{"id":146625,"date":"2018-07-25T06:30:32","date_gmt":"2018-07-24T22:30:32","guid":{"rendered":"\/\/m.iemloyee.com\/?p=146625"},"modified":"2018-07-24T22:32:53","modified_gmt":"2018-07-24T14:32:53","slug":"%e4%b9%9d%e7%af%87%e6%96%87%e7%ab%a0%e5%b8%a6%e4%bd%a0%e5%88%9d%e6%ad%a5%e4%ba%86%e8%a7%a3aie%e7%94%9f%e7%89%a9%e6%a3%80%e6%b5%8b%e4%b8%8e%e6%88%90%e5%83%8f%e7%9a%84%e5%8f%91%e5%b1%95%e5%8e%86","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=146625","title":{"rendered":"\u5341\u5e74\u56de\u9996 |AIE\u6750\u6599\u5728\u751f\u7269\u68c0\u6d4b\u4e0e\u6210\u50cf\u9886\u57df\u7684\u53d1\u5c55"},"content":{"rendered":"

\"\"<\/p>\n

\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149(aggregation-induced emission, AIE)\u662f\u7531\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u5510\u672c\u5fe0\u9662\u58eb\u56e2\u961f\u4e8e2001\u5e74\u5076\u7136\u53d1\u73b0\u7684\u4e00\u79cd\u5f02\u5e38\u7684\u53d1\u5149\u73b0\u8c61\u3002\u548c\u4f20\u7edf\u8367\u5149\u6750\u6599\u6240\u5177\u6709\u7684ACQ\uff08aggregation-caused quenching\uff09\u53d1\u5149\u73b0\u8c61\u76f8\u53cd\uff0c\u5177\u6709AIE\u6027\u8d28\u7684\u8367\u5149\u6750\u6599\u5728\u6eb6\u6db2\u4e2d\u4ee5\u5355\u5206\u5b50\u5f62\u5f0f\u5b58\u5728\u65f6\uff0c\u6fc0\u53d1\u6001\u7684\u7535\u5b50\u901a\u8fc7\u5206\u5b50\u5185\u7684\u8fd0\u52a8\u56de\u5230\u57fa\u6001\uff1b\u5f53\u5206\u5b50\u5904\u4e8e\u805a\u96c6\u6001\u65f6\uff0c\u5206\u5b50\u5185\u8fd0\u52a8\u53d7\u9650\uff0c\u6fc0\u53d1\u6001\u7684\u7535\u5b50\u53ea\u80fd\u901a\u8fc7\u8f90\u5c04\u8dc3\u8fc1\u7684\u65b9\u5f0f\u56de\u5230\u57fa\u6001\uff0c\u56e0\u800c\u53ef\u4ee5\u89c2\u5bdf\u5230\u8367\u5149\u589e\u5f3a\u7684\u73b0\u8c61\u3002\u8bfe\u9898\u7ec4\u5728\u6b64\u57fa\u7840\u4e0a\u8fdb\u884c\u4e86\u4e00\u7cfb\u5217\u6df1\u5165\u5730\u63a2\u7d22\u7814\u7a76\uff0c\u63d0\u51fa\u4e86\u805a\u96c6\u8bf1\u5bfc\u53d1\u5149\u7684\u65b0\u6982\u5ff5\uff0c\u5728\u8bf8\u591a\u9886\u57df\u90fd\u53d6\u5f97\u4e86\u5e7f\u9614\u7684\u5e94\u7528\u3002<\/p>\n

\u5728\u751f\u7269\u68c0\u6d4b\u548c\u6210\u50cf\u9886\u57df\uff0c\u7ecf\u8fc7\u79d1\u7814\u5de5\u4f5c\u8005\u4eec\u5341\u591a\u5e74\u7684\u52aa\u529b\u4e0e\u53d1\u5c55\uff0cAIE\u6750\u6599\u5728\u751f\u7269\u68c0\u6d4b\u3001\u751f\u7269\u6210\u50cf\u548c\u8bca\u7597\u4e00\u4f53\u5316\u7b49\u65b9\u9762\u90fd\u8868\u73b0\u51fa\u4e86\u663e\u8457\u7684\u4f18\u52bf\uff0c\u56e0\u6b64\u5438\u5f15\u4e86\u66f4\u591a\u6765\u81ea\u751f\u7269\u9886\u57df\u79d1\u5b66\u5bb6\u7684\u76ee\u5149\u3002\u8fd1\u4e94\u5e74\u6765\uff0c\u5173\u4e8eAIE\u6750\u6599\u5728\u751f\u7269\u68c0\u6d4b\u548c\u6210\u50cf\u7684\u6587\u7ae0\u53d1\u8868\u6570\u91cf\u548c\u5f15\u7528\u603b\u91cf\u7a33\u56fa\u589e\u52a0\u3002\u4ece2012\u5e74\u5230\u73b0\u5728\uff0c\u5df2\u7ecf\u6709\u5927\u4e8e600\u7bc7\u5173\u4e8eAIE\u6750\u6599\u5728\u751f\u7269\u68c0\u6d4b\u548c\u6210\u50cf\u7684SCI\u8bba\u6587\u53d1\u8868\u3002\u672c\u6587\u5c06\u4ee5\u8fd9\u4e5d\u7bc7\u6587\u732e\u6765\u68b3\u7406\u548c\u56de\u987eAIE\u6750\u6599\u8fd1\u5341\u5e74\u4ee5\u6765\u5728\u751f\u7269\u68c0\u6d4b\u548c\u6210\u50cf\u9886\u57df\u7684\u53d1\u5c55\u3002<\/p>\n

