{"id":146280,"date":"2018-07-20T06:30:00","date_gmt":"2018-07-19T22:30:00","guid":{"rendered":"\/\/m.iemloyee.com\/?p=146280"},"modified":"2018-07-19T14:01:58","modified_gmt":"2018-07-19T06:01:58","slug":"david-paramelle-acs-nano-%e7%94%9f%e7%89%a9%e7%9b%b8%e5%ae%b9%e6%80%a7%e8%82%bd%e6%b6%82%e5%b1%82%e8%b6%85%e5%b0%8f%e5%9e%8b%e8%b6%85%e9%a1%ba%e7%a3%81%e6%80%a7%e6%b0%a7%e5%8c%96%e9%93%81%e7%ba%b3","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=146280","title":{"rendered":"David Paramelle ACS Nano: \u751f\u7269\u76f8\u5bb9\u6027\u80bd\u6d82\u5c42\u8d85\u5c0f\u578b\u8d85\u987a\u78c1\u6027\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\u7528\u4e8e\u4f53\u5185\u5bf9\u6bd4\u589e\u5f3a\u78c1\u5171\u632f\u6210\u50cf"},"content":{"rendered":"
\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n \u57fa\u4e8e\u7eb3\u7c73\u9897\u7c92\u7684\u9020\u5f71\u5242\u7684\u5f00\u53d1\u53ca\u5176\u5411\u4e34\u5e8a\u5e94\u7528\u7684\u8f6c\u53d8\uff0c\u5b89\u5168\u4e14\u9ad8\u6027\u80fd\u7684\u7528\u4e8e\u533b\u5b66\u6210\u50cf\uff0c\u63d0\u4f9b\u4e86\u663e\u7740\u6539\u8fdb\u5404\u79cd\u75be\u75c5\uff08\u4f8b\u5982\u764c\u75c7\u548c\u795e\u7ecf\u75c5\u7406\u5b66\uff09\u7684\u8bca\u65ad\u548c\u6cbb\u7597\u3002\u76ee\u524d\u6700\u6210\u529f\u7684\u57fa\u4e8e\u7eb3\u7c73\u6750\u6599\u7684\u9020\u5f71\u5242\u662f\u8d85\u987a\u78c1\u6027\u6c27\u5316\u94c1\u7eb3\u7c73\u7c92\u5b50\uff08SPIONs\uff09\uff0c\u7528\u4e8e\u4eba\u4f53\u78c1\u5171\u632f\u6210\u50cf\uff08MRI\uff09\u3002\u6700\u4e3a\u91cd\u8981\u7684\u662f\uff0c\u8d85\u5c0f\u578b\u8d85\u987a\u78c1\u6027\u6c27\u5316\u94c1\u7eb3\u7c73\u7c92\u5b50\uff08USPIONs\uff09\u5df2\u88ab\u63d0\u8bae\u4f5c\u4e3a\u57fa\u4e8e\u9486\u7684\u9020\u5f71\u5242\uff08GBCA\uff09\u7684\u66ff\u4ee3\u54c1\uff0c\u7279\u522b\u662f\u5bf9\u4e8e\u5177\u6709\u80be\u6e90\u6027\u7cfb\u7edf\u6027\u7ea4\u7ef4\u5316\u98ce\u9669\u7684\u6162\u6027\u80be\u75c5\u60a3\u8005\u3002\u867d\u7136FDA\u6279\u51c6\u7528\u4e8e\u4eba\u7c7b\u7684\u7f3a\u4e4f\u6cbb\u7597\u5242\u6216MRI\u9020\u5f71\u5242\u7684SPION\u914d\u65b9\u79cd\u7c7b\u8d8a\u6765\u8d8a\u591a\uff0c\u4f46\u662f\u5728\u5927\u591a\u6570\u60c5\u51b5\u4e0b\uff0c\u5f3a\u7684\u526f\u4f5c\u7528\u548c\u7597\u6548\u7684\u98ce\u9669\u6027\u5bfc\u81f4\u5176\u5f88\u5feb\u5c31\u9000\u51fa\u5e02\u573a\u3002