{"id":153130,"date":"2018-09-14T06:08:27","date_gmt":"2018-09-13T22:08:27","guid":{"rendered":"\/\/m.iemloyee.com\/?p=153130"},"modified":"2018-09-13T20:08:54","modified_gmt":"2018-09-13T12:08:54","slug":"%e9%9f%a9%e5%9b%bd%e5%ba%86%e7%86%99%e5%a4%a7%e5%ad%a6youngmi-kim%e8%af%be%e9%a2%98%e7%bb%84j-am-chem-soc-%e9%80%9a%e8%bf%87j%e8%81%9a%e4%bd%93%e8%8d%a7%e5%85%89%e6%8e%a2%e9%92%88%e9%80%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=153130","title":{"rendered":"\u97e9\u56fd\u5e86\u7199\u5927\u5b66Youngmi Kim\u8bfe\u9898\u7ec4J. Am. Chem. Soc.: \u901a\u8fc7J\u805a\u4f53\u8367\u5149\u63a2\u9488\u9009\u62e9\u6027\u8ffd\u8e2a\u55dc\u9178\u7c92\u7ec6\u80de\u8fc7\u6c27\u5316\u9176\u6d3b\u6027"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u55dc\u9178\u7c92\u7ec6\u80de\u662f\u4e00\u7c7b\u767d\u7ec6\u80de\uff0c\u5728\u5bbf\u4e3b\u9632\u5fa1\u611f\u67d3\u548c\u53c2\u4e0e\u54ee\u5598\u548c\u8fc7\u654f\u7b49\u75be\u75c5\u8fc7\u7a0b\u4e2d\u626e\u6f14\u4e86\u5341\u5206\u91cd\u8981\u7684\u89d2\u8272\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u5305\u62ec\u81ea\u514d\u75ab\u75be\u75c5\u548c\u4f55\u6770\u91d1\u6c0f\u75c5\u5728\u5185\u7684\u7b49\u591a\u79cd\u75be\u75c5\u90fd\u4e0e\u55dc\u9178\u7c92\u7ec6\u80de\u7684\u6570\u91cf\u589e\u52a0\u5bc6\u5207\u76f8\u5173\u3002\u7c92\u7ec6\u80de\u7684\u7ec6\u80de\u6bd2\u6027\u4e3b\u8981\u6765\u81ea\u7c92\u7ec6\u80de\u53ef\u4ee5\u901a\u8fc7\u5364\u8fc7\u6c27\u5316\u7269\u9176\u6c27\u5316\u5364\u7d20\u5f62\u6210\u6c22\u5364\u9178\u3002\u4e2d\u6027\u7c92\u7ec6\u80de\u4e2d\u7684\u9ad3\u8fc7\u6c27\u5316\u7269\u9176\u53ef\u4ee5\u5c06\u6c2f\u79bb\u5b50\u8f6c\u5316\u4e3a\u6c22\u6c2f\u9178\uff0c\u800c\u55dc\u9178\u7c92\u7ec6\u80de\u8fc7\u6c27\u5316\u9176\u5219\u5c06\u6eb4\u79bb\u5b50\u6c27\u5316\u6210\u6c22\u6eb4\u9178\u3002\u7531\u4e8e\u55dc\u9178\u7c92\u7ec6\u80de\u7684\u7d0a\u4e71\uff0c\u6c22\u6eb4\u9178\u7684\u5f3a\u6c27\u5316\u6027\u548c\u5364\u5316\u6027\u4f1a\u5bfc\u81f4\u708e\u75c7\u548c\u7ec4\u7ec7\u635f\u4f24\u3002\u76ee\u524d\u4e3a\u6b62\uff0c\u9488\u5bf9MPO\u6d3b\u6027\u68c0\u6d4b\u7684\u8367\u5149\u63a2\u9488\u6709\u5f88\u591a\uff0c\u800c\u5bf9EPO\u6d3b\u6027\u7279\u5f02\u68c0\u6d4b\u7684\u8367\u5149\u63a2\u9488\u8fd8\u672a\u88ab\u62a5\u9053\u8fc7\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u97e9\u56fd\u5e86\u7199\u5927\u5b66<\/b><\/strong>Youngmi Kim<\/b><\/strong>\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09\u8bfe\u9898\u7ec4<\/b><\/strong>\u62a5\u5bfc\u4e86\u4e00\u79cd\u8367\u5149\u63a2\u9488\u53ef\u4ee5\u7279\u5f02\u6027\u5b9e\u73b0\u55dc\u9178\u7c92\u7ec6\u80de\u8fc7\u6c27\u5316\u9176\u7684\u68c0\u6d4b\u4e0e\u6210\u50cf\u3002\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u5229\u7528\u6c22\u6eb4\u9178\u76f8\u5bf9\u4e8e\u6c22\u6c2f\u9178\u7684\u9ad8\u52a8\u529b\u5b66\u9009\u62e9\u6027\uff0c\u53ef\u5c06\u63a2\u9488\u5364\u4ee3\u3002\u7531\u4e8e\u5364\u5316\u540e\u7684\u5206\u5b50\u901a\u8fc7\u81ea\u7ec4\u88c5\u5f62\u6210J\u805a\u4f53\uff0c\u8367\u5149\u4e0d\u4f46\u6ca1\u6709\u731d\u706d\uff0c\u53cd\u800c\u5f97\u5230\u589e\u5f3a\u3002\u63a2\u9488\u5206\u5b50\u5728\u7ec6\u80de\u548c\u5c0f\u9f20\u6d3b\u4f53\u6210\u50cf\u4e2d\u5747\u5f97\u5230\u5f88\u597d\u7684\u6548\u679c\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Selective Monitoring and Imaging of Eosinophil Peroxidase Activity with a J-Aggregating Probe<\/b><\/strong>“\u53d1\u8868\u5728J. Am. Chem. Soc.<\/b><\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

