{"id":155368,"date":"2018-10-05T06:55:23","date_gmt":"2018-10-04T22:55:23","guid":{"rendered":"\/\/m.iemloyee.com\/?p=155368"},"modified":"2018-10-04T12:56:03","modified_gmt":"2018-10-04T04:56:03","slug":"%e9%99%88%e5%b0%8f%e5%85%83%e6%88%b4%e5%bf%97%e9%a3%9e-chem-soc-rev-%e9%80%9a%e8%bf%87%e5%85%89%e7%83%ad%e6%b2%bb%e7%96%97%e5%92%8c%e5%85%89%e5%a3%b0%e6%88%90%e5%83%8f%e7%9a%84%e7%ba%b3%e7%b1%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=155368","title":{"rendered":"\u9648\u5c0f\u5143&\u6234\u5fd7\u98de Chem. Soc. Rev.: \u901a\u8fc7\u5149\u70ed\u6cbb\u7597\u548c\u5149\u58f0\u6210\u50cf\u7684\u7eb3\u7c73\u6cbb\u7597\u6cd5\u6cbb\u7597\u764c\u75c7"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u764c\u75c7\u662f\u5168\u4e16\u754c\u53d1\u75c5\u7387\u548c\u6b7b\u4ea1\u7387\u6700\u9ad8\u7684\u75be\u75c5\u3002\u5927\u7ea6\u6bcf\u5e74\u67091400\u4e07\u65b0\u764c\u75c7\u60a3\u8005\u548c800\u4e07\u4eba\u6b7b\u4e8e\u764c\u75c7\u76f8\u5173\u75be\u75c5\u3002\u9274\u4e8e\u764c\u75c7\u7684\u9ad8\u98ce\u9669\u548c\u9ad8\u6b7b\u4ea1\u7387\uff0c\u4e16\u754c\u5404\u5730\u7684\u7814\u7a76\u4eba\u5458\u4e00\u76f4\u5728\u52aa\u529b\u5f00\u53d1\u51fa\u66f4\u51c6\u786e\u3001\u66f4\u5feb\u901f\u7684\u8bca\u65ad\u7b56\u7565\u548c\u6709\u6548\u7684\u6cbb\u7597\u65b9\u6cd5\u6765\u6cbb\u7597\u764c\u75c7\u3002\u4f20\u7edf\u7684\u764c\u75c7\u7597\u6cd5\u5305\u62ec\u5316\u7597\u3001\u653e\u7597\u548c\u5916\u79d1\u624b\u672f\uff0c\u6709\u7740\u4e25\u91cd\u7684\u526f\u4f5c\u7528\u548c\u5dee\u7684\u6cbb\u7597\u6548\u679c\u3002\u76ee\u524d\uff0c\u764c\u75c7\u6cbb\u7597\u4e2d\u7684\u65b0\u5174\u7597\u6cd5\u5305\u62ec\u514d\u75ab\u7597\u6cd5\u3001\u57fa\u56e0\u7597\u6cd5\u3001\u5149\u52a8\u529b\u7597\u6cd5 (PDT)\u548c\u5149\u70ed\u7597\u6cd5 (PTT)\u7b49\uff0c\u5176\u5df2\u7ecf\u6539\u5584\u6216\u6709\u53ef\u80fd\u6539\u5584\u6cbb\u7597\u6548\u679c\u3002 PTT\u5229\u7528\u5149\u70ed\u8f6c\u6362\u5242 (PTAs)\u7684\u5149\u70ed\u6548\u5e94\uff0c\u5149\u80fd\u8f6c\u6362\u5242\u53ef\u4ee5\u4ece\u5149\u4e2d\u83b7\u53d6\u80fd\u91cf\u5e76\u5c06\u80fd\u91cf\u8f6c\u5316\u4e3a\u70ed\u91cf\u4ee5\u589e\u52a0\u5468\u56f4\u73af\u5883\u7684\u6e29\u5ea6\u5e76\u5f15\u53d1\u764c\u7ec6\u80de\u7684\u6b7b\u4ea1\u3002\u5c06\u5149\u80fd\u4ee5\u975e\u70ed\u8f90\u5c04\u5f62\u5f0f\u8f6c\u5316\u4e3a\u70ed\u80fd (\u5149\u70ed\u7597\u6cd5\uff0cPTT)\u6216\u58f0\u80fd (\u5149\u58f0\u6210\u50cf\uff0cPAI)\u5206\u522b\u7528\u4e8e\u6cbb\u7597\u548c\u8bca\u65ad\u764c\u75c7\u3002\u901a\u8fc7\u5229\u7528\u7eb3\u7c73\u8f7d\u4f53\uff0c\u5df2\u7ecf\u5f7b\u5e95\u7814\u7a76\u4e86\u6210\u50cf\u548c\u6cbb\u7597\u529f\u80fd\u4ee5\u53ca\u589e\u5f3a\u80bf\u7624\u5904\u7684\u7d2f\u79ef\uff0c\u4ee5\u63d0\u9ad8PAI\u548cPTT\u4e34\u5e8a\u524d\u7684\u6548\u7387\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0cChem. Soc. Rev.<\/strong> \u5728\u7ebf\u520a\u767b\u4e86\u5317\u4eac\u5927\u5b66\u7684\u6234\u5fd7\u98de\u6559\u6388\u548c\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662\u7684\u9648\u5c0f\u5143\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u603b\u7ed3\u201cPhotothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer\u201d<\/strong> \u7efc\u8ff0<\/strong>\u3002\u5728\u6587\u7ae0\u4e2d\uff0c\u9996\u5148\u603b\u7ed3\u4e86\u65e0\u673a\u548c\u6709\u673a\u7eb3\u7c73\u5149\u70ed\u8f6c\u6362\u5242 (PTAs)\u7684\u53d1\u5c55\u548c\u6539\u5584PTT\u6548\u679c\u7684\u7b56\u7565\uff0c\u5373\u5305\u62ec\u5e94\u7528\u9002\u5f53\u7684\u6fc0\u5149\u5242\u91cf\u3001\u6210\u50cf\u6280\u672f\u6307\u5bfc\u6cbb\u7597\u3001NIR-II\u533a\u4e2d\u5f00\u53d1\u5438\u6536PTAs \u3001\u63d0\u9ad8\u5149\u70ed\u8f6c\u6362\u6548\u7387 (PCE)\u548c\u589e\u52a0\u80bf\u7624\u4e2dPTAs\u7684\u79ef\u7d2f\u3002\u5176\u6b21\uff0c\u4ecb\u7ecd\u4e86PTT\u4e0e\u764c\u75c7\u6cbb\u7597\u4e2d\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408\u7684\u4f18\u52bf\u3002\u7b2c\u4e09\uff0c\u4e3e\u4f8bPAI\u5728\u764c\u75c7\u76f8\u5173\u7814\u7a76\u4e2d\u7684\u65b0\u5174\u5e94\u7528\u3002\u6700\u540e\uff0c\u8ba8\u8bba\u4e86PTT\u548cPAI\u5bf9\u6297\u764c\u75c7\u7684\u89c2\u70b9\u548c\u6311\u6218\uff0c\u7279\u522b\u662f\u5173\u4e8e\u5b83\u4eec\u7684\u4e34\u5e8a\u8f6c\u5316\u3002\u76f8\u4fe1\u5177\u6709\u503c\u5f97\u6ce8\u610f\u7684\u7279\u5f81\u7684PTT\u548cPAI\u5c06\u6210\u4e3a\u4e0b\u4e00\u4ee3\u975e\u4fb5\u5165\u6027\u7684\u764c\u75c7\u6cbb\u7597\u6280\u672f\uff0c\u5e76\u63d0\u9ad8\u6cbb\u7597\u764c\u75c7\u7684\u6548\u679c\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

1\u3001\u5149\u70ed\u8f6c\u6362\u5242 (PTAs)\u7684\u5206\u7c7b\u548c\u7279\u5f81<\/strong><\/p>\n

PTAs\u53ef\u4ee5\u5c06\u5438\u6536\u7684\u5149\u80fd\u8f6c\u5316\u4e3a\u70ed\u80fd\uff0c\u4ece\u800c\u63d0\u9ad8\u5468\u56f4\u73af\u5883\u7684\u6e29\u5ea6\u3002\u7406\u60f3\u60c5\u51b5\u4e0b\uff0c\u9884\u8ba1PTAs\u53ea\u4f1a\u5c40\u90e8\u5347\u9ad8\u6e29\u5ea6\uff0c\u4ee5\u51cf\u5c11\u5bf9\u4e0d\u5b58\u5728PTAs\u6216\u8d85\u51fa\u6fc0\u5149\u7167\u5c04\u8303\u56f4\u7684\u5065\u5eb7\u7ec4\u7ec7\u7684\u635f\u5bb3\u3002PTAs\u7684\u5438\u6536\u901a\u5e38\u8c03\u6574\u5230750-1350 nm\u4e4b\u95f4\uff0c\u5305\u62ec750-1000 nm (NIR-I)\u548c1000-1350 nm (NIR-II)\u3002 \u5176\u5b9ePTAs\u53ef\u5206\u4e3a\u65e0\u673a\u6750\u6599\u548c\u6709\u673a\u6750\u6599\u4e24\u7c7b\u3002\u65e0\u673a\u6750\u6599\u5305\u62ec\u8d35\u91d1\u5c5e\u6750\u6599\u3001\u91d1\u5c5e\u786b\u5c5e\u5316\u7269\u6750\u6599\u3001\u78b3\u57fa\u7eb3\u7c73\u6750\u6599\u548c\u5176\u4ed6\u4e8c\u7ef4 (2D)\u6750\u6599\u3002\u6709\u673aPTAs\u5305\u62ecNIR\u54cd\u5e94\u578b\u7684\u5c0f\u5206\u5b50\u548c\u534a\u5bfc\u4f53\u805a\u5408\u7269NPs (SPNPs)\u3002
\n \"\"Figure 1. \u7eb3\u7c73\u5149\u70ed\u8f6c\u6362\u5242(PTAs)\u7684\u5206\u7c7b\u3002<\/p>\n

