{"id":148973,"date":"2018-08-05T06:38:15","date_gmt":"2018-08-04T22:38:15","guid":{"rendered":"\/\/m.iemloyee.com\/?p=148973"},"modified":"2018-08-04T20:39:31","modified_gmt":"2018-08-04T12:39:31","slug":"%e6%9c%89%e6%9c%ba%e5%a4%a7%e7%89%9bdavid-w-c-macmillan%e6%9c%80%e6%96%b0nature%ef%bc%9a%e8%84%82%e8%82%aa%e6%97%8fc-h%e9%94%ae%e7%9b%b4%e6%8e%a5%e8%8a%b3%e5%9f%ba%e5%8c%96","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=148973","title":{"rendered":"\u6709\u673a\u5927\u725bDavid W.C. Macmillan\u6700\u65b0Nature\uff1a\u8102\u80aa\u65cfC-H\u952e\u76f4\u63a5\u82b3\u57fa\u5316"},"content":{"rendered":"<p><span style=\"color: #0000ff;\"><strong>\u3010\u5f15\u8a00\u3011<\/strong><\/span><\/p>\n<p>\u5c3d\u7ba1\u8fc7\u6e21\u91d1\u5c5e\u50ac\u5316\u88ab\u6210\u529f\u5e94\u7528\u4e8e\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\uff0c\u4f46\u4ecd\u5b58\u5728\u76f8\u5f53\u5927\u7684\u5c40\u9650\u6027\u3002\u8fd1\u5e74\u6765\uff0c\u5982\u5728sp<sup>3<\/sup>\u6742\u5316\u78b3\u539f\u5b50\u7684\u53cd\u5e94\u4e2d\uff0c\u5927\u90e8\u5206\u90fd\u662f\u4f9d\u9760\u5b98\u80fd\u5316\u7684\u70f7\u57fa\u91d1\u5c5e\u6216\u6eb4\u5316\u7269\u5076\u8054\u5242\u8fdb\u884c\u76f8\u5e94\u7684\u53cd\u5e94\u3002\u901a\u8fc7\u5929\u7136\u5b98\u80fd\u56e2\uff08\u5982\u7fa7\u9178\u3001\u70ef\u70c3\u548c\u9187\u7c7b\u7269\u8d28\uff09\u4e2d\u7684\u5b98\u80fd\u5316\u78b3-\u6c22\uff08C-H\uff09\u952e\uff0c\u80fd\u76f4\u63a5\u4f7f\u53cd\u5e94\u7684\u8f6c\u6362\u6548\u7387\u5f97\u5230\u63d0\u9ad8\u3002\u8fd9\u4e9b\u53cd\u5e94\u7684\u6548\u7387\u3001\u533a\u57df\u9009\u62e9\u6027\u3001\u5b98\u80fd\u56e2\u5bb9\u5fcd\u6027\u90fd\u5f88\u597d\uff0c\u5728\u5408\u6210\u9886\u57df\u88ab\u5e7f\u6cdb\u4f7f\u7528\uff0c\u4e0d\u8fc7\u5927\u90e8\u5206\u90fd\u9700\u8981\u5e95\u7269\u6d3b\u5316\u8fc7\u7a0b\u3002\u6709\u673a\u5206\u5b50\u4e00\u822c\u542b\u6709\u5927\u91cf\u7684sp<sup>3<\/sup>\u78b3\u6c22\u952e\uff08C-H\u952e\uff09\uff0c\u4f46\u5982\u4f55\u5728\u4e00\u4e2a\u6e29\u548c\u800c\u901a\u7528\u7684\u53cd\u5e94\u5e73\u53f0\u4e2d\u8ba9\u4e2d\u6027C\uff08sp<sup>3<\/sup>\uff09-H\u952e\u4e0e\u82b3\u57fa\u4eb2\u7535\u5b50\u8bd5\u5242\u76f4\u63a5\u5076\u8054\u5c1a\u672a\u5b9e\u73b0\u3002<\/p>\n<p><strong><span style=\"color: #0000ff;\">\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/span><\/strong><\/p>\n<p>\u8fd1\u65e5\uff0c\u7f8e\u56fd<strong>\u666e\u6797\u65af\u987f\u5927\u5b66<\/strong>\u5316\u5b66\u7cfb\u6559\u6388<strong>David W.C. 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bonds<\/strong>\u201d\u4e3a\u9898\u53d1\u8868\u5728\u56fd\u9645\u9876\u7ea7\u671f\u520a<strong>Nature<\/strong>\u4e0a\u3002\u82b3\u9999\u65cf\u6709\u673a\u7269\u542b\u6709\u5927\u91cf\u7684sp<sup>3<\/sup>\u78b3\u6c22\u952e\uff08C-H\u952e\uff09\uff0c\u901a\u8fc7\u5149\u9a71\u52a8\u6c27\u5316\u8fd8\u539f\u4ecb\u5bfc\u8f6c\u79fb\u7684\u6c22\u539f\u5b50\u548c\u954d\u50ac\u5316\u7ed3\u5408\uff0c\u4ee5\u954d\u4ecb\u5bfc\u4e3a\u4eb2\u6838\u8bd5\u5242\u5bf9\u82b3\u57fa\u6eb4\u5316\u7269\u8fdb\u884c\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u53ef\u4ee5\u5f97\u5230C\uff08sp<sup>3<\/sup>\uff09-C\uff08sp<sup>2<\/sup>\uff09\u4ea4\u53c9\