{"id":145904,"date":"2018-07-16T14:00:03","date_gmt":"2018-07-16T06:00:03","guid":{"rendered":"\/\/m.iemloyee.com\/?p=145904"},"modified":"2018-07-15T15:11:01","modified_gmt":"2018-07-15T07:11:01","slug":"nat-nanotechnol-%ef%bc%9a%e7%9f%b3%e5%a2%a8%e7%83%af%e9%87%8f%e5%ad%90%e7%82%b9%e9%a2%84%e9%98%b2%e5%b8%95%e9%87%91%e6%a3%ae%e7%9a%84%ce%b1-%e5%85%b1%e6%a0%b8%e8%9b%8b%e7%99%bd%e7%97%85","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=145904","title":{"rendered":"Nat. Nanotechnol.\uff1a\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u9884\u9632\u5e15\u91d1\u68ee\u7684\u03b1-\u5171\u6838\u86cb\u767d\u75c5"},"content":{"rendered":"

\u3010\u5f15\u8a00\u3011<\/strong><\/p>\n

\u5e15\u91d1\u68ee\u75c5\u662f\u4e00\u79cd\u6162\u6027\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u9000\u5316\u6027\u5931\u8c03\uff0c\u4f1a\u635f\u5bb3\u60a3\u8005\u7684\u52a8\u4f5c\u6280\u80fd\u3001\u8bed\u8a00\u80fd\u529b\u4ee5\u53ca\u5176\u4ed6\u529f\u80fd\uff0c\u5176\u4e34\u5e8a\u8868\u73b0\u4e3b\u8981\u5305\u62ec\u9759\u6b62\u6027\u9707\u98a4\u3001\u8fd0\u52a8\u8fdf\u7f13\u3001\u808c\u5f3a\u76f4\u548c\u59ff\u52bf\u6b65\u6001\u969c\u788d\uff0c\u540c\u65f6\u60a3\u8005\u53ef\u4f34\u6709\u6291\u90c1\u3001\u4fbf\u79d8\u548c\u7761\u7720\u969c\u788d\u7b49\u975e\u8fd0\u52a8\u75c7\u72b6\u3002\u6700\u8fd1\uff0c\u4e0d\u65ad\u6709\u8bc1\u636e\u8868\u660e\u5e15\u91d1\u68ee\u75c5\u7684\u53d1\u75c5\u673a\u5236\u4e0e\u4e2d\u8111\u4e2d\u03b1-\u5171\u6838\u86cb\u767d\u805a\u96c6\u4f53\u7684\u79ef\u7d2f\u548c\u4f20\u9012\u6709\u5bc6\u5207\u7684\u5173\u7cfb\u3002\u7136\u800c\uff0c\u4e34\u5e8a\u4e0a\u4f9d\u7136\u6ca1\u6709\u6297\u805a\u96c6\u5242\u662f\u5b9e\u73b0\u5e15\u91d1\u68ee\u75c5\u7684\u6709\u6548\u6cbb\u7597\u3002<\/p>\n

