{"id":149592,"date":"2018-08-14T06:30:03","date_gmt":"2018-08-13T22:30:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=149592"},"modified":"2018-08-12T23:08:13","modified_gmt":"2018-08-12T15:08:13","slug":"%e5%b1%b1%e4%b8%9c%e5%b8%88%e8%8c%83%e5%a4%a7%e5%ad%a6%e5%94%90%e6%b3%a2%e6%95%99%e6%8e%88%e5%9b%a2%e9%98%9fangew-%e8%bf%87%e6%b0%a7%e5%8c%96%e6%b0%a2%e6%b4%bb%e5%8c%96%e7%9a%84%e5%8f%8c%e5%85%89","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=149592","title":{"rendered":"\u5c71\u4e1c\u5e08\u8303\u5927\u5b66\u5510\u6ce2\u6559\u6388\u56e2\u961fAngew: \u8fc7\u6c27\u5316\u6c22\u6d3b\u5316\u7684\u53cc\u5149\u5b50\u4e00\u6c27\u5316\u78b3\u91ca\u653e\u5242"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u4f17\u6240\u5468\u77e5\uff0c\u4e00\u6c27\u5316\u78b3\u662f\u4e00\u79cd\u6bd2\u6027\u6c14\u4f53\u3002\u4f46\u662f\u8d8a\u6765\u8d8a\u591a\u7684\u7814\u7a76\u8868\u660e\uff0c\u8fd9\u79cd\u7531\u8840\u7ea2\u7d20\u4ee3\u8c22\u751f\u6210\u7684\u5185\u6e90\u6027\u6c14\u4f53\u662f\u4e00\u79cd\u91cd\u8981\u7684\u751f\u7406\u6c14\u4f53\u4fe1\u53f7\u5206\u5b50\uff0c\u5728\u7ec6\u80de\u4fdd\u62a4\u4ee5\u53ca\u7ef4\u6301\u7ec6\u80de\u5185\u73af\u5883\u5e73\u8861\u4e0a\u626e\u6f14\u7740\u4e0d\u53ef\u6216\u7f3a\u7684\u89d2\u8272\u3002\u7136\u800c\uff0c\u4e00\u6c27\u5316\u78b3\u548c\u8840\u7ea2\u86cb\u767d\u975e\u5e38\u5bb9\u6613\u7ed3\u5408\uff0c\u8fd9\u4f7f\u5f97\u4e00\u6c27\u5316\u78b3\u4f5c\u4e3a\u5438\u5165\u5f0f\u836f\u5242\u4f7f\u7528\u65f6\u4f1a\u51fa\u73b0\u8bf8\u5982\u5242\u91cf\u63a7\u5236\u3001\u9776\u5411\u9012\u9001\u7b49\u591a\u65b9\u9762\u95ee\u9898\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb<\/strong>\u3011<\/p>\n \u8fd1\u65e5\uff0c\u5c71\u4e1c\u5e08\u8303\u5927\u5b66\u7684<\/strong>\u738b\u6829\u6559\u6388\u4ee5\u53ca\u5510\u6ce2\u6559\u6388<\/strong>\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u53cc\u529f\u80fd\u6709\u673a\u5c0f\u5206\u5b50\uff08FB\uff09\u4ee5\u540c\u65f6\u5b9e\u73b0\u8fc7\u6c27\u5316\u6c22\uff08H2<\/sub>O2<\/sub>)\u68c0\u6d4b\u548c\u4e00\u6c27\u5316\u78b3\uff08CO\uff09\u7684\u91ca\u653e\u3002\u8fd9\u4e00\u6709\u673a\u5c0f\u5206\u5b50\u4e3b\u8981\u7531\u4e24\u90e8\u5206\u7ec4\u6210\uff1a\u9ec4\u916e\u9187\uff08F\uff09\uff08\u8367\u5149\u6bcd\u4f53\uff09\u548c\u787c\u9178\u916f\uff08H2<\/sub>O2<\/sub>\u54cd\u5e94\u57fa\u56e2\uff09\u3002\u9996\u5148\uff0cH2<\/sub>O2<\/sub>\u4e0eFB\u53cd\u5e94\u540e\u787c\u9178\u916f\u90e8\u5206\u6c34\u89e3\uff0c\u89e6\u53d1F\u6fc0\u53d1\u6001\u5206\u5b50\u5185\u8d28\u5b50\u8f6c\u79fb\uff0c\u4f7f\u5176\u5728\u957f\u6ce2\u5904\u6709\u660e\u663e\u7684\u8367\u5149\u201coff-on\u201d\u53d8\u5316\uff0c\u800c\u77ed\u6ce2\u5904\u65e0\u660e\u663e\u53d8\u5316\uff0c\u4ece\u800c\u5b9e\u73b0H2<\/sub>O2<\/sub>\u6bd4\u7387\u68c0\u6d4b\u3002\u4e0e\u6b64\u540c\u65f6\uff0c\u787c\u9178\u916f\u90e8\u5206\u6c34\u89e3\u540e\u4ea7\u751f\u7684F\u5728\u6fc0\u5149\u8f90\u7167\u4e0b\u53ef\u4ee5\u91ca\u653eCO\u3002F\u5149\u89e3\u540e\uff0c\u4ea7\u7269\u5747\u65e0\u8367\u5149\uff0c\u53ef\u901a\u8fc7\u8367\u5149\u7684\u201con-off\u201d\u53d8\u5316\u6765\u8ddf\u8e2aCO\u7684\u91ca\u653e\u3002\u56e0\u6b64\uff0c\u7814\u7a76\u8ba4\u4e3a\u5316\u5408\u7269FB\u53ef\u4ee5\u540c\u65f6\u5b9e\u73b0\u8fc7\u6c27\u5316\u6c22\u793a\u8e2a\u548c\u8fc7\u6c27\u5316\u6c22\u4ecb\u5bfc\u7684\u4e00\u6c27\u5316\u78b3\u5149\u63a7\u91ca\u653e\u3002\u5229\u7528\u8be5\u5206\u5b50FB\uff0c\u5728\u7ec6\u80de\u4ee5\u53ca\u6591\u9a6c\u9c7c\u6d3b\u4f53\u4e2d\uff0c\u53d1\u73b0\u4e86\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u7ed9\u836f\u540eH2O2\u6c34\u5e73\u660e\u663e\u4e0a\u8c03\uff0c\u4ece\u800c\u7ed9\u51fa\u4e86\u8840\u7ba1\u6536\u7f29\u5242II\u8bf1\u5bfcH2<\/sub>O2<\/sub>\u4ecb\u5bfc\u7684\u6c27\u5316\u5e94\u6fc0\u7684\u8bc1\u636e\u3002\u540c\u65f6\uff0c\u5728\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u523a\u6fc0\u8840\u7ba1\u6536\u7f29\u540e\uff0c\u901a\u8fc7\u7684\u5149\u63a7\u91ca\u653e\u5b9e\u73b0\u4e86\u8840\u7ba1\u7684\u6709\u6548\u6062\u590d\u30022018\u5e748\u67083\u65e5\uff0c\u76f8\u5173\u6210\u679c\u4ee5\u9898\u4e3a\u201cA Two-photon H2<\/sub>O2<\/sub>-activated CO Photoreleaser<\/strong>\u201d\u5728\u7ebf\u53d1\u8868\u5728Angew<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb<\/strong>\u3011<\/p>\n \u793a\u610f\u56fe1<\/strong> FB<\/strong>\u7684\u5316\u5b66\u7ed3\u6784\u4ee5\u53ca\u4e00\u6c27\u5316\u78b3\u5149\u63a7\u91ca\u653e\u673a\u7406<\/strong><\/p>\n \u56fe1 FB\u7684\u8fc7\u6c27\u5316\u6c22\u68c0\u6d4b\u80fd\u529b<\/strong><\/p>\n (a)\u8fc7\u6c27\u5316\u6c22\u6eb6\u6db2\u4e2d\u7684FB\u8367\u5149\u54cd\u5e94\u6027\u80fd<\/p>\n (b)\u8367\u5149\u6bd4\u7387\u54cd\u5e94\uff08585\/485nm\uff09\u6027\u80fd<\/p>\n \u56fe2 