{"id":154346,"date":"2018-09-26T06:20:57","date_gmt":"2018-09-25T22:20:57","guid":{"rendered":"\/\/m.iemloyee.com\/?p=154346"},"modified":"2018-09-25T20:21:28","modified_gmt":"2018-09-25T12:21:28","slug":"%e5%85%b0%e5%b7%9e%e5%a4%a7%e5%ad%a6-%e9%ad%8f%e5%8d%8e-macromolecules-%e5%90%ab%e5%bc%82%e7%9b%b8%e8%81%9a%e5%90%88%e7%89%a9%e5%88%b7%e7%9a%84%e7%8e%af%e7%8a%b6%e5%88%b7%e5%bd%a2%e8%81%9a%e5%90%88","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=154346","title":{"rendered":"\u5170\u5dde\u5927\u5b66 \u9b4f\u534e Macromolecules: \u542b\u5f02\u76f8\u805a\u5408\u7269\u5237\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\u7684\u5236\u5907\u53ca\u5176\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u7684\u7814\u7a76"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u5728\u8fc7\u53bb\u7684\u5341\u5e74\u4e2d\uff0c\u7531\u4e8e\u805a\u5408\u7269\u72ec\u7279\u7684\u62d3\u6251\u7ed3\u6784\uff0c\u81f4\u4f7f\u4ee5\u73af\u72b6\u805a\u5408\u7269\u53ca\u5176\u884d\u751f\u7684\u805a\u5408\u7269\u4e3a\u57fa\u7840\u5e76\u5b9e\u9645\u7814\u7a76\u800c\u51fa\u73b0\u4e86\u65b0\u7684\u6750\u6599\u3002\u6700\u8fd1\uff0c\u542b\u6709\u5bc6\u96c6\u63a5\u679d\u805a\u5408\u7269\u5237\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\uff08cb<\/em>\uff09\u7531\u4e8e\u80fd\u591f\u81ea\u7ec4\u88c5\u5f62\u6210\u6bd4\u5177\u6709\u76f8\u540c\u5206\u5b50\u91cf\u7684\u74f6\u5237\u5f62\u805a\u5408\u7269\uff08bb<\/em>\uff09\u66f4\u52a0\u7a33\u5b9a\u7684\u5355\u5206\u5b50\u80f6\u675f\uff0c\u8fd9\u4e00\u6027\u80fd\u4f7f\u5176\u4f5c\u4e3a\u8f7d\u4f53\u6750\u6599\u5728\u836f\u7269\u4f20\u9012\u4e0a\u5177\u6709\u91cd\u8981\u7684\u5e94\u7528\u524d\u666f\u548c\u7814\u7a76\u4ef7\u503c\u3002\u7136\u800c\uff0c\u4e0e\u5927\u91cf\u7531\u5747\u76f8\u805a\u5408\u7269\u5237\u6784\u7b51\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\u7684\u7814\u7a76\u76f8\u6bd4\uff0c\u5177\u6709\u5f02\u76f8\u805a\u5408\u7269\u5237\u7684\u73af\u72b6\u5237\u5f62\u5171\u805a\u7269\u7684\u5236\u5907\u548c\u5e94\u7528\u4ecd\u7136\u672a\u88ab\u63a2\u7d22\uff0c\u5b58\u5728\u5f88\u591a\u7684\u6311\u6218\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u5170\u5dde\u5927\u5b66\u5316\u5b66\u5316\u5de5\u5b66\u9662\u9b4f\u534e\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u4eba\u57fa\u4e8e\u4e8c\u5143\u5d4c\u6bb5\u5171\u805a\u7269\u7684\u73af\u72b6\u6a21\u677f\u9996\u6b