{"id":157198,"date":"2018-10-30T06:30:38","date_gmt":"2018-10-29T22:30:38","guid":{"rendered":"\/\/m.iemloyee.com\/?p=157198"},"modified":"2018-10-29T19:06:14","modified_gmt":"2018-10-29T11:06:14","slug":"%e6%be%b3%e9%97%a8%e5%a4%a7%e5%ad%a6%e9%99%88%e7%be%8e%e5%a9%89%e6%95%99%e6%8e%88%e5%92%8c%e8%8b%8f%e5%b7%9e%e5%a4%a7%e5%ad%a6%e5%88%98%e5%ba%84%e6%95%99%e6%8e%88nano-lett-%ef%bc%9a%e5%9f%ba%e4%ba%8eg","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=157198","title":{"rendered":"\u6fb3\u95e8\u5927\u5b66\u9648\u7f8e\u5a49\u6559\u6388\u548c\u82cf\u5dde\u5927\u5b66\u5218\u5e84\u6559\u6388Nano Lett.\uff1a\u57fa\u4e8eG-\u56db\u8054\u4f53\u7684\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u8c03\u8282\u80bf\u7624\u4e4f\u6c27\u548c\u5b9e\u73b0\u6838\u9776\u5411\u8f7d\u836f\u589e\u5f3a\u5149\u52a8\u529b\u5b66\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u88ab\u8ba4\u4e3a\u662f\u4e00\u79cd\u5b89\u5168\u548c\u53ef\u5bf9\u764c\u75c7\u8fdb\u884c\u9009\u62e9\u6027\u6cbb\u7597\u7684\u65b9\u6cd5\uff0c\u5176\u9700\u8981\u5149\u654f\u5242\u3001\u5149\u548c\u7ec4\u7ec7\u4e2d\u7684\u6c27\u4e09\u79cd\u7269\u8d28\u5171\u540c\u4f5c\u7528\uff0c\u6765\u4ea7\u751f\u5355\u7ebf\u6001\u6c27\u5bfc\u81f4DNA\u635f\u4f24\u548c\u7ec6\u80de\u51cb\u4ea1\u3002\u7531\u4e8e\u5355\u7ebf\u6001\u6c27\u6613\u731d\u706d\uff0c\u4e14\u6269\u6563\u8ddd\u79bb\u6781\u77ed\uff0c\u6545\u80fd\u5728\u7ec6\u80de\u6838\u4e2d\u4ea7\u751f\u7684\u5355\u7ebf\u6001\u6c27\u7684\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6548\u679c\u4f1a\u6bd4\u7ec6\u80de\u8d28\u548c\u7ec6\u80de\u819c\u4e2d\u7684\u66f4\u52a0\u6709\u6548\u3002\u7136\u800c\uff0c\u5c06\u5149\u654f\u5242\u8fd0\u8f93\u5230\u7ec6\u80de\u6838\u4e2d\uff0c\u5728\u4f20\u7edf\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u4e2d\u8fd8\u6ca1\u6709\u5b9e\u73b0\u5e7f\u6cdb\u5e94\u7528\u3002\u4e0e\u6b64\u540c\u65f6\uff0cBcl-2\u4f5c\u4e3a\u4e00\u79cd\u91cd\u8981\u7684\u6297\u51cb\u4ea1\u86cb\u767d\uff0c\u53ef\u4ee5\u901a\u8fc7\u963b\u788d\u7ec6\u80de\u8272\u7d20c\u7684\u91ca\u653e\u6765\u6291\u5236\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u3002\u6b64\u5916\uff0c\u80bf\u7624\u5fae\u73af\u5883\u4e2d\u6c27\u6c14\u542b\u91cf\u8f83\u4f4e\uff0c\u4e5f\u5927\u5927\u964d\u4f4e\u4e86\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u7684\u6548\u679c\u3002\u56e0\u6b64\uff0c\u6539\u5584\u80bf\u7624\u4e4f\u6c27\u548c\u5b9e\u73b0\u7ec6\u80de\u6838\u9776\u5411\u5bf9\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u80bf\u7624\u5341\u5206\u91cd\u8981\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u6fb3\u95e8\u5927\u5b66\u9648\u7f8e\u5a49\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u548c<\/b><\/strong>\u82cf\u5dde\u5927\u5b66\u5218\u5e84<\/b><\/strong>\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u5229\u7528\u9499\u79bb\u5b50\u548cAS1411 G-\u56db\u8054\u4f53\u7684\u914d\u4f4d\u4f5c\u7528\u5236\u5907\u4e86\u4e00\u79cd\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\uff0c\u5149\u654f\u5242Ce6\u548c\u8840\u7ea2\u7d20\u5d4c\u5165\u5230\u8be5\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u4e2d\u7684G-\u56db\u8054\u4f53\u4e2d\u3002\u901a\u8fc7PEG\u4fee\u9970\uff0c\u83b7\u5f97\u7684\u7eb3\u7c73\u7ed3\u6784Ca-AS1411\/Ce6\/hemin@pHis-PEG\uff08CACH-PEG\uff09\u53ef\u4ee5\u5c06Ce6\u8fd0\u8f93\u5230\u7ec6\u80de\u6838\u4e2d\u4ea7\u751f\u66f4\u5177\u7834\u574f\u529b\u7684\u6d3b\u6027\u6c27\uff1b\u540c\u65f6AS1411\u53ef\u4ee5\u6291\u5236Bcl-2\u7684\u8868\u8fbe\uff0c\u63d0\u9ad8\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6240\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u6548\u679c\u3002\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u4e2d\u7684\u8840\u7ea2\u7d20\/G-\u56db\u8054\u4f53\u53ef\u4ee5\u5206\u89e3\u80bf\u7624\u5185\u90e8\u7684H2<\/sub>O2<\/sub>\uff0c\u4ece\u800c\u514b\u670d\u56e0\u80bf\u7624\u73af\u5883\u7f3a\u6c27\u800c\u5bfc\u81f4\u7684\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy<\/b><\/strong>“\u53d1\u8868\u4e8eNano Lett.<\/b><\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