\u5f00\u521b\u7bc7<\/b><\/strong><\/p>\n

\"\"<\/p>\n

2010\u5e74\uff0c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7684\u5510\u672c\u5fe0\u9662\u58eb\u8bfe\u9898\u7ec4\u5229\u7528\u53cc\u8fb9\u4fee\u9970\u78fa\u9178\u76d0\u7684\u56db\u82ef\u57fa\u4e59\u70ef\uff08BSPOTPE\uff09\u5b9e\u73b0\u4e86\u5bf9\u4eba\u8840\u6e05\u86cb\u767d\uff08HSA\uff09\u7684\u68c0\u6d4b\u548c\u6784\u8c61\u8ffd\u8e2a\u3002BSPOTPE\u7684\u6c34\u6eb6\u6027\u975e\u5e38\u597d\uff0c\u56e0\u800c\u5728\u6c34\u6eb6\u6db2\u4e2d\u51e0\u4e4e\u6ca1\u6709\u8367\u5149\u3002\u5f53BSPOTPE\u4e0eHSA\u7ed3\u5408\uff0cBSPOTPE\u4f1a\u5d4c\u5165HSA\u7684\u758f\u6c34\u8154\u4e2d\uff0c\u56e0\u6b64\u56db\u82ef\u57fa\u4e59\u70ef\u7684\u82ef\u73af\u8fd0\u52a8\u53d7\u9650\uff0c\u8367\u5149\u589e\u5f3a\u3002BSPOTPE\u53ef\u68c0\u6d4b0-100nM\u6d53\u5ea6\u8303\u56f4\u5185\u7684HSA\uff0c\u68c0\u6d4b\u9650\u53ef\u8fbe1nM\u3002<\/p>\n

\u5c0f\u7ed3\uff1a<\/b><\/strong>\u8fd9\u4e00\u65f6\u671f\u7684\u63a2\u9488\u7279\u5f02\u6027\u8f83\u5dee\uff0c\u4f9d\u9760\u56db\u82ef\u57fa\u4e59\u70ef\u7684\u758f\u6c34\u6027\u8d28\u4e0e\u86cb\u767d\u8d28\u758f\u6c34\u8154\u7684\u4f5c\u7528\uff0c\u5176\u4ed6\u758f\u6c34\u6027\u86cb\u767d\u4f1a\u5bf9\u68c0\u6d4b\u7ed3\u679c\u9020\u6210\u8f83\u5927\u7684\u5f71\u54cd\uff0c\u56e0\u6b64\u5728\u540e\u7eed\u5de5\u4f5c\u4e2d\uff0c\u5728\u63a2\u9488\u7279\u5f02\u6027\u8f83\u5dee\u7684\u95ee\u9898\u4e0a\u505a\u4e86\u5f88\u5927\u7684\u6539\u8fdb\u3002<\/p>\n

\"\"<\/p>\n

2012\u5e74\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u9996\u6b21\u5c06\u4e00\u6bb5\u6709\u8bc6\u522b\u6027\u7684\u591a\u80bdcRGD\u8fde\u63a5\u5728\u56db\u82ef\u57fa\u567b\u54af\u4e0a\uff08TPS-2cRGD\uff09\uff0c\u5b9e\u73b0\u4e86\u5bf9\u6574\u5408\u7d20\u7684\u7279\u5f02\u6027\u68c0\u6d4b\u3002\u6574\u5408\u7d20\u662f\u5f88\u591a\u80bf\u7624\u7684\u751f\u7269\u6807\u8bb0\uff0c\u5e76\u4e14\u4e5f\u662fcRGD\u7684\u53d7\u4f53\u3002cRGD\u901a\u8fc7\u70b9\u51fb\u53cd\u5e94\u8fde\u63a5\u5230\u56db\u82ef\u57fa\u567b\u54af\u4e0a\uff0ccRGD\u672c\u8eab\u8f83\u597d\u7684\u6c34\u6eb6\u6027\u4f1a\u5927\u5927\u964d\u4f4e\u56db\u82ef\u57fa\u567b\u54af\u5728\u6c34\u4e2d\u7684\u80cc\u666f\u8367\u5149\u3002\u5f53cRGD\u4e0e\u6574\u5408\u7d20\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u8367\u5149\u589e\u5f3a\u3002TPS-2cRGD\u5728\u6574\u5408\u7d20\u7684\u68c0\u6d4b\u4e0a\u6709\u5f88\u597d\u7684\u7279\u5f02\u6027\u548c\u7075\u654f\u5ea6\uff0c\u68c0\u6d4b\u9650\u53ef\u8fbe0.5\u03bcg\/mL.\u9664\u4e86\u6eb6\u6db2\u6001\u7684\u5b9a\u91cf\u68c0\u6d4b\uff0cTPS-2cRGD\u8fd8\u53ef\u4ee5\u4e0e\u7ec6\u80de\u819c\u4e0a\u7684\u6574\u5408\u7d20\u7ed3\u5408\uff0c\u5b9e\u73b0\u7279\u5f02\u6027\u5730\u764c\u7ec6\u80de\u6210\u50cf\u3002<\/p>\n