\u56e0\u6b64\uff0c\u8fdb\u4e00\u6b65\u63d0\u9ad8SPION\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u6027\u80fd\uff0c\u57fa\u4e8e\u7eb3\u7c73\u9897\u7c92\u7684MRI\u9020\u5f71\u5242\uff08\u4f8b\u5982\u8d85\u5c0f\u578b\u8d85\u987a\u78c1\u6027\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\uff08USPION\uff09\uff09\u7684\u8868\u9762\u6d82\u5c42\u7684\u54c1\u8d28\u5bf9\u4e8e\u786e\u4fdd\u751f\u7269\u73af\u5883\u4e2d\u7684\u9ad8\u80f6\u4f53\u7a33\u5b9a\u6027\uff0c\u6539\u5584\u78c1\u6027\u80fd\u4ee5\u53ca\u5728\u5faa\u73af\u6d41\u4f53\u548c\u7ec4\u7ec7\u4e2d\u7684\u5206\u6563\u6027\uff0c\u4f7f\u5176\u8f6c\u5316\u4e3a\u4e34\u5e8a\u5e94\u7528\u81f3\u5173\u91cd\u8981\u3002<\/p>\n \u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n \u8fd1\u65e5\uff0c\u65b0\u52a0\u5761\u79d1\u6280\u7814\u7a76\u5c40\u7684David Paramelle\u6559\u6388\uff08\u901a\u8baf\u4f5c\u8005\uff09<\/strong>\u7b49\u62a5\u9053\u4e8621\u79cd\u591a\u80bd\u548c\u914d\u4f53\u7684\u8bbe\u8ba1\uff0c\u5e76\u5728USPIONs\u8868\u9762\u8868\u73b0\u51fa\u9ad8\u5ea6\u7a33\u5b9a\u7684\u81ea\u7ec4\u88c5\u5355\u5c42\u819c\u3002\u6309\u7167\u4e25\u683c\u7684\u6807\u51c6\u5236\u5907\u548c\u7b5b\u9009\u4e86\u603b\u5171\u670986\u79cd\u4e0d\u540c\u7684\u80bd\u6d82\u8986\u7684USPIONs\u8868\u9762\uff0c\u4f8b\u5982\u5728\u751f\u7406\u6761\u4ef6\u4e0b\u5bf9\u7535\u89e3\u8d28\u8bf1\u5bfc\u7684\u805a\u96c6\u7684\u7a33\u5b9a\u6027\uff0c\u9632\u6b62\u4e0e\u7ec6\u80de\u7684\u975e\u7279\u5f02\u6027\u7ed3\u5408\uff0c\u4ee5\u53ca\u6ca1\u6709\u7ec6\u80de\u6bd2\u6027\u548c\u5bf9\u6bd4\u589e\u5f3a\u7684\u4f53\u5185MRI\u3002\u5176\u4e2d2PG-S*<\/sup> VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u663e\u793a\u6700\u9ad8\u7684\u751f\u7269\u76f8\u5bb9\u6027\u548c\u6027\u80fd\uff0c\u5bf9\u6d3b\u7ec6\u80de\u6ca1\u6709\u53ef\u68c0\u6d4b\u7684\u6bd2\u6027\u548c\u7c98\u9644\u6027\u3002 2PG-S*<\/sup>VVVT-PEG4-ol\u6d82\u5c42\u7684USPIONs\u663e\u793a\u51fa\u589e\u5f3a\u7684\u78c1\u5171\u632f\u7279\u6027\u3002\u6b64\u5916\uff0c\u5b9e\u9a8c\u8bc1\u660e2PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u4f5c\u4e3aT2\u9020\u5f71\u5242\u7528\u4e8e\u4f53\u5185MRI\u5e94\u7528\u7684\u826f\u597d\u6548\u679c\uff0c\u5b9e\u73b0\u4e86\u809d\u810f\u7684\u9ad8\u5bf9\u6bd4\u5ea6\u589e\u5f3a\u4ee5\u53ca\u809d\u810f\u80bf\u7624\u7684\u