1.1\u3001\u8d35\u91d1\u5c5e\u6750\u6599<\/strong><\/p>\n

\u5177\u6709\u5f3a\u6297\u6c27\u5316\u6027\u7684\u8d35\u91d1\u5c5e\u6750\u6599\u662f\u7814\u7a76\u6700\u591a\u7684\u65e0\u673aPTAs\u4e2d\u7684\u4e00\u79cd\u3002 \u8d35\u91d1\u5c5ePTAs\uff0c\u5305\u62ecAu\u3001Ag\u3001Pt\u548cPd\uff0c\u53ef\u5438\u6536\u6fc0\u5149\u4ee5\u5c06\u7535\u5b50\u4ece\u57fa\u6001\u6fc0\u53d1\u5230\u6fc0\u53d1\u6001\uff0c\u7136\u540e\u901a\u8fc7\u975e\u8f90\u5c04\u8870\u53d8\u4ee5\u70ed\u7684\u5f62\u5f0f\u91ca\u653e\u80fd\u91cf\u3002
\n \"\"Figure 2.\uff08a-i\uff09\u4f7f\u7528CTAB\u548c\u6cb9\u9178\u94a0\u4f5c\u4e3a\u914d\u4f53\u5408\u6210\u7684Au\u7eb3\u7c73\u68d2\u7684TEM\u3002\uff08a\uff09200 nm\uff0c\uff08b\uff0950 nm\uff0c\uff08c-f\uff09100 nm\uff0c\uff08g\uff0ch\uff09200 nm\uff0c\u548c\uff08i\uff09100 nm\u3002\uff08j\uff09\u4ece\u5de6\u5230\u53f3\u5206\u522b\u662f\u5bf9\u5e94\u4e8e\u6837\u54c1a\u3001c\u3001d\u3001e\u3001f\u3001g\u3001h\u548ci\u7684Au\u7eb3\u7c73\u68d2\u7684\u5f52\u4e00\u5316\u6d88\u5149\u5149\u8c31\u3002\uff08k\uff09 Au\u7eb3\u7c73\u53cc\u73af\u9170\u80fa\u7684TEM\u3002\uff08l\uff09\u7528\u70ed\u654f\u805a\u5408\u7269\u6539\u6027\u7684Au\u7eb3\u7c73\u7b3c\u7684TEM\u3002\uff08m\uff09Pd\u7eb3\u7c73\u7247\u7684TEM\u3002\uff08n\uff09\u5177\u6709\u4e0d\u540c\u8fb9\u957f\u7684Pd\u7eb3\u7c73\u7247\u7684\u6d88\u5149\u5149\u8c31\u3002<\/p>\n

1.2\u3001\u77f3\u58a8\u70ef\u548c\u57fa\u4e8e\u77f3\u58a8\u70ef\u7c7b\u4f3c\u7269\u7684PTAs<\/strong><\/p>\n

\u57fa\u4e8e\u8d35\u91d1\u5c5e\u7684PTAs\u5728PTT\u4e2d\u7684\u5c40\u9650\u6027\u4fc3\u4f7f\u79d1\u5b66\u5bb6\u4eec\u5bfb\u6c42\u5176\u4ed6\u65e0\u673a\u6750\u6599\u6216\u8005\u78b3\u57fa\u6750\u6599\u4f5c\u4e3aPTAs\uff0c\u4f8b\u5982\u78b3\u7eb3\u7c73\u7ba1\u3001\u77f3\u58a8\u70ef\u3001\u6c27\u5316\u77f3\u58a8\u70ef\u3001\u78b3\u70b9\uff0c\u5177\u6709\u5e7f\u6cdb\u7684\u5149\u5b66\u5438\u6536\u548c\u5408\u7406\u7684\u5149\u70ed\u6027\u8d28\u5f15\u8d77\u4e86\u6781\u5927\u5173\u6ce8\u3002
\n \"\"Figure 3. \uff08a\uff09\u8fd8\u539f\u6c27\u5316\u77f3\u58a8\u70ef\u7684AFM\u56fe\u3002\uff08b\uff09\u6c27\u5316\u77f3\u58a8\u70ef\uff08\u9ed1\u8272\uff09\u548c\u8fd8\u539f\u6c27\u5316\u77f3\u58a8\u70ef\uff08\u7ea2\u8272\uff09\u7684\u5438\u6536\u5149\u8c31\u3002\uff08c\uff09\u6eb6\u5242\u70ed\u6cd5\u5408\u6210MoS2<\/sub>\u7eb3\u7c73\u7247\u7684\u793a\u610f\u56fe\u3002\uff08i\uff09TEM\u56fe\u50cf\u3002\uff08j\uff09\u6697\u89c6\u573aTEM\u56fe\u50cf\u3002\uff08k\uff09\u8d85\u8584Nb2<\/sub>C\u7eb3\u7c73\u7247\u7684\u5085\u7acb\u53f6\u53d8\u6362\u56fe\u6848\uff0c\u63d2\u56fe\u662f\u539f\u59cb\u7684SAED\u6a21\u5f0f\u3002<\/p>\n

1.3\u3001\u5176\u4ed6\u65e0\u673aPTAs<\/strong><\/p>\n

\u57fa\u4e8e\u8fc7\u6e21\u91d1\u5c5e\u7684PTAs\u7684\u8bb8\u591a\u5176\u4ed6\u5b9e\u4f8b\uff0c\u4f8b\u5982\u91cf\u5b50\u70b9\u548c\u91d1\u5c5e\u6c27\u5316\u7269NPs\u3002\u9664\u4e86\u8367\u5149\u53d1\u5c04\u4e4b\u5916\uff0c\u901a\u8fc7\u91cf\u5b50\u70b9\u6536\u83b7\u7684\u5149\u53ef\u4ee5\u901a\u8fc7\u975e\u8f90\u5c04\u8870\u53d8\u90e8\u5206\u5730\u8f6c\u6362\u6210\u70ed\u91cf\uff0c\u5176\u8fc7\u7a0b\u4e0eNPs\u7ed3\u6784\u6709\u5173\u3002<\/p>\n

1.4\u3001\u57fa\u4e8e\u5c0f\u5206\u5b50\u7684PTAs<\/strong>
\n \"\"Figure 4. \uff08a\uff09\u5206\u522b\u7528Rhod 123\u548cER-Tracker Green\u67d3\u8272\u540ePEG-PLD\uff08IR825\uff09\u57fa\u4e8e\u7eb3\u7c73\u80f6\u675f\u7684PTT\u7684\u5408\u6210\u548c\u7eb3\u7c73\u80f6\u675f\u5904\u7406\u7684HeLa\u7ec6\u80de\u7684\u5171\u805a\u7126\u56fe\u50cf\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09\u5177\u6709\u76f8\u4e92\u534f\u540c\u5206\u5b50\u9776\u5411\u6cbb\u7597\/PTT\u7684\u80f6\u675f\u7528\u4e8e\u9ad8\u6548\u764c\u75c7\u6cbb\u7597\u56fe\u793a\u3002\uff08c\uff09\u7528\u4e8e\u591a\u6a21\u5f0f\u6210\u50cf\u548c\u6297\u836f\u6027\u80bf\u7624\u7684\u7ec4\u5408\u7597\u6cd5\u7684\u9178\u53ef\u8f6c\u6362\u80f6\u675f\uff08PDPC\uff09\u7684\u81ea\u7ec4\u88c5\u548c\u7ed3\u6784\u7ec4\u6210\u7684\u56fe\u793a\u3002\uff08d\uff09\u5728655 nm\u6fc0\u5149\u7167\u5c04\u6216pH\u503c\u4e0b\uff0cPDPC\u80f6\u675f\u7684ROS\u4ea7\u751f\u548c\u5149\u70ed\u66f2\u7ebf\u4e0eCe6\u6d53\u5ea6\u7684\u5173\u7cfb\u3002<\/p>\n

