{"id":148081,"date":"2018-07-31T06:30:02","date_gmt":"2018-07-30T22:30:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=148081"},"modified":"2018-07-29T13:58:07","modified_gmt":"2018-07-29T05:58:07","slug":"%e5%88%98%e6%96%8c-angew-chem-int-ed-aie%e6%8e%a2%e9%92%88%e7%94%a8%e4%ba%8e%e8%8d%a7%e5%85%89%e7%82%b9%e4%ba%ae%e5%ae%9e%e6%97%b6%e7%94%9f%e7%89%a9%e6%ad%a3%e4%ba%a4%e8%82%bf","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=148081","title":{"rendered":"\u5218\u658c Angew. Chem. Int. Ed.: AIE\u63a2\u9488\u7528\u4e8e\u8367\u5149\u201c\u70b9\u4eae\u201d\u5b9e\u65f6\u751f\u7269\u6b63\u4ea4\u80bf\u7624\u6807\u8bb0\u548c\u5f71\u50cf\u5f15\u5bfc\u5149\u52a8\u529b\u6cbb\u7597"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u8fd1\u51e0\u5e74\uff0c\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u6280\u672f\u5728\u80bf\u7624\u7279\u5f02\u6027\u6210\u50cf\u548c\u836f\u7269\u9012\u9001\u7b49\u65b9\u9762\u5f97\u5230\u5e7f\u6cdb\u5173\u6ce8\u548c\u7814\u7a76\u3002\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u901a\u5e38\u6709\u4ee5\u4e0b\u4e24\u4e2a\u64cd\u4f5c\u6b65\u9aa4\uff1a\u7b2c\u4e00\u6b65\uff0c\u5229\u7528\u7cd6\u4ee3\u8c22\u5de5\u7a0b\uff0c\u5728\u76ee\u6807\u80bf\u7624\u7ec6\u80de\u8868\u9762\u5f15\u5165\u7528\u6d3b\u6027\u53cd\u5e94\u57fa\u56e2\uff0c\u5982\u53e0\u6c2e\u7b49\uff0c\u4f5c\u4e3a\u4eba\u5de5\u8bc6\u522b\u53d7\u4f53\uff1b\u7b2c\u4e8c\u6b65\uff0c\u5728\u6210\u50cf\u5242\uff08\u8367\u5149\u56e2\u3001\u653e\u5c04\u6027\u540c\u4f4d\u7d20\uff09\u6216\u6cbb\u7597\u5242\uff08\u5316\u7597\u836f\u7269\u3001\u5149\u654f\u5242\uff09\u4e0a\u4fee\u9970\u5bf9\u5e94\u7684\u6d3b\u6027\u53cd\u5e94\u57fa\u56e2\uff0c\u53ef\u4ee5\u4e0e\u80bf\u7624\u7ec6\u80de\u4e0a\u8868\u8fbe\u7684\u4eba\u5de5\u8bc6\u522b\u53d7\u4f53\u53d1\u751f\u5316\u5b66\u53cd\u5e94\uff0c\u4ece\u800c\u4ee5\u5171\u4ef7\u952e\u7684\u5f62\u5f0f\u8fde\u63a5\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u3002\u7531\u4e8e\u662f\u5171\u4ef7\u952e\u8fde\u63a5\uff0c\u5728\u5b9e\u73b0\u80bf\u7624\u7279\u5f02\u6027\u6210\u50cf\u548c\u80bf\u7624\u9776\u5411\u836f\u7269\u9012\u9001\u65b9\u9762\u6bd4\u4f20\u7edf\u7684\u4e3b\u52a8\u9776\u5411\u7b56\u7565\u663e\u5f97\u66f4\u6709\u6548\u3002\u6b64\u5916\uff0c\u4e3b\u52a8\u9776\u5411\u7b56\u7565\u4f9d\u8d56\u4e8e\u7ec6\u80de\u8868\u9762\u4e0a\u7684\u73b0\u6709\u8bc6\u522b\u53d7\u4f53\uff0c\u800c\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u6280\u672f\u4e0d\u53d7\u6b64\u9650\u5236\uff0c\u51e0\u4e4e\u53ef\u4ee5\u5728\u4efb\u610f\u76ee\u6807\u7ec6\u80de\u8868\u9762\u8868\u8fbe\u4eba\u5de5\u8bc6\u522b\u53d7\u4f53\u3002\u7136\u800c\uff0c\u5230\u76ee\u524d\u4e3a\u6b62\uff0c\u7531\u4e8e\u7f3a\u4e4f\u7528\u4e8e\u4f53\u5185\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