21\u62a5\u9053\u4e86\u542b\u6709\u5f02\u76f8\u805a\u5408\u7269\u5237\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\u7684\u5408\u6210\uff0c\u540c\u65f6\u8fd9\u4e00\u65b9\u6cd5\u4e5f\u4e3a\u4e24\u9762\u5f62\uff08Janus-type\uff09\u5171\u805a\u7269\u7684\u8bbe\u8ba1\u548c\u5408\u6210\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u5177\u4f53\u5730\uff0c\u901a\u8fc7\u8fde\u7eed\u7684\u539f\u5b50\u8f6c\u79fb\u81ea\u7531\u57fa\u805a\u5408\uff08ATRP\uff09\u3001\u6781\u7a00\u6761\u4ef6\u4e0b\u5206\u5b50\u5185\u70b9\u51fb\u5316\u5b66\u7684\u73af\u5316\u548c\u5f00\u73af\u805a\u5408\uff08ROP\uff09\u7684\u65b9\u6cd5\u8bbe\u8ba1\u5e76\u5408\u6210\u4e86\u7531\u5f02\u76f8\u4e24\u4eb2\u6027\u5be1\u805a\u805a\u4e59\u4e8c\u9187\uff08OEG\uff09\u548c\u5be1\u805a\u805a\u5df1\u5185\u916f\uff08OCL\uff09\u805a\u5408\u7269\u5237\u7ec4\u6210\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269cb<\/em>-P(OEGMA)-b<\/em>-P(HEMA-g-OCL)\u3002\u540c\u65f6\u8fd8\u5236\u5907\u4e86\u5177\u6709\u76f8\u540c\u7ec4\u6210\u7684\u74f6\u5237\u5f62\u805a\u5408\u7269bb<\/em>-P(OEGMA)-b<\/em>-P(HEMA-g-OCL)\u4f5c\u4e3a\u5bf9\u7167\u3002\u6709\u8da3\u7684\u662f\uff0c\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\u5728\u6a21\u62df\u7ec6\u80de\u5185\u9178\u6027\u6761\u4ef6\u4e0b\uff08pH 5.0\uff09\u8868\u73b0\u51fa\u6bd4\u74f6\u5237\u5f62\u805a\u5408\u7269\u66f4\u9ad8\u7684\u4f53\u5916\u836f\u7269\u7d2f\u79ef\u91ca\u653e\u91cf\uff0c\u8fdb\u800c\u5bfc\u81f4\u4e86\u6bd4\u74f6\u5237\u5f62\u805a\u5408\u7269\u9488\u5bf9HeLa\u7ec6\u80de\u66f4\u5f3a\u7684\u4f53\u5916\u7ec6\u80de\u6bd2\u6027\uff08\u66f4\u4f4e\u7684IC50<\/sub>\u503c\uff09\u3002\u56e0\u6b64\uff0c\u672c\u6587\u5f00\u53d1\u7684\u542b\u5f02\u76f8\u805a\u5408\u7269\u5237\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\u4e3a\u7814\u7a76\u65b0\u578b\u62d3\u6251\u7ed3\u6784\u805a\u5408\u7269\u7684\u7ec4\u88c5\u4e0e\u5176\u751f\u7269\u533b\u5b66\u5e94\u7528\u63d0\u4f9b\u4e86\u65b0\u7684\u5e73\u53f0\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cFabrication of Cyclic Brush Copolymers with Heterogeneous Amphiphilic Polymer Brushes for Controlled Drug Release\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aMacromolecules<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001\u5177\u6709\u5f02\u76f8\u4e24\u4eb2\u6027\u805a\u5408\u7269\u5237\u7684cb<\/em>-P(OEGMA)-b<\/em>-P(HEMA-g-OCL)\u548cbb<\/em>-P(OEGMA)-b<\/em>-P(HEMA-g-OCL)\u7684\u5408\u6210<\/strong> \u56fe\u4e8c\u3001\u805a\u5408\u7269\u76841<\/sup>H