1.5\u3001NIR\u5438\u6536\u7684SPNPs\u7528\u4e8ePTT<\/strong><\/p>\n

\u5728\u51e0\u79cd\u6709\u673a\u7eb3\u7c73\u5e73\u53f0\u4e2d\uff0c\u5177\u6709\u4f18\u5f02\u5149\u5b66\u6027\u8d28\u7684SPNPs\u6700\u8fd1\u83b7\u5f97\u4e86\u6781\u5927\u7684\u666e\u53ca\u3002SPNPs\u7684\u5927\u7684\u03c0-\u5171\u8f6d\u4e3b\u94fe\u548c\u9ad8\u7535\u5b50\u79bb\u57df\u7ed3\u6784\u5728NIR\u533a\u57df\u4e2d\u5177\u6709\u4f18\u5f02\u7684\u5149\u653e\u5927\u548c\u5149\u6536\u83b7\u7279\u6027\uff0c\u56e0\u6b64\u63d0\u4f9b\u4e86\u65b0\u7684\u673a\u4f1a\uff0c\u7279\u522b\u662f\u5728\u6210\u50cf\u548c\u5149\u7597\u9886\u57df\u3002
\n \"\"Figure 5. \uff08a\uff09\u589e\u5f3a\u7684D-A-D\u7ed3\u6784\u7684DPP-TPA NPs\u4f5c\u4e3aPAI\u5f15\u5bfc\u7684PDT\/PTT\u7684\u6cbb\u7597\u5242\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09\u6eb6\u89e3\u5728\u7532\u82ef\u4e2d\u7684\u6837\u54c1\u7684\u5438\u6536\u5149\u8c31\u3002 \uff08c\uff09\u5438\u6536\u5149\u8c31\uff0c\uff08d\uff09\u5149\u70ed\u52a0\u70ed\u548c\u81ea\u7136\u51b7\u5374\u5faa\u73af\uff0c\u548c\uff08e\uff09\u5728808 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u529f\u7387\u5bc6\u5ea6\u4e3a0.3 W.cm-2<\/sup>\u76844T1\u8377\u7624\u5c0f\u9f20\u7684IR\u70ed\u56fe\u50cf\u3002 \uff08f\uff09\u5728MPO\u548cH2<\/sub>O2<\/sub>\u5b58\u5728\u4e0bSPNV\u964d\u89e3\u7684\u793a\u610f\u56fe\u3002\uff08g\uff09\u7eb3\u7c73\u6c89\u6dc0\u6cd5\u548c\u4ee3\u8868\u6027TEM\u56fe\u50cf\u5236\u5907TPA-T-TQ ONPs\u7684\u793a\u610f\u56fe\u3002\uff08h\uff09TPA-T-TQ\u5728THF\u6eb6\u6db2\uff08\u9ed1\u8272\uff09\u548c\u5c01\u88c5\u7684ONPs\u5728\u6c34\uff08\u7ea2\u8272\uff09\u4e2d\u7684\u5149\u81f4\u53d1\u5149\u5149\u8c31\u3002\uff08i\uff09\u6297\u767d\u5149\u6f02\u767d\uff08\u4e94\u4e2a\u52a0\u70ed-\u51b7\u5374\u5faa\u73af\uff09\u548c\uff08j\uff09ONPs\u7684\u6297ROS\u7279\u6027\uff0cICG\uff0c\u548cICG NPs\u3002<\/p>\n

2\u3001\u63d0\u9ad8\u5149\u70ed\u6cbb\u7597\u6548\u679c\u7684\u65b9\u6cd5<\/strong><\/p>\n

2.1\u3001\u63a7\u5236\u9002\u5f53\u6fc0\u5149\u5242\u91cf<\/strong><\/p>\n

\u901a\u5e38\uff0c\u5177\u6709\u66f4\u957f\u6ce2\u957f\u548c\u66f4\u5f3a\u5f3a\u5ea6\u7684\u6fc0\u5149\u5177\u6709\u66f4\u6df1\u7684\u7a7f\u900f\u6027\u3002\u7136\u800c\uff0c\u5e94\u7528\u9002\u5f53\u7684\u6fc0\u5149\u5242\u91cf\u53ef\u4ee5\u5b9e\u73b0\u66f4\u597d\u7684PTT\u6548\u679c\u5e76\u907f\u514d\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u7684\u635f\u5bb3\u3002\u7814\u7a76\u8868\u660e\uff0c\u5149\u70ed\u8f90\u5c04\u53ef\u4ee5\u901a\u8fc7\u574f\u6b7b\u6216\u7ec6\u80de\u51cb\u4ea1\u5f15\u53d1\u7ec6\u80de\u6b7b\u4ea1\uff0c\u5177\u4f53\u53d6\u51b3\u4e8e\u8f90\u5c04\u5f3a\u5ea6\u3002
\n \"\"Figure 6. \uff08a-c\uff09\uff08a\uff09\u6838\u548c\uff08b\uff09\u6838-\u58f3\u4e0a\u8f6c\u6362NPs\u548c\uff08c\uff09\u5177\u6709\u78b3\u5c42\u7684\u6838-\u58f3\u4e0a\u8f6c\u6362NPs\uff08csUCNP @ C\uff09\u7684TEM\u3002\uff08d\uff09\u7279\u6b8a\u88c5\u7f6e\u7684\u793a\u610f\u56fe\uff0c\u7528\u4e8e\u540c\u65f6\u8868\u5f81csUCNP @ C NPs\u7684\u5b8f\u89c2\u6e29\u5347\u548c\u5fae\u89c2\u6e29\u5347\u3002\uff08e\uff09\u6807\u51c6\u66f2\u7ebf\uff0c\u8868\u793a\u6e29\u5ea6\u4e0e\u4e24\u4e2a\u6ce2\u957f\u7684\u8367\u5149\u5f3a\u5ea6\u6bd4\u4e4b\u95f4\u7684\u5173\u7cfb\u3002\uff08f\uff09\u901a\u8fc7\u7279\u6b8a\u8bbe\u7f6e\u786e\u5b9a\u7684\u5b8f\u89c2\uff08\u7a7a\u5fc3\u4e09\u89d2\u5f62\uff09\u4e0e\u5fae\u89c2\uff08\u5b9e\u5fc3\u4e09\u89d2\u5f62\uff09\u6e29\u5ea6\u5347\u9ad8\u7684\u66f2\u7ebf\u3002\uff08g\uff09\u5728\u6fc0\u5149\u7167\u5c04\u6216\u5916\u90e8\u52a0\u70ed\u4e0b\u7528\u9499\u9ec4\u7eff\u7d20AM\u548cPI\u5171\u67d3\u8272\u7684\u764c\u7ec6\u80de\u7684\u70ed\u56fe\u50cf\u548c\u8367\u5149\u6210\u50cf\u3002\uff08h\uff09\u5177\u6709\u6216\u4e0d\u5177\u6709\u5185\u5316\u7684csUCNP\u7684\u4e00\u7ec4\u76f8\u90bb\u764c\u7ec6\u80de\u7684PTT\u7684\u793a\u610f\u56fe\u3002\uff08i\uff09\u5728\u6fc0\u5149\u7167\u5c04\u4e4b\u524d\u548c\u4e4b\u540e\u5185\u5316\u7684\u5177\u6709\u6216\u4e0d\u5177\u6709csUCNP @ C\u7684\u76f8\u90bb\u764c\u7ec6\u80de\u7ec4\u7684\u660e\u89c6\u573a\u548c\u53d1\u5149\u6210\u50cf\u3002\uff08j\uff09\u6fc0\u5149\u7167\u5c04\u540e\u764c\u7ec6\u80de\u7684\u653e\u5927\u53d1\u5149\u6210\u50cf\u3002<\/p>\n