FB\u7684\u4e00\u6c27\u5316\u78b3\u91ca\u653e\u884c\u4e3a<\/strong><\/p>\n (a)405nm\u6fc0\u5149\u8f90\u7167\u4e0b\u542b\u6709\u8fc7\u6c27\u5316\u6c22\u7684FB\u6eb6\u6db2\u7684\u8367\u5149\u66f2\u7ebf<\/p>\n (b)\u76f8\u5e94\u7684\u6bd4\u7387\u53d8\u5316<\/p>\n \u56fe3 \u4f53\u5916\u4e00\u6c27\u5316\u78b3\u91ca\u653e\u884c\u4e3a\u4ee5\u53ca\u8fc7\u6c27\u5316\u6c22\u7684\u5206\u5e03<\/strong><\/p>\n a-e)\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u5728\u4e0d\u540c\u6d53\u5ea6\u8fc7\u6c27\u5316\u6c22\u8bf1\u5bfc\u7269\u6eb6\u6db2\u4e2d\u5b75\u80b2\u540e\u7684FB\u8367\u5149\u56fe\u50cf<\/p>\n (f-j)\u4e0d\u540c\u8f90\u7167\u65f6\u95f4\u4e2d\u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u7684FB\u8367\u5149\u56fe\u50cf<\/p>\n (k) \u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u7684\u8367\u5149\u6bd4\u7387\u53d8\u5316<\/p>\n (l) \u8840\u7ba1\u5e73\u6ed1\u808c\u7ec6\u80de\u4e2d\u6307\u5b9a\u5706\u5708\u533a\u57df\u7684\u8367\u5149\u6bd4\u7387\u53d8\u5316<\/p>\n \u56fe<\/strong>4\u00a0<\/strong>\u4f53\u5185\u4e00\u6c27\u5316\u78b3\u91ca\u653e\u884c\u4e3a\u4ee5\u53ca\u8fc7\u6c27\u5316\u6c22\u7684\u5206\u5e03<\/strong><\/p>\n (a-f)\u6591\u9a6c\u9c7c\u5728\u4e0d\u540c\u6d53\u5ea6\u8fc7\u6c27\u5316\u6c22\u8bf1\u5bfc\u7269\u6eb6\u6db2\u4e2d\u5b75\u80b2\u540e\u7684FB\u8367\u5149\u56fe\u50cf<\/p>\n (g-l)\u4e0d\u540c\u8f90\u7167\u65f6\u95f4\u4e2d\u6591\u9a6c\u9c7c\u7684FB\u8367\u5149\u56fe\u50cf<\/p>\n (m) (a-f)\u56fe\u50cf\u4e2d\u7684\u8367\u5149\u6bd4\u7387\u53d8\u5316<\/p>\n (n) (g-l)\u56fe\u50cf\u4e2d\u76ee\u6807\u533a\u57df\u7684\u8367\u5149\u6bd4\u7387\u53d8\u5316<\/p>\n \u56fe5 \u4e00\u6c27\u5316\u78b3\u7684\u8840\u7ba1\u6269\u5f20\u4f5c\u7528\u4ee5\u53ca\u8fc7\u6c27\u5316\u6c22\u7684\u542b\u91cf\u53d8\u5316<\/strong> (a)\u548c(e)\u6591\u9a6c\u9c7c\u7528FB\u6d78\u6ce115\u5206\u949f\u7684\u56fe\u50cf<\/p>\n (b)\u548c(f)\u6591\u9a6c\u9c7c\u7528FB\u6d78\u6ce115\u5206\u949f\u540e\u518d\u7528\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u8fdb\u884c\u7ed9\u836f\u7684\u56fe\u50cf<\/p>\n (c)\u548c(g)800nm\u6fc0\u5149\u8f90\u7167\u7528FB\u548c\u8840\u7ba1\u7d27\u7f29\u7d20\u2161\u5904\u7406\u8fc7\u7684\u6591\u9a6c\u9c7c\u56fe\u50cf<\/p>\n (d)(a-c)\u7684\u6bd4\u7387\u53d8\u5316<\/p>\n (h)(e-g)\u7684\u8840\u7ba1\u76f4\u5f84\u53d8\u5316<\/p>\n \u3010\u5c0f\u7ed3<\/strong>\u3011<\/p>\n \u8bfe\u9898\u7ec4\u5728\u672c\u6587\u4e2d\u5236\u5907\u4e86\u4e00\u79cd\u65b0\u578b\u53cc\u529f\u80fd\u53cc\u5149\u5b50\u5206\u5b50FB\uff0c\u5b9e\u73b0\u4e86\u7ec6\u80de\u548c\u6d3b\u4f53\u5185H2<\/sub>O2<\/sub>\u9ad8\u7075\u654f\u3001\u9ad8\u9009\u62e9\u6027\u4f20\u611f\u548cH2<\/sub>O2<\/sub>\u4ecb\u5bfc\u7684\u65f6\u7a7a\u53ef\u63a7\u7684CO\u91ca\u653e\u3002\u7ec6\u80de\u548c\u6591\u9a6c\u9c7c\u5c42\u9762\u7684\u5b9e\u9a8c\u53d1\u73b0\u8840\u7ba1\u7d27\u5f20\u7d20\u2161\u7ed9\u836f\u540e\u8840\u7ba1\u6536\u7f29\u5e76\u4e14\u8fc7\u6c27\u5316\u6c22\u6c34\u5e73\u660e\u663e\u4e0a\u8c03\uff0c\u6fc0\u5149\u8f90\u7167FB\u91ca\u653e\u4e00\u6c27\u5316\u78b3\u540e\u8840\u7ba1\u6709\u6548\u6062\u590d\u72b6\u6001\uff0c\u8840\u7ba1\u8212\u5f20\u4f5c\u7528\u4e5f\u80fd\u76f4\u63a5\u53ef\u89c6\u5316\u3002\u8be5\u5e73\u53f0\u7684\u6784\u5efa\u5bf9\u4e8e\u7814\u7a76\u6c27\u5316\u5e94\u6fc0\u9884\u8b66\u4ee5\u53caCO\u6c14\u4f53\u5149\u63a7\u91ca\u653e\u5177\u6709\u91cd\u8981\u7684\u610f\u4e49\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1a<\/strong>A Two-photon H2O2-activated CO Photoreleaser<\/a>\uff08Angew, 2018, DOI: 10.1002\/anie.201805806\uff09<\/p>\n \u3010\u4f5c\u8005\u7b80\u4ecb<\/strong>\u3011<\/p>\n \u5510\u6ce2\u6559\u6388\u8bfe\u9898\u7ec4\u4e3b\u8981\u4ece\u4e8b\u5206\u5b50\u4e0e\u7eb3\u7c73\u63a2\u9488\u7814\u5236\u3001\u7ec6\u80de\u53ca\u6d3b\u4f53\u5185\u751f\u7269\u6d3b\u6027\u5206\u5b50\u7684\u9ad8\u7075\u654f\u3001\u9ad8\u7279\u5f02\u4f20\u611f\u4e0e\u793a\u8e2a\uff0c\u4ee5\u53ca\u5206\u5b50\u7cbe\u51c6\u8bca\u7597\u7b49\u65b9\u9762\u7684\u7814\u7a76\u3002\u76f8\u5173\u5185\u5bb9\u8bf7\u53c2\u9605\u8bfe\u9898\u7ec4\u7f51\u9875http:\/\/www.tangb.sdnu.edu.cn\/kycg.htm<\/a><\/p>\n \u8fd1\u671f\u4ee3\u8868\u6027\u6587\u7ae0\u5982\u4e0b\uff1a<\/p>\n 1.Yong Li, Yingzheng Shu, Muwen Liang, Xilei Xie, Xiaoyun Jiao, Xu Wang*, and Bo Tang*.\u00a0 A Two-photon H2<\/sub>O2<\/sub>-activated CO Photoreleaser\uff0cAngew. Chem. Int. Ed.<\/strong>, 2018, Accepted, DOI: 10.1002\/anie.201805806<\/p>\n 2.W. Gao, Y. Sun, M. Cai, Y. Zhao, W. Cao, Z. Liu, G. Cui, B. Tang<\/strong>*, Copper sulfide nanoparticles as a photothermal switch for TRPV1 signaling to attenuate atherosclerosis. Nat. Commun.<\/em>, 2018<\/strong>, 9<\/em>, 231.