NMR\u8c31\u56fe \uff08b\uff09alkyne-P(OEGMA25<\/sub>)-b<\/em>-P(HEMA)5<\/sub>\u7684\u6c22\u8c31\uff1b<\/p>\n \uff08c\uff09c<\/em>-P(OEGMA25<\/sub>)-b<\/em>-P(HEMA)5<\/sub>\u7684\u6c22\u8c31\uff1b<\/p>\n \uff08d\uff09cb<\/em>-P(OEGMA25<\/sub>)-b<\/em>-P(HEMA-g-OCL6<\/sub>)5<\/sub>\u7684\u6c22\u8c31\u3002<\/p>\n \u56fe\u4e09\u3001\u5206\u5b50\u91cf\u6570\u636e<\/strong> \uff08b\uff09 bb<\/em>-P(OEGMA)25<\/sub>–b<\/em>-P-(HEMA-g-OCL6<\/sub>)5<\/sub>, cb<\/em>-P(OEGMA)25<\/sub>–b<\/em>-P(HEMA-g-OCL6<\/sub>)5<\/sub>, bb<\/em>-P-(OEGMA)25<\/sub>–b<\/em>-P(HEMA-g-OCL3<\/sub>)5<\/sub>, cb<\/em>-P(OEGMA)25<\/sub>–b<\/em>-P(HEMA-g-OCL3<\/sub>)5<\/sub>\u4ee5DMF\u4e3a\u6d17\u8131\u6db2\u7684SEC\u56fe\u3002<\/p>\n \u56fe\u56db\u3001CMC\u7684\u6d4b\u5b9a\uff08\u03bbex<\/sub>= 340 nm\uff0c[\u8298] = 2\u00d710-6<\/sup> M\uff09<\/strong> \u56fe\u4e94\u3001\u805a\u5408\u7269\u6d53\u5ea6\u4e3a0.25 mg \/ mL\u65f6\u6c34\u76f8\u4e2d\uff08a\u548cc\uff09bb1<\/sub><\/em>\u548c\uff08b\u548cd\uff09cb1<\/sub><\/em>\u80f6\u675f\u7684\u7c92\u5ea6\u5206\u5e03\u548cTEM\u56fe \u56fe\u516b\u3001\u572837 \u2103\u7684\u4e0d\u540c\u6761\u4ef6\u4e0b\uff0ccb2<\/sub><\/em>\u548cbb2<\/sub><\/em>\u7684\u8f7d\u836f\u80f6\u675f\u7684\u4f53\u5916\u836f\u7269\u91ca\u653e\u66f2\u7ebf \u56fe\u4e5d\u3001\u901a\u8fc7\u6d41\u5f0f\u7ec6\u80de\u4eea\u5728HeLa\u7ec6\u80de\u7cfb\u4e2dDOX\uff0c\u8d1f\u8f7dDOX\u7684cb2<\/sub><\/em>\u548cbb2<\/sub><\/em>\u80f6\u675f\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u7684\u5b9a\u91cf\u6d4b\u91cf \u56fe\u5341\u3001\u8f7d\u6709DOX\u7684bb2<\/sub><\/em>\u548ccb2<\/sub><\/em>\u80f6\u675f\u5728HeLa\u7ec6\u80de\u4e2d\u7684\u4f53\u5916\u7ec6\u80de\u6bd2\u6027 \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u7814\u7a76\u5e76\u9996\u6b21\u62a5\u9053\u4e86\u901a\u8fc7ATRP\u3001\u5206\u5b50\u5185\u70b9\u51fb\u5316\u5b66\u73af\u5316\u548cROP\u5408\u6210\u65b9\u6cd5\u7684\u8054\u7528\u5236\u5907\u4e86\u7531\u5f02\u76f8\u4e24\u4eb2\u6027\u5be1\u805a\u805a\u4e59\u4e8c\u9187\uff08OEG\uff09\u548c\u5be1\u805a\u805a\u5df1\u5185\u916f\uff08OCL\uff09\u805a\u5408\u7269\u5237\u7ec4\u6210\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269cb<\/em>-P(OEGMA)-b<\/em>-P(HEMA-g-OCL)\u3002\u867d\u7136MALDI-TOF