\"\"<\/p>\n

\u540c\u5e74\uff0c\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u9053\u4e86\u53e6\u5916\u4e00\u79cd\u591a\u80bd\u4e0eAIEgen\u7ed3\u5408\u7684\u63a2\u9488\uff0cTPE-KDVED-Ac\u3002TPE-KDVED-Ac\u662f\u7531\u758f\u6c34\u7684TPE\u8367\u5149\u751f\u8272\u56e2\u548c\u4eb2\u6c34\u7684KDVED\u591a\u80bd\u90e8\u5206\u7ec4\u5408\u800c\u6210\uff0c\u56e0\u800c\u5728\u6c34\u6eb6\u6db2\u4e2d\u8367\u5149\u80cc\u666f\u5f88\u4f4e\u3002\u5f53\u534a\u80f1\u5929\u51ac\u9176\u4e0e\u63a2\u9488\u4f5c\u7528\u65f6\uff0cDVED-Ac\u5e8f\u5217\u4f1a\u4eceTPE-KDVED-Ac\u4e0a\u8131\u843d\uff0c\u5269\u4e0b\u7684\u90e8\u5206\u56e0\u4e3a\u6c34\u6eb6\u6027\u8f83\u5dee\uff0c\u5728\u6c34\u6eb6\u6db2\u4e2d\u805a\u96c6\uff0c\u8367\u5149\u5f3a\u5ea6\u660e\u663e\u589e\u5f3a\u3002\u56e0\u6b64TPE-KDVED-Ac\u53ef\u4ee5\u5b9e\u73b0\u534a\u80f1\u5929\u51ac\u9176\u7684\u7279\u5f02\u6027\u68c0\u6d4b\u548c\u5b9e\u65f6\u8ffd\u8e2a\u7ec6\u80de\u51cb\u4ea1\u3002<\/p>\n

\u5c0f\u7ed3<\/b><\/strong>\uff1a\u76f8\u5bf9\u4e8e\u4f20\u7edfACQ\u6750\u6599\u800c\u8a00\uff0cAIE\u6750\u6599\u6700\u5927\u7684\u7279\u70b9\u662f\u5728\u5355\u5206\u5b50\u72b6\u6001\u4e0b\uff0c\u8367\u5149\u8f83\u5f31\u751a\u81f3\u4e0d\u53d1\u5149\uff0c\u800c\u5728\u805a\u96c6\u72b6\u6001\u4e0b\uff0c\u53d1\u5149\u663e\u8457\u589e\u5f3a\u3002\u56e0\u6b64\u65e9\u671f\u7684AIE\u63a2\u9488\u7684\u8bbe\u8ba1\u7684\u4e3b\u8981\u601d\u8def\u662f\uff0c\u6c34\u6eb6\u6027\u7684AIE\u63a2\u9488\u5206\u6563\u5728\u6c34\u73af\u5883\u4e2d\uff0c\u4e0d\u53d1\u5149\uff1b\u800c\u4e0e\u88ab\u68c0\u6d4b\u7269\u4f5c\u7528\u4ee5\u540e\uff0c\u6c34\u6eb6\u6027\u53d1\u751f\u6539\u53d8\u6216\u8005\u4e0e\u88ab\u68c0\u6d4b\u7269\u7ed3\u5408\u5bfc\u81f4\u5206\u5b50\u5185\u8fd0\u52a8\u53d7\u963b\uff0c\u56e0\u800c\u8367\u5149\u589e\u5f3a\uff0c\u4ece\u800c\u8fbe\u5230\u68c0\u6d4b\u7684\u76ee\u7684\u3002\u8fd9\u4e00\u65f6\u671f\u7684AIE\u63a2\u9488\u7684\u529f\u80fd\u8fd8\u6bd4\u8f83\u5355\u4e00\uff0c\u4e3b\u8981\u5728\u6eb6\u6db2\u6001\u7279\u5f02\u6027\u5730\u68c0\u6d4b\u67d0\u79cd\u7269\u8d28\u6216\u8005\u5bf9\u7ec6\u80de\u8fdb\u884c\u7279\u5f02\u6027\u6210\u50cf\u3002<\/p>\n