u7684\u8367\u5149\u201c\u70b9\u4eae\u201d\u63a2\u9488\uff0c\u73b0\u6709\u7684\u80bf\u7624\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u5728\u5f88\u5927\u7a0b\u5ea6\u4e0a\u662f\u4f9d\u8d56\u4e8e\u4ee3\u8c22\u6e05\u9664\u4f5c\u7528\u4ee5\u5c06\u9776\u6807\u4e0e\u5185\u5728\u63a2\u9488\u4fe1\u53f7\u533a\u5206\u5f00\uff0c\u9700\u8981\u8f83\u957f\u65f6\u95f4\u624d\u80fd\u5b9e\u73b0\u5bf9\u80bf\u7624\u7684\u7279\u5f02\u6027\u6210\u50cf\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u9996\u6b21\u62a5\u9053\u4e86\u4e00\u79cd\u57fa\u4e8e\u5177\u6709\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\uff08aggregation-induced emission, AIE\uff09\u7684\u8367\u5149\u201c\u70b9\u4eae\u201d\u63a2\u9488BCN-TPET-TEG\uff0c\u7528\u4e8e\u4f53\u5185\u751f\u7269\u6b63\u4ea4\u8367\u5149\u80bf\u7624\u6807\u8bb0\u3002BCN-TPET-TEG\u7531AIE \u5149\u654f\u5242\u3001\u65e0\u94dc\u70b9\u51fb\u7684\u73af\u8f9b\u7094\u548c\u4eb2\u6c34\u4e09\u7518\u9187\u94fe\u7ec4\u6210\u3002\u5176\u5177\u5728\u53ef\u89c1\u5149\u533a\u5177\u6709\u5bbd\u7684\u5438\u6536\u5149\u8c31\uff0c\u56fa\u6001NIR\u53d1\u5149\uff0c\u4ea7\u751f1<\/sup>O2<\/sub>\u7684\u91cf\u5b50\u4ea7\u7387\u9ad8\u8fbe59.1\uff05\u7684\u4f18\u70b9\u3002\u7531\u4e8e\u4e09\u7518\u9187\u94fe\u7684\u4eb2\u6c34\u6027\u53ca\u5176AIE\u53d1\u5149\u7279\u5f81\uff0cBCN-TPET-TEG\u5728\u6c34\u6027\u4ecb\u8d28\u4e2d\u53d1\u5c04\u8f83\u5f31\uff0c\u5e76\u4e14\u5728\u4e0e\u4e0d\u540c\u751f\u7269\u5206\u5b50\u5b75\u80b2\u65f6\u5176\u8367\u5149\u51e0\u4e4e\u4e0d\u4f1a\u6539\u53d8\u4ee5\u786e\u4fdd\u4f4e\u7684\u80cc\u666f\u4fe1\u53f7\u3002\u4f46\u662f\u5f53\u5b83\u901a\u8fc7\u7ec6\u80de\u65b0\u9648\u4ee3\u8c22\u4e0e\u5f15\u5165\u80bf\u7624\u7ec6\u80de\u8868\u9762\u7684\u53e0\u6c2e\u57fa\u56e2\u53cd\u5e94\u65f6\uff0c\u63a2\u9488\u7684\u8367\u5149\u589e\u5f3a\uff0c\u4ee5\u5b9e\u73b0\u5feb\u901f\u7684\u80bf\u7624\u7279\u5f02\u6027\u6210\u50cf\u3002\u4f18\u5f02\u7684\u5149\u654f\u6027\u80fd\u4e5f\u7528\u4e8e\u5f71\u50cf\u5f15\u5bfc\u7684\u80bf\u7624\u5149\u52a8\u529b\u6cbb\u7597\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cA Light-Up Probe with Aggregation-Induced Emission for Real-Time Bio-orthogonal Tumor Labeling and Image-Guided Photodynamic Therapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\u3002\u672c\u6587\u7684\u7b2c\u4e00\u4f5c\u8005\u4e3a\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u80e1\u65b9\u535a\u58eb\u548c\u6bdb\u94ce\u535a\u58eb<\/strong>\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe\u4e00\u3001BCN-TPET-TEG\u7684\u5316\u5b66\u7ed3\u6784\u548c\u8868\u5f81<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\u00a0\uff08a\uff09 BCN-TPET-TEG\u548cTAB\u7684\u5316\u5b66\u7ed3\u6784\u5f0f\uff1b<\/p>\n

