{"id":152777,"date":"2018-09-04T06:57:38","date_gmt":"2018-09-03T22:57:38","guid":{"rendered":"\/\/m.iemloyee.com\/?p=152777"},"modified":"2018-09-03T21:57:56","modified_gmt":"2018-09-03T13:57:56","slug":"%e5%8c%97%e5%8c%96%e5%b7%a5%e5%b0%b9%e6%a2%85%e8%b4%9e%e6%95%99%e6%8e%88%e7%ad%89%ef%bc%9a%e5%88%a9%e7%94%a8%e6%9c%ba%e6%a2%b0%e5%8a%9b%e8%b0%83%e6%8e%a7%e5%88%86%e5%ad%90%e5%86%85%e8%83%bd%e9%87%8f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=152777","title":{"rendered":"\u5317\u5316\u5de5\u5c39\u6885\u8d1e\u6559\u6388\u7b49\uff1a\u5229\u7528\u673a\u68b0\u529b\u8c03\u63a7\u5206\u5b50\u5185\u80fd\u91cf\u8f6c\u79fb\u5b9e\u73b0\u9ad8\u5bf9\u6bd4\u5ea6\u8367\u5149\u53d8\u8272"},"content":{"rendered":"<p>\u529b\u81f4\u53d8\u8272\u6750\u6599\u662f\u6307\u5728\u5916\u754c\u529b\u4f5c\u7528\u4e0b\u7269\u8d28\u7684\u5149\u5b66\u6027\u8d28\u53d1\u751f\u53ef\u9006\u6539\u53d8\u7684\u4e00\u7c7b\u529f\u80fd\u6750\u6599\uff0c\u5728\u5316\u5b66\u4f20\u611f\u5668\u3001\u4fe1\u606f\u5b58\u50a8\u3001\u5149\u7535\u8bbe\u5907\u4ee5\u53ca\u9632\u4f2a\u7eb8\u5f20\u7b49\u9886\u57df\u6709\u7740\u5e7f\u6cdb\u5e94\u7528\u3002\u76ee\u524d\uff0c\u5173\u4e8e\u529b\u81f4\u53d8\u8272\u6750\u6599\u7684\u7814\u7a76\u4e3b\u8981\u96c6\u4e2d\u4e8e\u8c03\u63a7\u6750\u6599\u7684\u8367\u5149\u989c\u8272\u3002\u7136\u800c\uff0c\u8fd9\u79cd\u5355\u7eaf\u57fa\u4e8e\u989c\u8272\u53d8\u5316\u7684\u529b\u54cd\u5e94\u6750\u6599\u5df2\u7ecf\u4e0d\u80fd\u6ee1\u8db3\u73b0\u9636\u6bb5\u6750\u6599\u53d1\u5c55\u7684\u9700\u6c42\uff0c\u8bbe\u8ba1\u5408\u6210\u5177\u6709\u53d1\u5149\u989c\u8272\u548c\u53d1\u5149\u5f3a\u5ea6\u53cc\u91cd\u53ef\u8c03\u7684\u9ad8\u5bf9\u6bd4\u5ea6\u8367\u5149\u53d8\u8272\u6750\u6599\u4e00\u76f4\u662f\u7814\u7a76\u4eba\u5458\u8ffd\u6c42\u7684\u76ee\u6807\uff0c\u4f46\u8fd9\u5bf9\u4e8e\u4f20\u7edf\u7684\u529b\u81f4\u53d8\u8272\u6750\u6599\u800c\u8a00\u662f\u5f88\u96be\u5b9e\u73b0\u7684\u3002<\/p>\n<p>\u6700\u8fd1\uff0c\u5c39\u6885\u8d1e\u6559\u6388\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u79cd\u57fa\u4e8e\u201c\u7f57\u4e39\u660e-\u87ba\u5421\u5583\u201d\u53cc\u53d1\u8272\u56e2\u7684\u529b\u54cd\u5e94\u8367\u5149\u53d8\u8272\u5206\u5b50<strong>P1<\/strong>\uff08\u56fe1\uff09\uff0c\u968f\u7740\u526a\u5207\u529b\u4f5c\u7528\u7684\u589e\u5f3a\uff0c<strong>P1<\/strong>\u8367\u5149\u53d1\u751f\u4e24\u9636\u6bb5\u7684\u9ad8\u5bf9\u6bd4\u5ea6\u989c\u8272\u53d8\u5316\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-152779 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/221.png\" alt=\"\" width=\"600\" height=\"440\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/221.