\u3010\u6210\u679c\u7b80\u4ecb\u3011<\/strong><\/p>\n

\u8fd1\u65e5\uff0c\u97e9\u56fd\u9996\u5c14\u56fd\u7acb\u5927\u5b66<\/strong>Byung Hee Hong<\/strong>\u6559\u6388<\/strong>\u8bfe\u9898\u7ec4\u4e0e\u7ea6\u7ff0\u970d\u666e\u91d1\u65af\u5927\u5b66\u533b\u5b66\u9662\u7684<\/strong>Han Seok Ko<\/strong>\u6559\u6388<\/strong>\u5408\u4f5c\uff0c\u63a2\u7d22\u5229\u7528\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6765\u6291\u5236\u03b1-\u5171\u6838\u86cb\u767d\u7684\u7ea4\u7ef4\u5316\u805a\u96c6\uff0c\u5e76\u5c1d\u8bd5\u5176\u4e0e\u6210\u719f\u7684\u539f\u7ea4\u7ef4\u76f4\u63a5\u76f8\u4e92\u4f5c\u7528\u5f15\u53d1\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7684\u89e3\u805a\u3002\u7814\u7a76\u8868\u660e\uff0c\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u80fd\u591f\u7a7f\u900f\u8840\u8111\u5c4f\u969c\u5e76\u6709\u6548\u6291\u5236\u91d1\u68ee\u75c5\u4e2d\u7684\u03b1-\u5171\u6838\u86cb\u767d\u5f62\u6210\u7ea4\u7ef4\u5316\u805a\u96c6\u4f53\u3002\u6b64\u5916\uff0c\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u5728\u4f53\u5916\u548c\u4f53\u5185\u5747\u6ca1\u6709\u660e\u663e\u7684\u4f53\u5185\u6bd2\u6027\uff0c\u6709\u671b\u6210\u4e3a\u6cbb\u7597\u5e15\u91d1\u68ee\u75c5\u7684\u4e34\u5e8a\u836f\u7269\u3002\u8be5\u6210\u679c\u4ee5\u9898\u4e3a”Graphene quantum dots prevent \u03b1-synucleinopathy in Parkinson\u2019s disease”<\/strong>\u53d1\u8868\u5728Nature Nanotechnology<\/strong>\u4e0a\u3002<\/p>\n

\u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n

\u56fe1 \u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u5bf9\u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u5316\u548c\u7ea4\u7ef4\u89e3\u4f53\u7684\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5728\u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u5316\u548c\u7ea4\u7ef4\u89e3\u4f53\u7684\u793a\u610f\u56fe\uff1b<\/p>\n

(b) ThT\u8367\u5149\u76d1\u6d4b\u7684\u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u5316\u52a8\u529b\u5b66\u8fc7\u7a0b\uff1b<\/p>\n

(c) \u6d4a\u5ea6\u6d4b\u5b9a\u76d1\u6d4b\u7684\u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u5316\u52a8\u529b\u5b66\u8fc7\u7a0b;<\/p>\n

(d) \u5728\u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u5316\u540e\u7684TEM\u7167\u7247\uff1b<\/p>\n

(e) ThT\u8367\u5149\u76d1\u6d4b\u7684\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4e0e\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u4f5c\u7528\u7684\u52a8\u529b\u5b66\u8fc7\u7a0b\uff1b<\/p>\n

(f) \u6d4a\u5ea6\u6d4b\u5b9a\u76d1\u6d4b\u7684\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4e0e\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u4f5c\u7528\u7684\u52a8\u529b\u5b66\u8fc7\u7a0b\uff1b<\/p>\n

(g) \u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u957f\u5ea6\u548c\u6bcf\u5e73\u65b9\u5fae\u7c73\u5185\u03b1-\u5171\u6838\u86cb\u767d\u7ea4\u7ef4\u6570\u76ee\u7684\u7edf\u8ba1;<\/p>\n

(h) \u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4f5c\u7528\u6761\u4ef6\u4e0b\u5269\u4f59\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7684\u6570\u76ee\u7edf\u8ba1\uff1b<\/p>\n

(i) \u5728\u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u4e0d\u540c\u65f6\u95f4\u70b9\u65f6\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7684TEM\u7167\u7247\uff1b<\/p>\n

(j) \u4e0d\u540c\u65f6\u95f4\u70b9\u65f6\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u6591\u70b9\u5370\u8ff9\u5206\u6790\u7684\u5178\u578b\u56fe\u50cf;<\/p>\n

(k) \u4e0d\u540c\u65f6\u95f4\u70b9\u65f6\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7684BN\u2013PAGE \u5206\u6790\u3002<\/p>\n

\u56fe2 \u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4e0e\u6210\u719f\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5728\u89e3\u79bb\u8fc7\u7a0b\u4e2d\u7684\u76f8\u4e92\u4f5c\u7528<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u751f\u7269\u7d20\u5316\u7684\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4e0e\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7ed3\u5408\u7684TEM\u7167\u7247\uff1b<\/p>\n

(b) \u5b75\u53161\u5c0f\u65f6\u540e\u5728\u89e3\u79bb\u8fc7\u7a0b\u4e2d\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5e73\u5747\u5bbd\u5ea6\u7684\u7edf\u8ba1\uff1b<\/p>\n

