{"id":150164,"date":"2018-08-13T06:30:15","date_gmt":"2018-08-12T22:30:15","guid":{"rendered":"\/\/m.iemloyee.com\/?p=150164"},"modified":"2018-08-12T23:37:26","modified_gmt":"2018-08-12T15:37:26","slug":"%e5%8d%97%e6%b4%8b%e7%90%86%e5%b7%a5%e6%b5%a6%e4%be%83%e8%a3%94adv-mater-%e6%9c%89%e6%9c%ba%e5%8d%8a%e5%af%bc%e4%bd%93%e6%9d%90%e6%96%99%e5%9c%a8","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=150164","title":{"rendered":"\u5357\u6d0b\u7406\u5de5\u6d66\u4f83\u88d4Adv. Mater.: \u6709\u673a\u534a\u5bfc\u4f53\u6750\u6599\u5728\u6df1\u5c42\u7ec4\u7ec7\u5206\u5b50\u6210\u50cf\u4e2d\u7684\u5e94\u7528"},"content":{"rendered":"

\u3010\u5f15\u8a00<\/b><\/strong>\u3011<\/p>\n

\u5149\u5b66\u6210\u50cf\u5728\u751f\u7269\u5b66\u548c\u533b\u5b66\u4e2d\u6709\u7740\u975e\u5e38\u91cd\u8981\u7684\u4f5c\u7528\uff0c\u4f46\u662f\u5176\u4f9d\u7136\u5b58\u5728\u8bf8\u591a\u95ee\u9898\uff0c\u6bd4\u5982\u7531\u4e8e\u5149\u6563\u5c04\u548c\u7ec4\u7ec7\u81ea\u53d1\u8367\u5149\u5f15\u8d77\u7684\u8f83\u4f4e\u7684\u4fe1\u566a\u6bd4\u548c\u8f83\u6d45\u7684\u7ec4\u7ec7\u63a2\u6d4b\u6df1\u5ea6\u3002\u4e3a\u4e86\u89e3\u51b3\u8fd9\u4e9b\u95ee\u9898\uff0cNIR-II\u8367\u5149\u6210\u50cf\u3001\u81ea\u53d1\u5149\u6210\u50cf\u548c\u5149\u58f0\u6210\u50cf\u6280\u672f\u5f00\u59cb\u51fa\u73b0\u5e76\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u8fd9\u4e9b\u6210\u50cf\u6280\u672f\u5206\u522b\u901a\u8fc7\u51cf\u5c11\u5149\u4e0e\u7ec4\u7ec7\u7684\u76f8\u4e92\u4f5c\u7528\u3001\u6d88\u9664\u5b9e\u65f6\u5149\u6fc0\u53d1\u548c\u68c0\u6d4b\u58f0\u97f3\u4fe1\u53f7\u6765\u8fbe\u5230\u66f4\u4f18\u8d28\u7684\u6210\u50cf\u6548\u679c\u3002\u56e0\u4e3a\u6ee1\u8db3\u5149\u8c31\u5438\u6536\/\u53d1\u5c04\u8303\u56f4\u8d85\u51fa\u53ef\u89c1\u5149\u533a\u57df\u7684\u5185\u6e90\u6027\u5206\u5b50\u7684\u7f3a\u5c11\uff0c\u6240\u4ee5\u9700\u8981\u5f00\u53d1\u663e\u5f71\u5242\u7528\u4e8e\u6df1\u5c42\u7ec4\u7ec7\u5149\u5b66\u6210\u50cf\u3002\u62e5\u6709\u03c0\u5171\u8f6d\u7ed3\u6784\u7684\u6709\u673a\u534a\u5bfc\u4f53\u6750\u6599\uff0c\u7531\u4e8e\u8f83\u5bb9\u6613\u7684\u5316\u5b66\u4fee\u9970\u548c\u660e\u786e\u7684\u7ed3\u6784-\u6027\u80fd\u5173\u7cfb\uff0c\u53ef\u4ee5\u901a\u8fc7\u4e0d\u540c\u7684\u8bbe\u8ba1\u4e0e\u5408\u6210\u6765\u6ee1\u8db3\u4e0d\u540c\u6210\u50cf\u6280\u672f\u7684\u8981\u6c42\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb<\/b><\/strong>\u3011<\/p>\n

