Kato H. Spectrometric characteristics and tumor-affinity of a novel photosensitizer: mono- l -aspartyl aurochlorin e6 (Au-NPe6). Photodiagnosis Photodyn Ther 2004;1.<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u79d1\u6280\u987e\u95ee\u5c0f\u6a59\u5b50<\/strong>\u4f9b\u7a3f\uff0c\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u7f16\u8f91\u3002<\/p>\n

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