\u56fe<\/b><\/strong>\u00a0<\/b><\/strong>1<\/b><\/strong>. <\/b><\/strong>CACH-PEG\u7684\u5236\u5907\u548c\u8868\u5f81<\/b><\/strong><\/p>\n

\u00a0\"\"<\/b><\/strong><\/p>\n

(a).\u56fe\u793aCACH-PEG\u7684\u5408\u6210<\/p>\n

(b,c).CACH-PEG\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u7684TEM\u56fe\u50cf<\/p>\n

(d).CACH-PEG\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u5206\u6563\u5728\u4e0d\u540c\u4ecb\u8d28\u4e2d\u7684\u6c34\u5316\u7c92\u5f84<\/p>\n

(e).Ce-6\uff0c\u8840\u7ea2\u7d20\u548cCACH-PEG\u7684\u5438\u6536\u5149\u8c31<\/p>\n

(f).\u52a0\u5165AS1411\/\u8840\u7ea2\u7d20\u540e\uff0c2mM H2<\/sub>O2<\/sub>\u6eb6\u6db2\u4e2d\u7684\u6c27\u6c14\u4ea7\u751f<\/p>\n

(g).\u5149\u8bf1\u5bfc\u7684\u5355\u7ebf\u6001\u6c27\u7684\u4ea7\u751f<\/p>\n

(h,i).pH7.4\u548cpH5.5\u65f6\u7684CACH-PEG\u7684TEM\u56fe<\/p>\n

(j).\u00a0CACH-PEG\u5728pH 7.4, pH6.5\u548cpH5.5\u00a0\u7684PBS\u4e00\u5c0f\u65f6\u540e\u7684\u6c34\u5316\u7c92\u5f84<\/p>\n

\u56fe<\/b><\/strong>2<\/b><\/strong>.<\/b><\/strong>\u00a0CACH-PEG\u7684\u4f53\u5916\u589e\u5f3a\u5149\u52a8\u529b\u5b66\u6cbb\u7597<\/b><\/strong><\/p>\n

\u00a0\"\"<\/b><\/strong><\/p>\n

(a).\u56fe\u793aCACH-PEG\u7684Ce6\u6838\u5185\u9012\u9001\u3001Bcl-2\u8868\u8fbe\u964d\u4f4e\u548c\u7ec6\u80de\u5185\u6c27\u6c14\u4ea7\u751f<\/p>\n

(b).Bcl-2\u8868\u8fbe\u6c34\u5e73<\/p>\n

(c).\u7ec6\u80de\u548cCDCH-PEG, AC\u548cCACH-PEG\u4e00\u8d77\u57f9\u80b2\u540e\u7684\u6fc0\u5149\u5171\u805a\u7126\u6210\u50cf<\/p>\n

(d,e).\u7ec6\u80de\u5b58\u6d3b\u7387<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>. <\/b><\/strong>CACH-PEG\u7684\u5c0f\u9f20\u4f53\u5185\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u6ce8\u5165CACH-PEG\u540e\u4e0d\u540c\u65f6\u95f4\u7684\u4f53\u5185\u8367\u5149\u6210\u50cf<\/p>\n