\u8fd1\u65e5\uff0c\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66<\/b><\/strong>\u7684\u6d66<\/b><\/strong>\u4f83\u88d4\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/b><\/strong>\u5728\u56fd\u9645\u6743\u5a01\u6742\u5fd7Adv. Mater.<\/b><\/strong>\u4e0a\u5728\u7ebf\u53d1\u8868\u4e86\u9898\u4e3a”Organic Semiconducting Agents for Deep-Tissue Molecular Imaging: Second Near-Infrared Fluorescence, Self-Luminescence, and Photoacoustics<\/b><\/strong>“\u7684\u7efc\u8ff0\u6587\u7ae0\u3002\u6587\u7ae0\u603b\u7ed3\u4e86\u57fa\u4e8e\u6709\u673a\u534a\u5bfc\u4f53\u6750\u6599\u7684\u5c0f\u5206\u5b50\u548c\u7eb3\u7c73\u7c92\u5b50\u663e\u5f71\u5242\u5728\u6df1\u5c42\u7ec4\u7ec7\u5149\u5b66\u6210\u50cf\u4e2d\u7684\u5e94\u7528\uff1b\u91cd\u70b9\u8ba8\u8bba\u4e86\u901a\u8fc7\u4f18\u5316\u5206\u5b50\u8bbe\u8ba1\u548c\u6750\u6599\u5236\u5907\u7b49\u7b56\u7565\u6765\u63d0\u9ad8\u663e\u50cf\u5242\u7684\u6210\u50cf\u7684\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u548c\u7075\u654f\u5ea6\uff1b\u5e76\u6700\u540e\u5c55\u671b\u4e86\u73b0\u9636\u6bb5\u9762\u4e34\u7684\u6311\u6218\u548c\u672a\u6765\u6f5c\u5728\u7684\u673a\u9047\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/b><\/strong><\/p>\n

NIR-<\/b><\/strong>\u2161<\/b><\/strong>\u8367\u5149<\/b><\/strong>\u6210\u50cf<\/b><\/strong><\/p>\n

NIR-\u2161\u8367\u5149\u6210\u50cf\u4e3b\u8981\u5229\u75281000-1700\u00a0nm\u6ce2\u957f\u8303\u56f4\u7684\u5149\u5b50\u8fdb\u884c\u6210\u50cf\u3002\u548cNIR-\u2160\u8367\u5149\u6210\u50cf\u76f8\u6bd4\uff0cNIR-\u2161\u8367\u5149\u6210\u50cf\u5177\u6709\u66f4\u5c11\u7684\u5149\u6563\u5c04\u548c\u66f4\u4f4e\u7684\u7ec4\u7ec7\u81ea\u53d1\u8367\u5149\uff0c\u56e0\u6b64\u5177\u6709\u66f4\u9ad8\u7684\u6210\u50cf\u4fe1\u566a\u6bd4\u548c\u7a7f\u900f\u6df1\u5ea6\u3002<\/b><\/strong><\/p>\n

\u81ea\u53d1\u5149\u6210\u50cf<\/b><\/strong><\/p>\n

\u81ea\u53d1\u5149\u6210\u50cf\u7531\u4e8e\u65e0\u9700\u5b9e\u65f6\u5149\u6fc0\u53d1\uff0c\u53ef\u4ee5\u5b8c\u5168\u907f\u514d\u5b9e\u65f6\u5149\u6fc0\u53d1\u6240\u9020\u6210\u7684\u7ec4\u7ec7\u81ea\u53d1\u8367\u5149\u3002\u56e0\u6b64\uff0c\u548c\u4f20\u7edf\u7684\u8367\u5149\u6210\u50cf\u6280\u672f\u76f8\u6bd4\uff0c\u81ea\u53d1\u5149\u6210\u50cf\u5177\u6709\u8f83\u4f4e\u7684\u6210\u50cf\u80cc\u666f\u503c\u548c\u8f83\u9ad8\u7684\u6210\u50cf\u4fe1\u566a\u6bd4\u3002\u81ea\u53d1\u5149\u6210\u50cf\u6709\u4e09\u79cd\u7c7b\u578b\uff1a\u751f\u7269\u53d1\u5149\u3001\u5316\u5b66\u53d1\u5149\u548c\u4f59\u8f89\u53d1\u5149\u3002\u751f\u7269\u53d1\u5149\u4f9d\u8d56\u4e8e\u9176\u53cd\u5e94\u6765\u4ea7\u751f\u5149\u5b50\uff1b\u5316\u5b66\u53d1\u5149\u662f\u901a\u8fc7\u57fa\u8d28\u4e0e\u6d3b\u6027\u6c27\u5316\u7269\u8d28\u4e4b\u95f4\u7684\u5316\u5b66\u53cd\u5e94\u6765\u4ea7\u751f\u5149\u5b50\uff1b\u4f59\u8f89\u53d1\u5149\u662f\u6750\u6599\u5728\u5149\u6fc0\u53d1\u7ed3\u675f\u540e\uff0c\u4ee5\u5149\u7684\u5f62\u5f0f\u5c06\u80fd\u91cf\u7f13\u6162\u91ca\u653e\u7684\u53d1\u5149\u73b0\u8c61\u3002<\/p>\n