Scheme<\/b><\/strong>\u00a0<\/b><\/strong>1<\/b><\/strong>.<\/b><\/strong>\u00a0<\/b><\/strong>\u70b9\u4eae\u8367\u5149\u63a2\u9488\u68c0\u6d4bEPO\u6d3b\u6027\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure <\/b><\/strong>1<\/b><\/strong>. <\/b><\/strong>\u63a2\u9488\u5206\u5b50\u7684\u7269\u7406\u6027\u8d28\u8868\u5f81<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u63a2\u9488\u5206\u5b50\u5728\u6c34\u548c\u4e59\u8148\u6df7\u5408\u6eb6\u6db2\u4e2d\u7684\u5438\u6536\u5149\u8c31\u548c\u53d1\u5c04\u5149\u8c31<\/p>\n

(b).\u63a2\u9488\u5206\u5b50\u7684\u7c92\u5f84\u5206\u6790<\/p>\n

(c).\u6fc0\u53d1\u78f7\u5149\u7ed8\u56fe<\/p>\n

(d).\u78f7\u5149\u5f1b\u8c6b\u548c\u62df\u5408\u66f2\u7ebf<\/p>\n

Figure <\/b><\/strong>2<\/b><\/strong>. <\/b><\/strong>\u63a2\u9488\u5206\u5b50\u5bf9\u6c22\u6eb4\u9178\u7684\u7279\u5f02\u6027\u68c0\u6d4b<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(ab).\u63a2\u9488\u5206\u5b50\u5728\u4e0e\u6c22\u6eb4\u9178\u53cd\u5e94\u524d\u540e\u7684\u5438\u6536\u548c\u53d1\u5c04\u5149\u8c31<\/p>\n

(c).\u63a2\u9488\u5206\u5b50\u5728\u4e0d\u540c\u6d53\u5ea6\u6c22\u6eb4\u9178\u5904\u7406\u524d\u540e\u7684\u5149\u8c31\u53d8\u5316<\/p>\n

(d).\u63a2\u9488\u5206\u5b50\u5bf9\u6c22\u6eb4\u9178\u7684\u7279\u5f02\u6027\u54cd\u5e94<\/p>\n

\u56fe<\/b><\/strong>3<\/b><\/strong>. <\/b><\/strong>\u63a2\u9488\u5206\u5b50\u5728\u6eb6\u6db2\u4e2d\u5bf9EPO\u7684\u54cd\u5e94<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a,b).\u63a2\u9488\u5206\u5b50\u4e0e\u4e0d\u540c\u6d53\u5ea6EPO\u4f5c\u7528\u7684\u5438\u6536\u5149\u8c31\u548c\u53d1\u5c04\u5149\u8c31<\/p>\n

(c).\u63a2\u9488\u5206\u5b50\u5728\u4e0d\u540c\u7ec4\u4efd\u6eb6\u6db2\u4e2d\u7684\u8367\u5149\u54cd\u5e94<\/p>\n

\u56fe<\/b><\/strong>4<\/b><\/strong>. <\/b><\/strong>\u63a2\u9488\u5206\u5b50\u5728MPO\/H<\/b><\/strong>2<\/b><\/sub><\/strong>O<\/b><\/strong>2<\/b><\/sub><\/strong>\/Cl<\/b><\/strong>–<\/b><\/sup><\/strong>\u548cEPO\/H<\/b><\/strong>2<\/b><\/sub><\/strong>O<\/b><\/strong>2<\/b><\/sub><\/strong>\/Br<\/b><\/strong>–<\/b><\/sup><\/strong>\u4f53\u7cfb\u4e2d\u7684\u989c\u8272\u548c\u8367\u5149\u54cd\u5e94<\/b><\/strong><\/p>\n