\uff08b\uff09 BCN-TPET-TEG\u5728THF \/H2<\/sub>O (v \/ v = 1:99)\u4e2d\u7684\u7d2b\u5916\u5438\u6536\u5149\u8c31\uff1b<\/p>\n

\uff08c\uff09 \u767d\u5149\u7167\u5c04\u4e0b\uff0cRose Bengal, BCN-TPET-TEG, BCN-TPET-TEG\u4e0eTAB\u5171\u805a1 h\u540e\u5bf9ABDA\u7684\u5206\u89e3\u901f\u7387\uff1b<\/p>\n

\uff08d\uff09 BCN-TPET-TEG\u548cTAB\u5728THF \/H2<\/sub>O\uff08v \/ v = 1:10\uff09\u4e2d\u4e0d\u540c\u805a\u5408\u53cd\u5e94\u65f6\u95f4\u4e0b\u7684\u8367\u5149\u5149\u8c31\uff1b<\/p>\n

\uff08e\uff09 BCN-TPET-TEG\u6216Az-TPET-TEG\u5728\u4e0d\u540c\u6761\u4ef6\u4e0b\u7684\u76f8\u5bf9\u8367\u5149\u5f3a\u5ea6\u3002<\/p>\n

\u56fe\u4e8c\u3001BCN-TPET-TEG\u7684\u4f53\u5916\u7ec6\u80de\u5b9e\u9a8c\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 \u53e0\u6c2e\u5316\u7269\u4e0e\u764c\u7ec6\u80de\u819c\u805a\u7cd6\u4f5c\u7528\u548c\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u6807\u8bb0\uff1b<\/p>\n

\uff08b\uff09 BCN-TPET-TEG\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u548cCellMask Green\u5904\u7406\u53ca\u53e0\u52a0\u540e4T1\u7684\u56fe\u50cf\uff1b<\/p>\n

\uff08c\uff09 BCN-TPET-TEG\u548cPBS\u5b75\u80b2\u540e\u4e0eAz-TPET-TEG, 4T1\u7ec6\u80de\u5171\u5b75\u80b2\u65f6\uff0cAzAcSA\u9884\u5904\u7406\u76844T1\u7684CLSM\u56fe\u50cf\u3002<\/p>\n

\u56fe\u4e09\u3001BCN-TPET-TEG\u7684\u4f53\u5185\u5c0f\u9f20\u5b9e\u9a8c\u00a0<\/strong><\/p>\n

\"\"<\/strong><\/p>\n

\uff08a\uff09 DBCO Cy5 \/BCN-TPET-TEG\u5728\u4e0d\u540c\u65f6\u95f4\u9759\u8109\u6ce8\u5c04\u540e\uff0c\u5728\u6709\u6216\u65e0AzAcSA\u7624\u5185\u9884\u5904\u7406\u76844T1\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u90e8\u4f4d\u7684\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

\uff08b\uff09 DBCO Cy5 \/BCN-TPET-TEG\u5728\u4e0d\u540c\u65f6\u95f4\u9759\u8109\u6ce8\u5c04\u540e\uff0c\u5728\u6709\u6216\u65e0AzAcSA\u7624\u5185\u9884\u5904\u7406\u76844T1\u8377\u7624\u5c0f\u9f20\u80bf\u7624\u90e8\u4f4d\u7684\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n

\uff08c\uff09 \u4e0d\u540c\u6761\u4ef6\u4e0b\u7ed9\u836f24 h\u540e\u80bf\u7624\u548c\u5668\u5b98\u7684\u8367\u5149\u6210\u50cf\uff1b<\/p>\n

\uff08d\uff09 \u4e0d\u540c\u6761\u4ef6\u4e0b\u7ed9\u836f24 h\u540e\u80bf\u7624\u548c\u5668\u5b98\u7684\u8367\u5149\u5f3a\u5ea6\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