\u5149\u58f0\u6210\u50cf<\/b><\/strong><\/p>\n

\u5149\u58f0\u6210\u50cf\u662f\u4e00\u79cd\u7ed3\u5408\u5149\u5b66\u5438\u6536\u548c\u8d85\u58f0\u6ce2\u4f20\u64ad\u7684\u65b0\u5f71\u50cf\u6280\u672f\uff0c\u5176\u5229\u7528\u8109\u51b2\u6fc0\u5149\u4f5c\u4e3a\u6fc0\u53d1\u6e90\uff0c\u5438\u6536\u4f53\u5c06\u5438\u6536\u7684\u5149\u80fd\u91cf\u8f6c\u5316\u4e3a\u70ed\u80fd\u5e76\u5f15\u8d77\u5c40\u90e8\u6e29\u5ea6\u5347\u9ad8\uff0c\u4ece\u800c\u5bfc\u81f4\u70ed\u81a8\u80c0\u5e76\u4ea7\u751f\u538b\u529b\u6ce2\uff0c\u5373\u5149\u58f0\u4fe1\u53f7\u3002\u56e0\u4e3a\u58f0\u97f3\u4fe1\u53f7\u5728\u7ec4\u7ec7\u4e2d\u7684\u6563\u5c04\u51e0\u4e4e\u53ef\u4ee5\u5ffd\u7565\uff0c\u6240\u4ee5\u5149\u58f0\u6210\u50cf\u7684\u7ec4\u7ec7\u63a2\u6d4b\u6df1\u5ea6\u4ec5\u53d6\u51b3\u4e8e\u6fc0\u53d1\u5149\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\uff0c\u800c\u4e0d\u50cf\u8367\u5149\u6210\u50cf\u540c\u65f6\u53d6\u51b3\u4e8e\u6fc0\u53d1\u5149\u548c\u53d1\u5c04\u5149\u7684\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\uff0c\u56e0\u6b64\u53ef\u4ee5\u5b9e\u73b0\u66f4\u6df1\u7ec4\u7ec7\u7684\u6210\u50cf\u3002<\/p>\n

Figure 1.\u00a0<\/b><\/strong>\u5149\u4e0e\u751f\u7269\u7ec4\u7ec7\u4e4b\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u793a\u610f\u56fe<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). \u8367\u5149\u6210\u50cf<\/p>\n

(b). \u81ea\u53d1\u5149\u6210\u50cf<\/p>\n

(c). \u5149\u58f0\u6210\u50cf<\/p>\n

(d). \u6c27\u5408\u8840\u7ea2\u86cb\u767d\u548c\u8131\u6c27\u8840\u7ea2\u86cb\u767d\u7684\u5438\u6536\u5149\u8c31<\/p>\n

(e). \u4e0d\u540c\u751f\u7269\u7ec4\u7ec7\u7684\u6563\u5c04\u7cfb\u6570<\/p>\n

(f). \u4e0d\u540c\u5c0f\u9f20\u5668\u5b98\u7684\u81ea\u8367\u5149\u5149\u8c31\u56fe<\/p>\n

Scheme 1. <\/b><\/strong>\u7528\u4e8e<\/b><\/strong>NIR-<\/b><\/strong>\u2161<\/b><\/strong>\u8367\u5149\u6210\u50cf<\/b><\/strong>\u7684<\/b><\/strong>SPs\/SMs<\/b><\/strong>\u7684\u5316\u5b66\u7ed3\u6784<\/b><\/strong>\u5f0f<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Scheme 2.<\/b><\/strong>\u4e0e<\/b><\/strong>SPs\/SMs<\/b><\/strong>\u5171\u6c89\u6dc0\u5236\u5907\u6709\u673a\u534a\u5bfc\u4f53\u7eb3\u7c73\u6750\u6599\u7684<\/b><\/strong>a) <\/b><\/strong>\u5c0f\u5206\u5b50\u548c<\/b><\/strong>b) <\/b><\/strong>\u4e24\u4eb2\u6027\u805a\u5408\u7269\u7684\u5316\u5b66\u7ed3\u6784\u5f0f<\/b><\/strong>\u3002<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 2. <\/b><\/strong>NIR-<\/b><\/strong>\u2161\u8367\u5149<\/b><\/strong>\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SPN1\u7684\u5438\u6536\u548c\u53d1\u5c04\u5149\u8c31<\/p>\n

(b). \u5c0f\u9f20\u7684\u80a1\u52a8\u8109NIR-\u2161\u8367\u5149\u6210\u50cf<\/p>\n

(c,d). \u57fa\u7ebf\u6263\u9664\u524d\u540e\u7684NIR-\u2161\u8367\u5149\u5f3a\u5ea6<\/p>\n

(e). \u5728\u4e0d\u540c\u65f6\u95f4\uff0c\u7ea2\u6846\u533a\u57df\u5185\u7684NIR-\u2161\u8367\u5149\u6210\u50cf<\/p>\n