2.2\u3001\u786e\u5b9a\u6700\u4f73\u6cbb\u7597\u7a97\u53e3<\/strong>
\n \"\"Figure 7. \uff08a\uff09\u4f7f\u7528\u4eba\u8840\u6e05\u86cb\u767d\u4f5c\u4e3a\u6a21\u677f\u5408\u6210Ag2<\/sub>S\u91cf\u5b50\u70b9\u7684\u793a\u610f\u56fe\u3002 \uff08b\uff09\u5e73\u5747\u76f4\u5f84\u4e3a9.8 nm\u7684Ag2<\/sub>S\u91cf\u5b50\u70b9\u7684TEM\u3002\uff08c\uff09\u8367\u5149\u5149\u8c31\u548c\uff08d\uff09\u76f4\u5f84\u4e3a4.1, 7.9\u548c9.8 nm\u7684Ag2<\/sub>S\u91cf\u5b50\u70b9\u7684\u5149\u70ed\u6e29\u5ea6\u4e0a\u5347\u66f2\u7ebf\u3002\uff08e\uff09\u6ce8\u5c04Ag2<\/sub>S\u91cf\u5b50\u70b9\u540e\u4e0d\u540c\u65f6\u95f4\u7684\u4f53\u5185NIR-II\u8367\u5149\u6210\u50cf\u548c\uff08f\uff09\u8ba1\u7b97\u7684\u8367\u5149\u5f3a\u5ea6\u3002\uff08g\uff09\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u5728PTT\u4e0b\u643a\u5e26\u80bf\u7624\u7684\u5c0f\u9f20\u7684\u80bf\u7624\u7684\u70ed\u56fe\u50cf\u3002\uff08h\uff09\u7528\u4e8e\u5316\u5b66\u8fd8\u539fAu NPs\u4e0a\u768464 Cu\u7684\u65e0\u87af\u5408\u5242\u540e\u6807\u8bb0\u65b9\u6cd5\u7684\u793a\u610f\u56fe\u3002\uff08i\uff09\u9759\u8109\u6ce8\u5c04\u5177\u6709RGD\u9776\u5411\u57fa\u56e2\u768464 Cu Au\u7eb3\u7c73\u68d2\u540e4, 16, 24\u548c45 h\u7684\u4ee3\u8868\u6027U87MG\u8377\u7624\u5c0f\u9f20\u7684\u5168\u8eab\u51a0\u72b6PET\u56fe\u50cf\u3002\uff08j\uff09\u5728\u6ca1\u6709\u548c\u6ca1\u6709\u6ce8\u5c04\u5177\u6709RGH\u9776\u5411\u57fa\u56e2\u7684Au\u7eb3\u7c73\u68d2\u7684\u60c5\u51b5\u4e0b\uff0c\u5728PTT\u671f\u95f4\u643a\u5e26U87MG\u80bf\u7624\u7684\u5c0f\u9f20\u4e2d\u7684\u80bf\u7624\u7684\u70ed\u56fe\u50cf\u548c\uff08k\uff09\u76f8\u5e94\u7684\u6e29\u5ea6\u4e0a\u5347\u66f2\u7ebf\u3002
\n \"\"Figure 8.\uff08a\uff09\u7528\u4e8e\u591a\u6a21\u6001\u6210\u50cf\u548cPTT\u7684NP\u6a21\u677f\u5916\u5408\u6210\u91d1\u5c5e\u79bb\u5b50\/\u5355\u5b81\u9178\u58f3\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09\u6ce8\u5c04\u805a\u5408\u7269NP @ FeIII<\/sup> \/\u97a3\u9178\u58f3\u4e4b\u524d\u548c\u4e4b\u540e\u80bf\u7624\u7684T1\u52a0\u6743MRI\u6210\u50cf\u3002\uff08c\uff09\u5206\u522b\u6ce8\u5c04PBS\u548c\u805a\u5408\u7269NP @ FeIII<\/sup> \/\u97a3\u9178\u58f3\u7684\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u7684\u70ed\u6210\u50cf\u3002\uff08d\uff09STEM\uff0c\uff08e\uff09Cu7<\/sub>S4<\/sub>-Au NPs\u7684HAADF-STEM\u56fe\u50cf\u548c\uff08f\uff09Cu7<\/sub>S4<\/sub>-Au NPs\u7684\u76f8\u5e94\u5143\u7d20\u6620\u5c04\u3002\uff08g\uff09\u6ce8\u5c04Cu7<\/sub>S4<\/sub>-Au NPs\u4e4b\u524d\u548c\u4e4b\u540e\u4f53\u5185\u80bf\u7624\u76841<\/sup>H-\u548c19<\/sup>F-MRI\u6210\u50cf\u3002\uff08h\uff09PTT\u671f\u95f4\u80bf\u7624\u533a\u57df\u7684\u6e29\u5ea6\u4e0a\u5347\u66f2\u7ebf\u3002<\/p>\n

2.3\u3001\u901a\u8fc7NIR-II PTAs\u589e\u5f3aPTT\u7597\u6548<\/strong>
\n \"\"Figure 9. \uff08a\uff09\u6df7\u5408\u591a\u5df4\u80fa\u548cAu\u524d\u4f53\u5408\u6210\u7b49\u79bb\u5b50\u4f53\u9ed1\u4f53\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09\u7b49\u79bb\u5b50\u4f53\u9ed1\u4f53\u7684TEM\u56fe\u50cf\u3002\uff08c\uff09PTT\u4e0a\u5177\u6709808 nm\u548c1064 nm\u6fc0\u5149\u7684PTT\u5728\u8986\u76d6\u67095 mm\u7ec4\u7ec7\u76844T1\u80bf\u7624\u4e0a\u7684\u793a\u610f\u56fe\u548cPTT\u540e\u7684\u5c0f\u9f20\u56fe\u7247\u3002\uff08d\uff09\u5728808 nm\u548c1064 nm\u6fc0\u5149\u5668\u4ee5\u5176MPE\u5242\u91cf\u7167\u5c04\u7684PTT\u671f\u95f4\u80bf\u7624\u533a\u57df\u7684\u6e29\u5ea6\u66f2\u7ebf\u548c\uff08e\uff09\u76f8\u5e94\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

2.4\u3001\u901a\u8fc7NP\u5de5\u7a0b\u589e\u5f3aPTAs\u7684PCE<\/strong>
\n \"\"Figure 10. \uff08a\uff09\u7167\u5c04NPs\u5206\u6563\u4f53\u65f6\u900f\u5c04\u548c\u6563\u5c04\u5149\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09\u5438\u6536\u548c\u6563\u5c04\u5149\u8c31\u5bf9\u6d88\u5149\u5149\u8c31\u7684\u8d21\u732e\u7684\u793a\u610f\u56fe\u3002\uff08c\uff09\u4ee3\u8868\u4e0d\u540c\u80fd\u91cf\u8f6c\u79fb\u673a\u5236\u7684\u793a\u610f\u56feJablonski\u56fe\u3002<\/p>\n

\"\"<\/p>\n

Figure 11. \uff08a\uff09\u5149\u8bf1\u5bfc\u7535\u5b50\u8f6c\u79fb\u8bf1\u5bfc\u7684\u6269\u589e\u6cbb\u7597\u8bca\u65adSPNP\u7684\u56fe\u793a\u3002 \uff08b\uff09\u8367\u5149\u7684\u4f53\u5916\u5b9a\u91cf\u3002\uff08c\uff09\u4f53\u5185PTT\uff1a\u4f5c\u4e3a\u6fc0\u5149\u7167\u5c04\u65f6\u95f4\uff08\u5728\u6ce8\u5c04\u540e6 h\uff09\u7684\u51fd\u6570\u7684\u5e73\u5747\u80bf\u7624\u6e29\u5ea6\u548c\uff08d\uff09\u5168\u8eab\u65bd\u7528\u76d0\u6c34\uff0cSPNP-F0\u6216\u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\uff0c\u6216 SPNP-F20\u3002\uff08e\uff09\u901a\u8fc7\u5355\u7ebf\u6001\u6c27\u4f20\u611f\u5668\u7eff\u8272\uff08SOSG\uff09\u8367\u5149\u5b9a\u91cf\u7684\u6fc0\u5149\u7167\u5c041 min\u540e\u7531\u535f\u5549\u4f53\u5408\u6210Mn-\u535f\u5549\u4f53\u7eb3\u7c73\u56ca\u6ce1\u548c\u5355\u7ebf\u6001\u6c27\u7684\u793a\u610f\u56fe\u3002\"\"<\/p>\n

Figure 12. \uff08a\uff09\u80bd-\u535f\u5549\u7f00\u5408\u7269\uff08TPP-G-FF\uff09\u5206\u5b50\u7ed3\u6784\u548c\u81ea\u7ec4\u88c5\u6210\u5149\u70ed\u80bd-\u535f\u5549\u7eb3\u7c73\u70b9\uff08PPP-ND\uff09\u3002\uff08b\uff09PPP-ND\u5728\u6c34\uff08\u9ed1\u8272\uff09\u548cTPPG-FF\u5728\u4e59\u9187\uff08\u7ea2\u8272\uff09\u4e2d\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u5149\u8c31\u3002\uff08c\uff09\u5728\u4f53\u5185\u8fde\u7eed\u7167\u5c04\u4e0b\u9759\u8109\u6ce8\u5c04PPP-ND\u6ce8\u5c04\u5c0f\u9f20\u7684IR\u70ed\u56fe\u50cf\u3002<\/p>\n

2.5\u3001\u589e\u52a0PTAs\u80bf\u7624\u5904\u79ef\u7d2f<\/strong><\/p>\n

2.5.1\u3001\u6539\u53d8PTA\u7684\u8868\u9762\u5316\u5b66\u4ee5\u589e\u5f3a\u80bf\u7624\u79ef\u7d2f<\/strong>
\n \"\"Figure 13. \uff08a\uff09\u5177\u6709PEG\u6d82\u5c42\u7684SPPVN\u7684\u5408\u6210\u7684\u793a\u610f\u56fe\uff0c\u6240\u8ff0PEG\u6d82\u5c42\u901a\u8fc7\u88ab\u52a8\u9776\u5411\u5728\u80bf\u7624\u4e2d\u7d2f\u79ef\u3002\uff08b\uff09\u901a\u8fc7\u4e3b\u52a8\u9776\u5411\u5728\u80bf\u7624\u4e2d\u79ef\u7d2fPFOB@IR825-HA-CY5.5 NP\u7684\u793a\u610f\u56fe\u3002\uff08c\uff09\u5177\u6709\u764c\u7ec6\u80de\u819c\u5305\u8863\u7684Dox NPs @ ICG @ CCC NPs\u7684\u5408\u6210\u7684\u793a\u610f\u56fe\u3002<\/p>\n