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/221-300x220.png 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p style=\"text-align: center;\"><strong>\u56fe1\u00a0<\/strong>\u00a0\u00a0\u00a0\u673a\u68b0\u529b\u8c03\u63a7\u5206\u5b50\u5185\u80fd\u91cf\u8f6c\u79fb\u5b9e\u73b0\u9ad8\u5bf9\u6bd4\u5ea6\u8367\u5149\u53d8\u8272\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p>\u4f5c\u8005\u5229\u7528\u82ef\u4e19\u6c28\u9178\u4e8c\u80bd\u4f5c\u4e3a\u8fde\u63a5\u81c2\uff0c\u5de7\u5999\u5730\u5c06\u7f57\u4e39\u660eB\u548c\u87ba\u5421\u5583\u8fd9\u4e24\u79cd\u529b\u54cd\u5e94\u57fa\u56e2\u5171\u4ef7\u8fde\u63a5\u8d77\u6765\uff0c\u8bbe\u8ba1\u5408\u6210\u4e86\u5206\u5b50<strong>P1<\/strong>\u3002\u521d\u59cb\u72b6\u6001\u4e0b\uff0c<strong>P1<\/strong>\u5e76\u4e0d\u53d1\u51fa\u8367\u5149\uff0c\u5f53\u8f7b\u8f7b\u7814\u78e8<strong>P1<\/strong>\u540e\uff0c\u5219\u5448\u73b0\u51fa\u4e00\u79cd\u975e\u540c\u5bfb\u5e38\u7684\u8367\u5149\u201c\u5f00\u542f\u201d\u73b0\u8c61\uff0c\u53d1\u51fa\u6a59\u8272\u8367\u5149\uff1b\u7ee7\u7eed\u5bf9<strong>P1<\/strong>\u65bd\u52a0\u529b\u523a\u6fc0\uff0c\u8367\u5149\u53d1\u5c04\u6ce2\u957f\u7ea2\u79fb\uff0c\u663e\u73b0\u51fa\u7ea2\u8272\u8367\u5149\uff0c\u8868\u73b0\u51fa\u8f83\u9ad8\u7684\u5bf9\u6bd4\u5ea6\u3002<\/p>\n<p>\u901a\u8fc7\u7ed3\u6784\u5206\u6790\u548c\u7406\u8bba\u6a21\u62df\u53d1\u73b0\uff0c\u7f57\u4e39\u660eB\u7ed3\u6784\u4e2d\u7684C-N\u952e\u4ee5\u53ca\u87ba\u5421\u5583\u7ed3\u6784\u4e2d\u7684C-O\u952e\u5728\u529b\u7684\u4f5c\u7528\u4e0b\u90fd\u4e0d\u7a33\u5b9a\uff0c\u4e14\u7531\u4e8eC-N\u952e\u7684\u952e\u80fd\u5c0f\u4e8eC-O\u952e\uff0c\u5bfc\u81f4\u4e24\u8005\u53d1\u751f\u529b\u8bf1\u5bfc\u5f00\u73af\u53cd\u5e94\u6240\u9700\u8981\u7684\u80fd\u91cf\u5b58\u5728\u660e\u663e\u5dee\u5f02\u3002\u56e0\u6b64\uff0c\u5728\u526a\u5207\u529b\u523a\u6fc0\u4e0b\uff0c\u7f57\u4e39\u660eB\u4e2dC-N\u952e\u7684\u65ad\u88c2\u8981\u5148\u4e8e\u87ba\u5421\u5583\u4e2d\u7684C-O\u952e\u3002\u5bf9<strong>P1<\/strong>\u65bd\u52a0\u529b\u523a\u6fc0\u65f6\uff0c\u5206\u5b50\u7ed3\u6784\u4e2d\u7684C-N\u952e\u6700\u5148\u53d7\u5230\u7834\u574f\uff0c\u53d1\u751f\u4e86\u529b\u5f00\u73af\u53cd\u5e94\uff0c\u7531\u65e0\u8367\u5149\u7684\u5185\u9170\u80fa\u7ed3\u6784\u8f6c\u53d8\u4e3a\u5171\u8f6d\u5ea6\u8f83\u597d\u7684\u6a59\u8272\u8367\u5149\u5f00\u73af\u5f02\u6784\u4f53\uff0c\u5f15\u8d77\u8367\u5149\u53d1\u5c04\u5f3a\u5ea6\u7684\u660e\u663e\u589e\u5f3a\u3002\u7ee7\u7eed\u5bf9<strong>P1<\/strong>\u65bd\u52a0\u66f4\u5f3a\u7684\u526a\u5207\u529b\uff0c\u87ba\u5421\u5583\u57fa\u56e2\u4e2dC-O\u952e\u65ad\u88c2\uff0c\u53d1\u5c04\u6ce2\u957f\u7ea2\u79fb\uff0c\u663e\u73b0\u51fa\u7ea2\u8272\u8367\u5149\u3002\u8fd9\u662f\u7531\u4e8e\u5f00\u73af\u540e\u87ba\u5421\u5583\u57fa\u56e2\u7684\u5438\u6536\u5149\u8c31\u548c\u5f00\u73af\u540e\u7f57\u4e39\u660e\u57fa\u56e2\u7684\u53d1\u5c04\u5149\u8c31\u6709\u8f83\u5927\u91cd\u53e0\uff0c\u5177\u6709\u8f83\u9ad8\u6548\u7387\u7684\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb (FRET) \u6548\u5e94\uff0c\u7f57\u4e39\u660e\uff08\u4f9b\u4f53\uff09\u7684\u8367\u5149\u80fd\u91cf\u8f6c\u79fb\u81f3\u87ba\u5421\u5583\uff08\u53d7\u4f53\uff09\uff0c\u6700\u7ec8\u5bfc\u81f4\u65e0\u6df7\u5408\u7684\u7ea2\u5149\u53d1\u5c04\uff0c\u663e\u793a\u51fa\u6781\u9ad8\u7684\u5bf9\u6bd4\u5ea6\u3002<\/p>\n<p>\u8be5\u7814\u7a76\u7684\u610f\u4e49\u5728\u4e8e\uff1a\u901a\u8fc7\u7f57\u4e39\u660e-\u87ba\u5421\u5583\u4f53\u7cfb\u5b9e\u73b0\u4e86\u673a\u68b0\u529b\u8c03\u63a7\u5206\u5b50\u5185\u80fd\u91cf\u8f6c\u79fb\uff0c\u83b7\u5f97\u4e86\u9ad8\u5bf9\u6bd4\u5ea6\u7684\u8367\u5149\u53d8\u8272\uff0c\u4e3a\u8bbe\u8ba1\u548c\u5408\u6210\u5177\u6709\u53d1\u5149\u989c\u8272\u548c\u53d1\u5149\u5f3a\u5ea6\u53cc\u91cd\u53ef\u8c03\u7684\u8367\u5149\u53d8\u8272\u6750\u6599\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u6b64\u5916\uff0c<strong>P1<\/strong>\u5728\u5177\u6709\u529b\u54cd\u5e94\u7684\u540c\u65f6\uff0c\u8fd8\u4fdd\u7559\u4e86\u87ba\u5421\u5583\u57fa\u56e2\u7684\u5149\u81f4\u53d8\u8272\u6027\u8d28\u3002\u5728\u7d2b\u5916\u5149\u7167\u4e0b<strong>P1<\/strong>\u53ef\u5b9e\u73b0\u4ece\u65e0\u5230\u6709\u7684\u8367\u5149\u8f6c\u53d8\uff0c\u5c55\u73b0\u51fa\u4f18\u5f02\u7684\u5149\u81f4\u53d8\u8272\u6027\u80fd\u3002\u4f5c\u4e3a\u4e00\u79cd\u4f18\u826f\u7684\u529b\u54cd\u5e94\u548c\u5149\u54cd\u5e94\u578b\u6750\u6599\uff0c<strong>P1<\/strong>\u5728\u538b\u529b\u4f20\u611f\u3001\u4fe1\u606f\u5b58\u50a8\u4ee5\u53ca\u9632\u4f2a\u6cb9\u58a8\u7b49\u9886\u57df\u5177\u6709\u6f5c\u5728\u5e94\u7528\u4ef7\u503c\u3002<\/p>\n<p>\u76f8\u5173\u6210\u679c\u8fd1\u671f\u5728\u7ebf\u53d1\u8868\u4e8e<em>Science China Chemistry<\/em>\u3002\u535a\u58eb\u751f<strong>\u83ab\u7533\u5fe0<\/strong>\u4e3a\u6587\u7ae0\u7b2c\u4e00\u4f5c\u8005\uff0c<strong>\u5c39\u6885\u8d1e<\/strong>\u6559\u6388\u548c<strong>\u5f20\u7430\u56fe<\/strong>\u6559\u6388\u4e3a\u901a\u8baf\u4f5c\u8005\u3002\u8be6\u89c1\uff1a<span lang=\"EN-US\">Mo SZ, Tan LN, Fang B, Wu Z, Su ZQ, Zhang YT, Yin MZ. Mechanically controlled FRET to achieve high-contrast fluorescence switching. <em>Science China Chemistry<\/em>, doi:10.1007\/s11426-018-9303-9.<\/span><\/p>\n<hr \/>\n<p><strong>\u901a\u8baf\u4f5c\u8005\u7b80\u4ecb<\/strong><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-152780 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/22.png\" alt=\"\" width=\"600\" height=\"660\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/22.