(f). \u5cf0\u503c\u5f3a\u5ea6\u548c\u5fc3\u810f\u8109\u640f\u4e4b\u95f4\u7684\u62df\u5408\u66f2\u7ebf<\/p>\n

(g). SMN3\u7684\u5438\u6536\u548c\u53d1\u5c04\u5149\u8c31<\/p>\n

(h). \u6ce8\u5c04SM3\u548cSWCNTs\u540e\uff0c\u5c0f\u9f20\u7684NIR-\u2161\u8367\u5149\u6210\u50cf<\/p>\n

(i).\u00a0\u6ce8\u5c04SM3\u540e\uff0c\u5c0f\u9f20\u5668\u5b98NIR-\u2161\u8367\u5149\u5f3a\u5ea6\u7684\u5b9a\u91cf<\/p>\n

(j). \u6ce8\u5c04SM3\u548cICG\u540e\uff0c\u5c0f\u9f20\u8111\u8840\u7ba1\u7684\u8367\u5149\u6210\u50cf<\/p>\n

(k). \u5c0f\u9f20\u63a5\u53d7NIR-\u2161\u8367\u5149\u6210\u50cf\u8f85\u52a9\u624b\u672f\u5207\u9664\u80bf\u7624\u524d\u540e\u7684\u8367\u5149\u6210\u50cf<\/p>\n

(l). NIR-\u2161\u8367\u5149\u6210\u50cf\u7684\u4fe1\u566a\u6bd4<\/p>\n

Figure 3. <\/b><\/strong>\u80bf\u7624\u7684\u8fd1\u7ea2\u5916\u751f\u7269\u53d1\u5149\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SPNs\u81ea\u53d1\u5149BRET-FRET\u793a\u610f\u56fe<\/p>\n

(b). SPNs-BF\u751f\u7269\u53d1\u5149\u53d1\u5c04\u5149\u8c31<\/p>\n

(c). SPN2-BF-cRGD\u7684\u751f\u7269\u53d1\u5149\u6210\u50cf\u548c\u8367\u5149\u6210\u50cf<\/p>\n

(d). c\u4e2d\u6210\u50cf\u56fe\u7684\u4fe1\u566a\u6bd4<\/p>\n

Scheme 3. <\/b><\/strong>\u7528\u4e8e\u81ea\u53d1\u5149\u6210\u50cf\u7684<\/b><\/strong>SPs<\/b><\/strong>\u548c<\/b><\/strong>SMs<\/b><\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u5f0f<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 4. <\/b><\/strong>\u8fd1\u7ea2\u5916\u5316\u5b66\u53d1\u5149\u548c\u8367\u5149\u5bf9\u836f\u7269\u8bf1\u5bfc\u809d\u6bd2\u6027\u7684\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SPN3-CF\u68c0\u6d4bH2<\/sub>O2<\/sub>\u548cONOO–<\/sup>\/–<\/sup>OCl\u7684\u5316\u5b66\u53d1\u5149\u901a\u9053\u548c\u8367\u5149\u901a\u9053\u793a\u610f\u56fe<\/p>\n

(b). \u5316\u5b66\u53d1\u5149\u5f3a\u5ea6\u968fH2<\/sub>O2<\/sub>\u6d53\u5ea6\u7684\u53d8\u5316<\/p>\n

(c). \u52a0\u5165ONOO–<\/sup>\uff0c\u8367\u5149\u5149\u8c31\u7684\u53d8\u5316<\/p>\n

(d). \u5c0f\u9f20\u7684\u5316\u5b66\u53d1\u5149\u6210\u50cf\u548c\u8367\u5149\u6210\u50cf\u56fe<\/p>\n

(e,f). \u809d\u810f\u7684\u5316\u5b66\u53d1\u5149\u5f3a\u5ea6\u548c\u8367\u5149\u5f3a\u5ea6<\/p>\n

Figure 5. <\/b><\/strong>\u795e\u7ecf\u708e\u75c7\u7684\u8fd1\u7ea2\u5916\u5316\u5b66\u53d1\u5149\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). CRET\u673a\u7406\u793a\u610f\u56fe<\/p>\n

(b). SPNs\u7684\u8367\u5149\u548c\u5316\u5b66\u53d1\u5149\u91cf\u5b50\u4ea7\u7387\u968f\u80fd\u5e26\u7684\u53d8\u5316<\/p>\n

(c). SPN7\u7684\u5316\u5b66\u53d1\u5149\u5149\u8c31\u548c\u8367\u5149\u5149\u8c31<\/p>\n

(d). \u5c0f\u9f20\u5316\u5b66\u53d1\u5149\u6210\u50cf\u56fe<\/p>\n

(e). \u5316\u5b66\u53d1\u5149\u5f3a\u5ea6<\/p>\n

Figure 6. <\/b><\/strong>\u4f53\u5185\u8d85\u957f\u78f7\u5149\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SMNs\u8d85\u957f\u78f7\u5149\u7684\u673a\u7406<\/p>\n