\"\"<\/p>\n

\u56fe<\/b><\/strong>5<\/b><\/strong>. <\/b><\/strong>\u63a2\u9488\u5206\u5b50\u7684\u7ec6\u80de\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u63a2\u9488\u5206\u5b50\u5728\u5de8\u566c\u7ec6\u80de\u4e2d\u7684\u8367\u5149\u6210\u50cf<\/p>\n

(b).\u63a2\u9488\u5206\u5b50\u5728\u4e0d\u540c\u7ec6\u80de\u6761\u4ef6\u4e0b\u7684\u8367\u5149\u53d8\u5316\u5dee\u5f02<\/p>\n

\u56fe<\/b><\/strong>6<\/b><\/strong>. <\/b><\/strong>\u63a2\u9488\u5206\u5b50\u7684\u5c0f\u9f20\u6d3b\u4f53\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a).\u6c99\u6c0f\u95e8\u83cc\u611f\u67d3\u5c0f\u9f20\u524d\u540e\uff0c\u5c0f\u9f20\u4f53\u5185\u7684\u55dc\u9178\u7c92\u7ec6\u80de\u548c\u55dc\u4e2d\u6027\u7c92\u7ec6\u80de\u6c34\u5e73\u7684\u5dee\u5f02<\/p>\n

(b).\u63a2\u9488\u5206\u5b50\u5728\u6c99\u6c0f\u95e8\u83cc\u611f\u67d3\u524d\u540e\u5c0f\u9f20\u4f53\u5185\u7684\u8367\u5149\u54cd\u5e94<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/b><\/strong><\/p>\n

\u5728\u8fd9\u4e2a\u5de5\u4f5c\u4e2d\uff0c\u4f5c\u8005\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u79cd\u8367\u5149\u63a2\u9488\uff0c\u53ef\u5bf9EPO\u4ea7\u751f\u7684\u6b21\u6eb4\u9178\u5b9e\u73b0\u9009\u62e9\u6027\u7684\u68c0\u6d4b\u548c\u6210\u50cf\uff0c\u5e76\u4e0d\u53d7\u5230MPO\u6240\u4ea7\u751f\u7684\u6b21\u6c2f\u9178\u7684\u5f71\u54cd\u3002\u63a2\u9488\u7684\u54cd\u5e94\u65f6\u95f4\u57282\u79d2\u4ee5\u5185\uff0c\u68c0\u6d4b\u9650\u53ef\u8fbe0.09\u00a0ng\/mL.<\/p>\n

Selective Monitoring and Imaging of Eosinophil Peroxidase Activity with a J-Aggregating Probe<\/a><\/p>\n

\u00a0(J. Am. Chem. Soc., 2018, DOI: 10. 1021\/jacs.8b07073)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0<\/p>\n

\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n

\u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu\u3002 \u00a0<\/p>\n","protected":false},"excerpt":{"rendered":"

\u3010\u5f15\u8a00\u3011 \u55dc\u9178\u7c92\u7ec6\u80de\u662f\u4e00\u7c7b\u767d\u7ec6\u80de\uff0c\u5728\u5bbf\u4e3b\u9632\u5fa1\u611f\u67d3\u548c\u53c2\u4e0e\u54ee\u5598\u548c\u8fc7\u654f\u7b49\u75be\u75c5\u8fc7\u7a0b\u4e2d\u626e\u6f14\u4e86\u5341\u5206\u91cd\u8981\u7684\u89d2\u8272\u3002\u4e0d\u4ec5\u5982\u6b64\uff0c\u5305\u62ec\u81ea\u514d\u75ab\u75be\u75c5\u548c\u4f55\u6770\u91d1\u6c0f\u75c5\u5728\u5185\u7684\u7b49\u591a\u79cd\u75be\u75c5\u90fd\u4e0e\u55dc\u9178\u7c92…<\/p>\n","protected":false},"author":7336,"featured_media":153138,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[215],"tags":[2939],"class_list":["post-153130","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-jiedu","tag-2939"],"_links":{"self":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/153130"}],"collection":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/users\/7336"}],"replies":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=153130"}],"version-history":[{"count":2,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/153130\/revisions"}],"predecessor-version":[{"id":153548,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/posts\/153130\/revisions\/153548"}],"wp:featuredmedia":[{"embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=\/wp\/v2\/media\/153138"}],"wp:attachment":[{"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=153130"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=153130"},{"taxonomy":"post_tag","embeddable":true,"href":"\/\/m.iemloyee.com\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=153130"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}