(b).\u56fe\u793aCACH-PEG\u4e2d99m<\/sup>Tc\u6807\u8bb0\u7684Ce6<\/p>\n

(c).99m<\/sup>Tc-CACH-PEG\u7684\u653e\u5c04\u6807\u8bb0\u7a33\u5b9a\u6027\u6d4b\u8bd5<\/p>\n

(d).99m<\/sup>Tc-CACH-PEG\u5728\u5c0f\u9f20\u4f53\u5185\u7684SPECT\u6210\u50cf<\/p>\n

(e).99m<\/sup>Tc-CACH-PEG\u5728\u5c0f\u9f20\u4f53\u5185\u8840\u6db2\u5faa\u73af<\/p>\n

(f).\u00a099m<\/sup>Tc-CACH-PEG\u5728\u5c0f\u9f20\u4f53\u5185\u7684\u7ec4\u7ec7\u5668\u5b98\u5206\u5e03<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>. <\/b><\/strong>CACH-PEG\u7684\u4f53\u5185\u5149\u52a8\u529b\u5b66\u6cbb\u7597<\/b><\/strong>\"\"<\/b><\/strong><\/p>\n

(a).\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684\u514d\u75ab\u8367\u5149\u6210\u50cf<\/p>\n

(b).\u5728\u6ce8\u5c04CACH-PEG\u540e\uff0c\u80bf\u7624\u4e2d\u4e4f\u6c27\u9762\u79ef\u7684\u5b9a\u91cf<\/p>\n

(c,d).\u80bf\u7624\u4e2dBcl-2\u7684\u8868\u8fbe\u6c34\u5e73<\/p>\n

(e).\u80bf\u7624\u751f\u957f\u66f2\u7ebf<\/p>\n

(f).\u4e0d\u540c\u5904\u7406\u65b9\u6cd5\u540e\uff0c\u80bf\u7624\u7684\u5e73\u5747\u91cd\u91cf<\/p>\n

(g).\u80bf\u7624\u7ec4\u7ec7\u5207\u7247\u7684\u82cf\u6728\u7cbe\u548c\u4f0a\u7ea2\u67d3\u8272<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u8be5\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u5229\u7528\u914d\u4f4d\u9a71\u52a8\u7684\u81ea\u7ec4\u88c5\uff0c\u5728\u6c34\u6eb6\u6db2\u4e2d\u901a\u8fc7Ca2+<\/sup>\u3001AS1411 G-\u56db\u8054\u4f53\u548cpHis-PEG\u5236\u5907\u4e86\u57fa\u4e8eDNA\u7684\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269CACH-PEG\u3002CACH-PEG\u53ef\u4ee5\u5c06Ce6\u8fd0\u8f93\u5230\u7ec6\u80de\u6838\u4e2d\u4ea7\u751f\u66f4\u5177\u7834\u574f\u529b\u7684\u6d3b\u6027\u6c27\uff0c\u540c\u65f6AS1411\u53ef\u4ee5\u6291\u5236Bcl-2\u7684\u8868\u8fbe\u6765\u63d0\u9ad8\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6240\u8bf1\u5bfc\u7684\u7ec6\u80de\u51cb\u4ea1\u6548\u679c\u3002\u8be5\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u4e2d\u7684\u8840\u7ea2\u7d20\/G-\u56db\u8054\u4f53\u53ef\u4ee5\u5206\u89e3\u80bf\u7624\u5185\u90e8H2<\/sub>O2<\/sub>\uff0c\u4ece\u800c\u514b\u670d\u56e0\u80bf\u7624\u73af\u5883\u7f3a\u6c27\u800c\u5bfc\u81f4\u7684\u5149\u52a8\u529b\u5b66\u6cbb\u7597\u6548\u679c\u4e0d\u4f73\u3002\u8fd9\u9879\u5de5\u4f5c\u53d1\u5c55\u4e86\u4e00\u79cd\u5236\u5907\u57fa\u4e8eDNA\u7684\u7eb3\u7c73\u914d\u4f4d\u805a\u5408\u7269\u7684\u7b80\u4fbf\u65b9\u6cd5\uff0c\u5728\u5b9e\u73b0\u6838\u5185\u5149\u654f\u5242\u9012\u9001\u7684\u540c\u65f6\uff0c\u4e0b\u8c03\u4e86\u6297\u51cb\u4ea1\u86cb\u767d\u7684\u8868\u8fbe\uff0c\u63d0\u9ad8\u4e86\u764c\u75c7\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n

G-Quadruplex-Based Nanoscale Coordination Polymers to Modulate Tumor Hypoxia and Achieve Nuclear-Targeted Drug Delivery for Enhanced Photodynamic Therapy<\/a><\/p>\n