(b). SMNs\u5f52\u4e00\u5316\u7684\u78f7\u5149\u5149\u8c31<\/p>\n

(c). \u68c0\u6d4b\u8d85\u957f\u78f7\u5149\u793a\u610f\u56fe<\/p>\n

(d). SMNs\u7684\u4f53\u5916\u8d85\u957f\u78f7\u5149\u6210\u50cf<\/p>\n

(e). \u6ce8\u5c04SMN11-T\u540e\uff0c\u6dcb\u5df4\u7ed3\u7684\u8d85\u957f\u78f7\u5149\u548c\u8367\u5149\u6210\u50cf<\/p>\n

(f). \u6dcb\u5df4\u7ed3\u6210\u50cf\u7684\u4fe1\u566a\u6bd4<\/p>\n

Figure 7. <\/b><\/strong>\u5206\u5b50\u4f59\u8f89<\/b><\/strong>\u53d1\u5149<\/b><\/strong>\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). \u57fa\u4e8ePPV\u7684SPNs\u4f59\u8f89\u53d1\u5149\u6210\u50cf\u673a\u7406<\/p>\n

(b). SPNs\u63ba\u6742NCBS\u540e\u7684\u4f59\u8f89\u53d1\u5149\u548c\u8367\u5149\u7684\u5b9a\u91cf<\/p>\n

(c). SPN2-NCBS5\u7a7f\u900f\u793a\u610f\u56fe<\/p>\n

(d). SPN2-NCBS5\u5728\u5c0f\u9f20\u4e2d\u7684\u4f59\u8f89\u6210\u50cf\u548c\u8367\u5149\u6210\u50cf<\/p>\n

(e). d\u4e2d\u7684\u4fe1\u566a\u6bd4<\/p>\n

(f). \u80bf\u7624\u6210\u50cf\u793a\u610f\u56fe<\/p>\n

(g). \u5c0f\u9f20\u7684\u80bf\u7624\u6210\u50cf\u548c\u4f59\u8f89\u6210\u50cf<\/p>\n

(h). \u4fe1\u566a\u6bd4\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(i). \u751f\u7269\u5def\u57fa\u6d3b\u5316\u7684\u4f59\u8f89\u6210\u50cf\u793a\u610f\u56fe<\/p>\n

(j). \u5c0f\u9f20\u7ecf\u8fc7\u4e0d\u540c\u5904\u7406\u540e\u7684\u4f59\u8f89\u6210\u50cf<\/p>\n

(k). \u809d\u810f\u4fe1\u566a\u6bd4\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

Figure 8. <\/b><\/strong>\u53ef\u6fc0\u6d3b\u7684\u5149\u58f0\u5206\u5b50\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SPNs\u7528\u4e8e\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe<\/p>\n

(b). ROS\u5904\u7406SPNs\u524d\u540e\u7684\u5149\u58f0\u8c31\u56fe<\/p>\n

(c). \u5728\u6ce8\u5c04SPN8\u540e\uff0c\u5c0f\u9f20\u7684PA\/\u8d85\u58f0\u6210\u50cf<\/p>\n

(d). \u5728\u6ce8\u5c04SPN8\u540e\uff0c\u5149\u58f0\u4fe1\u53f7\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(e). \u57fa\u4e8eSMN\u7684\u63a2\u9488\u7528\u4e8epH\u4f20\u611f<\/p>\n

(f,g). SMN\u7684\u80bf\u7624\u5149\u58f0\u6210\u50cf<\/p>\n

(h). \u5149\u58f0\u4fe1\u53f7\u968fSMN16\u6ce8\u5c04\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

Scheme 4. <\/b><\/strong>\u7528\u4e8e\u5149\u58f0\u6210\u50cf\u7684<\/b><\/strong>SPs<\/b><\/strong>\u548c<\/b><\/strong>SMs<\/b><\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u5f0f<\/b><\/strong><\/p>\n

\"\"<\/p>\n

Figure 9. <\/b><\/strong>\u63ba\u6742\u653e\u5927\u5149\u58f0\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SPNs\u901a\u8fc7PET\u7684\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe<\/p>\n

(b). SPN\u6eb6\u6db2\u5728\u79bb\u5fc3\u7ba1\u4e2d\u7684\u8367\u5149\u4fe1\u53f7\u548c\u5149\u58f0\u4fe1\u53f7<\/p>\n

(c). SPN\u6eb6\u6db2\u5728\u6fc0\u5149\u7167\u5c04300\u79d2\u4e4b\u540e\u7684\u7ea2\u5916\u56fe<\/p>\n