2.5.2\u3001\u8bbe\u8ba1PTA\u7684\u5927\u5c0f\u548c\u5f62\u72b6\u4ee5\u589e\u5f3a\u80bf\u7624\u79ef\u7d2f<\/strong>
\n \"\"Figure 14.\uff08a\uff09Au\u7eb3\u7c73\u73af\u3001Au\u7eb3\u7c73\u7403\u548cAu\u7eb3\u7c73\u7247\u5bf9\u5de8\u566c\u7ec6\u80de\u6444\u53d6\u548c\u80bf\u7624\u7d2f\u79ef\u7684\u5f62\u72b6\u6548\u5e94\u7684\u7814\u7a76\u7684\u793a\u610f\u56fe\u3002\uff08b\u3001c\uff09Au\u7eb3\u7c73\u73af\u3001Au\u7eb3\u7c73\u7247\u548cAu\u7eb3\u7c73\u7403\u7684\u5de8\u566c\u7ec6\u80de\u6444\u53d6\u3002\uff08d\uff09\u5728\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u7684\u5c0f\u9f20\u7684\u4ee3\u8868\u6027\u5168\u8eab\u51a0\u72b6PET\u56fe\u50cf\uff0c\u6307\u793aAu\u7eb3\u7c73\u73af\u3001Au\u7eb3\u7c73\u7403\u548cAu\u7eb3\u7c73\u7247\uff08\u4ece\u4e0a\u5230\u4e0b\uff09\u7684\u751f\u7269\u5206\u5e03\u548c\u80bf\u7624\u7d2f\u79ef\u4ee5\u53ca\u76f8\u5e94\u7684\u5e73\u5747\u6444\u53d6\u7684\u65f6\u95f4-\u6d3b\u6027\u66f2\u7ebf\u3002\uff08e\uff09\u5fc3\u810f\uff0c\uff08f\uff09\u809d\u810f\uff0c\uff08g\uff09\u813e\u810f\u548c\uff08h\uff09\u80bf\u7624\u4e2d\u7684\u8fd9\u4e9b\u7eb3\u7c73\u7ed3\u6784\u3002<\/p>\n

2.5.3\u3001\u54cd\u5e94\u65f6\u95f4\u589e\u52a0PTA\u7684\u80bf\u7624\u79ef\u7d2f<\/strong>
\n \"\"Figure 15. \uff08a\uff09POM\u56e2\u7c07\u5728\u9178\u6027\u73af\u5883\u4e2d\u81ea\u7ec4\u88c5\u6210\u5927\u805a\u96c6\u4f53\u7684\u793a\u610f\u56fe\u3002 \uff08b\uff09\u8868\u793a\u5728\u9178\u6027pH\u548c\u8fd8\u539f\u73af\u5883\u4e2dPOM\u7c07\u6eb6\u6db2\u5728808 nm\u5904\u7684\u5438\u6536\u589e\u5f3a\u7684\u56fe\u548c\uff08c\uff09\u5728808 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u5b83\u4eec\u7684\u76f8\u5e94\u6e29\u5ea6\u3002\uff08d\uff09\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9POM\u7c07\u7684\u751f\u7269\u5206\u5e03\u548c\u80bf\u7624\u79ef\u7d2f\u3002\uff08e\uff09\u6ce8\u5c04POM\u548c\u5176\u4ed6\u5bf9\u7167\u7ec4\u7684PTT\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002\uff08f\uff09MMP-2\u8bf1\u5bfc\u80bd\u7a33\u5b9a\u7684Au NP\u81ea\u7ec4\u88c5\u6210\u5927\u805a\u96c6\u4f53\u7684\u793a\u610f\u56fe\u3002\uff08g\uff09\u5728\u6ce8\u5c04\u540e\u7684\u4e0d\u540c\u65f6\u95f4\u70b9\u5b9a\u91cfAu NPs @ Pep1\/Pep2\uff0cCtrl1\u548cCtrl2\u7684\u80bf\u7624\u79ef\u7d2f\u3002 \uff08h\uff09\u6ce8\u5c04Au NPs @Pep1\/Pep2\u548c\u5176\u4ed6\u5bf9\u7167\u7ec4\u7684PTT\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002<\/p>\n

2.5.4\u3001\u901a\u8fc7\u5149\u70ed\u6548\u5e94\u589e\u5f3aPTA\u7684\u80bf\u7624\u9012\u9001<\/strong>
\n \"\"Figure 16. \uff08a\uff09PLT-Au\u7eb3\u7c73\u68d2\u7684\u5236\u5907\u548c\u5149\u70ed\u8bf1\u5bfc\u7684PLT-Au\u7eb3\u7c73\u68d2\u7684\u80bf\u7624\u6444\u53d6\u589e\u5f3a\u4ee5\u6539\u5584PTT\u7684\u793a\u610f\u56fe\u3002 \uff08b\uff09\u6ce8\u5165Au\u7eb3\u7c73\u68d2\uff08\u9ed1\u8272\uff09\uff0cPLT\u819c\u8986\u76d6\u7684Au\u7eb3\u7c73\u68d2\uff08PLT-M-Au\u7eb3\u7c73\u68d2\uff09\uff08\u7ea2\u8272\uff09\u548cPLT-Au\u7eb3\u7c73\u68d2\uff08\u84dd\u8272\uff09\u540e\u7684Au\u7684\u8840\u6db2\u6d53\u5ea6\u3002\uff08c\uff09\u5728\u6709\u6216\u6ca1\u6709\u6fc0\u5149\u7167\u5c04\u7684\u540e\u7eed\u5242\u91cf\u6ce8\u5c04\u540ePLT-Au\u7eb3\u7c73\u68d2\u7684\u80bf\u7624\u7d2f\u79ef\u3002\uff08d\uff09\u5728\u6bcf\u6b21\u5149\u70ed\u5904\u7406\u4e4b\u524d\u548c\u4e4b\u540e\u643a\u5e26HNSCC\u7684Tgfbr1\/Pten 2cKO\u5c0f\u9f20\u7684\u4ee3\u8868\u6027\u70ed\u56fe\u50cf\u3002\u4ece\u4e0a\u5230\u4e0b\u5206\u522b\u6ce8\u5c04Au\u7eb3\u7c73\u68d2\uff0cPLT-M-Au\u7eb3\u7c73\u68d2\u548cPLT-Au\u7eb3\u7c73\u68d2\u3002\uff08e\uff09\u5149\u70ed\u89e6\u53d1\u7684PCB-Bro\u5bf9\u80f6\u539f\u7684\u589e\u5f3a\u7684\u6d88\u5316\u6d3b\u6027\u7684\u793a\u610f\u56fe\uff0c\u4ee5\u589e\u52a0\u80bf\u7624\u4e2d\u7684NP\u79ef\u7d2f\u3002\uff08f\uff09\u5728\u6ce8\u5c04PCB\u548cPCB-Bro\u540e\u4e0d\u540c\u65f6\u95f4\u80bf\u7624\u533a\u57df\u7684\u8367\u5149\u5f3a\u5ea6\uff0c\u4f7f\u7528\u6216\u4e0d\u4f7f\u7528NIR\u6fc0\u5149\u7167\u5c04\u80bf\u7624\u533a\u57df\u3002\uff08g\uff09\u6ce8\u5c04PCB-Bro\uff08\u7b2c\u4e00\u6392\uff09\u3001PCB\uff08\u7b2c\u4e8c\u6392\uff09\u548c\u76d0\u6c34\uff08\u7b2c\u4e09\u6392\uff09\u540e6\u5c0f\u65f6\u8377\u7624\u5c0f\u9f20\u7684\u70ed\u56fe\u50cf\uff0c\u80bf\u7624\u66b4\u9732\u4e8eNIR\u6fc0\u51495 min\u3002<\/p>\n

3\u3001PTT\u4e0e\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408<\/strong><\/p>\n

\u5355\u4e00\u7597\u6cd5\u901a\u5e38\u4e0d\u8db3\u4ee5\u5f15\u53d1\u8db3\u591f\u7684\u6cbb\u7597\u53cd\u5e94\uff0cPTT\u4e5f\u4e0d\u4f8b\u5916\u3002\u867d\u7136\u5177\u6709\u5f88\u597d\u7684\u6cbb\u7597\u6548\u679c\uff0c\u4f46\u662f\u4e5f\u6709\u5b83\u4eec\u7684\u9650\u5236\uff0c\u4f8b\u5982\u5149\u7a7f\u900f\u6df1\u5ea6\u4e0d\u8db3\u53ef\u80fd\u5bfc\u81f4\u764c\u7ec6\u80de\u7684\u4e0d\u5b8c\u5168\u6d88\u9664\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u6cbb\u7597\u8fb9\u7f18\u7684\u6b8b\u7559\u80bf\u7624\u7ec6\u80de\uff0c\u5bfc\u81f4\u80bf\u7624\u590d\u53d1\u548c\u8fdc\u5904\u5668\u5b98\u7684\u8f6c\u79fb\u3002PTT\u548c\u5176\u4ed6\u7597\u6cd5\u7684\u7ec4\u5408\u53ef\u4ee5\u6539\u5584\u6574\u4f53\u6cbb\u7597\u7ed3\u679c\u3002\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\uff0c\u4e0d\u540c\u7597\u6cd5\u7684\u7ec4\u5408\u4e0d\u662f\u7b80\u5355\u7684\u6dfb\u52a0\u3002\u76f8\u53cd\uff0c\u4e00\u79cd\u7597\u6cd5\u53ef\u80fd\u4f1a\u53d7\u76ca\u4e8e\u5176\u4ed6\u7597\u6cd5\u7684\u7ed3\u679c\u6216\u6548\u679c\uff0c\u4ece\u800c\u5b9e\u73b0\u534f\u540c\u6cbb\u7597\u6548\u679c\u3002\u56e0\u6b64\uff0cPTT\u4e0e\u5176\u4ed6\u7597\u6cd5\u7684\u7ed3\u5408\u5177\u6709\u5b9e\u73b0\u534f\u540c\u6548\u5e94\u548c\u6539\u5584\u6cbb\u7597\u6027\u80fd\u7684\u5de8\u5927\u6f5c\u529b\u3002<\/p>\n

