{"id":146473,"date":"2018-07-23T14:00:40","date_gmt":"2018-07-23T06:00:40","guid":{"rendered":"\/\/m.iemloyee.com\/?p=146473"},"modified":"2018-07-23T18:43:17","modified_gmt":"2018-07-23T10:43:17","slug":"%e9%83%91%e6%b5%b7%e8%8d%a3%e5%88%98%e6%96%8c-adv-mater-nir-ii%e5%85%89%e7%83%ad%e6%b2%bb%e7%96%97%e7%a9%bf%e8%bf%87%e5%a4%b4%e7%9a%ae%e5%92%8c%e9%a2%85%e9%aa%a8%e6%b7%b1%e9%83%a8%e5%8e%9f","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=146473","title":{"rendered":"\u90d1\u6d77\u8363&\u5218\u658c Adv. Mater.: NIR-II\u5149\u70ed\u6cbb\u7597\u7a7f\u8fc7\u5934\u76ae\u548c\u9885\u9aa8\u6df1\u90e8\u539f\u4f4d\u8111\u80bf\u7624\u7684\u7cbe\u786e\u5149\u58f0\u6210\u50cf\u5f15\u5bfc"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u7531\u4e8e\u5b58\u5728\u8840\u8111\u5c4f\u969c\u548c\u8840\u8111\u80bf\u7624\u5c4f\u969c\u4ee5\u53ca\u7f3a\u4e4f\u9ad8\u6548\u8111\u80bf\u7624\u6cbb\u7597\u8303\u4f8b\uff0c\u8111\u80bf\u7624\u5df2\u6210\u4e3a\u6700\u81f4\u547d\u7684\u764c\u75c7\u4e4b\u4e00\u3002\u4f8b\u5982\u80f6\u8d28\u6bcd\u7ec6\u80de\u7624\uff08GBM\uff09\u7684\u6cbb\u7597\u662f\u975e\u5e38\u5177\u6709\u6311\u6218\u6027\u7684\u3002\u800cGBM\u6cbb\u7597\u5b58\u5728\u4ee5\u4e0b\u969c\u788d\uff1a\uff08i\uff09\u5176\u9ad8\u5ea6\u4fb5\u5165\u548c\u4fb5\u88ad\u6027\u7684\u7279\u5f81\uff0c\u963b\u788d\u4e86\u5e38\u89c4\u6cbb\u7597\u65b9\u5f0f\uff08\u624b\u672f\u548c\u8865\u5145\u5316\u7597\u6216\u653e\u7597\uff09\u83b7\u5f97\u6ee1\u610f\u7684\u7f13\u89e3;\uff08ii\uff09\u96be\u4ee5\u514b\u670d\u8840\u8111\u5c4f\u969c\u548c\u8840\u8111\u80bf\u7624\u5c4f\u969c\uff0c\u9650\u5236\u4e86\u8bca\u65ad\u548c\u6cbb\u7597\u836f\u7269\u7684\u80bf\u7624\u6e17\u900f\u7387;\uff08iii\uff09\u6700\u91cd\u8981\u7684\u662f\u7f3a\u4e4f\u6709\u6548\u7684\u6cbb\u7597\u624b\u6bb5\u6765\u6291\u5236\u80bf\u7624\u3002\u76ee\u524d\uff0c\u5927\u591a\u6570\u7814\u7a76\u81f4\u529b\u4e8e\u5f00\u53d1\u5148\u8fdb\u7684\u6cbb\u7597\u7cfb\u7edf\uff0c\u4f8b\u5982\u5316\u5b66\u548c\u57fa\u56e0\u6cbb\u7597\u3002\u4f46\u662f\u8fd9\u4e9b\u65b9\u6cd5\u4e25\u91cd\u4f9d\u8d56\u4e8e\u836f\u7269\u9012\u9001\u7cfb\u7edf\uff08DDS\uff09\u7684\u590d\u6742\u8bbe\u8ba1\uff0c\u4ee5\u628a\u836f\u7269\u6216\u57fa\u56e0\u8f6c\u8fd0\u5230\u80bf\u7624\u90e8\u4f4d\u5e76\u4ee5\u53d7\u63a7\u65b9\u5f0f\u5b9e\u73b0\u91ca\u653e\u3002\u7136\u800c\uff0cDDS\u5728\u6b63\u5e38\u7ec4\u7ec7\u4e2d\u7684\u79ef\u7d2f\u4f1a\u5bfc\u81f4\u4e0d\u826f\u7684\u526f\u4f5c\u7528\uff0c\u5e76\u4e14GBM\u7ec6\u80de\u53ef\u4ee5\u8fc5\u901f\u4ea7\u751f\u8010\u836f\u6027\u3002\u800