\u53d1\u5c55\u7bc7<\/b><\/strong><\/p>\n

\"\"<\/p>\n

2012\u5e74\uff0c\u5510\u672c\u5fe0\u9662\u58eb\u8bfe\u9898\u7ec4\u548c\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u5408\u4f5c\u9996\u6b21\u5229\u7528\u725b\u8840\u6e05\u86cb\u767d\uff08BSA\uff09\u4f5c\u4e3a\u805a\u5408\u7269\u57fa\u5e95\uff0c\u8d1f\u8f7d\u8fd1\u7ea2\u5916AIE\u67d3\u6599\uff0c\u5408\u6210\u4e86AIE\u7eb3\u7c73\u7c92\u5b50\u3002\u8fd9\u79cd\u8d1f\u8f7dAIE\u67d3\u6599\u7684BSA\u7eb3\u7c73\u7c92\u5b50\u5177\u6709\u5341\u5206\u5747\u4e00\u7684\u5c3a\u5bf8\uff0c\u5e76\u5728MCF-7\u7ec6\u80de\u6210\u50cf\u548c\u5c0f\u9f20\u80bf\u7624\u6210\u50cf\u4e2d\u8868\u73b0\u51fa\u5f88\u9ad8\u7684\u8367\u5149\u5f3a\u5ea6\u548c\u5f88\u4f4e\u7684\u7ec6\u80de\u6bd2\u6027\u3002\u9664\u6b64\u4e4b\u5916\uff0c\u8fd9\u4e9bAIE\u7eb3\u7c73\u7c92\u5b50\u7531\u4e8e\u80bf\u7624\u7684\u9ad8\u901a\u900f\u6027\u548c\u6ede\u7559\u6548\u5e94\uff08EPR\uff09\uff0c\u8868\u73b0\u51fa\u5f88\u597d\u7684\u764c\u7ec6\u80de\u541e\u566c\u6548\u679c\u548c\u6d3b\u4f53\u80bf\u7624\u9776\u5411\u80fd\u529b\u3002<\/p>\n

\u5c0f\u7ed3\uff1a\u76f8\u8f83\u4e8e\u666e\u901a\u6709\u673a\u5c0f\u5206\u5b50\u6210\u50cf\u800c\u8a00\uff0c\u7eb3\u7c73\u7c92\u5b50\u5177\u6709\u5149\u7a33\u5b9a\u6027\u66f4\u5f3a\u3001\u5c3a\u5bf8\u53ef\u63a7\u6027\u66f4\u597d\u3001\u8868\u9762\u4fee\u9970\u66f4\u5bb9\u6613\u7b49\u4f18\u70b9\uff0c\u56e0\u6b64\u5728\u6210\u50cf\u9886\u57df\u53d7\u5230\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002\u800c\u4f20\u7edf\u7684ACQ\u6750\u6599\uff0c\u5728\u805a\u96c6\u72b6\u6001\u4f1a\u6709\u8367\u5149\u81ea\u731d\u706d\u7684\u7f3a\u70b9\uff0c\u56e0\u800c\u9650\u5236\u4e86\u5176\u5728\u7eb3\u7c73\u7c92\u5b50\u6210\u50cf\u4e2d\u7684\u5e94\u7528\u3002\u56e0\u6b64\uff0cAIE\u7eb3\u7c73\u7c92\u5b50\u6210\u50cf\u7ed3\u5408\u4e86AIE\u6750\u6599\u548c\u7eb3\u7c73\u7c92\u5b50\u7684\u4f18\u70b9\uff0c\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002<\/p>\n

\"\"<\/p>\n

2012\u5e74\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u62a5\u5bfc\u4e86AIE\u7eb3\u7c73\u7c92\u5b50\u7684\u53cc\u5149\u5b50\u6210\u50cf\uff0c\u5b9e\u73b0\u4e86\u5bf9\u8840\u7ba1\u7684\u5b9e\u65f6\u6210\u50cf\u3002\u8fd9\u4e2a\u5de5\u4f5c\u62a5\u5bfc\u7684\u7eb3\u7c73\u7c92\u5b50\u5177\u6709\u5f88\u5c0f\u7684\u5c3a\u5bf8\uff0c\u53ef\u8fbe33nm\uff0c\u5e76\u4e14\u62e5\u6709\u8f83\u5927\u7684\u53cc\u5149\u5b50\u5438\u6536\u622a\u9762\uff0c\u53ef\u8fbe63000GM\u3002AIE\u7eb3\u7c73\u7c92\u5b50\u7684\u53cc\u5149\u5b50\u6210\u50cf\u8868\u73b0\u51fa\u5f88\u9ad8\u7684\u80f6\u675f\u7a33\u5b9a\u6027\u3001\u5149\u7a33\u5b9a\u6027\u548c\u6d3b\u4f53\u4f4e\u6bd2\u6027\uff0c\u5728\u6d3b\u4f53\u6210\u50cf\u65b9\u9762\u6709\u5e7f\u9614\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n

