{"id":147001,"date":"2018-07-24T06:30:18","date_gmt":"2018-07-23T22:30:18","guid":{"rendered":"\/\/m.iemloyee.com\/?p=147001"},"modified":"2018-07-23T09:52:43","modified_gmt":"2018-07-23T01:52:43","slug":"adv-sci-%e6%9e%9c%e7%b3%96%e5%b0%81%e9%97%ad%e8%8b%af%e7%a1%bc%e9%85%b8%e4%bf%ae%e9%a5%b0%e7%9a%84%e5%a4%9a%e4%bd%8d%e7%82%b9%e6%8a%97%e8%bd%ac%e7%a7%bb%e8%83%b6%e6%9d%9f%e8%87%aa%e4%bc%a0%e9%80%92","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=147001","title":{"rendered":"Adv. Sci.: 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Melanoma-Targeted Therapy by \u201cFru-Blocked\u201d Phenyboronic Acid-Modifed MultiphaseAntimetastatic Micellar Nanoparticles\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520a<strong>Adv. Sci.<\/strong>\u4e0a\u3002<\/p>\n<p><strong>\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n<p><strong>\u56fe\u4e00\u3001PLT NPs\u7684\u5236\u5907\u548c\u4f5c\u7528\u673a\u5236\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147002\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/1-62.jpg\" alt=\"\" width=\"600\" height=\"598\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/1-62.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/1-62-150x150.jpg 150w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/1-62-300x300.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 PLT \/ DOX NPs\u5236\u5907\u548c\u201c\u679c\u7cd6\u963b\u65ad\u201d\u7b56\u7565\u7684\u793a\u610f\u56fe\uff1b<\/p>\n<p>\uff08b-c\uff09\u5bf9\u9ed1\u7d20\u7624\u5b9e\u4f53\u7624\u548c\u6291\u5236\u80ba\u8f6c\u79fb\u7684PLT \/ DOX NP\u7684\u793a\u610f\u56fe\u3002<\/p>\n<p><strong>\u56fe\u4e8c\u3001NPs\u7684\u8868\u5f81\u548cFru\u3001SA\u548cPBA\u7ec4\u5408\u7684\u7814\u7a76<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147003\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/2-58.jpg\" alt=\"\" width=\"600\" height=\"515\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/2-58.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/2-58-300x258.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 PLT NPs\u7684DLS\u548cTEM\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 \u4e0d\u540c\u6d53\u5ea6\u7684PLT NPs\u57f9\u517b\u7684\u7ea2\u7ec6\u80de\u7684\u6eb6\u8840\u7387\uff1b<\/p>\n<p>\uff08c\uff09 \u4e0d\u540c\u6d53\u5ea6\u7684PLT NPs\u57f9\u517b\u7684\u7ea2\u7ec6\u80de\u7684\u6eb6\u8840\u7387\u7684\u7167\u7247\uff1b<\/p>\n<p>\uff08d\uff09 37<sup>o<\/sup>C\u4e0bPBS\u4e2dLT \/ DOX NPs\u548cPLT \/ DOX NPs\u7684DOX\u91ca\u653e\uff1b<\/p>\n<p>\uff08e\uff09 37<sup>o<\/sup>C\u4e0b50\uff05FBS\u5b75\u80b224 h\u540eNPs\u7684\u8840\u6e05\u7a33\u5b9a\u6027\uff1b<\/p>\n<p>\uff08f\uff09 pH 7.4\u548cpH 6.5 PBS\u4e2d\u6e38\u79bbPSA\u4e0eFry\u7684\u4eb2\u548c\u529b\uff1b<\/p>\n<p>\uff08g\uff09 pH 7.4\u548cpH 6.5 PBS\u4e2d\u6e38\u79bbPSA\u4e0e\u6e38\u79bbSA\u7684\u4eb2\u548c\u529b\uff1b<\/p>\n<p>\uff08h\uff09 