c\u5149\u7597\u6cd5\uff08PDT\u548cPTT\uff09\u53ef\u4ee5\u7cbe\u786e\u7684\u7834\u574f\u80bf\u7624\u7ec4\u7ec7\uff0c\u4e14\u5bf9\u6b63\u5e38\u7ec4\u7ec7\u6ca1\u6709\u660e\u663e\u7684\u4f24\u5bb3\u548c\u53ef\u4ee5\u5ffd\u7565\u4ea7\u751f\u8010\u836f\u6027\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u65b0\u52a0\u5761\u56fd\u7acb\u5927\u5b66\u7684\u5218\u658c\u6559\u6388\u548c\u4e2d\u79d1\u9662\u6df1\u5733\u5148\u8fdb\u6280\u672f\u7814\u7a76\u9662\u7684\u90d1\u6d77\u8363\u6559\u6388\uff08\u5171\u540c\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e86\u4e00\u79cdMPA\u4fee\u9970\u7684\u5177\u6709\u5f88\u597d\u751f\u7269\u76f8\u5bb9\u6027\u548c\u5149\u7a33\u5b9a\u6027\u7684\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u5728NIR-II\u6709\u5f3a\u5438\u6536\uff0c\u7528\u4e8e\u7a7f\u8fc7\u5934\u76ae\u548c\u5934\u9aa8\u7684\u8111\u80bf\u7624\u7cbe\u786e\u5149\u58f0\u6210\u50cf\u548c\u5149\u70ed\u6cbb\u7597\u3002\u4e0e\u5e38\u89c1\u7684808 nm\u6fc0\u5149\u76f8\u6bd4\uff0c1064 nm\u6fc0\u5149\u7a7f\u900f\u5934\u76ae\u548c\u5934\u9aa8\u7684\u6548\u7387\u66f4\u9ad8\uff0cNIR-II\u8111\u80bf\u7624\u5149\u70ed\u7597\u6cd5\u6548\u679c\u66f4\u597d\u3002\u6b64\u5916\uff0c\u901a\u8fc7\u5b9e\u65f6\u7684\u5149\u58f0\u6210\u50cf\u7cfb\u7edf\uff0c\u7eb3\u7c73\u9897\u7c92\u7a7f\u8fc7\u5934\u76ae\u548c\u9885\u9aa8\u53ef\u4ee5\u6e05\u6670\u5730\u5b9a\u4f4d\u8111\u80f6\u8d28\u7624\uff0c\u6df1\u5ea6\u8fd13 mm\uff0c\u4fe1\u566a\u6bd4\u9ad8\u8fbe90\u3002\u7ecf\u8fc7\u5149\u70ed\u6cbb\u7597\u540e\uff0c\u80bf\u7624\u88ab\u6709\u6548\u7684\u6291\u5236\u53ca\u5c0f\u9f20\u7684\u5b58\u6d3b\u671f\u660e\u663e\u88ab\u5ef6\u957f\u3002\u8be5\u7814\u7a76\u8868\u660e\uff0cNIR-II\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u6709\u671b\u7528\u4e8e\u8111\u80bf\u7624\u7684\u7cbe\u786e\u6210\u50cf\u548c\u6cbb\u7597\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cThrough Scalp and Skull NIR-II Photothermal Therapy of Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAdv. Mater.<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001P1RGD NPs\u7684\u5236\u5907\u548c\u4f5c\u7528\u539f\u7406\u53ca\u7406\u5316\u8868\u5f81<\/strong><\/p>\n \uff08a\uff09 P1RGD NPs\u7684\u5236\u5907\u548c\u4f53\u5185\u8111\u80bf\u7624\u5149\u70ed\u7597\u6cd5\u548c\u5149\u58f0\u6210\u50cf\u539f\u7406\uff1b<\/p>\n \uff08b\uff09 P1RGD NPs\u7684DLS\u548cTEM\u56fe\uff1b<\/p>\n \uff08c\uff09 P1 NPs\u548cP1RGD NPs\u7684UV-vis\u56fe\uff1b<\/p>\n \uff08d\uff09 1064 nm\uff081 W. cm-2<\/sup>\uff09\u6fc0\u53d1\u4e0b\u4e0d\u540c\u6d53\u5ea6P1 