\u5c0f\u7ed3<\/b><\/strong>\uff1a\u4e0e\u5355\u5149\u5b50\u6210\u50cf\u76f8\u6bd4\uff0c\u591a\u5149\u5b50\u6210\u50cf\u5728\u7ec4\u7ec7\u7a7f\u900f\u80fd\u529b\u3001\u751f\u7269\u4f53\u4fdd\u62a4\u3001\u4fe1\u566a\u6bd4\u548c\u65f6\u7a7a\u5206\u8fa8\u7387\u4e0a\u5747\u6709\u5f88\u597d\u7684\u8868\u73b0\u3002\u591a\u5149\u5b50\u6210\u50cf\u8981\u6c42\u6750\u6599\u5177\u6709\u8f83\u5927\u7684\u591a\u5149\u5b50\u5438\u6536\u622a\u9762\uff0c\u800c\u5f88\u591aAIE\u6750\u6599\u53ef\u4ee5\u6ee1\u8db3\u8fd9\u4e2a\u8981\u6c42\u3002\u548c\u5546\u4e1a\u7684\u591a\u5149\u5b50\u6210\u50cf\u6750\u6599\u76f8\u6bd4\uff0cAIE\u6750\u6599\u5177\u6709\u66f4\u597d\u7684\u5149\u7a33\u5b9a\u6027\uff0c\u5728\u6210\u50cf\u4e0a\u5177\u6709\u66f4\u597d\u7684\u5e94\u7528\u524d\u666f\u3002<\/p>\n

\"\"<\/p>\n

2012\u5e74\uff0c\u5510\u672c\u5fe0\u9662\u58eb\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u4e2a\u53ef\u4ee5\u7279\u5f02\u6027\u9776\u5411\u7ec6\u80de\u7ebf\u7c92\u4f53\u7684\u67d3\u6599TPE-TPP\u3002TPE-TPP\u53ef\u4ee5\u7279\u5f02\u5730\u9776\u5411\u7ec6\u80de\u7ebf\u7c92\u4f53\uff0c\u4e0e\u5546\u7528\u67d3\u6599\u7684\u91cd\u53e0\u7cfb\u6570\u9ad8\u8fbe0.96\u3002\u548c\u5546\u4e1a\u67d3\u6599\u76f8\u6bd4\uff0cTPE-TPP\u5177\u6709\u66f4\u597d\u7684\u5149\u7a33\u5b9a\u6027\uff0c\u56e0\u6b64\u672a\u6765\u5728\u7ec6\u80de\u5668\u67d3\u8272\u4e0a\u4f1a\u6709\u5f88\u5e7f\u9614\u7684\u5e94\u7528\u3002<\/p>\n

\u5c0f\u7ed3<\/b><\/strong>\uff1a\u548c\u521d\u671fAIE\u63a2\u9488\u76f8\u6bd4\uff0c\u4e00\u65b9\u9762\u8fd9\u4e00\u65f6\u671f\u7684AIE\u63a2\u9488\u4ece\u8bbe\u8ba1\u4e0a\u5df2\u7ecf\u5728\u601d\u8003\u5982\u4f55\u5229\u7528AIE\u6750\u6599\u76f8\u8f83\u4e8e\u4f20\u7edf\u8367\u5149\u6750\u6599\u7684\u4f18\u52bf\uff1b\u53e6\u4e00\u65b9\u9762\uff0cAIE\u63a2\u9488\u6750\u6599\u7684\u5e94\u7528\u4e5f\u6709\u4e86\u76f8\u5f53\u5927\u7684\u6269\u5c55\uff0c\u4ece\u5355\u4e00\u7684\u68c0\u6d4b\u6269\u5c55\u5230\u6210\u50cf\u65b9\u9762\uff0c\u53ef\u4ee5\u8bf4\u8fd9\u4e00\u65f6\u671f\u7684AIE\u63a2\u9488\u7684\u53d1\u5c55\u662f\u5f88\u5927\u7684\u3002\u4f46\u662f\u8fd9\u4e00\u65f6\u671f\u7684AIE\u63a2\u9488\u529f\u80fd\u4e0a\u4f9d\u7136\u5f88\u5355\u4e00\u3002<\/p>\n