PBA-Fru\u5171\u8f6d\u7269\u5728\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u7a33\u5b9a\u6027\u6d4b\u8bd5\u3002<\/p>\n<p><strong>\u56fe\u4e09\u3001\u4e0d\u540c\u5236\u5242\u5b75\u80b2\u540eB16F10\u7ec6\u80de\u7684\u6444\u53d6\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147004\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/3.webp_-1.jpg\" alt=\"\" width=\"600\" height=\"619\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/3.webp_-1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/3.webp_-1-291x300.jpg 291w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u4e0e\u6e38\u79bbDOX\u3001LT \/ DOX NPs\u3001PLT \/ DOX NPs\u3001PLT-BA \/ DOX NPs\u6216PLT-SA \/ DOX NPs\u5b75\u80b22 h\u540e\uff0cB16F10\u7ec6\u80de\u7684CLSM\uff1b<\/p>\n<p>\uff08b\uff09 \u6d41\u5f0f\u7ec6\u80de\uff08FACS\uff09\u5206\u6790\u7ade\u4e89\u6027\u6444\u53d6\u6d4b\u5b9a\u7684\u4ee3\u8868\u6027\u76f4\u65b9\u56fe\uff1b<\/p>\n<p>\uff08c\uff09 LT \/ DiD NPs\u3001PLT \/ DiD NPs\u3001PLT-Fru \/ DiD NPs\u548cPLT-SA \/ DiD NPs\u5206\u5728pH 6.5\u548cpH 7.4\u4e0b\u5b75\u80b22 h\u540e\uff0cB16F10\u7ec6\u80de\u7684\u5b9a\u91cf\u6444\u53d6\uff1b<\/p>\n<p>\uff08d\uff09 PLT \/ DOX NPs\u5b75\u80b22 h\u540eB16F10\u7ec6\u80de\u7684CLSM\u3002<\/p>\n<p><strong>\u56fe\u56db\u3001NPs\u5bf9B16F10\u7ec6\u80de\u4f53\u5916\u8fc1\u79fb\u548c\u4fb5\u88ad\u7684\u6291\u5236\u53ca\u4f53\u5185\u6297\u690d\u5165\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147005\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/4-57.jpg\" alt=\"\" width=\"600\" height=\"481\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/4-57.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/4-57-300x241.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 PBS\u3001LMWH\u3001LT NPs\u3001PLT NPs\u3001LT \/ DOX NPs\u548cPLT \/ DOX NPs\u5206\u522b\u4e0eB16F10\u7ec6\u80de\u5b75\u80b248 h\u540e\u7684\u56fe\uff1b<\/p>\n<p>\uff08b\uff09 Free DOX\u3001LMWH\u3001LT NPs\u3001PLT NPs\u3001LT \/ DOX NPs\u548cPLT \/ DOX NPs\u5206\u522b\u4e0eB16F10\u7ec6\u80de\u5b75\u80b224 h\u540e\u7684\u4f24\u53e3\u6108\u5408\u6d4b\u5b9a\u56fe\uff1b<\/p>\n<p>\uff08c\uff09 Free DOX\u3001LMWH\u3001LT NPs\u3001PLT NPs\u3001LT \/ DOX NPs\u548cPLT \/ DOX NPs\u5206\u522b\u4e0eB16F10\u7ec6\u80de\u5b75\u80b224 h\u540e\u7684\u4f24\u53e3\u6108\u5408\u6d4b\u5b9a\u7684\u6108\u5408\u7387\uff1b<\/p>\n<p>\uff08d\uff09 PBS\u3001LMWH\u3001LT NPs\u3001PLT NPs\u3001LT \/ DOX NPs\u548cPLT \/ DOX NPs\u5206\u522b\u4e0eB16F10\u7ec6\u80de\u5b75\u80b248 h\u540e\u7684\u5b9a\u91cf\u5206\u6790\uff1b<\/p>\n<p>\uff08e\uff09 \u4e0ePBS\u3001LMWH\u3001LT NPs\u3001PLT NPs\u3001LT \/ DOX NPs\u548cPLT \/ DOX NPs\u5206\u522b\u5b75\u80b230 h\u540e, ELISA\u68c0\u6d4bB16F10\u7ec6\u80de\u57f9\u517b\u57fa\u4e2dMMP-9\uff1b<\/p>\n<p>\uff08f\uff09 \u4f53\u5916\u9644\u7740\u4e8eB16F10\u7ec6\u80de\u7684\u8840\u5c0f\u677f\u8367\u5149\u5f3a\u5ea6\uff1b<\/p>\n<p>\uff08g\uff09 \u5206\u522b\u5b75\u80b2\u540e\u5229\u7528\u86cb\u767d\u8d28\u5370\u8ff9\u6d4b\u8bd5B16F10\u7ec6\u80de\u4e2dMMP-9\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08h\uff09 \u5206\u522b\u57f9\u517b\u540e\u5229\u7528\u86cb\u767d\u8d28\u5370\u8ff9\u68c0\u6d4bB16F10\u7ec6\u80de\u57f9\u517b\u57fa\u4e2d\u7684E-\u9499\u7c98\u86cb\u767d\u548cN-\u9499\u7c98\u86cb\u767d\u7684\u8868\u8fbe\uff1b<\/p>\n<p>\uff08i\uff09 \u80ba\u90e8\u51b0\u51bb\u5207\u7247\u7684CLSM\u3002<\/p>\n<p><strong>\u56fe\u4e94\u3001\u4f53\u5185NPs\u7684\u751f\u7269\u5206\u5e03\u548c\u8f6c\u79fb\u9776\u5411\u80fd\u529b\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147006\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/5.webp_-1.jpg\" alt=\"\" width=\"600\" height=\"474\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/5.webp_-1.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/5.webp_-1-300x237.jpg 300w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u5168\u8eab\u65bd\u7528\u8d1f\u8f7dDiD\u7684NPs 4 h\u540e\uff0c\u643a\u5e26B16F10\u80bf\u7624\u7684\u5c0f\u9f20\u7684\u4f53\u5185\u56fe\u50cf\uff1b<\/p>\n<p>\uff08b\uff09 \u5168\u8eab\u65bd\u7528\u8d1f\u8f7dDiD\u7684NPs 24 h\u540e\uff0c\u8377\u7624\u5c0f\u9f20\u7684\u80bf\u7624\u548c\u5668\u5b98\u7684\u79bb\u4f53\u56fe\u50cf\uff1b<\/p>\n<p>\uff08c\uff09 \u534a\u5b9a\u91cf\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u663e\u793a\u5168\u8eab\u7ed9\u836f24 h\u540e\u643a\u5e26DiD\u7684NPs\u5728B16F10\u8377\u7624\u5c0f\u9f20\u4e2d\u7684\u80bf\u7624\u548c\u5668\u5b98\u7684\u5206\u5e03\uff1b<\/p>\n<p>\uff08d\uff09 \u534a\u5b9a\u91cf\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u663e\u793aB16F10\u8f6c\u79fb\u6a21\u578b\u5c0f\u9f20\u5728\u7ed9\u4e88\u8d1f\u8f7dDiD\u7684NPs 6 h\u540e\u7684\u4f53\u5185\u56fe\u50cf\uff1b<\/p>\n<p>\uff08e\uff09 \u5168\u8eab\u65bd\u7528\u8d1f\u8f7dDiD\u7684NPs 6 h\u540e\uff0cB16F10\u8f6c\u79fb\u5c0f\u9f20\u6a21\u578b\u7684\u80ba\u79bb\u4f53\u56fe\u50cf\u548c\u534a\u5b9a\u91cf\u5e73\u5747\u8367\u5149\u5f3a\u5ea6\u7ed3\u679c\uff1b<\/p>\n<p>\uff08f\uff09 \u5168\u8eab\u65bd\u7528\u8d1f\u8f7dDiD\u7684NPs 6 h\u540e\uff0cB16F10\u8f6c\u79fb\u6a21\u578b\u5c0f\u9f20\u7684\u80ba\u5207\u7247\u7684CLSM\uff1b<\/p>\n<p>\uff08g\uff09 LT NPs\u3001PLT NPs\u548cPLT-Fru NPs\u5728\u8840\u6db2\u4e2d\u7684\u5faa\u73af\u7279\u5f81\u3002<\/p>\n<p><strong>\u56fe\u516d\u3001\u4f53\u5185B16F10\u5b9e\u4f53\u7624\u6cbb\u7597<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147007\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/6-29.jpg\" alt=\"\" width=\"600\" height=\"626\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/6-29.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/6-29-288x300.jpg 288w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 \u9759\u8109\u5185\u6ce8\u5c04PBS\u3001free DOX\u3001LT \/ DOX NPs\u3001PLT \/ DOX NPs\u3001 PLT-Fru \/ DOX NPs\u7684C57BL \/ 6\u5c0f\u9f20\u83b7\u53d6B16F10\u80bf\u7624\u7684\u56fe\u50cf\uff1b<\/p>\n<p>\uff08b\uff09 \u6cbb\u7597\u671f\u95f4\u643a\u5e26B16F10\u80bf\u7624\u7684C57BL \/ 6\u5c0f\u9f20\u7684\u80bf\u7624\u4f53\u79ef\u53d8\u5316\uff1b<\/p>\n<p>\uff08c\uff09 \u83b7\u53d6\u7684B16F10\u80bf\u7624\u7684\u91cd\u91cf\uff1b<\/p>\n<p>\uff08d\uff09 \u4e0d\u540cDOX\u5236\u5242\u5904\u7406\u7684C57BL \/ 6\u5c0f\u9f20\u4e2d\u7684DOX\u8840\u6d46\u6d53\u5ea6 \u4e0e\u65f6\u95f4\u7684\u5173\u7cfb\uff1b<\/p>\n<p>\uff08e\uff09 \u82cf\u6728\u7cbe\u548cH\uff06E\u6d4b\u5b9a\u7684\u7ec4\u7ec7\u5b66\u5206\u6790\u548cB16F10\u80bf\u7624\u7684MMP-9\u67d3\u8272\u7684\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u5206\u6790\u3002<\/p>\n<p><strong>\u56fe\u4e03\u3001\u4f53\u5185\u6297\u80bf\u7624\u8f6c\u79fb\u6cbb\u7597\u00a0<\/strong><\/p>\n<p><strong><img loading=\"lazy\" decoding=\"async\" class=\"aligncenter size-full wp-image-147008\" src=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/7-16.jpg\" alt=\"\" width=\"600\" height=\"649\" srcset=\"\/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/7-16.jpg 600w, \/\/m.iemloyee.com\/wp-content\/uploads\/2018\/07\/7-16-277x300.jpg 277w\" sizes=\"(max-width: 600px) 100vw, 600px\" \/><\/strong><\/p>\n<p>\uff08a\uff09 PBS\u3001free LMWH\u3001LT NPs\u6216PLT NPs\u4f5c\u7528\u540e\uff0c\u80ba\u80bf\u7624\u540e\u56fe\u7247\uff1b<\/p>\n<p>\uff08b\uff09 PBS\u3001free LMWH\u3001LT NPs\u6216PLT NPs\u4f5c\u7528\u540e\uff0c\u80ba\u8868\u9762B16F10\u8f6c\u79fb\u7684\u6570\u91cf\uff1b<\/p>\n<p>\uff08c\uff09 PBS\u3001free LMWH\u3001LT NPs\u6216PLT NPs\u9759\u8109\u6ce8\u5c04\u9884\u5904\u7406\u540eB16F10\u8f6c\u79fb\u5c0f\u9f20\u6a21\u578b\u80ba\u90e8\u7684H\uff06E\u67d3\u8272\u7684\u7ec4\u7ec7\u5b66\u5206\u6790\uff1b<\/p>\n<p>\uff08d\uff09 PBS\u3001free DOX\u3001free LMWH\u3001LT NPs\u3001LT \/ DOX NPs\u6216PLT \/ DOX NPs\u4f5c\u7528\u540e\uff0c\u80ba\u80bf\u7624\u540e\u56fe\u7247\uff1b<\/p>\n<p>\uff08e\uff09 PBS\u3001free DOX\u3001free LMWH\u3001LT NPs\u3001LT \/ DOX NPs\u6216PLT \/ DOX NPs\u4f5c\u7528\u540e\uff0c\u80ba\u8868\u9762B16F10\u8f6c\u79fb\u7684\u6570\u91cf\uff1b<\/p>\n<p>\uff08f\uff09 \u9759\u8109\u5185\u6ce8\u5c04PBS\u3001free DOX\u3001free LMWH\u3001LT NPs\u3001LT \/ DOX NPs\u6216PLT \/ DOX NPs\u5904\u7406\u540e\uff0cB16F10\u8f6c\u79fb\u5c0f\u9f20\u6a21\u578b\u80ba\u7684H\uff06E\u67d3\u8272\u7684\u7ec4\u7ec7\u5b66\u5206\u6790\u3002<\/p>\n<p><strong>\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n<p>\u4f5c\u8005\u7814\u7a76\u4e86\u80bf\u7624\u5fae\u73af\u5883\u53ef\u6d3b\u5316\u7684PBA\u4fee\u9970\u7684\u591a\u4f4d\u70b9\u6297\u80bf\u7624\u8f6c\u79fb\u80f6\u675f\u81ea\u4f20\u9012\u7cfb\u7edf\uff0c\u5176\u53ef\u540c\u65f6\u4f5c\u4e3a\u6297\u80bf\u7624\u8f6c\u79fb\u5242\u548c\u7eb3\u7c73\u8f7d\u4f53\u7528\u4e8e\u6cbb\u7597\u5b9e\u4f53\u80bf\u7624\u53ca\u5176\u8f6c\u79fb\u3002PLT \/ DOX NPs\u7684\u7ec4\u6210\u5305\u62ec\u6297\u80bf\u7624\u8f6c\u79fb\u6d3b\u6027\u6210\u5206LMWH\u3001TOS\u548c\u5316\u7597\u836f\u7269DOX\u3002 PLT 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href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/advs.201800229\" target=\"_blank\" rel=\"noopener\">Enhanced Melanoma-Targeted Therapy by \u201cFru-Blocked\u201dPhenyboronic Acid-Modifed Multiphase Antimetastatic Micellar Nanoparticles<\/a><\/strong>\uff08Adv. 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