(c) \u901a\u8fc71<\/sup>H\u201315<\/sup>N HSQC \u8c31\u56fe\u4e2d\u5f97\u5230\u7684\u6838\u78c1\u5316\u5b66\u4f4d\u79fb\u5dee\u5f02\uff1b<\/p>\n

(d) \u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4e0e\u6210\u719f\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u95f4\u76f8\u4e92\u4f5c\u7528\u7684\u65f6\u95f4\u8fc7\u7a0b\u52a8\u529b\u5b66\u6a21\u62df\uff1b<\/p>\n

(e) \u03b1 -\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5bf9\u7167\u7ec4\u548c\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u4e0e\u6210\u719f\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7ec4\u7684\u65f6\u95f4\u4f9d\u8d56\u8c31\u56fe\uff1b<\/p>\n

(f) \u7531DSSP\u7b97\u6cd5\u5f97\u5230\u7684\u65f6\u95f4\u4f9d\u8d56\u7684\u4e8c\u7ea7\u7ed3\u6784\u56fe\uff1b<\/p>\n

(g) \u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u5b75\u53167\u5929\u540e\u03b1-\u5171\u6838\u86cb\u767d\u5355\u4f53\u548c\u539f\u7ea4\u7ef4\u7684CD\u5149\u8c31\uff1b<\/p>\n

(h) \u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u548c\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u89e3\u79bb\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u4e2d\u4e8c\u7ea7\u7ed3\u6784\u542b\u91cf\u3002<\/p>\n

\u56fe3 \u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u5bf9\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u8bf1\u5bfc\u795e\u7ecf\u5143\u6b7b\u4ea1\uff0c\u75c5\u7406\u548c\u4f53\u5916\u4f20\u9012\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u7528\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5904\u7406\u65f6TUNEL\u65b9\u6cd5\u8bc4\u4f30\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u60c5\u51b5\uff1b<\/p>\n

(b) \u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u7528\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5904\u7406\u65f6\u963f\u5c14\u739b\u84dd\u65b9\u6cd5\u8bc4\u4f30\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u60c5\u51b5\uff1b<\/p>\n

(c) \u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u7528\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5904\u7406\u65f6LDH\u6d4b\u5b9a\u65b9\u6cd5\u8bc4\u4f30\u7684\u795e\u7ecf\u5143\u6b7b\u4ea1\u60c5\u51b5\uff1b<\/p>\n

(d) \u78f7\u9178\u5316\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u5b58\u5728\u6761\u4ef6\u4e0b\u7684\u5178\u578b\u514d\u75ab\u5370\u8ff9\u6c34\u5e73\uff1b<\/p>\n

(e) \u6807\u51c6\u5316\u81f3\u03b2-\u808c\u52a8\u86cb\u767d\u7684\u6c34\u5e73\u540eSDS\u4e0d\u6eb6\u6027\u7ea7\u5206\u7684\u91cf\u5316\uff1b<\/p>\n

(f) \u6297\u4f53\u5b58\u5728\u6761\u4ef6\u4e0b\u5178\u578b\u7684\u78f7\u9178\u5316\u03b1-\u5171\u6838\u86cb\u767d\u514d\u75ab\u67d3\u8272\u663e\u5fae\u7167\u7247\uff1b<\/p>\n

(g) \u6807\u51c6\u5316\u81f3PBS\u5bf9\u7167\u7ec4\u540e\u78f7\u9178\u5316\u03b1-\u5171\u6838\u86cb\u767d\u514d\u75ab\u8367\u5149\u5f3a\u5ea6\u7684\u91cf\u5316\uff1b<\/p>\n

(h) \u7528\u4e8e\u75c5\u7406\u6027\u03b1-\u5171\u6838\u86cb\u767d\u4f20\u64ad\u7684\u5fae\u6d41\u4f53\u88c5\u7f6e\u793a\u610f\u56fe;<\/p>\n

(i) \u6dfb\u52a0\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef414\u5929\u540e\u5fae\u6d41\u4f53\u88c5\u7f6e\u4e2d\u78f7\u9178\u5316\u03b1-\u5171\u6838\u86cb\u767d\u514d\u75ab\u67d3\u8272\u795e\u7ecf\u5143\u7684\u5178\u578b\u56fe\u7247\uff1b<\/p>\n