<\/p>\n 3.W. Zhang, J. Lu, X. Gao, P. Li*, W. Zhang, Y. Ma, H. Wang, B. Tang*<\/strong>, Enhanced Photodynamic Therapy by Reduced Levels of Intracellular Glutathione Obtained by Employing a Nano-MOF with CuII<\/sup> as Active Center. Angew. Chem. Int. Ed.<\/em>, 2018<\/strong>, 57<\/em>, 4891.<\/p>\n 4.B. Hu, F. Kong, X. Gao, L. Jiang, X. Li, W. Gao, K. Xu*, B. Tang*<\/strong>, Avoiding Thiol Compound Interference: A High-Fidelity Au-Se Bonding Nanoplatform and Its Biological Applications. Angew. Chem. Int. Ed<\/em>., 2018<\/strong>, 57<\/em>, 5306.<\/p>\n 5.Y. Ma, X. Y. Li, A. J. Li, P. Yang, C. Y. Zhang, B. Tang*<\/strong>, H\u2082S-activable MOF Nanoparticle Photosensitizer for Effective Photodynamic Therapy against Cancer with Controllable Singlet-oxygen Release, Angew. Chem. Int. Ed.<\/em>, 2017<\/strong>, 56<\/em>, 13752.<\/p>\n 6.K. H. Xu, D. R. Luan, X. T. Wang, B. Hu, X. J. Liu, F. P. Kong, B. Tang*<\/strong>, An Ultrasensitive Cyclization-Based Fluorescent Probe for Imaging Native HOBr in Live Cells and Zebrafish, Angew. Chem. Int. Ed.<\/em>, 2016<\/strong>, 55<\/em>, 12751.<\/p>\n 7.P. Li, L. Liu, H. B. Xiao, W. Zhang, L. L. Wang, B. Tang*<\/strong>, A New Polymer Nanoprobe Based on Chemiluminescence Resonance Energy Transfer (CRET) for Ultrasensitive Imaging of Intrinsic Superoxide Anion in Mice, J. Am. Chem. Soc.<\/em>, 2016<\/strong>, 138<\/em>, 2893.<\/p>\n 8.W. Zhang, W. Liu, P. Li*, H. B. Xiao, H. Wang, B. Tang*<\/strong>, A Fluorescence Nanosensor for Glycoproteins with Activity Based on the Molecularly Imprinted Spatial Structureof the Target and Boronate Affinity, Angew. Chem. Int. Ed.<\/em>, 2014<\/strong>, 53<\/em>, 12489.<\/p>\n 9.W. Zhang, P. Li, F. Yang, X. F. Hu, C. Z. Sun, W. Zhang, D. Z. Chen, B. Tang*<\/strong>, Dynamic and Reversible Fluorescence Imaging of Superoxide Anion Fluctuations in Live Cells and in Vivo, J. Am. Chem. Soc.<\/em>, 2013<\/strong>, 135<\/em>, 14956.<\/p>\n 10.Na Li, Chenyang Chang, Wei Pan, and Bo Tang*.A Multicolor Nanoprobe for Detection and Imaging of Tumor-Related mRNAs in Living Cells. Angew. Chem. Int. Ed.<\/em>, 2012, 51, 7426-7430<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u5b66\u672f\u7ec4NanoCJ\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n \u6750\u6599\u725b\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/a>\u3002\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n<\/p>\n
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