\u8fdb\u9636\u7bc7<\/b><\/strong><\/p>\n

\"\"<\/p>\n

2014\u5e74\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u4e86\u4e00\u79cd\u53ef\u9776\u5411\u764c\u7ec6\u80de\u7684\u8bca\u7597\u4f53\u7cfb\u3002\u8fd9\u4e2a\u8bca\u7597\u4f53\u7cfb\u7531\u4e24\u79cd\u836f\u7269\uff08\u987a\u94c2\u548c\u963f\u9709\u7d20\uff09\u3001TPE\u548c\u9776\u5411\u764c\u7ec6\u80de\u7684\u591a\u80bd\u7ec4\u6210\u3002\u963f\u9709\u7d20\u7684\u5438\u6536\u5149\u8c31\u548cTPE\u7684\u53d1\u5c04\u5149\u8c31\u91cd\u53e0\u5ea6\u5f88\u9ad8\uff0c\u56e0\u6b64\u4e24\u8005\u4e4b\u95f4\u53ef\u4ee5\u5f62\u6210\u8367\u5149\u5171\u632f\u80fd\u91cf\u8f6c\u79fb\u4f53\u7cfb\u3002TPE\u53d1\u51fa\u7684\u8367\u5149\u88ab\u963f\u9709\u7d20\u6240\u5438\u6536\u3002\u5f53\u8bca\u7597\u7cfb\u7edf\u5b8c\u6574\u65f6\uff0cTPE\u7684\u53d1\u5149\u4e0d\u80fd\u88ab\u89c2\u5bdf\u5230\uff1b\u5f53\u8bca\u7597\u7cfb\u7edf\u5728\u764c\u7ec6\u80de\u73af\u5883\u4e2d\u88ab\u7834\u574f\u65f6\uff0cTPE\u7684\u53d1\u5149\u53ef\u4ee5\u88ab\u68c0\u6d4b\u5230\uff0c\u8fd9\u65f6\uff0c\u91ca\u653e\u51fa\u963f\u9709\u7d20\u548c\u987a\u94c2\uff0c\u8fbe\u5230\u764c\u75c7\u6cbb\u7597\u7684\u76ee\u7684\u3002\u8fd9\u4e2a\u4f53\u7cfb\u6210\u529f\u5c06\u764c\u75c7\u7684\u8bca\u65ad\u548c\u836f\u7269\u6cbb\u7597\u7ed3\u5408\u5728\u4e00\u8d77\uff0c\u5e76\u5b9e\u73b0\u4e86\u836f\u7269\u91ca\u653e\u548c\u5206\u5e03\u7684\u53ef\u89c6\u5316\u3002<\/p>\n

\u5c0f\u7ed3<\/b><\/strong>\uff1a\u5c06\u8bca\u65ad\u6210\u50cf\u548c\u6cbb\u7597\u6548\u679c\u6574\u5408\u5230\u4e00\u4e2a\u4f53\u7cfb\u5185\uff0c\u53ef\u4ee5\u4f7f\u836f\u7269\u7684\u91ca\u653e\u548c\u5206\u5e03\u60c5\u51b5\u88ab\u8ffd\u8e2a\uff0c\u5b9e\u65f6\u4e14\u539f\u4f4d\u8bc4\u4f30\u836f\u7269\u7684\u6cbb\u7597\u6548\u679c\u3002\u8fd9\u6837\u7684\u201c\u8bca\u7597\u4e00\u4f53\u5316\u201d\u7814\u7a76\u5728\u4e34\u5e8a\u548c\u6750\u6599\u9886\u57df\u90fd\u53d7\u5230\u4e86\u5e7f\u6cdb\u7684\u5173\u6ce8\u3002<\/p>\n

\"\"<\/p>\n

2013\u5e74\uff0c\u9999\u6e2f\u79d1\u6280\u5927\u5b66\u7684\u5510\u672c\u5fe0\u9662\u58eb\u8bfe\u9898\u7ec4\u548c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\u8bfe\u9898\u7ec4\u5408\u4f5c\uff0c\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u79cd\u7528\u4e8e\u53cc\u6a21\u6001\u6210\u50cf\u7684\u7eb3\u7c73\u7c92\u5b50\u3002\u8fd9\u79cd\u7eb3\u7c73\u7c92\u5b50\u7531\u5728\u8fd1\u7ea2\u5916\u53d1\u5149\u7684AIE\u67d3\u6599\u548cGd\u7ec4\u6210\uff0c\u53ef\u540c\u65f6\u5b9e\u73b0\u8fd1\u7ea2\u5916\u6210\u50cf\u548c\u6838\u78c1\u5171\u632f\u6210\u50cf\u3002\u8fd9\u79cd\u7eb3\u7c73\u7c92\u5b50\u5728\u7a7f\u819c\u80bd\u7684\u4f5c\u7528\u4e0b\u8fdb\u5165\u7ec6\u80de\uff0cGd\u63d0\u4f9b\u7684\u6838\u78c1\u5171\u632f\u6210\u50cf\u53ef\u5b9e\u73b0\u764c\u7ec6\u80de\u5728\u4f53\u5185\u7684\u7cbe\u51c6\u5206\u5e03\uff0c\u800cAIE\u67d3\u6599\u6240\u5b9e\u73b0\u7684\u7ea2\u5916\u6210\u50cf\u53ef\u63d0\u4f9b\u5355\u7ec6\u80de\u6c34\u5e73\u7684\u4fe1\u606f\uff0c\u4e3a\u540e\u7eedAIE\u63a2\u9488\u5728\u591a\u6a21\u6001\u6210\u50cf\u9886\u57df\u7684\u53d1\u5c55\u63d0\u4f9b\u4e86\u4e00\u5b9a\u7684\u57fa\u7840\u3002<\/p>\n