(d). \u80bf\u7624\u5149\u58f0\u6210\u50cf<\/p>\n

(e). \u5149\u58f0\u4fe1\u53f7\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

Figure 10. <\/b><\/strong>\u8868\u9762<\/b><\/strong>\u4fee\u9970<\/b><\/strong>\u653e\u5927\u5149\u58f0\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). \u901a\u8fc7\u8868\u9762\u4fee\u9970\u7684SPNs\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe<\/p>\n

(b). SPN15\u548cSPN15-SiO2<\/sub>\u5728\u4e0d\u540c\u6d53\u5ea6\u7684\u5149\u751f\u6210\u50cf<\/p>\n

(c). \u901a\u8fc7\u6ce2\u51fd\u6570\u548c\u683c\u6797\u51fd\u6570\u6765\u6a21\u62df\u5149\u58f0\u6210\u50cf\u4fe1\u53f7<\/p>\n

(d). SPN15\u548cSPN15-SiO2<\/sub>\u7684COMSOL\u6a21\u62df\u793a\u610f\u56fe<\/p>\n

(e). SPNs\u8868\u9762\u6e29\u5ea6\u7684\u6a21\u62df<\/p>\n

(f). SPNs\u8868\u9762\u5149\u58f0\u4fe1\u53f7\u7684\u6a21\u62df<\/p>\n

Figure 11. <\/b><\/strong>\u81ea\u7ec4\u88c5\u589e\u5f3a\u5149\u58f0\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). \u81ea\u7ec4\u88c5\u589e\u5f3a\u5149\u58f0\u6210\u50cf\u793a\u610f\u56fe<\/p>\n

(b). SM17\u7684\u5149\u58f0\u632f\u5e45\u968f\u76f4\u5f84\u7684\u53d8\u5316<\/p>\n

(c). BSO\u5904\u7406\u548c\u672a\u5904\u7406\u7684\u5c0f\u9f20\u5149\u58f0\u6210\u50cf<\/p>\n

(d). BSO\u5904\u7406\u548c\u672a\u5904\u7406\u7684\u5c0f\u9f20\u4e2d\uff0c\u5149\u58f0\u4fe1\u53f7\u632f\u5e45\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

Figure 12.<\/b><\/strong>\u00a0NIR-<\/b><\/strong>\u2161<\/b><\/strong>\u5149\u58f0\u6210\u50cf<\/b><\/strong><\/p>\n

\"\"<\/p>\n

(a). SPN11-\u2160\u548cSPN16-\u2161\u7684\u5438\u6536\u5149\u8c31<\/p>\n

(b). SPN11-\u2160\u548cSPN16-\u2161\u7684\u5149\u58f0\u8c31\u56fe<\/p>\n

(c). \u542b\u6709\u4e0d\u540c\u6d53\u5ea6SPN16-\u2161\u7684\u51dd\u80f6\u7684\u56fe\u50cf<\/p>\n

(d). \u542b\u6709SPN16-\u2161\u7684\u51dd\u80f6\u7684\u5149\u58f0\u56fe\u50cf<\/p>\n

