{"id":145425,"date":"2018-07-11T14:00:02","date_gmt":"2018-07-11T06:00:02","guid":{"rendered":"\/\/m.iemloyee.com\/?p=145425"},"modified":"2018-07-09T18:52:26","modified_gmt":"2018-07-09T10:52:26","slug":"%e9%bb%84%e5%89%91%e4%b8%9cjuyoung-yoon-angew-chem-int-ed-%e9%85%9e%e8%8f%81%e8%87%aa%e7%bb%84%e8%a3%85%e7%9a%84%e7%ba%b3%e7%b1%b3%e7%82%b9%e4%bd%9c%e4%b8%ba%e5%85%89%e6%95%8f%e5%89%82%ef%bc%8c","status":"publish","type":"post","link":"\/\/m.iemloyee.com\/?p=145425","title":{"rendered":"\u9ec4\u5251\u4e1c&Juyoung Yoon Angew. Chem. Int. Ed.: \u915e\u83c1\u81ea\u7ec4\u88c5\u7684\u7eb3\u7c73\u70b9\u4f5c\u4e3a\u5149\u654f\u5242\uff0c\u7528\u4e8e\u9ad8\u6548I\u578b\u5149\u53cd\u5e94\u7684\u5149\u52a8\u529b\u7597\u6cd5"},"content":{"rendered":"
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4, 6 – \u4e09 -\uff08N, N-\u4e8c\u7532\u57fa\u6c28\u57fa\u7532\u57fa\uff09\u82ef\u6c27\u57fa\u53d6\u4ee3\u7684\u4e0d\u5bf9\u79f0\u950c\uff08II\uff09\u915e\u83c1(PcA)\uff0cPcA\u5728\u6c34\u6eb6\u6db2\u4e2d\u53ef\u4ee5\u81ea\u7ec4\u88c5\u5f62\u6210\u7a33\u5b9a\u7684\u7eb3\u7c73\u70b9\uff08NanoPcA\uff09\u3002\u5728\u8fd1\u7ea2\u5916\u5149\u7167\u5c04\u4e0bNanoPcA\u53ef\u4ee5\u901a\u8fc7I\u578b\u673a\u7406\u9ad8\u6548\u5730\u751f\u6210ROS\u3002\u6297\u83cc\u5b9e\u9a8c\u7ed3\u679c\u8868\u660eNanoPcA\u786e\u5b9e\u5177\u6709\u6f5c\u5728\u7684PDT\u5e94\u7528\u3002\u7814\u7a76\u6210\u679c\u4ee5\u9898\u4e3a\u201cPhthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy\u201d<\/strong>\u53d1\u5e03\u5728\u56fd\u9645\u8457\u540d\u671f\u520aAngew. Chem. Int. Ed.<\/strong>\u4e0a\u3002<\/p>\n \u3010\u56fe\u6587\u5bfc\u8bfb\u3011<\/strong><\/p>\n \u56fe\u4e00\u3001NanoPcA \u7684\u5236\u5907\u548c\u8868\u5f81\u00a0<\/strong><\/p>\n \uff08a\uff09 PcA\u7684\u5206\u5b50\u7ed3\u6784\u53ca\u5176\u7eb3\u7c73\u7ed3\u6784\u81ea\u7ec4\u88c5\u7684\u793a\u610f\u56fe\uff1b<\/p>\n \uff08b\uff09 DLS\u6d4b\u5b9aNanoPcA\uff0820 \u03bcm\uff09\u5728\u6c34\u548cPBS\u4e2d\u7684\u5c3a\u5bf8\u5206\u5e03\uff1b<\/p>\n \uff08c\uff09 NanoPcA\u7684TEM\u56fe\u3002<\/p>\n \u56fe\u4e8c\u3001NanoPcA\u7684\u81ea\u7ec4\u88c5\u8fc7\u7a0b\u548c\u7a33\u5b9a\u6027\u00a0<\/strong><\/p>\n \uff08a\uff09 PcA\u52a0\u5165\u6c34\u4e2d\uff0cNanoPcA\u7684\u5c3a\u5bf8\u53d8\u5316\uff1b<\/p>\n \uff08b\uff09 NanoPcA\u5728\u6c34\u548cPBS\u4e2d\u4e0d\u540c\u65f6\u95f4\u70b9\u7684\u5e73\u5747\u5c3a\u5bf8\u5927\u5c0f\uff1b<\/p>\n \uff08c\uff09 NanoPcA\u5728\u6c34\u548cPBS\u4e2d\u7684Zeta\u7535\u4f4d\u503c\uff1b<\/p>\n \uff08d\uff09 \u4e0d\u540c\u6d53\u5ea6\u7684NanoPcA\u7684\u5c3a\u5bf8\u53d8\u5316\u3002<\/p>\n \u56fe\u4e09\u3001NanoPcA\u7684\u5149\u7269\u7406\u548c\u5149\u5316\u5b66\u6027\u8d28\u00a0<\/strong><\/p>\n \uff08a\uff09 \u8367\u5149\u63a2\u9488\u68c0\u6d4b\u5149\u7167\u5c04\u6c34\u6eb6\u6db2\u4e2d\u7684NanoPcA\u548cMB\u4ea7\u751fROS\u7684\u6548\u7387\uff1b<\/p>\n \uff08b\uff09 ESR\u5206\u6790\u68c0\u6d4b\u5149\u7167\u5c04\u6c34\u6eb6\u6db2\u4e2d\u7684NanoPcA\u548cMB \u4ea7\u751f\u76841<\/sup>O2<\/sub>\u7684\u6548\u7387\uff1b<\/p>\n \uff08c\uff09 \u8367\u5149\u63a2\u9488\u68c0\u6d4b\u5149\u7167\u5c04\u6c34\u6eb6\u6db2\u4e2d\u7684NanoPcA\u548cMB\u751f\u6210\u7684O2<\/sub>.