3.1\u3001PTT\u8054\u5408\u5316\u7597<\/strong>
\n \"\"Figure 17. \uff08a\uff09\u542b\u6709Pt\uff08IV\uff09\u524d\u836f\u548cCypate\uff08P\/C-\u80f6\u675f\uff09\u7684\u80f6\u675f\u7528\u4e8e\u514b\u670dMDR\u4ee5\u53caPTT\u548c\u5316\u5b66\u7597\u6cd5\u7684\u7ec4\u5408\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09A549R\u548cA549\u7ec6\u80de\u4ee5\u6e38\u79bb\u836f\u7269\u6216P\/C-\u80f6\u675f\u7684\u6709\u6548\u8f7d\u8377\u7684\u5f62\u5f0f\u6444\u53d6Pt\uff08IV\uff09\u524d\u836f\u3002\uff08c\uff09\u4e0e\u542b\u6709\u80f6\u675f\u7684\u6e38\u79bbPt\uff08IV\uff09\u524d\u836f\u6216Pt\uff08IV\uff09\u524d\u836f\u4e00\u8d77\u6e29\u80b2\u540e\uff0c\u6765\u81eaA549R\u548cA549\u7ec6\u80de\u7684Pt\uff08IV\uff09\u524d\u836f\u7684\u6d41\u51fa\u3002\uff08d\uff09\u5149\u70ed\u6548\u5e94\u548cGSH\u5f15\u53d1\u7684\u4ece\u8d85\u5206\u5b50\u80f6\u675f\u91ca\u653e\u836f\u7269\u7684\u793a\u610f\u56fe\u3002\uff08e\uff09\u7528PTT\u548c\u5316\u7597\u548c\u5176\u4ed6\u5bf9\u7167\u7597\u6cd5\u7684\u7ec4\u5408\u6cbb\u7597\u7684\u539f\u4f4d4T1\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u80bf\u7624\u751f\u957f\u66f2\u7ebf\u3002\uff08f\uff09\u6bcf\u7ec4\u80ba\u8868\u9762\u5b58\u5728\u7684\u80bf\u7624\u7ed3\u8282\u6570\u3002<\/p>\n

3.2\u3001PTT\u8054\u5408\u514d\u75ab\u6cbb\u7597<\/strong>
\n \"\"Figure 18\uff0e\uff08a\uff09\u5c16\u523aAu NP @\u591a\u5df4\u80fa\u6838-\u58f3NP\uff08SGNP @ PDA\uff09\u7684\u5408\u6210\u793a\u610f\u56fe\u3002\uff08b\uff09PTT\u548c\u4e9a\u6cbb\u7597\u5242\u91cf\u7684Dox\u7684\u7ec4\u5408\u5982\u4f55\u89e6\u53d1\u6297\u80bf\u7624\u514d\u75ab\u6cbb\u7597\u539f\u53d1\u6027\u80bf\u7624\u548c\u80bf\u7624\u8f6c\u79fb\u4ee5\u53ca\u9884\u9632\u80bf\u7624\u590d\u53d1\u7684\u793a\u610f\u56fe\u3002<\/p>\n

3.3\u3001\u7ed3\u5408PTT\u4e0ePDT\u6216\u5149\u70ed\u8bf1\u5bfc\u7684\u4ea7\u751fROS\u7597\u6cd5<\/strong>
\n \"\"Figure 19. \uff08a\uff09\u7528\u4e8e\u5149\u7597\u7684Au\u7eb3\u7c73\u7b3c-Ce6\u7eb3\u7c73\u7ed3\u6784\u7684\u793a\u610f\u56fe\uff0c\u63a5\u7740\u662fAu\u7eb3\u7c73\u676f\u7684\u4ee3\u8868\u6027SEM\u3002 \uff08b\uff09IRDye800CW\u6807\u8bb0\u7684\u5149\u654f\u5242ZnF16<\/sub>Pc\u8d1f\u8f7d\u7684PDI\u7eb3\u7c73\u6ef4\uff08PS-PDI-PAnD\uff09\uff0c\u7528\u4e8e\u4f53\u5185\u591a\u6a21\u6210\u50cf\u5f15\u5bfc\u7684\u7ec4\u5408\u5149\u70ed\u548c\u6c27\u81ea\u5bcc\u96c6PDT\u548c\u4ee3\u8868\u6027TEM\u3002\uff08c\uff09AIBI @ Au\u7eb3\u7c73\u7b3c\u5171\u805a\u7269\u5408\u6210\u53ca\u5176NIR\u54cd\u5e94\u6027\u81ea\u7531\u57fa\u91ca\u653e\u80fd\u529b\u3002\uff08d\uff09Au\u7eb3\u7c73\u7b3c\u7684TEM\u3002\uff08e\uff09\u5728\u5e38\u6c27\u548c\u7f3a\u6c27\u6761\u4ef6\u4e0b\uff0cAu\u7eb3\u7c73\u7b3c\u3001AIBI\u548cAIBI @ Au\u7eb3\u7c73\u7b3c\u5bf94T1\u7ec6\u80de\u7684\u5149\u6bd2\u6027\uff08f\uff09\u70ed\u54cd\u5e94\u6027HCP @ HPE\u5355\u5206\u5b50\u80f6\u675f\u7684\u5408\u6210\u548c2P-FRET\u4e0eNIR\u5bf9PDT\u7684\u5149\u70ed\u6548\u5e94\u7684\u7ec4\u5408\u7684\u8bf4\u660e\u3002\uff08g\uff09\u5728650 nm\u6216800 nm\u7167\u5c04\u540e\uff0c\u643a\u5e26HeLa\u80bf\u7624\u7684\u88f8\u9f20\u4f53\u5185\u80bf\u7624\u751f\u957f\u3002\uff08h\uff09\u6784\u4ef6\u7684\u5316\u5b66\u7ed3\u6784\uff0cPc-4TEG\u548cPc-4TEG-B\u3002\uff08i\uff09\u4f7f\u7528TEM\u6d4b\u5b9a\uff0c\u5728\u52a0\u5165\u6297\u751f\u7269\u7d20\u86cb\u767d\u4e4b\u524d\u548c\u4e4b\u540e\u4ee5\u53ca\u5728\u9759\u7f6e24 h\u4e4b\u540e\uff0c\u5728\u6c34\u4e2dNanoPcTB\u5f62\u6001\u53d1\u751f\u53d8\u5316\u3002<\/p>\n

3.4\u3001PTT\u8054\u5408\u5916\u79d1\u624b\u672f<\/strong>
\n \"\"Figure 20. \uff08a\uff09\u5e38\u89c4PTT\uff08cPTT\uff09\u548c\u80bf\u7624\u533a\u57df\u4e2d\u6fc0\u5149\u80fd\u91cf\u7684\u6a21\u62df\u5206\u5e03\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09aPTT\u7684\u793a\u610f\u56fe\u548c\u624b\u672f\u5e8a\u4e2d\u6fc0\u5149\u80fd\u91cf\u7684\u6a21\u62df\u5206\u5e03\u3002 \uff08c\uff09cPTT\u548caPTT\u671f\u95f4\u8377\u7624\u5c0f\u9f20\u7684\u70ed\u56fe\u50cf\u3002\uff08d\uff09\u4e0d\u540c\u6cbb\u7597\u7ec4\u7684\u4e0d\u540c\u80bf\u7624\u5c0f\u9f20\u7684\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff0c\u5305\u62ec\u5bf9\u7167\u7ec4\u3001\u4ec5\u7528\u624b\u672f\u6cbb\u7597\u7684\u7ec4\u3001\u4ec5\u7528cPTT\u6cbb\u7597\u7684\u7ec4\u4ee5\u53ca\u7528\u624b\u672f\u548caPTT\u7ec4\u5408\u6cbb\u7597\u7684\u7ec4\u3002<\/p>\n

4\u3001\u901a\u8fc7PAI\u6539\u5584\u764c\u75c7\u8bca\u65ad\u548c\u6cbb\u7597<\/strong><\/p>\n

4.1\u3001\u7528\u4e8e\u80bf\u7624\u6210\u50cf\u7684PAI\u7eb3\u7c73\u63a2\u9488<\/strong>
\n \"\"Figure 21. \uff08a\uff09TPA\u7684\u57fa\u672c\u5316\u5b66\u7ed3\u6784\u548c\u901a\u8fc7\u81ea\u7ec4\u88c5\u8bf4\u660e\u6cbb\u7597\u8bca\u65ad\u7684TNM\u3002\uff08b\uff09\u5728710 nm\u6fc0\u5149\u7167\u5c04\u4e0b\u901a\u8fc7\u5c3e\u9759\u8109\u6ce8\u5c04TNM\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u80bf\u7624\u7ec4\u7ec7\uff08\u7bad\u5934\uff09\u7684\u4f53\u5185\u5149\u58f0\uff08MSOT\uff09\u56fe\u50cf\u3002\uff08c\uff09\u9776\u5411SPNP\uff08SPNP10-RGD\uff09\u7684\u5408\u6210\u3002\uff08d\uff09\u5206\u522b\u5728\u5168\u8eab\u65bd\u7528SPNP10-RGD\u6216SPNP10\u540e0, 4\u548c24 h\u7684\u80bf\u7624\u4f53\u5185PAI\u3002<\/p>\n