(e). PA\u4fe1\u566a\u6bd4\u968f\u65f6\u95f4\u7684\u53d8\u5316<\/p>\n

(f). SPN16-\u2161\u7684\u4f53\u5185\u5149\u58f0\u6210\u50cf<\/p>\n

(g). f\u4e2d\u7684\u4fe1\u566a\u6bd4<\/p>\n

\u3010\u7ed3\u8bba\u4e0e\u5c55\u671b\u3011<\/b><\/strong><\/p>\n

\u548c\u4f20\u7edf\u7684\u8fd1\u7ea2\u5916\u6210\u50cf\u76f8\u6bd4\uff0cNIR-\u2161\u8367\u5149\u6210\u50cf\u5177\u6709\u8f83\u5c11\u7684\u5149\u4e0e\u7ec4\u7ec7\u7684\u76f8\u4e92\u4f5c\u7528\uff0c\u81ea\u53d1\u5149\u6210\u50cf\u53ef\u6d88\u9664\u5b9e\u65f6\u5149\u6fc0\u53d1\u5f15\u8d77\u7684\u81ea\u53d1\u8367\u5149\uff0c\u4ee5\u53ca\u5149\u58f0\u6210\u50cf\u901a\u8fc7\u68c0\u6d4b\u57fa\u672c\u65e0\u6563\u5c04\u7684\u58f0\u97f3\u4fe1\u53f7\uff0c\u56e0\u6b64\u5927\u5927\u63d0\u9ad8\u4e86\u6210\u50cf\u4fe1\u566a\u6bd4\u4ee5\u53ca\u7ec4\u7ec7\u7a7f\u900f\u6df1\u5ea6\u3002\u5c3d\u7ba1\u5df2\u6709\u8bf8\u591a\u57fa\u4e8e\u6709\u673a\u534a\u5bfc\u4f53\u6750\u6599\u7684\u663e\u50cf\u5242\u88ab\u5f00\u53d1\u51fa\u6765\uff0c\u5e76\u53d6\u5f97\u4e86\u4f18\u5f02\u7684\u6210\u50cf\u6027\u80fd\uff0c\u4f46\u662f\u8fd8\u6709\u8bf8\u591a\u95ee\u9898\u4e9f\u5f85\u653b\u514b\u4e0e\u89e3\u51b3\uff0c\u6bd4\u5982\u8fdb\u4e00\u6b65\u63d0\u9ad8NIR-\u2161\u8367\u5149\u663e\u50cf\u5242\u7684\u91cf\u5b50\u4ea7\u7387\u00a0\uff0c\u5f00\u53d1\u53ef\u6fc0\u6d3b\u7684NIR-\u2161\u8367\u5149\u548c\u5149\u58f0\u663e\u50cf\u5242\u4ee5\u53ca\u591a\u529f\u80fd\u5206\u5b50\u663e\u50cf\u6750\u6599\u7b49\u3002\u672a\u6765\u5c06\u4f1a\u6709\u66f4\u591a\u66f4\u4f18\u6210\u50cf\u6027\u80fd\u7684\u663e\u5f71\u5242\u7528\u4e8e\u6df1\u5c42\u7ec4\u7ec7\u6210\u50cf\u7684\u6750\u6599\u88ab\u5f00\u53d1\u51fa\u6765\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1a<\/strong>Organic Semiconducting Agents for Deep-Tissue Molecular Imaging: Second Near-Infrared Fluorescence, Self-Luminescence, and Photoacoustics<\/a>\u00a0(Adv. Mater., 2018,\u00a0DOI\uff1a10.1002\/adma.201801778)<\/p>\n

\u8bfe\u9898\u7ec4\u4ecb\u7ecd\uff1a<\/p>\n

\u6d66\u4f83\u88d4\u00a0(Pu Kanyi) \u6559\u6388\u73b0\u4e3a\u65b0\u52a0\u5761\u5357\u6d0b\u7406\u5de5\u5927\u5b66\uff08QS World University Rankings #12\uff09\u5316\u5b66\u4e0e\u751f\u7269\u533b\u5b66\u5de5\u7a0b\u5b66\u9662(SCBE)\u526f\u6559\u6388\u3002\u76ee\u524d\u7684\u7814\u7a76\u65b9\u5411\u4fa7\u91cd\u4e8e\u6709\u673a\u5149\u5b66\u7eb3\u7c73\u63a2\u9488\u5728\u75be\u75c5\u8bca\u7597\u4e0e\u836f\u7269\u6bd2\u6027\u68c0\u6d4b\u4e2d\u7684\u5e94\u7528\uff0c\u6d89\u53ca\u667a\u80fd\u54cd\u5e94\u578b\u6d3b\u4f53\u8367\u5149\u3001\u5149\u58f0\u6210\u50cf\uff0c\u7eb3\u7c73\u533b\u836f\uff0c\u5149\u70ed\u8c03\u63a7\u79bb\u5b50\u901a\u9053\u4e0e\u57fa\u56e0\u8868\u8fbe\u7b49\u7814\u7a76\u3002\u9996\u6b21\u63d0\u51fa\u7684\u53ef\u964d\u89e3\u5171\u8f6d\u805a\u5408\u7269\u7528\u4e8e\u4f59\u8f89\u5206\u5b50\u6210\u50cf(molecular afterglow imaging)\u8fd1\u671f\u53d1\u8868\u4e8eNature Biotechnology\u3002\u81ea2015\u5e746\u6708\u6210\u7acb\u81f3\u4eca\uff0c\u8be5\u56e2\u961f\u5df2\u5728\u56fd\u9645\u4e3b\u6d41\u671f\u520a\u4e0a\u53d1\u8868\u9ad8\u6c34\u5e73\u6587\u7ae050\u591a\u7bc7\uff08\u5305\u62ecNat. Biotechnol., Nat. Nanotechnol., Nat. Commun., J. Am. Chem. Soc., Angew. Chem., Int. Ed., Adv. Mater., Nano Lett.\u7b49\uff09\u3002\u6d66\u4f83\u88d4\u6559\u6388\u81f3\u4eca\u7d2f\u8ba1\u53d1\u8868\u9ad8\u6863\u6b21\u6587\u7ae0100\u591a\u7bc7\uff0cSCI H-index = 48\u3002<\/p>\n

\u8bfe\u9898\u7ec4\u4e3b\u9875\uff1ahttp:\/\/www.ntu.edu.sg\/home\/kypu\/index.html<\/p>\n