(Nano Lett., 2018, DOI: 10.1021\/acs.nanolett.8b02732)\u00a0<\/p>\n

\u56e2\u961f<\/b><\/strong>\u4ecb\u7ecd\uff1a<\/b><\/strong><\/p>\n

\u9648\u7f8e\u5a49\uff0c\u6fb3\u95e8\u5927\u5b66\u526f\u6559\u6388\uff0c\u535a\u5bfc\u3002\u4e3b\u8981\u4ece\u4e8b\u751f\u7269\u6750\u6599\u548c\u7eb3\u7c73\u533b\u5b66\u7684\u7814\u7a76\uff0c\u91cd\u70b9\u96c6\u4e2d\u5728\u6297\u80bf\u7624\u9776\u5411\u836f\u7269\u4f20\u9012\u7cfb\u7edf\uff0c\u540c\u65f6\u8fd8\u53d1\u5c55\u7eb3\u7c73\u6280\u672f\u5728\u4e2d\u897f\u836f\u8054\u5408\u6cbb\u7597\u4e2d\u7684\u5e94\u7528\u3002\u4f5c\u4e3a\u8bfe\u9898\u8d1f\u8d23\u4eba\u627f\u62c5\u4e86\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u3001\u6fb3\u95e8\u79d1\u5b66\u6280\u672f\u53d1\u5c55\u57fa\u91d1\u548c\u6fb3\u95e8\u5927\u5b66\u57fa\u91d1\u7b4910\u4f59\u9879\u7814\u7a76\u9879\u76ee\u30022010\u5e74\u52a0\u5165\u6fb3\u95e8\u5927\u5b66\u81f3\u4eca\uff0c\u53d1\u8868\u7b2c\u4e00\/\u901a\u8baf\u4f5c\u8005SCI\u8bba\u6587\u517180\u4f59\u7bc7\uff0c\u6210\u679c\u53d1\u8868\u4e8eAdvanced Materials\u3001ACS Nano\u3001Nano Letters\u3001Biomaterials\u548cMolecular Pharmaceutics\u7b49\u836f\u5242\u5b66\u548c\u751f\u7269\u6750\u6599\u9886\u57df\u7684\u56fd\u9645\u6743\u5a01\u671f\u520a\u3002\u53c2\u4e0e6\u90e8\u4e2d\u82f1\u6587\u5b66\u672f\u8457\u4f5c\u7684\u7f16\u5199\u548c6\u9879\u4e13\u5229\u7684\u7533\u8bf7\u3002\u8363\u83b7\u7b2c\u4e00\/\u4e8c\/\u56db\u5c4a\u6fb3\u95e8\u7279\u522b\u884c\u653f\u533a\u81ea\u7136\u79d1\u5b66\uff082012\/2014\/2018\u5e74\uff09\u3002\u6307\u5bfc\u535a\u7855\u58eb20\u4f59\u540d\uff1a\u8363\u83b71\u9879\u7b2c\u4e5d\u5c4a\u4e2d\u56fd\u9752\u5c11\u5e74\u79d1\u6280\u521b\u65b0\u5956\u30017\u9879\u6fb3\u95e8\u7814\u7a76\u751f\u79d1\u7814\u5956\u548c30\u4f59\u9879\u6d77\u5185\u5916\u4f1a\u8bae\u5956\u52b1\u7b49\u3002\u62c5\u4efbCurrent Drug Delivery\u3001Current Traditional Medicine\u3001Journal of Cancer Research Updates\u7b49\u6742\u5fd7\u7f16\u59d4\uff0c\u4e16\u754c\u4e2d\u8054\u4e2d\u836f\u836f\u5242\u59d4\u5458\u4f1a\u7b2c\u4e09\u5c4a\u7406\u4e8b\u4f1a\u5e38\u52a1\u7406\u4e8b\u517c\u526f\u79d8\u4e66\u957f\u3001\u4e2d\u56fd\u751f\u7269\u6750\u6599\u5b66\u4f1a\u751f\u7269\u533b\u7528\u9ad8\u5206\u5b50\u6750\u6599\u5206\u4f1a\u59d4\u5458\u548c\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u7eb3\u7c73\u751f\u7269\u6280\u672f\u5206\u4f1a\u59d4\u5458\u7b49\u3002<\/p>\n

Lab website\uff1ahttps:\/\/sklqrcm.umac.mo\/meiwan-chen<\/u><\/a><\/p>\n

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Lab website\uff1ahttp:\/\/nano.suda.edu.cn\/lz_en<\/u><\/a><\/p>\n

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