(j) \u78f7\u9178\u5316\u03b1-\u5171\u6838\u86cb\u767d\u514d\u75ab\u8367\u5149\u5f3a\u5ea6\u7684\u91cf\u5316\u3002<\/p>\n

\u56fe4 \u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u5bf9\u4f53\u5185\u03b1 -\u5171\u6838\u86cb\u767d\u8bf1\u5bfc\u7684\u75c5\u7406\u5b66\u5f71\u54cd<\/strong><\/p>\n

\"\"<\/p>\n

(a) \u5728C57BL\/6\u5c0f\u9f20\u4e2d\u6ce8\u5c04\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u7684\u6ce8\u5c04\u5750\u6807\u793a\u610f\u56fe\uff1b<\/p>\n

(b) \u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u5728\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u534a\u7403\u6ce8\u5c04\u9ed1\u8d28\u4e2d\u5178\u578b\u7684TH\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u56fe\u50cf\uff1b<\/p>\n

(c) \u6709\u65e0\u77f3\u58a8\u70ef\u91cf\u5b50\u70b9\u6761\u4ef6\u4e0b\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u6ce8\u5c046\u4e2a\u6708\u540e\u9ed1\u8d28\u4e2dTH-\u548cNissl-\u9633\u6027\u795e\u7ecf\u5143\u7684\u4f53\u89c6\u8ba1\u6570\uff1b<\/p>\n

(d) \u5728\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u6ce8\u5c04\u7684\u7eb9\u72b6\u4f53\u534a\u7403\u4e2d\u5178\u578b\u7684TH\u514d\u75ab\u7ec4\u7ec7\u5316\u5b66\u56fe\u50cf\uff1b<\/p>\n

(e) \u7eb9\u72b6\u4f53\u4e2dTH\u514d\u75ab\u9633\u6027\u7ea4\u7ef4\u5bc6\u5ea6\u7684\u91cf\u5316\uff1b<\/p>\n

(f) \u5728\u6c14\u7f38\u6d4b\u8bd5\u4e2d\u7528\u524d\u722a\u6d4b\u91cf\u7684\u884c\u4e3a\u7f3a\u9677\u8bc4\u4f30\uff1b<\/p>\n

(g) \u901a\u8fc7\u638c\u63e1\u548c\u4e0b\u964d\u7684\u80fd\u529b\u6765\u8bc4\u4f30\u884c\u4e3a\u7f3a\u9677\uff1b<\/p>\n

(h) \u5728\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u6ce8\u5c04\u7684\u7eb9\u72b6\u4f53\u548c\u9ed1\u8d28\u534a\u7403\u4e2d\u5178\u578b\u7684\u514d\u75ab\u67d3\u8272\u56fe\u50cf\uff1b<\/p>\n

(i) \u5728\u7eb9\u72b6\u4f53\u548c\u9ed1\u8d28\u4e2d\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u514d\u75ab\u53cd\u5e94\u795e\u7ecf\u5143\u7684\u91cf\u5316\uff1b<\/p>\n

(j) \u6ce8\u5c04\u9884\u5148\u5f62\u6210\u7684\u03b1-\u5171\u6838\u86cb\u767d\u539f\u7ea4\u7ef4\u534a\u7403\u7684\u4e2d\u67a2\u795e\u7ecf\u7cfb\u7edf\u4e2d\u7684\u75c5\u7406\u5206\u5e03\u56fe\u3002<\/p>\n

\u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n

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\u6587\u732e\u94fe\u63a5\uff1aGraphene quantum dots prevent \u03b1-synucleinopathy in Parkinson\u2019s disease\u00a0<\/a>\u00a0(Nat. Nanotechnol. \uff0c2018, DOI: 10.1038\/s41565-018-0179-y)<\/strong><\/p>\n

\u672c\u6587\u7531\u6750\u6599\u4eba\u9ad8\u5206\u5b50\u548c\u751f\u7269\u5b66\u672f\u7ec4Gaxy\u4f9b\u7a3f\uff0c\u6750\u6599\u725b\u5ba1\u6838\u6574\u7406\u3002\u6750\u6599\u725b\u7f51\u7ad9\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u53ca\u884c\u4e1a\u4ece\u4e1a\u5458\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n

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