u5076\u8054\u4ea7\u7269\u3002\u8be5\u6280\u672f\u53ef\u7701\u53bb\u4e00\u7cfb\u5217\u590d\u6742\u7684\u6709\u673a\u5408\u6210\u8fc7\u7a0b\uff0c\u80fd\u591f\u5355\u6b65\u5b9e\u73b0\u4ea7\u7269\u7684\u751f\u6210\u3002\u8fd9\u79cd\u6e29\u548c\u65b9\u6cd5\u57fa\u4e8e\u70ed\u529b\u5b66\u548cC-H\u952e\u6781\u6027\u8868\u73b0\u51fa\u53ef\u9884\u6d4b\u7684\u53cd\u5e94\u6a21\u5f0f\uff0c\u6709\u9009\u62e9\u6027\u5730\u5728\u6709\u73af\u548c\u65e0\u73af\u7cfb\u7edf\u4e2d\u5b98\u80fd\u5316\u8102\u80aa\u65cf\u7684sp<sup>3<\/sup>C-H\u952e\uff0c\u533a\u57df\u9009\u62e9\u6027\u3001\u6536\u7387\u3001\u5b98\u80fd\u56e2\u5bb9\u5fcd\u6027\u90fd\u5f88\u597d\u3002<\/p>\n<p><span style=\"color: #0000ff;\"><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/span><\/p>\n<p>\u56fe\u4e00\uff1a\u65e0\u5bfc\u5411\u57fa\u56e2\u53c2\u4e0e\u7684\u8102\u80aa\u65cfC-H\u952e\u82b3\u57fa\u5316\u53cd\u5e94<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-149161\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/08\/N-1.jpg\" alt=\"\" width=\"600\" height=\"801\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/08\/N-1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/08\/N-1-225x300.jpg 225w\" sizes=\"(max-width: 600px) 100vw, 600px\" 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\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/08\/N-5-300x188.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/p>\n<p><span style=\"color: #0000ff;\"><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/span><\/p>\n<p>\u672c\u6587\u901a\u8fc7\u5c06\u5149\u5316\u5b66\u6c27\u5316\u8fd8\u539f\u4ecb\u5bfc\u7684\u6c22\u539f\u5b50\u8f6c\u79fb\uff08hydrogen atom transfer, HAT\uff09\u548c\u954d\u50ac\u5316\u7ed3\u5408\uff0c\u5f00\u53d1\u51fa\u4e86\u5177\u6709\u9ad8\u5ea6\u9009\u62e9\u6027\u548c\u666e\u904d\u6027\u7684C-H\u82b3\u57fa\u5316\u65b9\u6cd5\uff0c\u80fd\u591f\u6fc0\u6d3b\u591a\u79cdC-H\u952e\uff0c\u8fdb\u884c\u4ea4\u53c9\u5076\u8054\u53cd\u5e94\u3002\u4f5c\u8005\u6f14\u793a\u4e86\u8fd9\u79cdC-H\u952e\u76f4\u63a5\u82b3\u57fa\u5316\u7684\u539f\u7406\u53ca\u5176\u5e94\u7528\uff0c\u5229\u7528\u8be5\u65b9\u6cd5\u80fd\u5feb\u901f\u5408\u6210\u590d\u6742\u7684\u5177\u6709\u836f\u5b66\u76f8\u5173\u6027\u7684\u6709\u673a\u7269\u3002\u672c\u6587\u987a\u5229\u5408\u6210\u4e86\u4e00\u79cd\u5177\u6709\u5f3a\u6548\u7684\u975e\u963f\u7247\u7c7b\u9547\u75db\u836f\uff0c\u5b83\u65e0\u6bd2\uff0c\u5177\u6709\u975e\u5e38\u5e7f\u9614\u7684\u5546\u4e1a\u524d\u666f\u3002<\/p>\n<p><strong>\u6587\u732e\u94fe\u63a5<\/strong>\uff1a<a href=\"https:\/\/www.nature.com\/articles\/s41586-018-0366-x\">Direct arylation of strong aliphatic C\u2013H bonds<\/a>\u00a0(Nature, 2018, 560, 70\u201375 )<\/p>\n<p>\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u98de\u7d6e\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u6574\u7406\u7f16\u8f91\u3002<\/p>\n<p>\u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com\u3002<\/p>\n<p>\u6295\u7a3f\u53ca\u5185\u5bb9\u5408\u4f5c\u8bf7\u52a0\u5fae\u4fe1cailiaokefu\u3002<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u3010\u5f15\u8a00\u3011 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