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/22-273x300.png 273w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u5c39\u6885\u8d1e\u00a0\u00a0\u00a0\u00a0<\/strong>\u5317\u4eac\u5316\u5de5\u5927\u5b66\u6750\u6599\u5b66\u9662\u6559\u6388\u3001\u535a\u58eb\u751f\u5bfc\u5e08\u30022004\u5e74\u4e8e\u5fb7\u56fd\u5fb7\u7d2f\u65af\u987f\u7406\u5de5\u5927\u5b66\u83b7\u535a\u58eb\u5b66\u4f4d\uff0c\u66fe\u5728\u5fb7\u56fd\u9ad8\u5206\u5b50\u9a6c\u666e\u6240\u505a\u535a\u58eb\u540e\u30022009\u5e74\u4efb\u5317\u4eac\u5316\u5de5\u5927\u5b66\u6750\u6599\u5b66\u9662\u6559\u6388\u3002\u8fd1\u51e0\u5e74\u6765\uff0c\u4ee5\u7b2c\u4e00\/\u901a\u8baf\u4f5c\u8005\u5728<em>J. Am. Chem. Soc.<\/em>, <em>Angew. Chem. Int. Ed.<\/em>, <em>Adv. Mater.<\/em>, <em>Chem. Soc. Rev.<\/em>, <em>ACS Nano<\/em>,\u00a0<em>Adv. Func. Mater.<\/em>, <em>Chem. Sci.<\/em>\u7b49\u56fd\u9645\u9876\u7ea7\u671f\u520a\u53d1\u8868\u76f8\u5173SCI\u7814\u7a76\u8bba\u658780\u4f59\u7bc7\uff0c\u7533\u8bf7\u4e13\u522922\u9879\uff0c\u6388\u674318\u9879\u30022010\u5e74\u83b7\u5f97\u6559\u80b2\u90e8\u65b0\u4e16\u7eaa\u4f18\u79c0\u4eba\u624d\u652f\u6301\u8ba1\u5212\uff0c2016\u5e74\u83b7\u5f97\u7b2c\u5341\u4e09\u5c4a\u201c\u4e2d\u56fd\u9752\u5e74\u5973\u79d1\u5b66\u5bb6\u5956\u201d\u30012017\u5e74\u83b7\u7b2c\u4e5d\u5c4a\u4faf\u5fb7\u699c\u5316\u5de5\u79d1\u6280\u5956\uff08\u521b\u65b0\u5956\uff09\uff0c2017\u5e74\u5165\u9009\u7b2c\u4e09\u6279\u201c\u4e07\u4eba\u8ba1\u5212\u201d\u79d1\u6280\u521b\u65b0\u9886\u519b\u4eba\u624d\u3002\u4e3b\u8981\u7814\u7a76\u9886\u57df\u5305\u62ec\uff1a\u6c34\u6eb6\u6027\u8367\u5149\u67d3\u6599\u7684\u7ec6\u80de\/\u7ec4\u7ec7\u6807\u8bb0\u3001\u81ea\u7ec4\u88c5\u5206\u5b50\u7684\u529f\u80fd\u5316\u3001\u8367\u5149\u529f\u80fd\u8f7d\u4f53\uff08\u57fa\u56e0\/\u86cb\u767d\/\u836f\u7269\uff09\u3001\u8367\u5149\u764c\u75c7\u8bca\u7597\u5206\u5b50\u8bbe\u8ba1\u53ca\u6297\u764c\u5e94\u7528\u3001\u591a\u529f\u80fd\u6709\u673a-\u65e0\u673a\u8367\u5149\u7eb3\u7c73\u7c92\u5b50\u7b49\u3002<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"size-full wp-image-152781 aligncenter\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/23.png\" alt=\"\" width=\"600\" height=\"731\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/23.png 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/09\/23-246x300.png 246w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><strong>\u5f20\u7430\u56fe<\/strong>\u00a0\u00a0\u00a0\u00a0\u5ef6\u5b89\u5927\u5b66\u5316\u5b66\u4e0e\u5316\u5de5\u5b66\u9662\u6559\u6388\u3001\u7855\u58eb\u751f\u5bfc\u5e08\u3001\u9662\u957f\u30021993\u5e74\u6bd5\u4e1a\u4e8e\u5ef6\u5b89\u5927\u5b66\u5316\u5b66\u7cfb\u5e76\u7559\u6821\u4efb\u6559\uff0c\u4e4b\u540e\u4e8e\u6e05\u534e\u5927\u5b66\u505a\u535a\u58eb\u540e\u3002\u5728<em>Nanoscale\uff0c J. Chromatogra. A<\/em>\uff0c<em>Anal. Chim. Acta<\/em>\uff0c<em>J. Agri. 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