{"id":157273,"date":"2018-10-25T08:10:26","date_gmt":"2018-10-25T00:10:26","guid":{"rendered":"\/\/m.iemloyee.com\/?p=157273"},"modified":"2018-10-25T08:14:57","modified_gmt":"2018-10-25T00:14:57","slug":"%e7%be%8e%e5%9b%bd%e5%af%86%e6%ad%87%e6%a0%b9%e5%a4%a7%e5%ad%a6%e4%bb%8a%e6%97%a5nature%ef%bc%9a%e9%85%b8%e6%80%a7%e6%b0%9f%e5%8c%96%e7%89%a9%e7%9a%84%e6%97%a0%e7%a2%b1%e9%95%8d%e5%82%ac%e5%8c%96","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=157273","title":{"rendered":"\u7f8e\u56fd\u5bc6\u6b47\u6839\u5927\u5b66\u4eca\u65e5Nature\uff1a\u9178\u6027\u6c1f\u5316\u7269\u7684\u65e0\u78b1\u954d\u50ac\u5316\u8131\u7fb0Suzuki &#8211; Miyaura\u5076\u8054\u53cd\u5e94"},"content":{"rendered":"<p>\u3010\u524d\u8a00\u3011<\/p>\n<p>\u6709\u673a\u787c\u4eb2\u6838\u8bd5\u5242\u4e0e\u5364\u5316\u82b3\u57fa\u4eb2\u7535\u8bd5\u5242\u7684Suzuki\u2013Miyaura\u4ea4\u53c9\u5076\u8054\u662f\u6709\u673a\u548c\u836f\u7269\u5316\u5b66\u4e2d\u4f7f\u7528\u6700\u5e7f\u6cdb\u7684\u78b3-\u78b3\u952e\u5f62\u6210\u53cd\u5e94\u4e4b\u4e00\u3002\u4e0e\u8fd9\u4e9b\u8f6c\u5316\u76f8\u5173\u7684\u4e00\u4e2a\u5173\u952e\u6311\u6218\u662f\u5b83\u4eec\u901a\u5e38\u9700\u8981\u6dfb\u52a0\u5916\u6e90\u78b1\uff0c\u5176\u4f5c\u7528\u662f\u5b9e\u73b0\u6709\u673a\u787c\u4eb2\u6838\u8bd5\u5242\u548c\u91d1\u5c5e\u50ac\u5316\u5242\u4e4b\u95f4\u7684\u91d1\u5c5e\u4ea4\u6362\u53cd\u5e94\u3002\u8fd9\u4e00\u8981\u6c42\u9650\u5236\u4e86\u53cd\u5e94\u5e95\u7269\u7684\u9009\u62e9\u8303\u56f4\uff0c\u56e0\u4e3a\u6dfb\u52a0\u7684\u78b1\u4fc3\u8fdb\u4e86\u8bb8\u591a\u6709\u673a\u787c\u5e95\u7269\u7684\u7ade\u4e89\u6027\u5206\u89e3\u3002\u56e0\u6b64\uff0c\u76f8\u5f53\u591a\u7684\u7814\u7a76\u96c6\u4e2d\u5728\u964d\u4f4e\u78b1\u4ecb\u5bfc\u7684\u526f\u53cd\u5e94\u7684\u7b56\u7565\u4e0a\u3002\u4ee5\u524d\u7684\u79d1\u7814\u5de5\u4f5c\u4e3b\u8981\u96c6\u4e2d\u5728\u8bbe\u8ba1\u63a9\u853d\u7684\u6709\u673a\u787c\u8bd5\u5242(\u4ee5\u51cf\u7f13\u78b1\u4ecb\u5bfc\u7684\u5206\u89e3)\u6216\u5f00\u53d1\u9ad8\u6d3b\u6027\u94af\u524d\u50ac\u5316\u5242(\u4ee5\u52a0\u901f\u76f8\u5bf9\u4e8e\u78b1\u4ecb\u5bfc\u7684\u5206\u89e3\u9014\u5f84\u7684\u4ea4\u53c9\u5076\u8054)\u3002\u50ac\u5316\u5242\u548c\u4eb2\u7535\u8bd5\u5242\u7684\u7ed3\u5408\uff0c\u5c06\u4f7f\u5f97Suzuki\u2013Miyaura\u578b\u53cd\u5e94\u80fd\u591f\u5728\u6ca1\u6709\u5916\u6e90\u78b1\u7684\u60c5\u51b5\u4e0b\u8fdb\u884c\u3002<\/p>\n<p>\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/p>\n<p>\u4eca\u65e5\uff0c\u6765\u81ea<strong>\u7f8e\u56fd\u5bc6\u6b47\u6839\u5927\u5b66\u7684<\/strong><strong>Melanie S. Sanford<\/strong><strong>\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u5728Nature\u53d1\u8868\u6587\u7ae0\uff0c\u9898\u4e3a\u201cBase-free nickel-catalysed decarbonylative Suzuki\u2013Miyaura coupling of acid fluorides\u201d\u3002\u4f5c\u8005\u4f7f\u7528\u50ac\u5316\u5242\u548c\u4eb2\u7535\u8bd5\u5242\u7684\u7ed3\u5408\u7684\u65b9\u6cd5\u6765\u5f00\u53d1\u82b3\u57fa\u787c\u9178\u4e0e\u6c1f\u5316\u9178\u7684\u954d\u50ac\u5316\u5076\u8054\uff0c\u6c1f\u5316\u9178\u662f\u7531\u5bb9\u6613\u83b7\u5f97\u7684\u7fa7\u9178\u539f\u4f4d\u5f62\u6210\u7684\u3002\u50ac\u5316\u5242\u548c\u4eb2\u7535\u8bd5\u5242\u7684\u8fd9\u79cd\u7ec4\u5408\u80fd\u591f\u5f62\u6210\u4e00\u79cd\u673a\u68b0\u6b67\u7ba1\uff0c\u5176\u4e2d\u5728\u50ac\u5316\u5faa\u73af\u4e2d\u76f4\u63a5\u751f\u6210\u201c\u91d1\u5c5e\u4ea4\u6362\u6d3b\u6027\u201d\u82b3\u57fa\u6c1f\u5316\u954d\u4e2d\u95f4\u4f53\u3002\u56e0\u6b64\uff0c\u8fd9\u