NPs\u7684\u5149\u70ed\u52a0\u70ed\u6548\u679c\uff1b<\/p>\n \uff08e\uff09 P1 NPs\u7684\u5faa\u73af\u5149\u70ed\u52a0\u70ed\u548c\u51b7\u5374\u65f6\u95f4\u56fe\u3002<\/p>\n \u56fe\u4e8c\u3001P1 NPs\u548cP1RGD NPs\u7684\u4f53\u5916\u5b9e\u9a8c\u6548\u679c\u5bf9\u6bd4\u00a0<\/strong><\/p>\n \uff08a\uff09 808\u548c1064 nm\u5728\u4e0d\u540c\u539a\u5ea6\u7684\u9e21\u7ec4\u7ec7\u7684\u7a7f\u900f\u6548\u679c\u7684\u5b9a\u91cf\u7ed3\u679c\uff1b<\/p>\n \uff08b\uff09 P1 NPs\u548cP1RGD NPs\u60ac\u6d6e\u6db2\u7684\u4f53\u5916PA\u5149\u8c31\uff1b<\/p>\n \uff08c\uff09 1064 nm\u5728\u4e0d\u540c\u539a\u5ea6\u9e21\u7ec4\u7ec7\u4e2dP1 NPs\u7a7f\u900f\u6df1\u5ea6\u5b9e\u9a8c\u7684\u5b9a\u91cf\u7ed3\u679c\uff1b<\/p>\n \uff08d\uff09 1064 nm\uff080.8W cm-2<\/sup>\uff09\u7167\u5c04\u4e0b\u4f53\u5916\u5149\u70ed\u6cbb\u75975 min\u7684\u5b9a\u91cf\u7ed3\u679c\uff1b<\/p>\n \uff08e\uff09 \u4f53\u5916\u5149\u70ed\u7597\u6cd5\u7684\u8367\u5149\u56fe\u3002<\/p>\n \u56fe\u4e09\u3001P1 NPs\u548cP1RGD NPs\u7684\u5c0f\u9f20\u4f53\u5185\u5b9e\u9a8c\u6548\u679c\u5bf9\u6bd4\u00a0<\/strong><\/p>\n \uff08a\uff09 P1 NPs\u548cP1RGD NPs\u6ce8\u5c04\u540e\u7684\u4e0d\u540c\u65f6\u95f4\u70b9\uff0c\u5c0f\u9f20\u5728\u76ae\u4e0bU87\u5f02\u79cd\u79fb\u690d\u80bf\u7624\u6a21\u578b\u4e2d\u7684\u4f53\u5185\u975e\u4fb5\u5165\u6027PA\u6210\u50cf\uff1b<\/p>\n \uff08b\uff09 \u5149\u70ed\u5904\u74065 min\u5c0f\u9f20\u7684\u7ea2\u5916\u70ed\u56fe\u50cf\uff1b<\/p>\n \uff08c\uff09 \u4e0d\u540c\u7ec4\u5c0f\u9f20\u7684\u5b58\u6d3b\u66f2\u7ebf\uff1b<\/p>\n \uff08d\uff09 \u80bf\u7624\u5927\u5c0f\u66f2\u7ebf\uff1b<\/p>\n \uff08e\uff09 \u5c0f\u9f20\u4f53\u91cd\u53d8\u5316\u66f2\u7ebf\uff1b<\/p>\n \uff08f\uff09 H\uff06E\u67d3\u8272\u7528PTT\u5904\u7406\u8fc7\u7684\u5c0f\u9f20\u7684\u80bf\u7624\u5207\u7247\u56fe\u3002<\/p>\n \u56fe\u56db\u3001P1 NPs\u548cP1RGD NPs\u6cbb\u7597GBM\u7684\u6548\u679c\u5bf9\u6bd4\u00a0<\/strong><\/p>\n \uff08a\uff09 NPs\u6ce8\u5c04\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u5c0f\u9f20\u8111\u80bf\u7624\u7684\u5934\u76ae\u548c\u5934\u9885\u65e0\u521bPA\u6210\u50cf\uff1b<\/p>\n \uff08b\uff09 \u4e0d\u540c\u7ec4\u8fdb\u884cPA\u6210\u50cf\u4e4b\u524d\uff0c\u643a\u5e26\u8367\u5149\u7d20\u9176\u6807\u8bb0\u7684\u795e\u7ecf\u80f6\u8d28\u7624\u7ec6\u80de\u7684\u5c0f\u9f20\u7684\u751f\u7269\u53d1\u5149\u56fe\u50cf\uff1b<\/p>\n \uff08c\uff09 \u5c0f\u9f20\u8111\u4e2d\u4e0d\u540c\u7ec4\u7ec7\u7684MRI\u56fe\u50cf\uff1b<\/p>\n \uff08d\uff09 NPs\u7ed9\u836f\u540e\u4e0d\u540c\u65f6\u95f4\u70b9\u80bf\u7624PA\u5f3a\u5ea6\u7684\u5b9a\u91cf\u7ed3\u679c\uff1b<\/p>\n \uff08e\uff09 \u7b2c19\u5929PTT\u6cbb\u7597\u540e\u8111\u5207\u7247\u7684H\uff06E\u67d3\u8272\u7ed3\u679c\uff1b<\/p>\n \uff08f\uff09 \u5149\u70ed\u5904\u7406\u540e\u5c0f\u9f20\u7684\u5b58\u6d3b\u7387\u3002<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u9996\u6b21\u7814\u7a76\u7a7f\u8fc7\u5934\u76ae\u548c\u9885\u9aa8\u7684NIR-II\u5149\u70ed\u7597\u6cd5\u5e76\u5f00\u53d1\u4e86\u4e00\u79cd\u6709\u6548\u7684\u8111\u7624\u6cbb\u7597\u8303\u4f8b\uff0c\u4f7f\u7528\u6d3b\u6027\u9776\u5411\u914d\u4f53\u4fee\u9970\u7684NIR-II\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u8fdb\u884c\u7cbe\u786e\u7684\u5149\u58f0\u6210\u50cf\u5f15\u5bfc\u3002\u7eb3\u7c73\u9897\u7c92\u5177\u6709\u826f\u597d\u7684\u5149\u7a33\u5b9a\u6027\u3001\u4f18\u5f02\u7684\u751f\u7269\u76f8\u5bb9\u6027\u3001\u5f3a\u5149\u6355\u83b7\u80fd\u529b\u548c\u826f\u597d\u7684\u5149\u70ed\u8f6c\u6362\u6027\u3002\u4e0e\u5e38\u7528\u7684808 nm PTT\u76f8\u6bd4\uff0c1064 nm\u80fd\u66f4\u6709\u6548\u5730\u7a7f\u900f\u9885\u9aa8\u548c\u5934\u76ae\uff0c\u6709\u4f4e\u4e8e\u6fc0\u5149\u5b89\u5168\u6781\u9650\u7684\u6cbb\u7597\u5fc5\u9700\u529f\u7387\u5bc6\u5ea6\u503c\u3002\u5b9e\u9a8c\u7814\u7a76\u8bc1\u5b9e\uff0c\u4e0e\u4f7f\u7528\u672a\u4fee\u9970\u7684\u7eb3\u7c73\u9897\u7c92\u7684\u60c5\u51b5\u76f8\u6bd4\uff0cc-RGD NPs\u53ef\u4ee5\u5b9e\u73b0\u6d3b\u8dc3\u7684\u8111\u80bf\u7624\u9776\u5411\uff0c\u8fdb\u4e00\u6b65\u663e\u7740\u589e\u52a0\u5149\u58f0\u6210\u50cf\u5bf9\u6bd4\u5ea6\u4ee5\u53ca\u4fe1\u566a\u6bd4\u9ad8\u8fbe90\uff0c\u6539\u5584\u4e86\u539f\u4f4d\u8111\u80bf\u7624\u6a21\u578b\u7684\u6cbb\u7597\u6548\u679c\u3002\u603b\u4e4b\uff0c\u5177\u6709\u5149\u7a33\u5b9a\u6027\u548c\u826f\u597d\u751f\u7269\u76f8\u5bb9\u6027\u7684NIR-II\u5171\u8f6d\u805a\u5408\u7269\u7eb3\u7c73\u9897\u7c92\u6709\u671b\u901a\u8fc7\u53cc\u5149\u58f0\u6210\u50cf\u548c\u5149\u70ed\u7597\u6cd5\u4ee5\u7cbe\u786e\u548c\u6709\u6548\u7684\u65b9\u5f0f\u7528\u4e8e\u8111\u80bf\u7624\u6cbb\u7597\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1aThrough Scalp and Skull NIR-II Photothermal Therapyof Deep Orthotopic Brain Tumors with Precise Photoacoustic Imaging Guidance<\/a><\/strong>\uff08Adv. Mater., 2018,<\/strong> DOI: 10.1002\/adma.201802591\uff09.<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n \u6750\u6599\u725b\u7f51\u662f\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a><\/strong>\u3002<\/p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n
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