68c0\u6d4b\uff0c\u663e\u7740\u6539\u5584\u4e86\u80bf\u7624\u4e0e\u809d\u810f\u7684\u5bf9\u6bd4\u5ea6\u3002\u62a5\u9053\u7684\u80bd\u5305\u88ab\u7684USPIONs\u5177\u6709\u5141\u8bb8\u80bf\u7624\u7279\u5f02\u6027\u9776\u5411\u6027\u548cMRI\u65e9\u671f\u68c0\u6d4b\u764c\u75c7\u7684\u6f5c\u529b\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cBiocompatible Peptide-Coated Ultrasmall Superparamagnetic Iron Oxide Nanoparticles for In Vivo Contrast-Enhanced Magnetic Resonance Imaging\u201d<\/strong>\u53d1\u8868\u5728\u56fd\u9645\u8457\u540d\u671f\u520aACS Nano<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001\u5236\u5907\u548c\u9009\u62e9\u9ad8\u6548\u591a\u80bd\u5305\u88abUSPIONs\u7684 MRI\u9020\u5f71\u5242\u7684\u65b9\u6cd5\u00a0<\/strong><\/p>\n \u56fe\u4e8c\u3001\u6cb9\u9178\u6d82\u8986\u548c\u6c34\u6eb6\u6027TMAOH\u6d82\u8986\u7684USPIONs\u7684\u8868\u5f81\u00a0<\/strong><\/p>\n \uff08a\uff09 100\u4e2a\u6cb9\u9178\u6d82\u8986\u7684USPIONs\u7684\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n \uff08b\uff09 100\u4e2aTMAOH\u6d82\u8986\u7684USPIONs\u7684\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n \uff08c\uff09\u6cb9\u9178\u6d82\u8986\u7684USPIONs\u7684X\u5c04\u7ebf\u7c89\u672b\u884d\u5c04\uff1b<\/p>\n \uff08d\uff09TMAOH\u6d82\u8986\u7684USPIONs\u7684X\u5c04\u7ebf\u7c89\u672b\u884d\u5c04;<\/p>\n \uff08e\uff09 \u6cb9\u9178\u6d82\u5c42USPIONs\u5177\u6709\u5355\u7ed3\u6676\u5ea6\u548c\u6676\u683c\u6761\u7eb9\u7684\u9ad8\u5206\u8fa8TEM\u56fe\uff1b<\/p>\n \uff08f\uff09TMAOH\u6d82\u8986\u7684USPION\u7684DLS\u56fe\u3002<\/p>\n \u56fe\u4e09\u3001\u591a\u80bd\u5305\u88ab\u7684USPIONs\u5bf9\u7535\u89e3\u8d28\u8bf1\u5bfc\u805a\u96c6\u7684\u7a33\u5b9a\u6027<\/strong>\u00a0<\/p>\n \uff08a-c\uff09\u5355\u80bd\u5305\u88ab\u7684USPIONs\u7684\u6807\u51c6\u5316\u805a\u96c6\u53c2\u6570\u503c\uff1b<\/p>\n \uff08d\uff09\u4e0d\u540c\u7684\u80bd\u548c\u914d\u4f53\uff08PO3<\/sub>H2<\/sub>\uff09-SC16-OH\u5f62\u6210\u7684\u6df7\u5408\u591a\u80bd\u5305\u88ab\u7684USPIONs \u7684\u6807\u51c6\u5316\u805a\u96c6\u53c2\u6570\u503c\uff1b<\/p>\n \uff08e\uff09 \u4e0d\u540c\u7684\u914d\u4f53\u548c2PG-S*<\/sup>VVVT-ol\u5f62\u6210\u7684\u6df7\u5408\u591a\u80bd\u5305\u88abUSPIONs \u7684\u6807\u51c6\u5316\u805a\u96c6\u53c2\u6570\u503c\uff1b<\/p>\n \uff08f\uff09\u4e0d\u540c\u7684\u914d\u4f53\u548c\u4e0d\u540c\u6469\u5c14\u6bd4\u76842PG-S*<\/sup>VVVT-ol\u5f62\u6210\u7684\u6df7\u5408\u591a\u80bd\u5305\u88abUSPIONs \u7684\u6807\u51c6\u5316\u805a\u96c6\u53c2\u6570\u503c\u3002<\/p>\n \u56fe\u56db\u3001\u591a\u80bd\u5305\u88ab\u7684USPIONs\u7684\u4f53\u5916\u8bc4\u4f30\u00a0<\/strong><\/p>\n \uff08a\uff09 PLC \/ PRF5\u7ec6\u80de\u9009\u62e9\u76842PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u6d4b\u5b9a\uff1b<\/p>\n \uff08b\uff09 PLC \/ PRF5\u7ec6\u80de\u9009\u62e92PG-S*<\/sup>VVVT-ol:(PO3<\/sub>H2<\/sub>)-S-C11-EG3-OH\uff087:3\uff09\u5305\u88ab\u7684USPIONs\u7684\u7ec6\u80de\u5b58\u6d3b\u7387\u6d4b\u5b9a\uff1b<\/p>\n \uff08c\uff09 \u5728\u6ca1\u6709USPIONs\u7684\u60c5\u51b5\u4e0b\u5b75\u80b2\u7684PLC \/ PRF5\u7ec6\u80de\uff1b<\/p>\n \uff08d\uff09 TMAOH\u5305\u88ab\u7684USPIONs\u7684\u60c5\u51b5\u4e0b\u5b75\u80b2\u7684PLC \/ PRF5\u7ec6\u80de\uff1b<\/p>\n \uff08e-f\uff092PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u7684\u60c5\u51b5\u4e0b\u5b75\u80b2\u7684PLC \/ PRF5\u7ec6\u80de\uff1b<\/p>\n \uff08g-h\uff092PG-S*<\/sup>VVVT-ol:(PO3<\/sub>H2<\/sub>)-S-C11-EG3-OH(7:3)\u5305\u88ab\u7684USPIONs\u7684\u60c5\u51b5\u4e0b\u5b75\u80b2\u7684PLC \/ PRF5\u7ec6\u80de\u3002<\/p>\n \u56fe\u4e94\u30012PG-S *<\/sup> VVVT-PEG4-ol\u6d82\u8986\u7684USPIONs\u9020\u5f71\u5242\u8fdb\u884c\u4f53\u5185MRI\u00a0<\/strong><\/p>\n \uff08a\uff09 \u9759\u8109\u6ce8\u5c042PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u540e\uff0cNCr\u88f8\u9f20\u51a0\u72b6\uff08\u9876\u90e8\uff09\u548c\u6a2a\u5411\uff08\u5e95\u90e8\uff09\u5e73\u9762\u7684\u4f53\u5185MR\u56fe\u50cf\uff1b<\/p>\n \uff08b\uff09 1.0 mg Fe \/ kg\u7684\u5242\u91cf\u5728NCr\u88f8\u9f20\u4e2d\u7d2f\u79ef\u591a\u80bd\u5305\u88ab\u7684USPIONs\u540e\u6536\u96c6\u7684\u809d\u810f\u5bf9\u6bd4\u5ea6\u7684\u5b9a\u91cf\uff1b<\/p>\n \uff08c\uff09 \u9759\u8109\u6ce8\u5c042PG-S*<\/sup>VVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u540e\uff0c\u539f\u4f4d\u5f02\u79cd\u79fb\u690d\u809d\u80bf\u7624\u6a21\u578b\u7684\u51a0\u72b6\uff08\u9876\u90e8\uff09\u548c\u6a2a\u5411\uff08\u5e95\u90e8\uff09\u5e73\u9762\u4e2d\u7684\u4f53\u5185MR\u56fe\u50cf\uff1b<\/p>\n \uff08d\uff09 2.0 mg Fe \/ kg\u7684\u5242\u91cf\u7d2f\u79ef2PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u540e\uff0c\u5b9a\u91cf\u80bf\u7624\u4e0e\u809d\u810f\u5bf9\u6bd4\u7684CNR\uff1b<\/p>\n \uff08e-f\uff09\u9759\u8109\u6ce8\u5c042.0 mg Fe \/ kg \u76842PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u540e\uff0c\u5c0f\u9f20\u809d\u810f\u7684\u7ec4\u7ec7\u75c5\u7406\u5b66\u5206\u6790\u3002<\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u8bbe\u8ba1\u7814\u7a76\u4e86\u4e00\u7cfb\u5217\u591a\u80bd\u548c\u914d\u4f53\uff0c\u80fd\u591f\u5728USPIONs\u8868\u9762\u5f62\u6210\u9ad8\u5ea6\u7a33\u5b9a\u7684SAMs\u3002\u53cc\u78f7\u9178\u5316\u7684\u80bd\u548c\u914d\u4f53\u4f18\u4e8e\u5176\u5176\u5b83\u540c\u6e90\u7269\uff0c\u5176\u901a\u5e38\u7528\u4e8e\u5305\u88f9\u6c27\u5316\u94c1\u7eb3\u7c73\u9897\u7c92\u3002\u7814\u7a76\u53d1\u73b02PG-S*<\/sup>VVVTPEG4-ol\u5305\u88ab\u7684USPIONs\u5728\u751f\u7406\u6761\u4ef6\u4e0b\u8868\u73b0\u51fa\u4e86\u5bf9\u7535\u89e3\u8d28\u8bf1\u5bfc\u805a\u96c6\u7684\u957f\u671f\u7a33\u5b9a\u6027\u3001\u6ca1\u6709\u53ef\u68c0\u6d4b\u7684\u4e0e\u6d3b\u7ec6\u80de\u7684\u975e\u7279\u5f02\u6027\u7ed3\u5408\u548c\u9ad8\u6d53\u5ea6\u4e0b\u6ca1\u6709\u7ec6\u80de\u6bd2\u6027\u7684\u4f18\u70b9\u3002\u800c\u4e14\uff0c2PG-S*<\/sup>VVVT-PEG4-ol\u5305\u88ab\u7684USPIONs\u5728\u4f53\u5185\u809d\u810f\u548c\u80bf\u7624\u809d\u810f\u5904\u5c55\u73b0\u51fa\u5f3a\u70c8\u4e14\u6301\u4e45\u7684\u5bf9\u6bd4\u5f3a\u5ea6\u3002\u7528\u751f\u7269\u6807\u8bb0\u7269\u529f\u80fd\u5316\u7cbe\u5fc3\u8bbe\u8ba1\u7684\u591a\u80bd\u5305\u88ab\u7684USPIONs\u5c06\u80fd\u591f\u8ddf\u8e2a\u7279\u5b9a\u7ec4\u7ec7(\u4f8b\u5982\u4e73\u817a\u764c)\uff0c\u5e76\u901a\u8fc7\u4f53\u5185\u9ad8\u5206\u8fa8\u7387\u5bf9\u6bd4\u589e\u5f3aMRI\u7528\u4e8e\u65e9\u671f\u764c\u75c7\u8bca\u65ad\u7684\u9776\u5411\u9020\u5f71\u5242\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1aBiocompatible Peptide-Coated Ultrasmall Superparamagnetic Iron Oxide Nanoparticles for In Vivo Contrast-Enhanced Magnetic Resonance Imaging<\/a><\/strong>\uff08ACS Nano, 2018<\/strong>, DOI: 10.1021\/acsnano.7b07572\uff09<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1\u3002<\/strong><\/p>\n \u6750\u6599\u725b\u7f51\u662f\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a><\/strong>\u3002<\/p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n<\/strong><\/p>\n
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