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\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u4e59\u809d\u75c5\u6bd2\uff08HBV\uff09\u611f\u67d3\u80fd\u591f\u5f15\u8d77\u4e00\u7cfb\u5217\u4e25\u91cd\u809d\u810f\u75be\u75c5\uff0c\u4e00\u76f4\u4ee5\u6765\u90fd\u662f\u4e16\u754c\u6027\u7684\u516c\u5171\u536b\u751f\u96be\u9898\u3002\u5c3d\u7ba1\u5df2\u6709\u75ab\u82d7\u53ef\u9884\u9632HBV\u611f\u67d3,\u4f46\u5bf9\u4e8e\u6162\u6027HBV\u611f\u67d3\u76ee\u524d\u88ab\u6279\u51c6\u7684\u836f\u7269\u5c1a\u4e0d\u80fd\u5b9e\u73b0\u6709\u6548\u529f\u80fd\u6027\u6cbb\u6108\uff0c\u6025\u9700\u53d1\u5c55\u65b0\u7684\u6cbb\u7597\u7b56\u7565\u3002HBV\u7279\u5f02\u6027\u53d7\u4f53hNTCP\u81ea2012\u5e74\u88ab\u53d1\u73b0\u4ee5\u6765\u4e00\u76f4\u662f\u56fd\u5185\u5916\u91cd\u70b9\u7814\u7a76\u7684HBV\u6cbb\u7597\u9776\u70b9\uff0c\u7136\u800c\u5982\u4f55\u5728\u65b0\u578b\u836f\u7269\u9012\u9001\u7cfb\u7edf\u6709\u6548\u642d\u8f7d\u5e76\u52a0\u4ee5\u8fd0\u7528\u4e00\u76f4\u662f\u56f0\u6270\u7814\u7a76\u4eba\u5458\u7684\u96be\u70b9\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n

\u53d7\u5230\u673a\u4f53\u80de\u5916\u56ca\u6ce1\u53ef\u4f5c\u4e3a\u5929\u7136\u7684\u819c\u86cb\u767d\u8f7d\u4f53\u7684\u542f\u53d1\uff0c\u53a6\u95e8\u5927\u5b66\u7684<\/strong>\u5218\u521a\u6559\u6388\u4ee5\u53ca\u8881\u6743\u526f\u6559\u6388<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u7b49\u4eba\u6210\u529f\u5236\u5907\u51fa\u4e86\u4e00\u79cd\u8868\u9762\u53ef\u4ee5\u8868\u8fbehNTCP\u7b49\u591a\u79cd\u9776\u5411\u86cb\u767d\u914d\u4f53\u7684\u751f\u7269\u819c\u7eb3\u7c73\u56ca\u6ce1\uff08MVs\uff09\u3002\u7814\u7a76\u4eba\u5458\u91c7\u7528\u81ea\u4e0a\u800c\u4e0b\u7684\u5236\u5907\u65b9\u6cd5\uff0c\u901a\u8fc7\u6784\u5efaNTCP\u91cd\u7ec4\u7ec6\u80de\u53ef\u4f7f\u7ec6\u80de\u819c\u8fc7\u8868\u8fbehNTCP\uff0c\u4ece\u800c\u83b7\u5f97\u4e86\u53ef\u7279\u5f02\u6027\u7ed3\u5408HBV\u7684\u4eff\u751f\u4e59\u809d\u75c5\u6bd2\u53d7\u4f53\u56ca\u6ce1\uff08hNTCP-MVs\uff09\u3002\u4f53\u5916\u548c\u52a8\u7269\u6d3b\u4f53\u5b9e\u9a8c\u8868\u660e\uff0c hNTCP-MVs\u80fd\u591f\u4e8e\u6e38\u79bb\u7684HBV\u75c5\u6bd2\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u4ece\u800c\u964d\u4f4eHBV\u75c5\u6bd2\u8fdb\u5165\u6b63\u5e38\u809d\u7ec6\u80de\u7684\u53ef\u80fd\u6027\uff0c\u6700\u7ec8\u6709\u6548\u5730\u6291\u5236HBV\u7684\u611f\u67d3\u548c\u6269\u6563\u30022018\u5e748\u67088\u65e5\uff0c\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201cBioinspired Artificial Nanodecoys for Hepatitis B Virus<\/strong>\u201d\u5728\u7ebf\u53d1\u8868\u5728Angew<\/strong>\u4e0a\uff08Hot Paper<\/strong>\uff09\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb<\/strong>\u3011<\/p>\n