\u7814\u7a76\u4e86\u4e00\u79cd\u591a\u529f\u80fdAIEgen\u8367\u5149\u201c\u70b9\u4eae\u201d\u63a2\u9488BCN-TPET-TEG\uff0c\u7528\u4e8e\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u4f53\u5185\u80bf\u7624\u6210\u50cf\u548c\u56fe\u50cf\u5f15\u5bfc\u5149\u52a8\u529b\u6cbb\u7597\u3002\u5728\u80bf\u7624\u7ec6\u80de\u8868\u9762\u4e0a\u4e0e\u8868\u8fbe\u7684\u53e0\u6c2e\u5316\u7269\u8fdb\u884c\u751f\u7269\u6b63\u4ea4\u53cd\u5e94\u540e\uff0c\u5206\u5b50\u8fd0\u52a8\u53d7\u5230\u9650\u5236\u4f7f\u5f97\u5206\u5b50\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\uff0cBCN-TPET-TEG\u7684\u8367\u5149\u663e\u7740\u589e\u5f3a\u3002\u901a\u8fc7\u8be5\u53d1\u5149\u63a2\u9488\u5bf9\u80bf\u7624\u8fdb\u884c\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u53ef\u4ee5\u5b9e\u73b0\u5feb\u901f\u7684\u80bf\u7624\u7279\u5f02\u6027\u6210\u50cf\u5e76\u5b9e\u65f6\u76d1\u6d4b\u5171\u4ef7\u6807\u8bb0\u7684BCN-TPET-TEG\u5728\u80bf\u7624\u4e0a\u7684\u91cf\u3002\u6b64\u5916\uff0c\u5728\u53d1\u5149\u8367\u5149\u4fe1\u53f7\u7684\u6307\u5bfc\u4e0b\uff0c\u4f7f\u7528BCN-TPET-TEG\u63d0\u4f9b\u7684PDT\u6210\u529f\u5b9e\u73b0\u4e86\u80bf\u7624\u751f\u957f\u6291\u5236\u3002\u8fd9\u662f\u5206\u5b50\u63a2\u9488\u9886\u57df\u7684\u9996\u6b21\u8bc1\u660e\u4f53\u5185\u751f\u7269\u6b63\u4ea4\u6807\u8bb0\u80bf\u7624\u6210\u50cf\u548c\u539f\u4f4dPDT\u6cbb\u7597\u3002<\/p>\n

\u6587\u732e\u94fe\u63a5\uff1aA Light-Up Probe with Aggregation-Induced Emission for Real-Time Bio-orthogonal Tumor Labeling and Image-Guided Photodynamic Therapy<\/a><\/strong>\uff08Angew. Chem. Int. Ed., 2018<\/strong>, DOI: 10.1002\/anie.201805446\uff09<\/p>\n

\u5218\u658c\u6559\u6388\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u5316\u5b66\u548c\u751f\u7269\u5206\u5b50\u5de5\u7a0b\u7cfb\u3002\u8bfe\u9898\u7ec4\u7f51\u9875\uff1a<\/strong><\/p>\n

http:\/\/cheed.nus.edu.sg\/stf\/cheliub\/<\/a><\/strong><\/p>\n

\u4e2a\u4eba\u83b7\u5956\u548c\u8363\u8a89\u60c5\u51b5\uff1a<\/strong><\/p>\n

Highly Cited Researcher by Clarivate Analytics (2017)
\n Fellow of the Academy of Engineering, Singapore (2017)
\n President’s Technology Award (2016)
\n Fellow of Royal Society of Chemistry (2016)
\n The World\u2019s Most Influential Minds; Top 1% Highly Cited Researchers in Materials Science by Thomson Reuters (2015)
\n Materials in Society Lectureship, Elsevier (2015)
\n Singapore National Research Foundation Investigatorship (2014)
\n The World\u2019s Most Influential Minds (Highly cited researchers by Thomson Reuters 2014)
\n Singapore National Institute of Chemistry (SNIC)-BASF Materials Award (2014)
\n Invited Lecturer of Asia Excellence, Japanese Polymer Society (2013)
\n Asia Rising Star, 15th Asia Chemical Congress (2013)
\n National University of Singapore Young Researcher Award (2013)
\n National University of Singapore Faculty Young Researcher Award (2012)
\n L\u2019Oreal-Singapore Women in Science National Fellowship (2011)
\n Defense Research and Innovative Program Award (2010)
\n Singapore National Science and Technology Young Scientist Award (2008)
\n National University of Singapore Young Investigator Award (2006)<\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n

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