79cd\u8f6c\u5316\u4e0d\u9700\u8981\u5916\u6e90\u78b1\uff0c\u9002\u7528\u4e8e\u5e7f\u6cdb\u7684\u78b1\u654f\u611f\u787c\u9178\u548c\u751f\u7269\u6d3b\u6027\u7fa7\u9178\u3002<\/p>\n<p>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/p>\n<p>\u56fe1. \u76f4\u63a5\u5408\u6210\u91d1\u5c5e\u4ea4\u6362\u6d3b\u6027[Ar\u2013M\u2013X*]\u4e2d\u95f4\u4f53\u7684Suzuki\u2013Miyaura\u53cd\u5e94\u548c\u673a\u7406\u8bbe\u8ba1<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-157275\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/1-28.png\" alt=\"\" width=\"600\" height=\"297\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/1-28.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/1-28-300x149.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe2. \u8131\u7fb0\u53cd\u5e94\u4ea7\u751f\u7684\u91d1\u5c5e\u4ea4\u6362\u6d3b\u6027\u6c1f\u5316\u954d\u4e2d\u95f4\u4f53\u7684\u53d1\u73b0\u4f7f\u5f97\u7fa7\u9178\u548c\u82b3\u57fa\u787c\u9178\u80fd\u591f\u8fdb\u884cSuzuki\u2013Miyaura\u53cd\u5e94<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-157276\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/2-27.png\" alt=\"\" width=\"600\" height=\"439\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/2-27.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/2-27-300x220.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe3. \u954d\u50ac\u5316\u7684\u53bb\u7fb0\u57faSuzuki\u2013Miyaura\u53cd\u5e94\u4e0e\u5404\u79cd\u7fa7\u9178\u7684\u9002\u7528\u8303\u56f4<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-157277\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/3-28.png\" alt=\"\" width=\"600\" height=\"425\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/3-28.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/3-28-300x213.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u56fe4. \u954d\u50ac\u5316\u7684\u53bb\u7fb0\u57faSuzuki\u2013Miyaura\u5076\u8054\u5404\u79cd\u6709\u673a\u787c\u8bd5\u5242\u7684\u9002\u7528\u8303\u56f4<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-157274\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/4-27.png\" alt=\"\" width=\"600\" height=\"474\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/4-27.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/10\/4-27-300x237.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p>\u3010\u603b\u7ed3\u3011<\/p>\n<p>\u6240\u6709\u7528\u4e8e\u4e0eNi(o-tolyl)(PPh<sub>2<\/sub>Me)<sub>2<\/sub>Cl\u548cCsF\u53cd\u5e94\u7684\u50ac\u5316\u5242\u548c\u8bd5\u5242\u90fd\u5728\u53f0\u9762\u4e0a\u79f0\u91cd\uff0c\u4e0d\u9700\u8981\u5728\u624b\u5957\u7bb1\u4e2d\u8fdb\u884c\u3002\u56e0\u6b64\uff0c\u8fd9\u4e00\u8fdb\u5c55\u5c06\u4f7f\u8fd9\u4e9b\u5076\u8054\u53cd\u5e94\u66f4\u52a0\u5b9e\u7528\uff0c\u5e76\u53ef\u4e3a\u5404\u79cd\u5408\u6210\u548c\u836f\u7269\u5316\u5b66\u7814\u7a76\u4eba\u5458\u6240\u5229\u7528\u3002<\/p>\n<p>\u6587\u732e\u94fe\u63a5\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0628-7\" target=\"_blank\" rel=\"noopener\">Base-free nickel-catalysed decarbonylative Suzuki\u2013Miyaura coupling of acid fluorides<\/a>, (Nature, 2018, DOI:10.1038\/ s41586-018-0628-7)<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u5b66\u672f\u7ec4<strong><b>Z,Chen<\/b><\/strong>\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1\uff1atougao@cailiaoren.com\u3002<\/p>\n<p>\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u524d\u8a00\u3011 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