\u5c0f\u7ed3<\/b><\/strong>\uff1a\u6bcf\u4e00\u79cd\u5355\u4e00\u7684\u6210\u50cf\u6a21\u5f0f\u90fd\u5177\u6709\u5404\u81ea\u7684\u4f18\u70b9\u548c\u7f3a\u70b9\u3002\u5f53\u51e0\u79cd\u4e0d\u540c\u7684\u6210\u50cf\u6a21\u5f0f\u6574\u5408\u5230\u4e00\u4e2a\u4f53\u7cfb\u5185\u65f6\uff0c\u5b83\u4eec\u4e4b\u95f4\u5c31\u4f1a\u5f62\u6210\u4e00\u79cd\u4e92\u8865\u7684\u5173\u7cfb\uff0c\u8fbe\u5230\u201c1+1>2\u201d\u7684\u6548\u679c\u3002\u5c06\u4e24\u79cd\u6216\u591a\u79cd\u529f\u80fd\u6574\u5408\u5230\u4e00\u4e2a\u5355\u4e00\u7684\u63a2\u9488\u4e0a\u65f6\uff0c\u8fd9\u4e2a\u63a2\u9488\u7684\u8bbe\u8ba1\u96be\u5ea6\u4e5f\u4f1a\u589e\u52a0\u3002<\/p>\n

\"\"<\/p>\n

2014\u5e74\uff0c\u4e2d\u79d1\u9662\u5316\u5b66\u6240\u7684\u5f20\u5fb7\u6e05\u6559\u6388\u8bfe\u9898\u7ec4\u8bbe\u8ba1\u5408\u6210\u4e86\u4e00\u79cd\u53d1\u7ea2\u5149\u7684AIE\u63a2\u9488TPE-red-2AP2H\u3002\u591a\u80bd\u4f7fAIE\u63a2\u9488\u7684\u80cc\u666f\u8367\u5149\u5927\u5927\u964d\u4f4e\uff0c\u53ef\u5b9e\u73b0\u764c\u7ec6\u80de\u7684\u9776\u5411\u6210\u50cf\u3002\u9664\u6b64\u4e4b\u5916\uff0cTPE-red-2AP2H\u672c\u8eab\u662f\u4e00\u4e2a\u5149\u654f\u5242\uff0c\u7535\u5b50\u4ece\u6fc0\u53d1\u6001\u56de\u5230\u57fa\u6001\u7684\u8fc7\u7a0b\u4e2d\uff0c\u4e0e\u6c27\u6c14\u4f5c\u7528\uff0c\u4ea7\u751f\u5177\u6709\u7ec6\u80de\u6bd2\u6027\u7684\u5355\u7ebf\u6001\u6c27\uff0c\u8d77\u5230\u6740\u6b7b\u764c\u7ec6\u80de\u7684\u4f5c\u7528\u3002\u56e0\u6b64\u8fd9\u4e2a\u63a2\u9488\u5728\u7279\u5f02\u6027\u6210\u50cf\u7684\u540c\u65f6\u4e5f\u8d77\u5230\u4e86\u6cbb\u7597\u7684\u6548\u679c\u3002<\/p>\n

\u5c0f\u7ed3<\/b><\/strong>\uff1a\u8fd9\u4e00\u65f6\u671f\u7684AIE\u63a2\u9488\u76f8\u6bd4\u4e8e\u4e0a\u4e00\u4e2a\u9636\u6bb5\uff0c\u5728\u529f\u80fd\u4e0a\u6709\u4e86\u660e\u663e\u7684\u53d8\u5316\u3002\u4ece\u5355\u4e00\u7684\u6210\u50cf\u6216\u8005\u68c0\u6d4b\uff0c\u8fc7\u6e21\u5230\u68c0\u6d4b\u4e0e\u6210\u50cf\u4e3a\u4e00\u4f53\uff0c\u8bca\u65ad\u4e0e\u6cbb\u7597\u4e8e\u4e00\u8eab\u7684\u9636\u6bb5\u3002\u63a2\u9488\u7684\u8bbe\u8ba1\u4e5f\u66f4\u52a0\u7684\u590d\u6742\uff0c\u4e5f\u4ece\u5355\u4e00\u7684\u4ee5\u79d1\u5b66\u7814\u7a76\u4e3a\u76ee\u7684\u8fc7\u6e21\u5230\u5e94\u7528\u4e0a\u3002<\/p>\n