4.2\u3001\u7528\u4e8e\u6dcb\u5df4\u7ed3\u6210\u50cf\u548c\u7ec6\u80de\u8ffd\u8e2a\u7684PA\u7eb3\u7c73\u63a2\u9488<\/strong>
\n \"\"Figure 22. \uff08a\uff09PDI NP\u5408\u6210\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09\u4ee3\u8868\u6027\u8986\u76d6\u51a0\u72b6PAI\u548c\u8d85\u58f0\u56fe\u50cf\uff0c\u5176\u663e\u793a\u5728\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9pop\u7a9d\u6dcb\u5df4\u7ed3\uff08LN\uff09\u548c\u5750\u9aa8\u795e\u7ecfLN\u4e2d\u7684\u5c3a\u5bf8\u4f9d\u8d56\u6027\u6444\u53d6\u3002\uff08c\uff09\u901a\u8fc7\u4f53\u5185\u6e17\u6f0f\u7684\u8109\u7ba1\u7cfb\u7edf\u5c06Au\u7f00\u5408\u7269\u5168\u8eab\u9012\u9001\u548c\u79ef\u805a\u5230\u80bf\u7624\u4e2d\u3002\uff08d\uff09PNB\u7684\u58f0\u5b66\u4fe1\u53f7\u751a\u81f3\u62a5\u544a\u5b9e\u4f53\u7ec4\u7ec7\u4e2d\u7684\u5355\u4e2a\u764c\u7ec6\u80de\u3002<\/p>\n

4.3\u3001\u7528\u4e8eTME\u6210\u50cf\u7684PAI\u7eb3\u7c73\u63a2\u9488<\/strong>
\n \"\"Figure 23. \uff08a\uff09\u52a8\u6001\u5149\u6563\u5c04\uff0cTEM\u56fe\u50cf\u548c\uff08b\uff09SON50<\/sub>\u5728\u4e0d\u540cpH\u503c\u4e0b\u7684\u7d2b\u5916-\u53ef\u89c1\u5438\u6536\u5149\u8c31\u3002\uff08c\uff09\u9759\u8109\u5185\u65bd\u7528SON50\u4e4b\u524d\u548c\u4e4b\u540e6 h\u88f8\u9f20\u4e2d\u76ae\u4e0bHeLa\u80bf\u7624\u7684\u5149\u58f0\u548c\u6bd4\u7387\u56fe\u50cf\uff08\u2206PAI680<\/sub>\/\u2206PAI750<\/sub>\uff09\u3002\uff08d\uff09\u5b9a\u91cf680 nm\u5904\u7684\u5149\u58f0\u5f3a\u5ea6\u589e\u91cf\u548c\u4f5c\u4e3aSON50<\/sub>\u6ce8\u5165\u540e\u65f6\u95f4\u7684\u51fd\u6570\u7684\u6bd4\u7387\u5149\u58f0\u4fe1\u53f7\u3002\uff08e\uff09SOA\u7eb3\u7c73\u63a2\u9488\u7684\u4f20\u611f\u673a\u5236\u7684\u793a\u610f\u56fe\u3002\uff08f\uff09\u5728\u4e0d\u5b58\u5728\u548c\u5b58\u5728ClO-\u7684\u60c5\u51b5\u4e0b\u4f53\u5916PAI\u3002\uff08g\uff09\u5bf9PBS\u7f13\u51b2\u6db2\u4e2d\u4e0d\u540cROS\u7684\u6bd4\u7387\u5149\u58f0\u54cd\u5e94\uff08PAI780<\/sub>\/PAI680<\/sub>\uff09\u3002\uff08h\uff09\u9759\u8109\u5185\u65bd\u7528\u7eb3\u7c73\u63a2\u9488\u4e4b\u524d\u548c\u4e4b\u540e2, 4, 6, 8\u548c24 h\u7684\u88f8\u9f20\u76ae\u4e0b4T1\u80bf\u7624\u7684\u4f53\u5185PAI\u548c\u4f5c\u4e3a\u6ce8\u5c04\u540e\u65f6\u95f4\u7684\u51fd\u6570\u7684\u6bd4\u7387\u5149\u58f0\u4fe1\u53f7\u3002\uff08i\uff09\u4f5c\u4e3a\u6ce8\u5c04\u540e\u65f6\u95f4\u7684\u51fd\u6570\u7684\u5149\u58f0\u4fe1\u53f7\u7684\u6bd4\u7387\u5b9a\u91cf\u3002
\n \"\"Figure 24. \uff08a\uff09\u4f53\u5185PAI\u548c\uff08b\uff09\u4f7f\u7528rSPNP2\u6216SPNP2\u5b9a\u91cf\u86cb\u767d\u8d28\u6b21\u78fa\u9178\u3002\uff08c\uff09\u7528\u53cd\u82ef\u786b\u9178\u6297\u4f53\u8fdb\u884c\u514d\u75ab\u8367\u5149\u67d3\u8272\u7684\u673a\u5236\u548c\u7ec4\u7ec7\u5b66\u5206\u6790\u7684\u8bf4\u660e\u3002\uff08d\uff09\u6ce8\u5c04\u540e48 h\u7528rSPNP2\u6216SPNP2\u5904\u7406\u7684\u5c0f\u9f20\u7684\u80bf\u7624\u5207\u7247\u7684\u8367\u5149\u663e\u5fae\u955c\u68c0\u67e5\uff08\u6765\u81earSPNP2\u6216SPNP2\u7684\u7ea2\u8272\u4fe1\u53f7\uff0c\u6765\u81ea\u7528\u6297\u786b\u9178\u6297\u4f53\u67d3\u8272\u7684\u7eff\u8272\u4fe1\u53f7\u548c\u6765\u81ea\u7ec6\u80de\u6838\u67d3\u8272\u7684\u84dd\u8272\uff09\u3002\uff08e\uff09\u5728\u6ce8\u5c04HyP-1\u4e4b\u524d\u548c\u4e4b\u540e5 h\uff0c\u643a\u5e26\u80bf\u7624\u548c\u5bf9\u7167\u4fa7\u7ffc\u7684\u4f53\u5185\u5149\u58f0\u56fe\u50cf\uff08770 nm\uff09\u3002\uff08f\uff09\u7f3a\u8840\u80a2\u4f53\u548c\u5bf9\u7167\u7684\u65f6\u95f4\u4f9d\u8d56\u6027\u5149\u58f0\u4fe1\u53f7\u3002<\/p>\n

4.4\u3001\u4e0b\u4e00\u4ee3\u7684PAI\u5bf9\u6bd4\u5242<\/strong>
\n \"\"Figure 25. \uff08a\uff09\u5236\u5907SPNP-II\u7684\u793a\u610f\u56fe\u3002\uff08b\uff09SPNP-II\u7684UV-vis-NIR\u5438\u6536\u5149\u8c31\u3002\uff08c\uff09\u5728750\uff08NIR-1\uff09\u548c1064 nm\uff08NIR-II\uff09\u6ce8\u5c04SPNP-II\u540e70 min\u7684\u5927\u9f20\u8111\u76ae\u8d28\u7684\u4f53\u5185PAI\u548c\uff08d\uff09SNR\u3002<\/p>\n