\u8fd1\u671f\u4f18\u8d28\u6587\u732e\u63a8\u8350\uff1a<\/p>\n

    \n
  1. Yuyan Jiang, Kanyi Pu. Multimodal biophotonics of semiconducting polymer nanoparticles, Acc. Chem. Res., 2018, DOI: 10.1021\/acs.accounts.8b00242.<\/li>\n
  2. Qingqing Miao, Kanyi Pu. Organic Semiconducting Agents for Deep\u2013tissue Molecular Imaging: \u00a0Second Near\u2013Infrared Fluorescence, Self\u2013luminescence, and Photoacoustics. Adv. Mater., 2018, 30, 1801778.<\/li>\n
  3. Xu Zhen, Kanyi Pu et al. Macrotheranosticprobe with disease-activated near-infrared fluorescence, photoacoustic and photothermal signals for imaging-guided therapy.\u00a0Angew. Chem., Int. Ed., 2018, 57, 7804\u20137808.\u00a0<\/li>\n
  4. Chen Xie, Kanyi Pu et al. Self-assembled semiconducting polymer nanoparticles for ultrasensitive near-infrared afterglow imaging of metastatic tumors. Adv. Mater., 2018, 30, 1801331.<\/li>\n
  5. Jingchao Li, Kanyi Pu et al. Semiconducting polymer nanoenzymes with photothermic activity for enhanced cancer therapy. Angew. Chem., Int. Ed., 2018, 2018, 57, 3995\u20133998.<\/li>\n
  6. Xu Zhen, Kanyi Pu et al. Temperature-correlated afterglow of a semiconducting polymer nanococktail for imaging-guided photothermal therapy. Angew. Chem., Int. Ed., 2018, 57, 3938\u20133942. (VIP)<\/li>\n
  7. Qingqing Miao, Kanyi Pu et al. Near-infrared fluorescent molecular probe for sensitive imaging of keloid. Angew. Chem., Int. Ed., 2018, 57,1256-1260.<\/li>\n
  8. Yuyan Jiang, Kanyi Pu et al. Dual-peak absorbing semiconducting copolymer nanoparticles for first and second near-infrared window photothermal therapy: a comparative study. Adv. Mater., 2018, 30, 1705980.<\/li>\n
  9. Xu Zhen, Kanyi Pu et al. Semiconducting photothermal nanoagonist for remote-controlled specific cancer therapy. Nano Lett., 2018, 18, 1498-1505.<\/li>\n
  10. Houjuan Zhu, Kanyi Pu et al. Oxygenic hybrid semiconducting nanoparticles for enhanced photodynamic therapy. Nano Lett., 2018, 10, 586-594.<\/li>\n
  11. Qingqing Miao, Kanyi Pu et al. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles. Nat. Biotechnol., 2017, 35, 1102-1110.<\/li>\n
  12. Yan Lyu, Kanyi Pu et al. Dendronized semiconducting polymer as photothermal nanocarrier for remote activation of gene expression. Angew. Chem., Int. Ed., 2017, 129, 9283-9287.<\/li>\n
  13. Chen Xie, Kanyi Pu et al. Nanoparticle regrowth enhances photoacoustic signals of semiconducting macromolecular probe for in vivo imaging. Adv. Mater., 2017, 29, 1703693.<\/li>\n
  14. Xu Zhen, Kanyi Pu et al. Ultralong phosphorescence of water-soluble organic nanoparticles for in vivo afterglow imaging. Adv. Mater., 2017, 29, 1606665.<\/li>\n
  15. Jianjian Zhang, Kanyi Pu et al. Activatable photoacoustic nanoprobes for in vivo ratiometric imaging of peroxynitrite. Adv. Mater., 2017, 29, 1604764.<\/li>\n
  16. Yuyan Jiang, Kanyi Pu et al. Broadband absorbing semiconducting polymer nanoparticles for photoacoustic imaging in second near-infrared window. Nano Lett., 2017, 17, 4964-4969.<\/li>\n
  17. Yan Lyu, Kanyi Pu et al. Semiconducting polymer nanobioconjugates for targeted photothermal activation of neurons. J. Am. Chem. Soc., 2016, 138, 9049-9052.<\/li>\n
  18. Qingqing Miao, Kanyi Pu et al. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH. Adv. Mater., 2016, 28, 3662-3668.<\/li>\n
  19. Yan Lyu, Kanyi Pu et al. Intraparticle molecular orbital engineering of semiconducting polymer nanoparticles as amplified theranostics for in vivo photoacoustic imaging and photothermal therapy. ACS Nano, 2016, 10, 4472\u20134481.<\/li>\n<\/ol>\n

    \u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002 \u00a0\u00a0<\/p>\n

    \u6750\u6599\u725b\u7f51\u662f\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a><\/strong>\u3002<\/div>\n
    \u00a0<\/div>\n
    \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/div>\n
    \u00a0<\/div>\n
    \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/div>\n
    \u00a0<\/div>\n
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