\u56fe1 hNTCP-MVs\u7684\u5236\u5907\u548c\u6297\u75c5\u6bd2\u6cbb\u7597\u673a\u5236<\/strong><\/p>\n

\"\"<\/p>\n

(A)hNTCP\u8fc7\u8868\u8fbe\u7ec6\u80de\u884d\u751fhNTCP-MVs<\/p>\n

(B) hNTCP-MVs\u7684\u6297\u75c5\u6bd2\u6cbb\u7597<\/p>\n

\u56fe2 hNTCP-MVs\u7684\u5236\u5907\u548c\u8868\u5f81<\/strong><\/p>\n

\"\"<\/p>\n

(A-B)\u5efa\u7acbhNTCP\u8fc7\u8868\u8fbe\u7ec6\u80de\u7684\u793a\u610f\u56fe\u4ee5\u53ca\u514d\u75ab\u8367\u5149\u67d3\u8272\u89c2\u5bdfhNTCP\u8868\u8fbe\u60c5\u51b5<\/p>\n

(C-D)hNTCP\u8fc7\u8868\u8fbe\u7ec6\u80de\u4e0eHBV\u75c5\u6bd2\u591a\u80bd\u7684\u7ed3\u5408\u6d3b\u6027\u8bc4\u4f30<\/p>\n

(E)hNTCP-MVs\u7684TEM\u56fe\u50cf<\/p>\n

(F)hNTCP-MVs\u7684DLS\u7c92\u5f84\u5206\u5e03<\/p>\n

(G)WB\u68c0\u6d4b\u5206\u6790hNTCP-MVs\u8868\u8fbehNTCP<\/p>\n

(H-I)hNTCP-MVs\u4e0e\u7a7a\u767dMVs\u7ade\u4e89\u6027\u7ed3\u5408HBV\u75c5\u6bd2\u8bc4\u4ef7<\/p>\n

(J)HBV-hNTCP-MVs\u590d\u5408\u7269\u7684TEM\u56fe\u50cf<\/p>\n

\u56fe3 hNTCP-MVs\u7684\u4f53\u5916\u6297\u75c5\u6bd2\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

(A)hNTCP-MVs\u6cbb\u7597HBV\u611f\u67d3\u7684hNTCP\u8fc7\u8868\u8fbe\u7ec6\u80de\u7684\u793a\u610f\u56fe<\/p>\n

(B-C)hNTCP\u8fc7\u8868\u8fbe\u7ec6\u80de\u4e0a\u6e05\u6db2\u4e2dHBV\u7684DNA\u548c\u8868\u9762\u6297\u539f\u76f8\u5bf9\u6c34\u5e73<\/p>\n

(D)HBV\u8868\u9762\u6297\u539f\u7684\u514d\u75ab\u8367\u5149\u67d3\u8272\u56fe\u50cf<\/p>\n

(E-H)\u5728\u53ef\u6301\u7eed\u8868\u8fbeHBV\u57fa\u56e0\u7684\u7ec6\u80de\u4e2dhNTCP-MVs\u6291\u5236HBV\u57fa\u56e0\u6c34\u5e73\u7684\u60c5\u51b5<\/p>\n

\u56fe4<\/strong> hNTCP-MVs\u5728\u5c0f\u9f20\u6d3b\u4f53\u4e2d\u963b\u6b62HBV\u611f\u67d3\u8bc4\u4ef7<\/strong><\/p>\n

\"\"<\/p>\n

(A) hNTCP-MVs\u6cbb\u7597HBV\u611f\u67d3\u5c0f\u9f20\u7684\u793a\u610f\u56fe<\/p>\n

(B-C)\u8840\u6e05\u4e2dHBV\u8868\u9762\u6297\u539f\u548cDNA\u6c34\u5e73<\/p>\n

(D)\u809d\u53f6\u4e2dHBV\u6297\u539f\u8868\u8fbe\u7684\u514d\u75ab\u7ec4\u5316\u5206\u6790<\/p>\n