5\u3001\u603b\u7ed3\u4e0e\u5c55\u671b<\/strong><\/p>\n

\u603b\u4e4b\uff0c\u7eb3\u7c73\u6280\u672f\u7684\u5feb\u901f\u53d1\u5c55\u6781\u5927\u5730\u4fc3\u8fdb\u4e86PTT\u548cPAI\u5728\u764c\u75c7\u6cbb\u7597\u548c\u8bca\u65ad\u4e2d\u7684\u8fdb\u6b65\u3002PTT\u662f\u4e00\u79cd\u6709\u6548\u7684\u3001\u65e0\u521b\u7684\u3001\u9ad8\u5ea6\u9488\u5bf9\u6027\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u3002\u5df2\u7ecf\u53d1\u660e\u4e86\u5177\u6709\u6539\u8fdb\u7684PCE\u7684\u65b0\u7684\u751f\u7269\u76f8\u5bb9\u4e14\u53ef\u964d\u89e3\u7684PTA\u6750\u6599\uff0c\u5e76\u4e14\u8bc1\u660e\u5176\u81f3\u5c11\u5728\u4e34\u5e8a\u524d\u5b9e\u9a8c\u4e2d\u662f\u6709\u6548\u7684\u3002\u4e00\u76f4\u5728\u7814\u7a76PTA\u7684\u5f62\u72b6\u3001\u5927\u5c0f\u548c\u8868\u9762\u6d82\u5c42\u5bf9\u901a\u8fc7EPR\u6548\u5e94\u6216\u4e3b\u52a8\u9776\u5411\u6539\u5584\u5176\u80bf\u7624\u9012\u9001\u6548\u7387\u7684\u5f71\u54cd\u3002\u968f\u7740\u9776\u5411\u6cbb\u7597\u7684\u8fdb\u6b65\u53d1\u5c55\uff0c\u80bf\u7624\u79ef\u7d2f\u5df2\u7ecf\u53d7\u76ca\u4e8e\u5168\u7403\u5149\u70ed\u6cbb\u7597\u7684\u4e34\u5e8a\u524d\u6210\u529f\u589e\u52a0\u6240\u89c2\u5bdf\u5230\u7684\u3002\u6b64\u5916\uff0c\u5149\u70ed\u6548\u5e94\u53ef\u4ee5\u8c03\u8282TME\u4ee5\u63d0\u9ad8\u80bf\u7624\u9012\u9001\u6548\u7387\uff0c\u8fd9\u53ef\u4ee5\u901a\u8fc7\u5411PTA\u6dfb\u52a0\u54cd\u5e94\u6027\u8d28\u4ee5\u4f7f\u5176\u201c\u806a\u660e\u201d\u6765\u8fdb\u4e00\u6b65\u6539\u5584\u3002\u6700\u91cd\u8981\u7684\u662f\uff0c\u5df2\u7ecf\u5f7b\u5e95\u7814\u7a76\u4e86\u65b0\u7684\u9897\u7c92\u5185\u5de5\u7a0b\u65b9\u6cd5\uff0c\u4ee5\u6700\u5927\u5316\u975e\u8f90\u5c04\u80fd\u91cf\u8f6c\u79fb\uff0c\u4ece\u800c\u5bfc\u81f4\u66f4\u9ad8\u7684PCE\u3002\u8fd9\u6210\u529f\u5730\u5bfc\u81f4\u4e86\u591a\u6a21\u5f0f\u6210\u50cf\u5f15\u5bfcPTT\u7684\u53d1\u5c55\uff0c\u5bfc\u81f4\u5728\u4f53\u5185\u52a8\u7269\u6a21\u578b\u4e2d\u540c\u65f6\u76d1\u6d4b\u6cbb\u7597\u529f\u6548\u548c\u6cbb\u7597\u53cd\u5e94\u3002\u6b64\u5916\uff0c\u4e0e\u5355\u72ec\u7684PTT\u76f8\u6bd4\uff0c\u5c06PTT\u4e0e\u5176\u4ed6\u7597\u6cd5\u76f8\u7ed3\u5408\u53ef\u4ee5\u6f5c\u5728\u5730\u6cbb\u7597\u6fc0\u5149\u7167\u5c04\u8303\u56f4\u4e4b\u5916\u7684\u80bf\u7624\u5e76\u83b7\u5f97\u66f4\u597d\u7684\u6cbb\u7597\u6548\u679c\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aPhotothermal therapy and photoacoustic imaging via nanotheranostics in fighting cancer<\/a><\/strong>\uff08Chem. Soc. Rev., 2018<\/strong>, DOI: 10.1039\/c8cs00618k\uff09<\/p>\n

\n \u901a\u8baf\u4f5c\u8005\u53ca\u5176\u56e2\u961f\u7b80\u4ecb<\/strong><\/p>\n

\u9648\u5c0f\u5143\u6559\u6388\uff1a<\/strong>1993\u5e74\u548c1996\u5e74\u5206\u522b\u83b7\u5f97\u5357\u4eac\u5927\u5b66\u5316\u5b66\u5b66\u58eb\u548c\u7855\u58eb\u5b66\u4f4d\uff0c\u968f\u540e1999\u5e74\u83b7\u5f97\u7f8e\u56fd\u7231\u8fbe\u8377\u5927\u5b66\u535a\u58eb\u5b66\u4f4d\u3002\u7ecf\u8fc7Syracuse\u5927\u5b66\u548cWashington\u5927\u5b66\u5723\u8def\u6613\u5206\u6821\u535a\u58eb\u540e\u8bad\u7ec3\uff0c\u4e8e2002\u5e74\u8fdb\u5165\u5357\u52a0\u5dde\u5927\u5b66\u653e\u5c04\u5b66\u7cfb\u4efb\u52a9\u7406\u6559\u6388\uff0c2004\u5e74\u8f6c\u5165\u65af\u5766\u798f\u5927\u5b66\uff0c2008\u5e74\u5347\u4e3a\u526f\u6559\u6388\u30022009\u5e74\u9648\u535a\u58eb\u52a0\u5165\u7f8e\u56fd\u56fd\u7acb\u536b\u751f\u7814\u7a76\u9662(NIH)\u751f\u7269\u533b\u5b66\u5f71\u50cf\u53ca\u533b\u5b66\u5de5\u7a0b\u6240(NIBIB)\u4efb\u7ec8\u8eab\u8d44\u6df1\u7814\u7a76\u5458<\/strong>\uff0c\u5206\u5b50\u5f71\u50cf\u53ca\u7eb3\u7c73\u533b\u5b66\u5b9e\u9a8c\u5ba4\u4e3b\u4efb\u30022010\uff0c2012\u5e74\u83b7NIBIB Mentor Award, 2014\u5e74\u83b7 NIH Director\u2019s Award<\/strong>\u3002\u9648\u535a\u58eb\u7684\u79d1\u7814\u65b9\u5411\u4e3b\u8981\u6d89\u53ca\u4f53\u5916\u8bca\u65ad\uff0c\u4f53\u5185\u6210\u50cf\uff0c\u57fa\u56e0\/\u836f\u7269\u7684\u7eb3\u7c73\u8f7d\u4f53\uff0c\u4ee5\u53ca\u8bca\u7597\u4e00\u4f53\u5316\u3002ACS Nano\u7b49\u591a\u5bb6\u6742\u5fd7\u7684\u7f16\u59d4\uff0cTheranostics\u6742\u5fd7\u7684\u521b\u520a\u4e3b\u7f16\uff0c\u4e2d\u7f8e\u6838\u533b\u5b66\u53ca\u5206\u5b50\u5f71\u50cf\u5b66\u4f1a(CASNMMI)\u524d\u4efb\u4e3b\u59d4\uff0c\u4e2d\u7f8e\u7eb3\u7c73\u533b\u5b66\u53ca\u7eb3\u7c73\u751f\u7269\u6280\u672f\u5b66\u4f1a\uff08CASNN\uff09\u73b0\u4efb\u4e3b\u59d4\u3002<\/p>\n

\u6234\u5fd7\u98de\u6559\u6388\uff1a\u00a0<\/strong>\u5317\u4eac\u5927\u5b66\u5de5\u5b66\u9662\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u7cfb\uff0c\u6559\u6388\uff0c\u535a\u5bfc\uff0c\u56fd\u5bb6\u6770\u51fa\u9752\u5e74\u57fa\u91d1\u83b7\u5f97\u8005\u3001\u6559\u80b2\u90e8\u65b0\u4e16\u7eaa\u4f18\u79c0\u4eba\u624d\u3001\u56fd\u5bb6\u91cd\u70b9\u7814\u53d1\u8ba1\u5212\u9996\u5e2d\u79d1\u5b66\u5bb6<\/strong>\u30021998\u5e74\u4e8e\u4e2d\u79d1\u9662\u7406\u5316\u6240\u83b7\u535a\u58eb\u5b66\u4f4d\u5e76\u7559\u6240\u5de5\u4f5c\uff0c\u5148\u540e\u524d\u5f80\u65e5\u672c\u3001\u5fb7\u56fd\u548c\u7f8e\u56fd\u5de5\u4f5c\u30022005\u5e74\u88ab\u54c8\u5de5\u5927\u751f\u547d\u79d1\u5b66\u9662\u5f15\u8fdb\u56de\u56fd\uff0c2012\u5e74\u52a0\u76df\u5317\u4eac\u5927\u5b66\u5de5\u5b66\u9662\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u7cfb\u3002\u73b0\u62c5\u4efb\u4e2d\u56fd\u533b\u5e08\u534f\u4f1a\u4ecb\u5165\u533b\u5e08\u5206\u4f1a\u4ecb\u5165\u533b\u5b66\u5de5\u7a0b\u4e13\u59d4\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3001\u4e2d\u56fd\u751f\u7269\u533b\u5b66\u5149\u5b50\u5b66\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3001\u4e2d\u56fd\u533b\u836f\u751f\u7269\u6280\u672f\u534f\u4f1a\u7eb3\u7c73\u751f\u7269\u6280\u672f\u5206\u4f1a\u526f\u4e3b\u4efb\u59d4\u5458\u3001\u4e2d\u56fd\u533b\u5b66\u8d85\u58f0\u88c5\u5907\u534f\u4f1a\u5e38\u52a1\u59d4\u5458\uff0c\u4e2d\u56fd\u8d85\u58f0\u5206\u5b50\u5f71\u50cf\u4e13\u4e1a\u59d4\u5458\u4f1a\u5e38\u52a1\u59d4\u5458\u3001\u4e2d\u56fd\u58f0\u5b66\u5b66\u4f1a\u59d4\u5458\uff0cBioconjugate Chem\u526f\u4e3b\u7f16\uff0c\u4ee5\u53caTheranostics\u3001J Interdiscip Nanomed\u3001\u300a\u4e2d\u534e\u6838\u533b\u5b66\u4e0e\u5206\u5b50\u5f71\u50cf\u6742\u5fd7\u300b\u7b49\u671f\u520a\u7f16\u59d4\u3002<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n

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