MS\u7684\u53cd\u590d\u6d4b\u91cf\u672a\u80fd\u6210\u529f\u5730\u8868\u5f81cb<\/em>\u5171\u805a\u7269\u4e2d\u53ef\u80fd\u5b58\u5728\u7684bb\u6742\u8d28\uff0c\u4f46\u4e8c\u8005\u4f5c\u4e3a\u836f\u7269\u8f7d\u4f53\u4f53\u5916\u6027\u80fd\u7684\u7814\u7a76\u8868\u660e\u5236\u5907\u5f97\u5230\u7684cb<\/em>\u5171\u805a\u7269\u5177\u6709\u6bd4bb<\/em>\u5bf9\u7167\u663e\u8457\u63d0\u9ad8\u7684\u836f\u7269\u8d1f\u8f7d\u91cf\u548c\u4f53\u5916\u7ec6\u80de\u6bd2\u6027\u3002\u8fd9\u4e00\u7ed3\u679c\u8bc1\u5b9e\u4e86\u805a\u5408\u7269\u62d3\u6251\u7ed3\u6784\u5bf9\u5176\u6027\u80fd\u7684\u5de8\u5927\u5f71\u54cd\uff0c\u4ee5\u53ca\u5236\u5907\u5f97\u5230\u7684cb<\/em>\u5177\u6709\u9ad8\u7684\u7eaf\u5ea6\u3002\u4ee5\u4e0a\u7ed3\u679c\u8868\u660e\u542b\u5f02\u76f8\u805a\u5408\u7269\u5237\u7684\u73af\u72b6\u5237\u5f62\u805a\u5408\u7269\u4e3a\u7814\u7a76\u65b0\u578b\u62d3\u6251\u7ed3\u6784\u805a\u5408\u7269\u7684\u7ec4\u88c5\u4e0e\u5176\u751f\u7269\u533b\u5b66\u5e94\u7528\u63d0\u4f9b\u4e86\u65b0\u7684\u5e73\u53f0\u3002\u4e0b\u4e00\u6b65\u7814\u7a76\u5c06\u96c6\u4e2d\u5728\u901a\u8fc7MALDI-TOF MS\u5206\u6790\u5177\u6709\u8f83\u4f4e\u5206\u5b50\u91cf\u7684cb<\/em>\u5171\u805a\u7269\u7684\u7ed3\u6784\uff0c\u4ee5\u53ca\u5236\u5907\u523a\u6fc0\u54cd\u5e94\u6027cb<\/em>\u5171\u805a\u7269\u5e76\u7814\u7a76\u5176\u73af\u5883\u654f\u611f\u6027\u7684\u7ec4\u88c5\u4e0e\u89e3\u7ec4\u88c5\u884c\u4e3a\u3002<\/p>\n
\n <\/p>\n
<\/strong>
\n \uff08a\uff09alkyne-P(OEGMA25<\/sub>)-Br\u7684\u6c22\u8c31\uff1b<\/p>\n
\n \uff08a\uff09 alkyne-P(OEGMA)25<\/sub>-Br, alkyne-P(OEGMA)25<\/sub>–b<\/em>-P(HEMA)5<\/sub>-Br, alkyne-P(OEGMA)25<\/sub>–b<\/em>-P(HEMA)5<\/sub>-N3<\/sub>, c<\/em>-P(OEGMA)25<\/sub>–b<\/em>-P(HEMA)5<\/sub>\u4ee5DMF\u4e3a\u6d17\u8131\u6db2\u7684SEC\u6d17\u8131\u75d5\u8ff9\uff1b<\/p>\n
<\/p>\n
<\/strong>
\n \u56fe\u516d\u3001\u805a\u5408\u7269\u6d53\u5ea6\u4e3a0.25 mg \/ mL\u65f6\u6c34\u76f8\u4e2d\uff08a\u548cc\uff09bb2<\/sub><\/em>\u548c\uff08b\u548cd\uff09cb2<\/sub><\/em>\u80f6\u675f\u7684\u7c92\u5ea6\u5206\u5e03\u548cTEM\u56fe<\/strong>
\n \u56fe\u4e03\u3001\u5728\u5404\u79cd\u805a\u5408\u7269\u6d53\u5ea6\u4e0b\uff0c(a) bb2<\/sub><\/em>\u3001(b) cb2<\/sub><\/em>\u3001(c)bb1<\/sub><\/em>\u548c(d) cb1<\/sub><\/em>\u5728\u6c34\u76f8\u4e2d\u81ea\u7ec4\u88c5\u7684\u80f6\u675f\u7684\u5e73\u5747\u5c3a\u5bf8<\/strong><\/p>\n
<\/strong><\/p>\n
\n <\/strong><\/p>\n
<\/strong><\/p>\n