\u3010\u5c0f\u7ed3<\/strong>\u3011<\/p>\n

\u8be5\u9879\u7814\u7a76\u901a\u8fc7\u6784\u5efa\u8868\u9762\u5c55\u793aHBV\u7279\u5f02\u6027\u53d7\u4f53hNTCP\u7684\u7ec6\u80de\u819c\u56ca\u6ce1\uff0c\u521d\u6b65\u63a2\u7d22\u4e86\u7ec6\u80de\u819c\u4eff\u751f\u7b56\u7565\u7528\u4e8eHBV\u6cbb\u7597\u7684\u6f5c\u529b\u3002\u5728HBV\u4f53\u5916\u611f\u67d3\u6a21\u578b\u53ca\u590d\u5236\u6a21\u578b\u4e2d\uff0chNTCP-MVs\u88ab\u8bc1\u660e\u5177\u5907\u7279\u5f02\u6027\u7ed3\u5408HBV\u7684\u80fd\u529b\uff0c\u4ece\u800c\u8d77\u5230\u6291\u5236\u75c5\u6bd2\u5165\u80de\u7684\u4f5c\u7528\u3002\u6b64\u5916\uff0c\u8bfe\u9898\u7ec4\u5229\u7528\u4eba\u6e90\u5316\u809d\u810f\u5d4c\u5408\u5c0f\u9f20\u6a21\u578bHu-FRGS\u9a8c\u8bc1\u4e86hNTCP-MVs\u5728\u5728\u6d3b\u4f53\u5185\u963b\u6b62HBV\u611f\u67d3\u7684\u80fd\u529b\u3002\u8fd9\u4e00\u7cfb\u5217\u7684\u5b9e\u9a8c\u63a2\u7d22\u4e3a\u540e\u7eed\u7684\u9776\u5411\u836f\u7269\u9012\u9001\u3001\u591a\u836f\u7269\u8054\u5408\u6cbb\u7597\u548c\u9006\u8f6c\u514d\u75ab\u8010\u53d7\u673a\u5236\u7b49\u7814\u7a76\u6253\u4e0b\u4e86\u575a\u5b9e\u7684\u57fa\u7840\u3002\uff08\u4e0a\u8ff0\u7814\u7a76\u5de5\u4f5c\u5f97\u5230\u4e86\u79d1\u6280\u90e8\u91cd\u5927\u4e13\u9879\u8bfe\u9898\u3001973\u8bfe\u9898\u3001\u56fd\u5bb6\u81ea\u7136\u79d1\u5b66\u57fa\u91d1\u59d4\u4f18\u79c0\u9752\u5e74\u57fa\u91d1\u7b49\u9879\u76ee\u7684\u652f\u6301\uff09<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aBioinspired Artificial Nanodecoys for Hepatitis B Virus<\/a>\uff08Angew, 2018, DOI: 10.1002\/anie.201807212\uff09<\/p>\n

\u3010\u76f8\u5173\u6587\u732e\u9605\u8bfb\u3011<\/strong><\/p>\n

Adv Mater. 2018, 30(7):1705350; Sci Bull. 2018. 63(11): 663-665; Nano Today. 2017. 13: 7-9; Angew Chem Int Ed Engl. 2017, 56(11): 3031-3035; Hum Vaccin Immunother. 2017, 13(11):2678-2687; Hum Vaccin Immunother. 2016,12(8): 2090-2091; PNAS. 2015, 112(45): E6129-E6138.<\/p>\n

\u3010\u4f5c\u8005\u7b80\u4ecb<\/strong>\u3011<\/p>\n

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\u8881\u6743\u526f\u6559\u6388\uff0c\u535a\u5bfc\uff0c\u798f\u5efa\u7701\u6770\u9752\uff0c\u56fd\u5bb6\u4f20\u67d3\u75c5\u8bca\u65ad\u8bd5\u5242\u4e0e\u75ab\u82d7\u5de5\u7a0b\u6280\u672f\u7814\u7a76\u4e2d\u5fc3(NIDVD)\u53ca\u5206\u5b50\u75ab\u82d7\u5b66\u4e0e\u5206\u5b50\u8bca\u65ad\u5b66\u56fd\u5bb6\u91cd\u70b9\u5b9e\u9a8c\u5ba4(SKLVD)\u75c5\u6bd2\u6027\u809d\u708e\u7814\u7a76\u7ec4\u7ec4\u957f\uff0c\u5728Sci Transl Med\u3001Nat Commun\u3001PNAS\u3001Gut\u3001 J Hepatol\u7b49\u56fd\u9645\u77e5\u540d\u6742\u5fd7\u53d1\u8868\u5b66\u672f\u8bba\u658740\u4f59\u7bc7\u5e76\u4f5c\u4e3a\u56e2\u961f\u9aa8\u5e72\u8363\u83b72015\u5e74\u5ea6\u201c\u6c42\u662f\u6770\u51fa\u79d1\u6280\u6210\u5c31\u96c6\u4f53\u5956\u201d\u3002<\/p>\n

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