\u53c2\u8003\u6587\u732e<\/b><\/strong><\/p>\n

1.<\/b><\/strong>Quantitation, Visualization, and Monitoring of<\/b><\/strong>\u00a0<\/b><\/strong>Conformational Transitions of Human<\/b><\/strong>\u00a0<\/b><\/strong>Serum<\/b><\/strong>\u00a0<\/b><\/strong>Albumin by a Tetraphenylethene Derivative with<\/b><\/strong>\u00a0<\/b><\/strong>Aggregation-Induced Emission Characteristics<\/b><\/strong><\/a><\/p>\n

Anal. Chem. 2010, 82, 7035-7043<\/b><\/strong><\/p>\n

2.<\/b><\/strong>Speci<\/b><\/strong>fi<\/b><\/strong>c Detection of Integrin \u03b1<\/b><\/strong>v<\/b><\/sub><\/strong>\u03b2<\/b><\/strong>3<\/b><\/sub><\/strong>\u00a0by Light-Up Bioprobe with<\/b><\/strong>\u00a0<\/b><\/strong>Aggregation-Induced Emission Characteristics<\/b><\/strong><\/a><\/p>\n

J. Am. Chem. Soc. 2012, 134, 9569-9572<\/b><\/strong><\/p>\n

3.<\/b><\/strong>Real-Time Monitoring of Cell Apoptosis and Drug Screening Using<\/b><\/strong>\u00a0<\/b><\/strong>Fluorescent Light-Up Probe with Aggregation-Induced Emission<\/b><\/strong>\u00a0<\/b><\/strong>Characteristics<\/b><\/strong><\/a><\/p>\n

J. Am. Chem. Soc. 2012, 134, 17972-17981<\/b><\/strong><\/p>\n

4.Biocompatible Nanoparticles with Aggregation-Induced Emission Characteristics as Far-Red\/Near-Infrared Fluorescent Bioprobes for In Vitro and In Vivo Imaging Applications<\/a><\/b><\/strong><\/p>\n

Adv. Funct. Mater. 2012, 22, 771-779<\/b><\/strong><\/p>\n

5.<\/b><\/strong>Ultrabright Organic Dots with Aggregation-Induced<\/b><\/strong>\u00a0<\/b><\/strong>Emission Characteristics for Real-Time Two-Photon<\/b><\/strong>\u00a0<\/b><\/strong>Intravital Vasculature Imaging<\/b><\/strong><\/a><\/p>\n

Adv. Mater. 2013, 25, 6083-6088<\/b><\/strong><\/p>\n

6.<\/b><\/strong>Photostable AIE Lu<\/b><\/strong>A\u00a0<\/b><\/strong>minogen for Speci<\/b><\/strong>fi<\/b><\/strong>c Mitochondrial Imaging<\/b><\/strong>\u00a0<\/b><\/strong>and Tracking<\/b><\/strong><\/a><\/p>\n

J. Am. Chem. Soc. 2013, 135, 62-65<\/b><\/strong><\/p>\n

7.Targeted theranostic prodrugs based on an aggregation-induced emission (AIE) luminogen for real-time dual-drug tracking<\/a><\/b><\/strong><\/p>\n

Chem. Commun. 2014, 50, 11465<\/b><\/strong><\/p>\n

8.<\/b><\/strong>Gadolinium-Functionalized Aggregation-Induced Emission<\/b><\/strong>\u00a0<\/b><\/strong>Dots as Dual-Modality Probes for Cancer Metastasis Study<\/b><\/strong><\/a><\/p>\n

Adv. Healthcare Mater. 2013, 2, 1600-1605<\/b><\/strong><\/p>\n

9.<\/b><\/strong>Targeted Bioimaging and Photodynamic Therapy of Cancer Cells<\/b><\/strong>\u00a0<\/b><\/strong>with an Activatable Red Fluorescent Bioprobe<\/b><\/strong><\/a><\/p>\n

Anal. Chem. 2014, 86, 7987-7995<\/b><\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u7f16\u8f91\u90e8\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u7f16\u8f91\u6574\u7406\u3002<\/p>\n

\u6750\u6599\u4eba\u7f51\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u7f16\u8f91\u90e8<\/u><\/a>\u3002<\/p>\n

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