-<\/sup> \u7684\u6548\u7387\uff1b<\/p>\n \uff08d\uff09 NanoPcA\u5149\u7269\u7406\u5149\u5316\u5b66\u53cd\u5e94\u8fc7\u7a0b\u7684\u53ef\u80fd\u673a\u7406\u793a\u610f\u56fe\uff1b<\/p>\n \uff08e-g\uff09\u8367\u5149\u63a2\u9488\u68c0\u6d4b\u5149\u7167\u5c04\u6c34\u6eb6\u6db2\u4e2d\u7684NanoPc\u3001NanoPcA\u3001NanoPcA4\u4ea7\u751fO2<\/sub>.-<\/sup>\u7684\u6548\u7387\uff1b<\/p>\n \u56fe\u56db\u3001NanoPcA\u7528\u4e8ePDT\u6291\u5236\u5927\u80a0\u6746\u83cc\u548c\u91d1\u9ec4\u8272\u8461\u8404\u7403\u83cc\u7684\u5b9e\u9a8c\u00a0<\/strong><\/p>\n \u56fe\u4e94\u3001NanoPcA\u5904\u7406\u5927\u80a0\u6746\u83cc\u7684\u5e95\u7269TEM\u56fe\u00a0<\/strong><\/p>\n \u3010\u5c0f\u7ed3\u3011<\/strong><\/p>\n \u7814\u7a76\u8868\u660e\uff1a\u7531\u4e00\u79cd\u4e0d\u5bf9\u79f0\u915e\u83c1\u7ec4\u88c5\u800c\u6210\u7684\u7eb3\u7c73\u7ed3\u6784\uff08NanoPcA\uff09\uff0c\u53ef\u4ee5\u901a\u8fc7I\u578b\u673a\u5236\u6709\u6548\u5730\u4ea7\u751fROS\u3002\u8fd9\u79cd\u65b0\u578b\u7eb3\u7c73\u5149\u654f\u5242\u5bf9\u5e38\u89c1\u548c\u5177\u6709\u6297\u751f\u7d20\u6297\u6027\u7684\u7ec6\u83cc\u83cc\u682a\u90fd\u663e\u793a\u51fa\u4f18\u5f02\u7684\u5149\u52a8\u529b\u6297\u83cc\u6d3b\u6027\u3002NanoPcA\u8bbe\u8ba1\u7406\u5ff5\u53ef\u4ee5\u6269\u5c55\u5230\u5176\u4ed6\u5206\u5b50\u7ec4\u88c5\u4f53\uff0c\u7528\u4ee5\u521b\u5efa\u5177\u6709\u53ef\u8c03\u8282\u6297\u83cc\u6d3b\u6027\u7684\u5149\u654f\u5242\u3002\u6b64\u5916\uff0c\u56e0\u4e3a\u5b83\u662f\u901a\u8fc7\u4fc3\u8fdb\u72ec\u7279\u7684I\u578b\u5149\u53cd\u5e94\u6765\u8d77\u4f5c\u7528\uff0c\u6240\u4ee5\u8fd9\u79cd\u7eb3\u7c73PS\u53ef\u80fd\u4e5f\u9002\u7528\u4e8e\u4e4f\u6c27\u80bf\u7624PDT\u6cbb\u7597\u3002<\/p>\n \u6587\u732e\u94fe\u63a5\uff1a<\/strong>Phthalocyanine-Assembled Nanodots as Photosensitizers for Highly Efficient Type I Photoreactions in Photodynamic Therapy<\/a>\uff08Angew. Chem. Int. Ed., 2018<\/strong>, DOI: 10.1002\/anie.201806551\uff09<\/p>\n \u672c\u6587\u7531\u6750\u6599\u4eba\u751f\u7269\u6750\u6599\u7ec4\u5c0f\u80d6\u7eb8\u7f16\u8bd1<\/strong>\u3002<\/p>\n \u6750\u6599\u725b\u7f51\u662f\u4e13\u6ce8\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u53ca\u884c\u4e1a\u8fdb\u5c55\uff0c\u8fd9\u91cc\u6c47\u96c6\u4e86\u5404\u5927\u9ad8\u6821\u7855\u535a\u751f\u3001\u4e00\u7ebf\u79d1\u7814\u4eba\u5458\u4ee5\u53ca\u884c\u4e1a\u4ece\u4e1a\u8005\uff0c\u5982\u679c\u60a8\u5bf9\u4e8e\u8ddf\u8e2a\u6750\u6599\u9886\u57df\u79d1\u6280\u8fdb\u5c55\uff0c\u89e3\u8bfb\u9ad8\u6c34\u5e73\u6587\u7ae0\u6216\u662f\u8bc4\u8ff0\u884c\u4e1a\u6709\u5174\u8da3\uff0c\u70b9\u6211\u52a0\u5165\u6750\u6599\u4eba\u7f16\u8f91\u90e8<\/a>\u3002<\/p>\n \u6b22\u8fce\u5927\u5bb6\u5230\u6750\u6599\u4eba\u5ba3\u4f20\u79d1\u6280\u6210\u679c\u5e76\u5bf9\u6587\u732e\u8fdb\u884c\u6df1\u5165\u89e3\u8bfb\uff0c\u6295\u7a3f\u90ae\u7bb1tougao@cailiaoren.com.<\/p>\n \u6295\u7a3f\u4ee5\u53ca\u5185\u5bb9\u5408\u4f5c\u53ef\u52a0\u7f16\u8f91\u5fae\u4fe1\uff1acailiaokefu.<\/p>\n<\/strong><\/p>\n
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